Gene: TREX1

11277
AGS1|CRV|DRN3|HERNS
three prime repair exonuclease 1
protein-coding
3p21.31
Ensembl:ENSG00000213689 MIM:606609 Vega:OTTHUMG00000190127 UniprotKB:Q9NSU2
NG_009820.2
PubMed
0   ANCO-SNPs
ND
1   
3.744e-1 (AD)  9.924e-1 (ND)   (Frontal_Cortex)
9.406e-1 (AD)  6.842e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09882118chr3:48508272TREX14.490e-9Maternal smoking in pregnancy27040690
cg21788755chr3:48508391TREX12.500e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PMF10.741
HMGCL0.736
G6PC30.733
SHARPIN0.732
TMEM1290.725
DHX580.72
IDH20.719
TRAPPC6A0.712
ORMDL30.711
ZFPL10.71

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.521
OR4F29-0.507
BEND4-0.271
FER1L6-0.264
MTRNR2L9-0.254
RAB39A-0.247
UNC45B-0.245
MUC15-0.244
MTRNR2L6-0.242
SPRR4-0.236

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TREX1 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TREX1 mRNA"27188386
C0067574-biphenylamine4-biphenylamine results in decreased expression of TREX1 mRNA24857880
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TREX1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of TREX1 mRNA17562736
D000638AmiodaroneAmiodarone results in increased expression of TREX1 mRNA19774075
D000661AmphetamineAmphetamine results in increased expression of TREX1 mRNA20298760
D000661AmphetamineAmphetamine results in increased expression of TREX1 protein20298760
D000661Amphetamineeticlopride inhibits the reaction [Amphetamine results in increased expression of TREX1 mRNA]20298760
D000661Amphetamineeticlopride inhibits the reaction [Amphetamine results in increased expression of TREX1 protein]20298760
D000661AmphetamineMifepristone inhibits the reaction [Amphetamine results in increased expression of TREX1 mRNA]20298760
C072019benzo(a)pyrene diolepoxide Ibenzo(a)pyrene diolepoxide I results in increased expression of TREX1 mRNA27694624
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TREX1 mRNA20511593|2769462
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TREX1 protein20511593
D001564Benzo(a)pyreneBenzo(a)pyrene affects the localization of TREX1 protein20511593
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to TREX1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TREX1 mRNA20511593
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TREX1 protein20511593
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TREX1 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of TREX1 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of TREX1 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of TREX1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TREX1 gene28505145
C546611brevetoxin 2brevetoxin 2 results in increased expression of TREX1 mRNA20498034
C016274bromoacetatebromoacetate results in decreased expression of TREX1 mRNA19753638
D002330CarmustineCarmustine results in increased expression of TREX1 mRNA23578789
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TREX1 mRNA25270620
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TREX1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of TREX1 mRNA26272509
D002994ClofibrateClofibrate results in decreased expression of TREX1 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in decreased expression of TREX1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of TREX1 mRNA19549813
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of TREX1 mRNA21878529
C017160cypermethrincypermethrin results in increased expression of TREX1 mRNA21142847
D003976DiazinonDiazinon results in increased methylation of TREX1 gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TREX1 mRNA27392435
D002117CalcitriolCalcitriol results in decreased expression of TREX1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of TREX1 mRNA21592394
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of TREX1 mRNA21893156
C045989eticloprideeticlopride inhibits the reaction [Amphetamine results in increased expression of TREX1 mRNA]20298760
C045989eticloprideeticlopride inhibits the reaction [Amphetamine results in increased expression of TREX1 protein]20298760
D005485FlutamideFlutamide results in increased expression of TREX1 mRNA24136188
C054368fotemustineFOS mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]23578789
C054368fotemustinefotemustine promotes the reaction [JUN protein binds to TREX1 promoter]23578789
C054368fotemustinefotemustine results in increased expression of TREX1 mRNA23578789
C054368fotemustinefotemustine results in increased expression of TREX1 protein23578789
C054368fotemustineJUN mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]23578789
C054368fotemustineTREX1 affects the susceptibility to fotemustine23578789
C007834genipingenipin inhibits the reaction [Lipopolysaccharides results in increased expression of TREX1 mRNA]22687549
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of TREX1 mRNA20511593
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of TREX1 protein20511593
C056493imiquimodimiquimod results in increased expression of TREX1 mRNA21878529
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TREX1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of TREX1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of TREX1 mRNA]25890327
D008070Lipopolysaccharidesgenipin inhibits the reaction [Lipopolysaccharides results in increased expression of TREX1 mRNA]22687549
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of TREX1 mRNA]25890327
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TREX1 mRNA22687549|2589032
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TREX1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TREX1 mRNA26378955
D015735MifepristoneMifepristone inhibits the reaction [Amphetamine results in increased expression of TREX1 mRNA]20298760
C005246myristicinmyristicin results in decreased expression of TREX1 mRNA24792648
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TREX1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TREX1 mRNA"25554681
D015376NimustineFOS mutant form inhibits the reaction [Nimustine results in increased expression of TREX1 mRNA]23578789
D015376NimustineJUN mutant form inhibits the reaction [Nimustine results in increased expression of TREX1 mRNA]23578789
D015376NimustineNimustine promotes the reaction [JUN protein binds to TREX1 promoter]23578789
D015376NimustineNimustine results in increased expression of TREX1 mRNA23578789
D015376NimustineNimustine results in increased expression of TREX1 protein23578789
D015376NimustineTREX1 affects the susceptibility to Nimustine23578789
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of TREX1 mRNA25729387
D010081OxazoloneOxazolone results in increased expression of TREX1 mRNA21893156
D010416PentachlorophenolPentachlorophenol results in increased expression of TREX1 mRNA23892564
D010862PilocarpinePilocarpine results in increased expression of TREX1 mRNA17971868
D011441PropylthiouracilPropylthiouracil results in increased expression of TREX1 mRNA24780913
D019257QuinpiroleQuinpirole results in increased expression of TREX1 mRNA20298760
D012643SeleniumSelenium results in increased expression of TREX1 mRNA19244175
D012645SelenomethionineSelenomethionine affects the expression of TREX1 mRNA17222674
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TREX1 mRNA19073995
D012834SilverSilver results in decreased expression of TREX1 mRNA27131904
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TREX1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TREX1 mRNA26378955
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of TREX1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of TREX1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TREX1 mRNA21570461|2468072
D019772TopotecanFOS mutant form inhibits the reaction [Topotecan results in increased expression of TREX1 mRNA]23578789
D019772TopotecanJUN mutant form inhibits the reaction [Topotecan results in increased expression of TREX1 mRNA]23578789
D019772TopotecanTopotecan promotes the reaction [JUN protein binds to TREX1 promoter]23578789
D019772TopotecanTopotecan results in increased expression of TREX1 mRNA23578789
D019772TopotecanTopotecan results in increased expression of TREX1 protein23578789
D019772TopotecanTREX1 affects the susceptibility to Topotecan23578789
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of TREX1 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TREX1 mRNA21893156
D014635Valproic AcidValproic Acid affects the expression of TREX1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of TREX1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of TREX1 mRNA17963808
C034028vanadyl sulfatevanadyl sulfate results in increased expression of TREX1 mRNA16330358
D014640VancomycinVancomycin results in decreased expression of TREX1 mRNA18930951
D014750VincristineVincristine results in decreased expression of TREX1 mRNA23649840
D014810Vitamin EVitamin E results in decreased expression of TREX1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003697single-stranded DNA binding-TAS10391904  
GO:00082963'-5'-exodeoxyribonuclease activity-IBA21873635  
GO:00082963'-5'-exodeoxyribonuclease activity-ISS-  
GO:00084083'-5' exonuclease activity-IDA10391904  
GO:00084083'-5' exonuclease activity-TAS11278605  
GO:0008853exodeoxyribonuclease III activity-IEA-  
GO:0032405MutLalpha complex binding-IDA16713580  
GO:0032407MutSalpha complex binding-IDA16713580  
GO:0042803protein homodimerization activity-NAS10391904  
GO:0042803protein homodimerization activity-TAS11278605  
GO:0046872metal ion binding-NAS10391904  
GO:0046872metal ion binding-TAS11278605  
GO ID GO Term Qualifier Evidence PubMed
GO:0006259DNA metabolic process-ISS-  
GO:0006260DNA replication-NAS10391904  11278605  
GO:0006281DNA repair-TAS10393201  
GO:0006298mismatch repair-NAS10391904  11278605  
GO:0006310DNA recombination-NAS10391904  11278605  
GO:0032479regulation of type I interferon production-TAS-  
GO:0090305nucleic acid phosphodiester bond hydrolysis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-NAS10391904  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
hsa04623Cytosolic DNA-sensing pathway
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-1834941STING mediated induction of host immune responsesTAS
R-HSA-1834949Cytosolic sensors of pathogen-associated DNA TAS
R-HSA-3134975Regulation of innate immune responses to cytosolic DNATAS
R-HSA-3248023Regulation by TREX1TAS
R-HSA-3270619IRF3-mediated induction of type I IFNTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29380913Review: Vascular dementia: clinicopathologic and genetic considerations. (2018 Apr)Vinters HVNeuropathol Appl Neurobiol