Gene: FILIP1L

11259
DOC-1|DOC1|GIP130|GIP90
filamin A interacting protein 1 like
protein-coding
3q12.1
Ensembl:ENSG00000168386 MIM:612993 Vega:OTTHUMG00000159055 UniprotKB:Q4L180
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.852e-1 (AD)  4.805e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRCH10.673
SEC24D0.648
SYNPO20.646
AKAP130.631
MFAP30.616
ARID3A0.611
CTTNBP2NL0.608
ATP8B10.607
STAT60.604
UHRF20.6

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEU4-0.406
HPDL-0.406
HES5-0.382
SOX3-0.381
C16orf74-0.381
RBP1-0.372
PIPOX-0.371
ZFHX4-AS1-0.369
C1orf61-0.367
BTBD17-0.367

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of FILIP1L mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FILIP1L mRNA"19167446
C0261142-xylene2-xylene results in increased expression of FILIP1L mRNA20359517
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FILIP1L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FILIP1L mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FILIP1L mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of FILIP1L mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of FILIP1L mRNA17562736
D000111AcetylcysteineAcetylcysteine results in decreased expression of FILIP1L mRNA16084531
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FILIP1L gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FILIP1L mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FILIP1L mRNA19770486
D000667AmpicillinAmpicillin results in increased expression of FILIP1L mRNA21632981
C015001arsenitearsenite affects the expression of FILIP1L mRNA22959463
D001374AzacitidineAzacitidine results in decreased expression of FILIP1L mRNA20823114
D001554BenzeneBenzene results in increased expression of FILIP1L mRNA20359517
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of FILIP1L mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FILIP1L mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FILIP1L mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FILIP1L mRNA"26238291
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of FILIP1L mRNA20823114
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FILIP1L mRNA19619570
D004958EstradiolEstradiol results in decreased expression of FILIP1L mRNA20106945
D004958EstradiolEstradiol results in increased expression of FILIP1L mRNA19619570
C006780bisphenol Abisphenol A results in decreased expression of FILIP1L mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FILIP1L mRNA19010381
D002110CaffeineCaffeine results in increased expression of FILIP1L mRNA20864626
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FILIP1L mRNA27339419
C018021cobaltous chloridecobaltous chloride results in decreased expression of FILIP1L mRNA24386269
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FILIP1L mRNA"19167446
D003474CurcuminCurcumin results in increased expression of FILIP1L mRNA21594647
D016572CyclosporineCyclosporine results in decreased expression of FILIP1L mRNA25562108|2798913
C014347decitabinedecitabine results in decreased methylation of FILIP1L gene27923600
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FILIP1L mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FILIP1L mRNA21266533
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of FILIP1L mRNA20823114
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of FILIP1L mRNA27392435
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of FILIP1L mRNA21658437
D002117CalcitriolCalcitriol results in decreased expression of FILIP1L mRNA26485663
D004237DiuronDiuron results in increased expression of FILIP1L mRNA21551480
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of FILIP1L mRNA16084531
C004912ethylbenzeneethylbenzene results in increased expression of FILIP1L mRNA20359517
D005472FluorouracilFILIP1L protein affects the susceptibility to Fluorouracil15352031
D005472FluorouracilFluorouracil results in increased expression of FILIP1L protein15352031
D007052IbuprofenIbuprofen results in decreased expression of FILIP1L mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of FILIP1L mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of FILIP1L mRNA27392435
C544151jinfukangjinfukang results in decreased expression of FILIP1L mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of FILIP1L mRNA23430699
C045463leflunomideleflunomide results in increased expression of FILIP1L mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of FILIP1L mRNA27339419
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of FILIP1L mRNA20823114
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of FILIP1L mRNA20864626
D008752Methylene ChlorideMethylene Chloride results in increased expression of FILIP1L mRNA20359517
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FILIP1L mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FILIP1L mRNA20864626
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of FILIP1L mRNA20864626
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of FILIP1L mRNA"25554681
C029938nickel sulfatenickel sulfate results in decreased expression of FILIP1L mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of FILIP1L mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of FILIP1L mRNA25729387
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of FILIP1L protein26879310
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FILIP1L mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FILIP1L mRNA26272509
D011374ProgesteroneProgesterone results in increased expression of FILIP1L mRNA21540246
D011374ProgesteroneProgesterone results in increased expression of FILIP1L mRNA19690047
D011794QuercetinQuercetin results in decreased expression of FILIP1L mRNA21632981
D015125OxyquinolineOxyquinoline results in increased expression of FILIP1L mRNA21632981
D012822Silicon DioxideSilicon Dioxide results in increased expression of FILIP1L mRNA25351596
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FILIP1L mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FILIP1L mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FILIP1L mRNA19619570|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FILIP1L mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FILIP1L mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FILIP1L mRNA21724226
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of FILIP1L mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of FILIP1L protein24648495
D013853ThioacetamideThioacetamide results in increased expression of FILIP1L mRNA23411599
D014050TolueneToluene results in increased expression of FILIP1L mRNA20359517
D014050TolueneToluene results in increased expression of FILIP1L mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of FILIP1L mRNA25729387
D019772TopotecanTopotecan results in increased expression of FILIP1L mRNA25729387
D014212TretinoinTretinoin results in increased expression of FILIP1L mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased expression of FILIP1L mRNA20359517
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of FILIP1L mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of FILIP1L mRNA20846491
D014635Valproic AcidValproic Acid affects the expression of FILIP1L mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FILIP1L mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of FILIP1L mRNA24383497|2800136
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in increased expression of FILIP1L mRNA]19225232
C088658zoledronic acidzoledronic acid results in decreased expression of FILIP1L mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IEA-  
GO:0016020membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23512105Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (2013 Jul)Beaty THHum Genet