Gene: KLF12

11278
AP-2rep|AP2REP|HSPC122
Kruppel like factor 12
protein-coding
13q22.1
Ensembl:ENSG00000118922 MIM:607531 Vega:OTTHUMG00000017078 UniprotKB:Q9Y4X4
NC_000013.11
PubMed|SNP Mapped
4   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.779e-1 (AD)  9.636e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs58598658chr13:73887726-73887733 (GRCh38.p7)dupA / dupAAalcohol dependenceIndel(Insertion and Deletion)
rs2875670chr13:73964931 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs9318238chr13:73963883 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs9318232chr13:73956142 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM170B0.866
NCOA20.866
PBX10.861
PUM20.851
NR3C20.847
FAM217B0.846
TCF40.843
NLGN4X0.842
NF10.841
PPP1R12A0.838

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.517
OR4F29-0.461
SFN-0.399
GNG8-0.387
ANXA13-0.385
TNFRSF12A-0.381
C9orf135-0.369
TFPI2-0.366
SNHG18-0.365
CSAG1-0.36

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of KLF12 mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KLF12 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of KLF12 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KLF12 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KLF12 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KLF12 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KLF12 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF12 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF12 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KLF12 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of KLF12 mRNA19770486
D001151ArsenicArsenic affects the methylation of KLF12 gene25304211
C015001arsenitearsenite results in increased methylation of KLF12 promoter23974009
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of KLF12 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KLF12 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KLF12 mRNA19770486
D004958EstradiolEstradiol results in decreased expression of KLF12 mRNA21795739
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of KLF12 mRNA26496021
C006780bisphenol Abisphenol A affects the methylation of KLF12 promoter27334623
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of KLF12 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of KLF12 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of KLF12 mRNA29097150
C018475butyraldehydebutyraldehyde results in decreased expression of KLF12 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of KLF12 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of KLF12 mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of KLF12 mRNA16934159
D002994ClofibrateClofibrate results in decreased expression of KLF12 mRNA25270620
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of KLF12 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of KLF12 mRNA19167446
C029892cupric chloridecupric chloride results in increased expression of KLF12 mRNA24650576
D016572CyclosporineCyclosporine results in decreased expression of KLF12 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of KLF12 mRNA19770486
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of KLF12 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of KLF12 mRNA27392435
C121718dicyclanildicyclanil results in decreased expression of KLF12 mRNA15664270
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of KLF12 mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of KLF12 mRNA]17942915
C118739entinostatentinostat results in decreased expression of KLF12 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KLF12 mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of KLF12 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of KLF12 mRNA23649840
C001277geldanamycingeldanamycin results in increased expression of KLF12 mRNA26705709
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of KLF12 mRNA25270620
D017313FenretinideFenretinide results in increased expression of KLF12 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KLF12 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of KLF12 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of KLF12 mRNA27392435
C045463leflunomideleflunomide results in decreased expression of KLF12 mRNA19751817
D008558MelphalanMelphalan results in decreased expression of KLF12 mRNA22363485
D008628MercuryMercury results in decreased expression of KLF12 mRNA19937285
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of KLF12 mRNA23179753
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of KLF12 mRNA23649840
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of KLF12 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of KLF12 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of KLF12 mRNA"25554681|2562005
C507134ON 01910ON 01910 results in increased expression of KLF12 mRNA22351695
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KLF12 mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the expression of KLF12 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KLF12 mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of KLF12 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of KLF12 mRNA20813756|2527062
C116926rofecoxibrofecoxib affects the expression of KLF12 mRNA17070997
D012643SeleniumSelenium results in increased expression of KLF12 mRNA17293063
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of KLF12 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of KLF12 mRNA23221170
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KLF12 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to KLF12 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KLF12 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLF12 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of KLF12 mRNA16979875
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KLF12 mRNA25613284
D013849ThimerosalThimerosal results in increased expression of KLF12 mRNA27188386
C009495titanium dioxidetitanium dioxide results in decreased expression of KLF12 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of KLF12 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of KLF12 mRNA20133372
D014212TretinoinTretinoin results in increased expression of KLF12 mRNA23724009
C057693troglitazonetroglitazone results in decreased expression of KLF12 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF12 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of KLF12 mRNA23179753|2597931
D014635Valproic AcidValproic Acid results in decreased expression of KLF12 mRNA24935251|2519280
D014635Valproic AcidValproic Acid results in increased expression of KLF12 mRNA24383497|2627250
D014638VanadatesVanadates results in increased expression of KLF12 mRNA22714537
D014640VancomycinVancomycin results in increased expression of KLF12 mRNA18930951
D014750VincristineVincristine results in decreased expression of KLF12 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of KLF12 mRNA26682919
C111237vorinostatvorinostat results in decreased expression of KLF12 mRNA27188386
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of KLF12 mRNA16979875

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IDA16615998  
GO:0003700DNA-binding transcription factor activity-IDA16615998  
GO:0003714transcription corepressor activity-TAS10704285  
GO:0005515protein binding-IPI16189514  25416956  27107012  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA16615998  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-TAS10704285  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28226201Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms. (2017 May)Adkins AEAlcohol Clin Exp Res