Gene: SP140

11262
LYSP100|LYSP100-A|LYSP100-B
SP140 nuclear body protein
protein-coding
2q37.1
Ensembl:ENSG00000079263 MIM:608602 Vega:OTTHUMG00000153670 UniprotKB:Q13342
NG_051286.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.418e-1 (AD)  5.604e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDX60L0.844
SP140L0.817
TFEC0.806
IL150.805
ARHGAP150.805
MX20.799
SAMD90.797
RHOH0.796
SCIMP0.793
TLR30.788

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT7A-0.297
HRH3-0.283
MYADML2-0.282
WFDC1-0.277
KCNIP3-0.273
ZNF835-0.268
CPLX3-0.266
ARSF-0.263
SLC29A4-0.263
ADRA2C-0.259

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SP140 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SP140 mRNA"25380136
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SP140 mRNA24449571
C006780bisphenol Abisphenol A affects the methylation of SP140 promoter27334623
C018475butyraldehydebutyraldehyde results in increased expression of SP140 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SP140 mRNA26472689
D003471CuprizoneCuprizone results in increased expression of SP140 mRNA26577399
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SP140 mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of SP140 mRNA25016146
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of SP140 mRNA25380136
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of SP140 intron27776689
D004397FonofosFonofos results in increased methylation of SP140 promoter22847954
C544151jinfukangjinfukang results in increased expression of SP140 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SP140 mRNA23086925|2691137
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SP140 mRNA22235868
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of SP140 mRNA25926378
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of SP140 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SP140 mRNA"25554681
D009532NickelNickel results in increased expression of SP140 mRNA24768652|2558310
D017239PaclitaxelSP140 protein affects the susceptibility to Paclitaxel16217747
D010278ParathionParathion results in increased methylation of SP140 promoter22847954
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of SP140 mRNA21334430
C005556propionaldehydepropionaldehyde results in increased expression of SP140 mRNA26079696
D012834SilverSilver results in increased expression of SP140 mRNA27131904
D012999SomanSoman results in increased expression of SP140 mRNA19281266
C012568terbufosterbufos results in increased methylation of SP140 promoter22847954
D014212TretinoinTretinoin results in increased expression of SP140 mRNA23830798
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate affects the expression of SP140 mRNA"26179874

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-TAS8695863  
GO:0005515protein binding-IPI24267382  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006952defense response-TAS8910577  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-TAS8910577  
GO:0005635nuclear envelope-TAS8695863  
GO:0005654nucleoplasm-TAS8695863  
GO:0005739mitochondrion-IDA-  
GO:0016605PML body-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28816579Application of the distance-based F test in an mGWAS investigating beta diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci. (2018 Jan 2)Ruhlemann MCGut Microbes