Gene: PMF1

11243
-
polyamine modulated factor 1
protein-coding
1q22
Ensembl:ENSG00000160783 MIM:609176 Vega:OTTHUMG00000177123 UniprotKB:Q6P1K2
NC_000001.11
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1052067chr1:156236330 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPE0.881
POLR2G0.881
PSMD90.878
MRPL430.873
GABARAP0.868
PGLS0.867
NELFE0.866
MRPL400.866
CHMP2A0.865
ATRAID0.864

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.727
OR4F29-0.706
RAX2-0.258
MOGAT2-0.227
MTRNR2L6-0.22
EPPIN-0.217
SIX4-0.206
MTRNR2L9-0.204
RAB39A-0.2
MUC15-0.196

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PMF1 mRNA"18648102
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of PMF1 mRNA21298039
D001151ArsenicArsenic affects the methylation of PMF1 gene25304211
D001280AtrazineAtrazine results in decreased expression of PMF1 mRNA22378314
C044887beta-methylcholinebeta-methylcholine affects the expression of PMF1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of PMF1 mRNA25181051
D002104CadmiumCadmium results in decreased expression of PMF1 mRNA23369406
D002251Carbon TetrachloridePLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PMF1 mRNA]16006527
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PMF1 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of PMF1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of PMF1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of PMF1 mRNA26577399
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PMF1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PMF1 mRNA17361019
D002945CisplatinCisplatin results in decreased expression of PMF1 mRNA22023808
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of PMF1 mRNA]15016801
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PMF1 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PMF1 gene20938992
D008727MethotrexateMethotrexate affects the expression of PMF1 mRNA18502557
C013598methoxyacetic acidmethoxyacetic acid results in decreased expression of PMF1 mRNA15103026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PMF1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PMF1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PMF1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PMF1 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PMF1 mRNA25729387
C006253pirinixic acidpirinixic acid results in increased expression of PMF1 mRNA18301758
C005556propionaldehydepropionaldehyde results in decreased expression of PMF1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of PMF1 mRNA24780913
C016104sodium bichromatesodium bichromate results in decreased expression of PMF1 mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of PMF1 mRNA22155349
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PMF1 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PMF1 mRNA19042947
D014520UrethaneUrethane results in decreased expression of PMF1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PMF1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PMF1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of PMF1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of PMF1 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of PMF1 mRNA19136453
C111237vorinostatvorinostat results in decreased expression of PMF1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-IMP11256947  
GO:0005515protein binding-IPI15371340  15502821  20360068  25416956  26496610  
GO:0043522leucine zipper domain binding-IPI11256947  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006366transcription by RNA polymerase II-TAS10419538  
GO:0007049cell cycle-IEA-  
GO:0007059chromosome segregation-IMP15502821  
GO:0051301cell division-IEA-  
GO:1903508positive regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000444MIS12/MIND type complex-IDA16585270  
GO:0000777condensed chromosome kinetochore-IDA15371340  
GO:0000818nuclear MIS12/MIND complex-IEA-  
GO:0005654nucleoplasm-IDA-  
GO:0005667transcription factor complex-TAS10419538  
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-TAS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-141424Amplification of signal from the kinetochoresTAS
R-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2500257Resolution of Sister Chromatid CohesionTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69618Mitotic Spindle CheckpointTAS
R-HSA-69620Cell Cycle CheckpointsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28346444Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility. (2017 May)Wright DJNat Genet
26670299Genetic risk factors for spontaneous intracerebral haemorrhage. (2016 Jan)Carpenter AMNat Rev Neurol