Gene: KLHL2

11275
ABP-KELCH|MAV|MAYVEN
kelch like family member 2
protein-coding
4q32.3
Ensembl:ENSG00000109466 MIM:605774 Vega:OTTHUMG00000161294 UniprotKB:O95198
NC_000004.12
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.242e-1 (AD)  8.079e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12513327chr4:165224668 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLG10.885
ZFR0.877
FAM122B0.874
ARHGAP210.873
SERINC10.87
NAP1L10.869
RABEP10.869
DNAJC210.867
IGIP0.862
FSD1L0.86

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.662
OR4F5-0.62
KCNK5-0.301
NXNL1-0.273
MTRNR2L10-0.266
GLI1-0.266
C17orf82-0.257
ADAMTSL5-0.256
SYPL2-0.255
RNF43-0.252

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of KLHL2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLHL2 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of KLHL2 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLHL2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KLHL2 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of KLHL2 mRNA24449571
C547126AZM551248AZM551248 results in decreased expression of KLHL2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KLHL2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KLHL2 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KLHL2 mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KLHL2 mRNA"19150397
D004958EstradiolEstradiol results in decreased expression of KLHL2 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of KLHL2 mRNA25181051
D003010ClorgylineClorgyline results in increased expression of KLHL2 mRNA19691856
C018021cobaltous chloridecobaltous chloride results in increased expression of KLHL2 mRNA19376846
D003471CuprizoneCuprizone results in decreased expression of KLHL2 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of KLHL2 mRNA27989131
D004041Dietary FatsDietary Fats results in decreased expression of KLHL2 mRNA18042831
D004317DoxorubicinDoxorubicin results in increased expression of KLHL2 mRNA25896364
D005485FlutamideFlutamide results in increased expression of KLHL2 mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of KLHL2 mRNA22634610
D017313FenretinideFenretinide results in decreased expression of KLHL2 mRNA28973697
D007545IsoproterenolIsoproterenol results in increased expression of KLHL2 mRNA20003209
D007657Ketone BodiesKetone Bodies results in increased expression of KLHL2 mRNA16807920
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of KLHL2 mRNA26011545
C008493methylselenic acidmethylselenic acid affects the expression of KLHL2 mRNA14617803
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of KLHL2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KLHL2 mRNA"25554681
D009532NickelNickel results in increased expression of KLHL2 mRNA12540486
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of KLHL2 mRNA25729387
D010126Ozonepyrazolanthrone inhibits the reaction [Ozone results in increased expression of KLHL2 mRNA]17460151
D000073878Palm OilPalm Oil results in decreased expression of KLHL2 mRNA18042831
D010672PhenytoinPhenytoin results in increased expression of KLHL2 mRNA20345932
C006253pirinixic acidpirinixic acid results in increased expression of KLHL2 mRNA17426115
C045950propiconazolepropiconazole results in decreased expression of KLHL2 mRNA21278054
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Ozone results in increased expression of KLHL2 mRNA]17460151
D011794QuercetinQuercetin results in decreased expression of KLHL2 mRNA21632981
D053260SootSoot results in increased expression of KLHL2 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KLHL2 mRNA20106945|2163298
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of KLHL2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KLHL2 mRNA21215274
C009495titanium dioxidetitanium dioxide results in increased expression of KLHL2 mRNA27760801
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of KLHL2 mRNA25729387
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLHL2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of KLHL2 mRNA26272509
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of KLHL2 mRNA"26179874
D014520UrethaneUrethane results in increased expression of KLHL2 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of KLHL2 mRNA23179753|2519280

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IDA10397770  
GO:0005515protein binding-IPI16189514  21516116  21784977  25416956  25910212  27107014  
GO:0042802identical protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0016567protein ubiquitination-ISS-  
GO:0043687post-translational protein modification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-IEA-  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-TAS-  
GO:0015629actin cytoskeleton-IDA10397770  
GO:0030027lamellipodium-IEA-  
GO:0031463Cul3-RING ubiquitin ligase complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal