Gene: DUSP12

11266
DUSP1|YVH1
dual specificity phosphatase 12
protein-coding
1q23.3
Ensembl:ENSG00000081721 MIM:604835 Vega:OTTHUMG00000034540 UniprotKB:Q9UNI6
NC_000001.11
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.226e-1 (AD)  1.786e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RSL24D10.931
PSMC60.914
PSMD70.913
GNL30.908
PSMA40.905
MRPS230.905
PSMA10.904
POLB0.903
TIMM17A0.902
MRPS350.9

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.606
OR4F29-0.569
P2RY14-0.333
GLI3-0.322
MTRNR2L10-0.311
MTRNR2L6-0.308
NHSL1-0.3
KCNK5-0.297
MTRNR2L9-0.293
PLIN4-0.293

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DUSP12 mRNA"19114083
D000082AcetaminophenAcetaminophen results in increased expression of DUSP12 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of DUSP12 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DUSP12 mRNA27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of DUSP12 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DUSP12 mRNA16483693
D000966Antimony Potassium TartrateAntimony Potassium Tartrate inhibits the reaction [BMP6 protein results in increased expression of DUSP12 mRNA]28713220
D001280AtrazineAtrazine results in increased expression of DUSP12 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DUSP12 mRNA20064835
C006780bisphenol Abisphenol A results in increased methylation of DUSP12 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of DUSP12 mRNA25181051
C059041calyculin Acalyculin A results in decreased expression of DUSP12 mRNA25270620
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of DUSP12 mRNA24763279
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of DUSP12 mRNA28472532
D002922CiguatoxinsCiguatoxins affects the expression of DUSP12 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in increased expression of DUSP12 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in increased expression of DUSP12 mRNA24386269
D016572CyclosporineCyclosporine results in increased expression of DUSP12 mRNA20106945
C089595cylindrospermopsincylindrospermopsin results in increased expression of DUSP12 mRNA24921660
C024629dimethyl phthalatedimethyl phthalate affects the expression of DUSP12 mRNA26924002
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DUSP12 mRNA17942748
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of DUSP12 mRNA24763279
C008261lead acetatelead acetate results in decreased expression of DUSP12 mRNA22641619
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of DUSP12 mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DUSP12 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DUSP12 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in decreased expression of DUSP12 mRNA29191790
C016030pantogabpantogab results in decreased expression of DUSP12 mRNA17379144
D012715Sesame OilSesame Oil results in increased expression of DUSP12 mRNA29191790
C017947sodium arsenitesodium arsenite inhibits the reaction [BMP6 protein results in increased expression of DUSP12 mRNA]28713220
C016104sodium bichromatesodium bichromate affects the expression of DUSP12 mRNA22110744
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DUSP12 mRNA17942748
D014635Valproic AcidValproic Acid affects the expression of DUSP12 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of DUSP12 gene29154799
D014635Valproic AcidValproic Acid affects the expression of DUSP12 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-IEA-  
GO:0004725protein tyrosine phosphatase activity-IEA-  
GO:0005515protein binding-IPI16189514  21516116  25416956  
GO:0008138protein tyrosine/serine/threonine phosphatase activity-IBA21873635  
GO:0008138protein tyrosine/serine/threonine phosphatase activity-IEA-  
GO:0008270zinc ion binding-IDA10446167  
GO:0016791phosphatase activity-IDA10446167  24531476  
GO:0019900kinase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006464cellular protein modification process-TAS10446167  
GO:0006470protein dephosphorylation-IBA21873635  
GO:0016311dephosphorylation-IDA10446167  24531476  
GO:0033133positive regulation of glucokinase activity-IBA21873635  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10446167  
GO:0005737cytoplasm-IDA10446167  
GO:0005829cytosol-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal