Gene: PADI2

11240
PAD-H19|PAD2|PDI2
peptidyl arginine deiminase 2
protein-coding
1p36.13
Ensembl:ENSG00000117115 MIM:607935 Vega:OTTHUMG00000002295 UniprotKB:Q9Y2J8
NG_033958.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.731e-1 (AD)  3.963e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GM2A0.862
PREX10.854
C1orf1980.854
MTMR100.843
QKI0.841
VAMP30.83
FGFR20.825
MYO60.824
GSN0.815
DOCK10.813

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAQR9-0.482
OR4F29-0.452
KCNH5-0.448
WNT2-0.447
TPBG-0.443
MYOZ3-0.436
RTP1-0.435
OPRD1-0.433
ANKRD34C-0.433
PRSS12-0.425

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00155L-CitrullineSmall Molecule372-75-8Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PADI2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PADI2 mRNA"27188386
C0757734-phenylbutyric acid4-phenylbutyric acid results in decreased expression of PADI2 mRNA28698385
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PADI2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PADI2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PADI2 gene27153756
D000447AldehydesAldehydes results in increased expression of PADI2 mRNA25014914
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of PADI2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PADI2 mRNA16483693
D004958EstradiolEstradiol results in increased expression of PADI2 mRNA21185374
D004958EstradiolEstradiol results in increased expression of PADI2 mRNA15289156|1948475
C006780bisphenol Abisphenol A results in increased expression of PADI2 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of PADI2 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of PADI2 mRNA26496021
C013418bromfenacoumbromfenacoum results in increased expression of PADI2 protein28903499
C018475butyraldehydebutyraldehyde results in increased expression of PADI2 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PADI2 mRNA16239168
C016366dibenzothiophenedibenzothiophene results in decreased expression of PADI2 mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PADI2 mRNA21266533
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PADI2 mRNA15289156
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PADI2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PADI2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PADI2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PADI2 mRNA12655037|1583489
D0150732-AcetylaminofluoreneTRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PADI2 mRNA]17317680
D005485FlutamideFlutamide results in increased expression of PADI2 mRNA21525395
D004397FonofosFonofos results in increased methylation of PADI2 promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of PADI2 mRNA28937961
C039281furanfuran results in increased expression of PADI2 mRNA27387713
D019833GenisteinGenistein results in increased expression of PADI2 mRNA15289156
C412815GW 4064GW 4064 results in increased expression of PADI2 mRNA26655953
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PADI2 mRNA25613284
C544151jinfukangjinfukang results in increased expression of PADI2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PADI2 mRNA26752646
D007657Ketone BodiesKetone Bodies results in decreased expression of PADI2 mRNA16807920
D007854LeadLead affects the expression of PADI2 mRNA28903495
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PADI2 mRNA21641980
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PADI2 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PADI2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PADI2 mRNA"25554681
D009532NickelNickel results in decreased expression of PADI2 mRNA25583101
D010100OxygenOxygen deficiency results in increased expression of PADI2 mRNA26516004
D017239PaclitaxelPaclitaxel results in decreased expression of PADI2 protein15907983
D010278ParathionParathion results in increased methylation of PADI2 promoter22847954
D010416PentachlorophenolPentachlorophenol results in decreased expression of PADI2 protein20732397
C046012pentanalpentanal results in increased expression of PADI2 mRNA26079696
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PADI2 mRNA19710929
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PADI2 mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of PADI2 mRNA22238285
C005556propionaldehydepropionaldehyde results in increased expression of PADI2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of PADI2 mRNA24780913
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of PADI2 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PADI2 mRNA25895662
D012906SmokeSmoke results in decreased expression of PADI2 mRNA21095227
D012969Sodium FluorideSodium Fluoride results in increased expression of PADI2 protein28918527
C559087SR 1078SR 1078 results in increased expression of PADI2 mRNA28698385
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PADI2 mRNA21641980
D013629TamoxifenTamoxifen affects the expression of PADI2 mRNA17555576
C012568terbufosterbufos results in increased methylation of PADI2 promoter22847954
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of PADI2 mRNA26496021
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PADI2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PADI2 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PADI2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of PADI2 mRNA29128614
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PADI2 mRNA28065790
D014212TretinoinTretinoin results in increased expression of PADI2 mRNA15894607
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PADI2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PADI2 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of PADI2 mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PADI2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of PADI2 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of PADI2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PADI2 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of PADI2 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PADI2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of PADI2 mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004668protein-arginine deiminase activity-IBA21873635  
GO:0004668protein-arginine deiminase activity-IDA12392711  15629448  18645041  22853951  
GO:0005509calcium ion binding-IEA-  
GO:0030331estrogen receptor binding-IPI22853951  
GO ID GO Term Qualifier Evidence PubMed
GO:0010848regulation of chromatin disassembly-IDA22853951  
GO:0018101protein citrullination-IDA12392711  15629448  
GO:0021762substantia nigra development-HEP22926577  
GO:0030520intracellular estrogen receptor signaling pathway-IMP22853951  
GO:0036413histone H3-R26 citrullination-IDA22853951  
GO:0036414histone citrullination-IBA21873635  
GO:0043312neutrophil degranulation-TAS-  
GO:0048096chromatin-mediated maintenance of transcription-IMP22853951  
GO:0070100negative regulation of chemokine-mediated signaling pathway-IDA18645041  
GO:1901624negative regulation of lymphocyte chemotaxis-IDA18645041  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA12392711  
GO:0005829cytosol-TAS-  
GO:0035327transcriptionally active chromatin-IDA22853951  
GO:0035578azurophil granule lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29287593Upregulation of citrullination pathway: From Autoimmune to Idiopathic Lung Fibrosis. (2017 Dec 29)Samara KDRespir Res
21960546Peptidylarginine deiminases present in the airways during tobacco smoking and inflammation can citrullinate the host defense peptide LL-37, resulting in altered activities. (2012 Feb)Kilsgard OAm J Respir Cell Mol Biol