Gene: KLF8

11279
BKLF3|ZNF741
Kruppel like factor 8
protein-coding
Xp11.21
Ensembl:ENSG00000102349 MIM:300286 Vega:OTTHUMG00000021666 UniprotKB:O95600
NG_011949.2
SNP Mapped
0   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC16A140.845
RPS6KA60.842
MKL20.836
MEF2A0.831
RGS7BP0.828
CEP680.822
FRY0.82
CHM0.82
RASAL20.817
CDKL20.817

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.557
ROM1-0.514
PPP1R14B-0.474
RBP1-0.47
CDKN2C-0.468
TST-0.454
MPST-0.451
NKX2-2-0.447
FAM181B-0.446
TSC22D4-0.445

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of KLF8 mRNA26690555
C006780bisphenol Abisphenol A results in decreased methylation of KLF8 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of KLF8 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of KLF8 mRNA29097150
C018475butyraldehydebutyraldehyde results in decreased expression of KLF8 mRNA26079696
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of KLF8 mRNA23518002
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of KLF8 protein23518002
D002117CalcitriolCalcitriol results in increased expression of KLF8 mRNA16002434
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KLF8 mRNA29097150
C056507gemcitabinegemcitabine results in increased expression of KLF8 mRNA17039268
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of KLF8 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of KLF8 mRNA"20188158
D009532NickelNickel results in decreased expression of KLF8 mRNA24768652
C045362prochlorazprochloraz results in increased expression of KLF8 mRNA21470553
C005556propionaldehydepropionaldehyde results in decreased expression of KLF8 mRNA26079696
C502851quinocetonequinocetone results in increased expression of KLF8 mRNA27046791
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of KLF8 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of KLF8 mRNA12377979
D014635Valproic AcidValproic Acid results in decreased expression of KLF8 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of KLF8 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KLF8 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10756197  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10756197  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IMP10756197  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP10756197  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0016235aggresome-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal