Gene: IL17F

112744
CANDF6|IL-17F|ML-1|ML1
interleukin 17F
protein-coding
6p12.2
Ensembl:ENSG00000112116 MIM:606496 Vega:OTTHUMG00000014845 UniprotKB:Q96PD4
NG_031869.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.532e-1 (AD)  2.797e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PNMA6A0.385
HDAC100.358
FOXO60.347
SLC22A18AS0.339
CD520.337
F2RL30.336
SLC10A30.335
ZNF6280.334
SPTBN50.333
BARX20.325

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL1-0.25
PROKR1-0.243
KRT1-0.24
ASB4-0.238
KRT2-0.23
ANGPTL1-0.229
TNNI1-0.228
RBMS3-0.226
HIST2H4A-0.226
MFAP5-0.22

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of IL17F mRNA"27291303
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of IL17F mRNA"18648102
C0297284-phenylenediamine4-phenylenediamine results in increased expression of IL17F mRNA23445166
D039741Antigens, Dermatophagoides"[Antigens, Dermatophagoides co-treated with Particulate Matter] results in increased expression of IL17F protein"24060272
D039741Antigens, Dermatophagoides"[Antigens, Dermatophagoides co-treated with Vehicle Emissions] results in increased expression of IL17F protein"24060272
D001548Benzalkonium CompoundsBenzalkonium Compounds results in increased expression of IL17F mRNA23445166
C006780bisphenol Abisphenol A affects the expression of IL17F mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of IL17F mRNA26079696
C014347decitabinedecitabine results in increased expression of IL17F mRNA27915011
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of IL17F mRNA23445166
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in increased expression of IL17F mRNA24768708
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in increased expression of IL17F mRNA24768708
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17F mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IL17F mRNA26387944
D007840LatexLatex analog results in increased expression of IL17F mRNA24768652
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of IL17F mRNA"20188158
D009532NickelNickel results in increased expression of IL17F mRNA24768652
D010269ParaquatParaquat results in increased expression of IL17F mRNA22938100
D052638Particulate Matter"[Antigens, Dermatophagoides co-treated with Particulate Matter] results in increased expression of IL17F protein"24060272
D052638Particulate MatterParticulate Matter results in increased expression of IL17F20061214
D052638Particulate MatterParticulate Matter results in increased expression of IL17F protein24060272
D010476PerfumePerfume results in decreased expression of IL17F mRNA24768652
D015232Dinoprostone[Dinoprostone co-treated with IL23A] results in increased expression of IL17F19273625
D015232DinoprostoneDinoprostone promotes the reaction [[IL1B co-treated with IL23A] results in increased expression of IL17F]19273625
D015232DinoprostoneDinoprostone promotes the reaction [IL1B results in increased expression of IL17F]19273625
D010936Plant ExtractsPlant Extracts results in decreased expression of IL17F mRNA23557933
D012822Silicon DioxideSilicon Dioxide results in increased expression of IL17F mRNA20421647
D012834SilverSilver affects the expression of IL17F mRNA27131904
D019821SimvastatinSimvastatin results in decreased secretion of IL17F protein21856936
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17F mRNA25613284
D001335Vehicle Emissions"[Antigens, Dermatophagoides co-treated with Vehicle Emissions] results in increased expression of IL17F protein"24060272
D001335Vehicle EmissionsVehicle Emissions results in increased expression of IL17F protein24060272

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IDA11591732  
GO:0005126cytokine receptor binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0019955cytokine binding-IDA11574464  
GO:0042803protein homodimerization activity-IDA11574464  
GO ID GO Term Qualifier Evidence PubMed
GO:0006954inflammatory response-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0016525negative regulation of angiogenesis-IDA11591732  
GO:0017015regulation of transforming growth factor beta receptor signaling pathway-IDA11591732  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0042089cytokine biosynthetic process-IDA11591732  
GO:0042109lymphotoxin A biosynthetic process-IDA11591732  
GO:0045076regulation of interleukin-2 biosynthetic process-IDA11591732  
GO:0045408regulation of interleukin-6 biosynthetic process-IDA11574464  
GO:0045414regulation of interleukin-8 biosynthetic process-IDA11574464  
GO:0045423regulation of granulocyte macrophage colony-stimulating factor biosynthetic process-IDA11574464  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0051216cartilage development-IDA11574464  
GO:0097400interleukin-17-mediated signaling pathway-TAS-  
GO:1900017positive regulation of cytokine production involved in inflammatory response-IEA-  
GO:2000778positive regulation of interleukin-6 secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS11574464  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-448424Interleukin-17 signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28912468Cytokine-based Predictive Models to Estimate the Probability of Chronic Periodontitis: Development of Diagnostic Nomograms. (2017 Sep 14)Tomas ISci Rep
28631723Pharmacogenetic biomarkers of response in Crohn's disease. (2018 Jan)Linares-Pineda TMPharmacogenomics J
23036591Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis. (2012 Oct 4)Kazantseva MGArthritis Res Ther