Gene: AKAP2

11217
AKAP-2|AKAPKL|MISP2|PRKA2
A-kinase anchoring protein 2
protein-coding
9q31.3
Ensembl:ENSG00000241978 MIM:604582 Vega:OTTHUMG00000156811 UniprotKB:Q9Y2D5
NG_028265.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.583e-2 (AD)  5.719e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10125067chr9:110171501 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCTD100.826
MBD20.807
VMP10.799
ARF60.796
CORO1C0.796
HAUS20.789
RBMS10.789
TPM40.789
NUP980.786
CAST0.785

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.478
OR4F5-0.46
DIAPH3-0.392
NXNL1-0.316
PPP1R3G-0.314
BTBD17-0.305
ARSF-0.302
KCNJ16-0.294
HES5-0.293
WNT7B-0.283

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of AKAP2 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AKAP2 mRNA"19114083
C496492abrineabrine results in increased expression of AKAP2 mRNA22595364
D000082AcetaminophenAcetaminophen affects the expression of AKAP2 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of AKAP2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AKAP2 mRNA19770486
D001151ArsenicArsenic affects the methylation of AKAP2 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AKAP2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AKAP2 mRNA19770486
D004958EstradiolEstradiol results in decreased expression of AKAP2 mRNA19484750
D004958EstradiolEstradiol results in decreased expression of AKAP2 mRNA20068009
C006780bisphenol Abisphenol A results in increased expression of AKAP2 mRNA25181051|2717856
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AKAP2 mRNA28628672
C013418bromfenacoumbromfenacoum results in decreased expression of AKAP2 protein28903499
D000074262Canola OilCanola Oil metabolite results in decreased expression of AKAP2 mRNA27363782
D002737ChloropreneChloroprene results in increased expression of AKAP2 mRNA23125180
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of AKAP2 mRNA16197558
D016572CyclosporineCyclosporine results in decreased expression of AKAP2 mRNA19770486
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AKAP2 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of AKAP2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of AKAP2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of AKAP2 mRNA19561079|2739243
D004041Dietary FatsDietary Fats results in increased expression of AKAP2 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of AKAP2 mRNA]19030233
D004041Dietary FatsDietary Fats results in increased expression of AKAP2 mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of AKAP2 mRNA]21852083
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of AKAP2 mRNA27614199
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of AKAP2 protein23301498
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AKAP2 mRNA17942748
C082360fipronilfipronil results in increased expression of AKAP2 mRNA23962444
D005485FlutamideFlutamide results in decreased expression of AKAP2 mRNA24793618
C069837fullerene C60fullerene C60 results in increased expression of AKAP2 mRNA19167457
D005839GentamicinsGentamicins results in decreased expression of AKAP2 mRNA22061828
D017313FenretinideFenretinide results in increased expression of AKAP2 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AKAP2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AKAP2 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of AKAP2 mRNA27392435
C045463leflunomideleflunomide results in increased expression of AKAP2 mRNA28988120
D008713MethimazoleMethimazole results in increased expression of AKAP2 mRNA22504374
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of AKAP2 mRNA28001369
C523799MRK 003AKAP2 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of AKAP2 protein"21135415
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of AKAP2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AKAP2 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of AKAP2 mRNA19812364
C028007nickel monoxidenickel monoxide results in increased expression of AKAP2 mRNA19167457
D010634PhenobarbitalPhenobarbital affects the expression of AKAP2 mRNA23091169
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of AKAP2 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of AKAP2 mRNA25270620
C006253pirinixic acidpirinixic acid results in increased expression of AKAP2 mRNA23811191
D011441PropylthiouracilPropylthiouracil results in increased expression of AKAP2 mRNA22504374
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of AKAP2 mRNA]21852083
C089032rimonabantrimonabant affects the expression of AKAP2 mRNA19030233
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of AKAP2 mRNA]19030233
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of AKAP2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of AKAP2 mRNA23221170
D012969Sodium FluorideSodium Fluoride results in decreased expression of AKAP2 mRNA27862939
D012999SomanSoman results in increased expression of AKAP2 mRNA19281266
D053260SootSoot results in increased expression of AKAP2 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AKAP2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AKAP2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AKAP2 mRNA19770486|2527062
C009495titanium dioxidetitanium dioxide affects the expression of AKAP2 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of AKAP2 mRNA16604517
C012589trichostatin Atrichostatin A results in increased expression of AKAP2 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of AKAP2 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of AKAP2 mRNA19101580|2493525
D014635Valproic AcidValproic Acid results in increased methylation of AKAP2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of AKAP2 gene25560391
C025643vinclozolinvinclozolin affects the expression of AKAP2 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of AKAP2 mRNA23034163
C111237vorinostatvorinostat results in increased expression of AKAP2 mRNA18769122

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0051018protein kinase A binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007015actin filament organization-IEA-  
GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway-IEA-  
GO:0008104protein localization-IEA-  
GO:0023052signaling-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal