Gene: NRM

11270
NRM29
nurim
protein-coding
6p21.33
Ensembl:ENSG00000137404 Vega:OTTHUMG00000031223 UniprotKB:Q8IXM6
NC_000006.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2269705chr6:30689070 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FXYD50.844
NXN0.793
IFITM10.792
TCIRG10.791
TAGLN20.791
LTBR0.788
TGFB1I10.787
PKN30.787
GSDMD0.785
S100A110.781

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.511
PPEF1-0.511
MARCH4-0.485
CRH-0.477
HTR6-0.474
ABCC12-0.474
AARD-0.47
GRIN3A-0.467
ADRA1D-0.462
GPR61-0.462

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of NRM mRNA19933214
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of NRM mRNA"19167446
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NRM mRNA"23196670
D000393Air PollutantsAir Pollutants analog results in decreased expression of NRM mRNA21757418
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of NRM mRNA"22863853
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of NRM mRNA25566086
C006780bisphenol Abisphenol A affects the expression of NRM mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of NRM mRNA25979313
D002509CephaloridineCephaloridine results in increased expression of NRM mRNA18500788
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of NRM20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NRM gene20938992
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of NRM mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of NRM mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of NRM mRNA19167446
D003471CuprizoneCuprizone results in increased expression of NRM mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of NRM mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NRM mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NRM mRNA21266533
D002117CalcitriolCalcitriol results in decreased expression of NRM mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of NRM mRNA21592394
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NRM mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NRM mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NRM mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of NRM20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NRM gene20938992
D017313FenretinideFenretinide results in decreased expression of NRM mRNA28973697
D007213IndomethacinIndomethacin results in decreased expression of NRM mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NRM mRNA25613284
C544151jinfukangjinfukang results in increased expression of NRM mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NRM mRNA24796395
C410337K 7174K 7174 results in decreased expression of NRM mRNA24086573
C045463leflunomideleflunomide results in decreased expression of NRM mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of NRM mRNA"24972896
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of NRM mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of NRM mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of NRM20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NRM gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NRM mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of NRM promoter"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NRM mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NRM mRNA"25554681
D010269ParaquatParaquat results in decreased expression of NRM mRNA15458575
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of NRM mRNA26678675
D010634PhenobarbitalPhenobarbital affects the expression of NRM mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NRM mRNA19710929
D011205Povidone[Silver analog co-treated with Povidone] results in decreased expression of NRM mRNA25194297
D011374ProgesteroneProgesterone results in decreased expression of NRM mRNA23012394
D011441PropylthiouracilPropylthiouracil results in increased expression of NRM mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of NRM mRNA19167446
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of NRM mRNA19564919
D012834Silver[Silver analog co-treated with Povidone] results in decreased expression of NRM mRNA25194297
D012969Sodium FluorideSodium Fluoride results in increased expression of NRM mRNA27862939
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of NRM mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of NRM mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of NRM mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of NRM mRNA21592394
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of NRM mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NRM mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NRM mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NRM mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NRM mRNA19933214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NRM mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of NRM mRNA27188386
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NRM mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of NRM mRNA22378314
C029297vinylidene chloridevinylidene chloride results in increased expression of NRM mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-IDA10402458  
GO:0005637nuclear inner membrane-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0031965nuclear membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal