Gene: USP18

11274
ISG43|PTORCH2|UBP43
ubiquitin specific peptidase 18
protein-coding
22q11.21
Ensembl:ENSG00000184979 MIM:607057 Vega:OTTHUMG00000150104 UniprotKB:Q9UMW8
NC_000022.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.941e-1 (AD)  2.754e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OASL0.908
OAS30.902
IFIH10.898
OAS10.886
IFIT30.882
DDX60L0.876
DDX580.874
RSAD20.872
OAS20.868
RTP40.849

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFTPC-0.203
PROC-0.182
MYADML2-0.179
OR4F29-0.177
OR4F5-0.173
SPRR2G-0.172
FIBCD1-0.172
PNMA6A-0.168
RHO-0.166
CYP1A2-0.159

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of USP18 mRNA"23146750
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of USP18 mRNA"21346803
C0261142-xylene2-xylene results in increased expression of USP18 mRNA20359517
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of USP18 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of USP18 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of USP18 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of USP18 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of USP18 mRNA29067470
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of USP18 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of USP18 mRNA]17585979
D000497AlloysAlloys results in increased expression of USP18 mRNA23499988
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of USP18 mRNA26377693
D001554BenzeneBenzene results in increased expression of USP18 mRNA20359517
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of USP18 mRNA20713471
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of USP18 mRNA23735875
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of USP18 mRNA19619570
D004958EstradiolEstradiol results in increased expression of USP18 mRNA19619570|2118537
D004958EstradiolEstradiol results in increased expression of USP18 mRNA19484750
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of USP18 mRNA28628672
C006780bisphenol Abisphenol A results in decreased methylation of USP18 promoter27312807
C006780bisphenol Abisphenol A affects the methylation of USP18 promoter27415467
C006780bisphenol Abisphenol A results in increased expression of USP18 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of USP18 mRNA15003993
D019256Cadmium ChlorideCadmium Chloride results in increased expression of USP18 mRNA25993096
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of USP18 promoter22457795
D002737ChloropreneChloroprene results in decreased expression of USP18 mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of USP18 mRNA28472532
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of USP18 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of USP18 mRNA23811191
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of USP18 mRNA]17585979
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of USP18 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of USP18 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of USP18 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of USP18 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of USP18 mRNA22147139
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of USP18 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of USP18 mRNA27392435
D002945CisplatinCisplatin results in increased expression of USP18 mRNA27392435
D002945CisplatinUSP18 protein results in decreased susceptibility to Cisplatin22752428
D004041Dietary FatsDietary Fats affects the expression of USP18 mRNA17086191|1968055
D004041Dietary FatsDietary Fats results in decreased expression of USP18 mRNA18042831
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats affects the expression of USP18 mRNA]17086191
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of USP18 mRNA27405655
C014476diethyl maleatediethyl maleate results in decreased expression of USP18 mRNA21161181
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of USP18 mRNA17602206
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of USP18 mRNA21658437
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of USP18 mRNA19647056
C004912ethylbenzeneethylbenzene results in increased expression of USP18 mRNA20359517
D005485FlutamideFlutamide results in increased expression of USP18 mRNA24136188
C056933fumonisin B1fumonisin B1 results in increased expression of USP18 mRNA16221962
C007834genipingenipin inhibits the reaction [Lipopolysaccharides results in increased expression of USP18 mRNA]22687549
C412815GW 4064GW 4064 results in decreased expression of USP18 mRNA26655953
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of USP18 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of USP18 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of USP18 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of USP18 mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of USP18 mRNA]25890327
C008261lead acetatelead acetate results in decreased expression of USP18 mRNA22641619
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of USP18 mRNA"24972896
D008070Lipopolysaccharidesgenipin inhibits the reaction [Lipopolysaccharides results in increased expression of USP18 mRNA]22687549
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of USP18 mRNA]25890327
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of USP18 mRNA22687549|2589032
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of USP18 mRNA21641980
D008345ManganeseManganese results in increased expression of USP18 mRNA23499988
D008727MethotrexateMethotrexate affects the expression of USP18 mRNA18502557
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of USP18 mRNA20713471
D008752Methylene ChlorideMethylene Chloride results in increased expression of USP18 mRNA20359517
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of USP18 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of USP18 mRNA"20188158
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of USP18 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of USP18 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of USP18 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of USP18 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of USP18 mRNA"25554681
D009532NickelNickel results in increased expression of USP18 mRNA24768652
C029938nickel sulfatenickel sulfate results in increased expression of USP18 mRNA22714537
D009966OrphenadrineOrphenadrine affects the expression of USP18 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of USP18 mRNA25729387
D010081OxazoloneOxazolone results in increased expression of USP18 mRNA19647056
D000073878Palm OilPalm Oil affects the expression of USP18 mRNA19680557
D000073878Palm OilPalm Oil results in decreased expression of USP18 mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of USP18 mRNA23892564
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of USP18 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of USP18 mRNA19482888
D010936Plant ExtractsPlant Extracts results in increased expression of USP18 mRNA21297082
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of USP18 mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of USP18 mRNA19690047
C045950propiconazolepropiconazole results in increased expression of USP18 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of USP18 mRNA24780913
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats affects the expression of USP18 mRNA]17086191
D012834SilverSilver affects the expression of USP18 mRNA27131904
C017947sodium arsenitesodium arsenite affects the expression of USP18 mRNA22058191
D012999SomanSoman results in increased expression of USP18 mRNA19281266
D053260SootSoot results in decreased expression of USP18 mRNA22461453
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of USP18 mRNA21641980
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of USP18 mRNA"26680231
C013698tallowtallow affects the expression of USP18 mRNA19680557
D013629TamoxifenTamoxifen affects the expression of USP18 mRNA20937368
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of USP18 mRNA27914987
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of USP18 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of USP18 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of USP18 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of USP18 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of USP18 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of USP18 mRNA21889950|2629044
D013853ThioacetamideThioacetamide results in decreased expression of USP18 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of USP18 mRNA23557971|2776080
C479163tofacitinibtofacitinib results in decreased expression of USP18 mRNA25487280
D014050TolueneToluene results in increased expression of USP18 mRNA20359517|2824598
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of USP18 mRNA"19647056
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of USP18 mRNA25729387
D019772TopotecanTopotecan results in increased expression of USP18 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of USP18 mRNA16249480|2372400
D014212TretinoinTretinoin results in increased expression of USP18 mRNA20935222
D014212TretinoinTretinoin results in increased expression of USP18 protein20935222
D014212TretinoinUSP18 protein affects the susceptibility to Tretinoin20935222
D014212TretinoinTretinoin results in increased expression of USP18 mRNA20935222
D014212TretinoinUSP18 protein results in decreased susceptibility to Tretinoin22752428
D014241TrichloroethyleneTrichloroethylene results in increased expression of USP18 mRNA20359517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of USP18 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of USP18 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of USP18 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of USP18 mRNA28001369
D014638VanadatesVanadates results in decreased expression of USP18 mRNA22714537
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of USP18 mRNA20370541
D015032ZincZinc deficiency results in increased expression of USP18 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004197cysteine-type endopeptidase activity-IBA21873635  
GO:0004843thiol-dependent ubiquitin-specific protease activity-IBA21873635  
GO:0004843thiol-dependent ubiquitin-specific protease activity-TAS10777664  
GO:0005515protein binding-IPI16189514  16710296  25307056  25416956  
GO:0019785ISG15-specific protease activity-EXP11788588  
GO:0036459thiol-dependent ubiquitinyl hydrolase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006511ubiquitin-dependent protein catabolic process-IEA-  
GO:0016579protein deubiquitination-IBA21873635  
GO:0016579protein deubiquitination-TAS-  
GO:0031647regulation of protein stability-IBA21873635  
GO:0050727regulation of inflammatory response-IMP27325888  
GO:0060338regulation of type I interferon-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1169408ISG15 antiviral mechanismTAS
R-HSA-1169410Antiviral mechanism by IFN-stimulated genesTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-912694Regulation of IFNA signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25110502Effects of smoking cessation on gene expression in human leukocytes of chronic smoker. (2014 Jul)Kim SJPsychiatry Investig