Gene: CHRM1

1128
HM1|M1|M1R
cholinergic receptor muscarinic 1
protein-coding
11q12.3
Ensembl:ENSG00000168539 MIM:118510 Vega:OTTHUMG00000167765 UniprotKB:P11229
NC_000011.10
PubMed
ND|AD
2   
4.433e-1 (AD)  3.628e-1 (ND)   (Frontal_Cortex)
9.180e-1 (AD)  2.793e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NGEF0.953
CACNG30.95
CACNG80.945
LRTM20.944
AMER30.942
SPRN0.941
RHOBTB20.937
GABRD0.937
STX1B0.935
PRRT30.935

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WWTR1-0.639
CNN2-0.604
REST-0.59
KIAA0040-0.585
YES1-0.583
TFPI2-0.583
WEE1-0.575
ZNF114-0.574
RAI14-0.573
RBPMS-0.57

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00185CevimelineSmall Molecule107233-08-9ApprovedTarget
DB00202SuccinylcholineSmall Molecule306-40-1ApprovedTarget
DB00209TrospiumSmall Molecule47608-32-2ApprovedTarget
DB00215CitalopramSmall Molecule59729-33-8ApprovedTarget
DB00219OxyphenoniumSmall Molecule14214-84-7ApprovedTarget
DB00245BenzatropineSmall Molecule86-13-5ApprovedTarget
DB00246ZiprasidoneSmall Molecule146939-27-7ApprovedTarget
DB00280DisopyramideSmall Molecule3737-09-5ApprovedTarget
DB00321AmitriptylineSmall Molecule50-48-6ApprovedTarget
DB00332Ipratropium bromideSmall Molecule22254-24-6ApprovedTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00340MetixeneSmall Molecule4969-02-2ApprovedTarget
DB00342TerfenadineSmall Molecule50679-08-8Approved|WithdrawnTarget
DB00354BuclizineSmall Molecule82-95-1ApprovedTarget
DB00363ClozapineSmall Molecule5786-21-0ApprovedTarget
DB00366DoxylamineSmall Molecule469-21-6ApprovedTarget
DB00376TrihexyphenidylSmall Molecule144-11-6ApprovedTarget
DB00383OxyphencyclimineSmall Molecule125-53-1ApprovedTarget
DB00387ProcyclidineSmall Molecule77-37-2ApprovedTarget
DB00392EthopropazineSmall Molecule522-00-9ApprovedTarget
DB00408LoxapineSmall Molecule1977-10-2ApprovedTarget
DB00411CarbacholSmall Molecule51-83-2ApprovedTarget
DB00420PromazineSmall Molecule58-40-2ApprovedTarget
DB00424HyoscyamineSmall Molecule101-31-5ApprovedTarget
DB00434CyproheptadineSmall Molecule129-03-3ApprovedTarget
DB00458ImipramineSmall Molecule50-49-7ApprovedTarget
DB00462Methylscopolamine bromideSmall Molecule155-41-9ApprovedTarget
DB00477ChlorpromazineSmall Molecule50-53-3Approved|InvestigationalTarget
DB00483Gallamine TriethiodideSmall Molecule65-29-2ApprovedTarget
DB00496DarifenacinSmall Molecule133099-04-4Approved|InvestigationalTarget
DB00505TridihexethylSmall Molecule60-49-1WithdrawnTarget
DB00508TriflupromazineSmall Molecule146-54-3ApprovedTarget
DB00517Anisotropine MethylbromideSmall Molecule80-50-2ApprovedTarget
DB00540NortriptylineSmall Molecule72-69-5ApprovedTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00572AtropineSmall Molecule51-55-8ApprovedTarget
DB00622NicardipineSmall Molecule55985-32-5Approved|InvestigationalTarget
DB00670PirenzepineSmall Molecule28797-61-7ApprovedTarget
DB00715ParoxetineSmall Molecule61869-08-7Approved|InvestigationalTarget
DB00725Homatropine MethylbromideSmall Molecule80-49-9ApprovedTarget
DB00747ScopolamineSmall Molecule51-34-3Approved|InvestigationalTarget
DB00767BenzquinamideSmall Molecule63-12-7WithdrawnTarget
DB00771ClidiniumSmall Molecule7020-55-5ApprovedTarget
DB00777PropiomazineSmall Molecule362-29-8ApprovedTarget
DB00782PropanthelineSmall Molecule298-50-0ApprovedTarget
DB00785CryptenamineSmall Molecule1356-18-9ApprovedTarget
DB00804DicyclomineSmall Molecule77-19-0ApprovedTarget
DB00805MinaprineSmall Molecule25905-77-5ApprovedTarget
DB00809TropicamideSmall Molecule1508-75-4Approved|InvestigationalTarget
DB00810BiperidenSmall Molecule514-65-8Approved|InvestigationalTarget
DB00835BrompheniramineSmall Molecule86-22-6ApprovedTarget
DB00875FlupentixolSmall Molecule2709-56-0Approved|Investigational|WithdrawnTarget
DB00907CocaineSmall Molecule50-36-2Approved|IllicitTarget
DB00934MaprotilineSmall Molecule10262-69-8Approved|InvestigationalTarget
DB00940MethanthelineSmall Molecule5818-17-7Approved|InvestigationalTarget
DB00942CycrimineSmall Molecule77-39-4ApprovedTarget
DB00979CyclopentolateSmall Molecule512-15-2ApprovedTarget
DB00986GlycopyrroniumSmall Molecule740028-90-4Approved|InvestigationalTarget
DB01019BethanecholSmall Molecule674-38-4ApprovedTarget
DB01036TolterodineSmall Molecule124937-51-5Approved|InvestigationalTarget
DB01062OxybutyninSmall Molecule5633-20-5Approved|InvestigationalTarget
DB01069PromethazineSmall Molecule60-87-7Approved|InvestigationalTarget
DB01085PilocarpineSmall Molecule92-13-7Approved|InvestigationalTarget
DB01142DoxepinSmall Molecule1668-19-5Approved|InvestigationalTarget
DB01148FlavoxateSmall Molecule15301-69-6ApprovedTarget
DB01151DesipramineSmall Molecule50-47-5Approved|InvestigationalTarget
DB01175EscitalopramSmall Molecule128196-01-0Approved|InvestigationalTarget
DB01224QuetiapineSmall Molecule111974-69-7ApprovedTarget
DB01231DiphenidolSmall Molecule972-02-1Approved|Investigational|WithdrawnTarget
DB01233MetoclopramideSmall Molecule364-62-5Approved|InvestigationalTarget
DB01238AripiprazoleSmall Molecule129722-12-9Approved|InvestigationalTarget
DB01239ChlorprothixeneSmall Molecule113-59-7Approved|Investigational|WithdrawnTarget
DB01403MethotrimeprazineSmall Molecule60-99-1Approved|InvestigationalTarget
DB01409TiotropiumSmall Molecule186691-13-4ApprovedTarget
DB01591SolifenacinSmall Molecule242478-37-1ApprovedTarget
DB01618MolindoneSmall Molecule7416-34-4ApprovedTarget
DB02010StaurosporineSmall Molecule62996-74-1ExperimentalTarget
DB03128AcetylcholineSmall Molecule51-84-3ApprovedTarget
DB04365ArecolineSmall Molecule63-75-2ExperimentalTarget
DB04843MepenzolateSmall Molecule25990-43-6ApprovedTarget
DB05152NGX267Small Molecule-InvestigationalTarget
DB05752ALKS 27Small Molecule-InvestigationalTarget
DB05766ACP-104Small Molecule-InvestigationalTarget
DB06702FesoterodineSmall Molecule286930-02-7ApprovedTarget
DB06787HexocycliumSmall Molecule6004-98-4ApprovedTarget
DB08897AclidiniumSmall Molecule727649-81-2ApprovedTarget
DB09076UmeclidiniumSmall Molecule869185-19-3ApprovedTarget
DB09167DosulepinSmall Molecule113-53-1ApprovedTarget
DB09262ImidafenacinSmall Molecule170105-16-5Approved|InvestigationalTarget
DB11156PyrantelSmall Molecule15686-83-6ApprovedTarget
DB00454PethidineSmall Molecule57-42-1ApprovedTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB00568CinnarizineSmall Molecule298-57-7Approved|InvestigationalTarget
DB00726TrimipramineSmall Molecule739-71-9ApprovedTarget
DB01221KetamineSmall Molecule6740-88-1ApprovedTarget
DB09194EtoperidoneSmall Molecule52942-31-1WithdrawnTarget
ID Drug Name Action PubMed
C5326261-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one binds to and results in increased activity of CHRM1 protein"21682298
C425227(1-(2,2-diphenyl-(1,3)dioxolan-4-yl)-ethyl)-dimethyl-amine"(1-(2,2-diphenyl-(1,3)dioxolan-4-yl)-ethyl)-dimethyl-amine analog binds to and results in decreased activity of CHRM1 protein"11206470
C425227(1-(2,2-diphenyl-(1,3)dioxolan-4-yl)-ethyl)-dimethyl-amine"(1-(2,2-diphenyl-(1,3)dioxolan-4-yl)-ethyl)-dimethyl-amine binds to and results in decreased activity of CHRM1 protein"11206470
C5612371-((4-cyano-4-pyridin-2-ylpiperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid1-((4-cyano-4-pyridin-2-ylpiperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid binds to and results in increased activity of CHRM1 protein21682298
C5612371-((4-cyano-4-pyridin-2-ylpiperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid1-((4-cyano-4-pyridin-2-ylpiperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid binds to and results in increased activity of CHRM1 protein21682298
C5612371-((4-cyano-4-pyridin-2-ylpiperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid1-((4-cyano-4-pyridin-2-ylpiperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid binds to and results in increased activity of CHRM1 protein21682298
C5612371-((4-cyano-4-pyridin-2-ylpiperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid1-((4-cyano-4-pyridin-2-ylpiperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid binds to and results in increased activity of CHRM1 protein21682298
C5612371-((4-cyano-4-pyridin-2-ylpiperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid1-((4-cyano-4-pyridin-2-ylpiperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid binds to and results in increased activity of CHRM1 protein21682298
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]"18316702
C0382371-oleoyl-2-acetylglycerol1-oleoyl-2-acetylglycerol promotes the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CHRM1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CHRM1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CHRM1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CHRM1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CHRM1 mRNA"25510870
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CHRM1 mRNA"18648102
C0423754-diphenylacetoxy-1,1-dimethylpiperidinium"4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]"11306684
C0423754-diphenylacetoxy-1,1-dimethylpiperidinium"4-diphenylacetoxy-1,1-dimethylpiperidinium binds to and results in decreased activity of CHRM1 protein"11689195
C0423754-diphenylacetoxy-1,1-dimethylpiperidinium"4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased activity of CHRM1 protein"15115163
C4966414-(N-(4-chlorophenyl)carbamoyloxy)-4-pent-2-ammonium iodide4-(N-(4-chlorophenyl)carbamoyloxy)-4-pent-2-ammonium iodide binds to and results in increased activity of CHRM1 protein15251036
C4565204-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine hydrogen chloride4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine hydrogen chloride binds to and results in increased activity of CHRM1 protein21682298
C0415944-nonylphenol4-nonylphenol results in decreased expression of CHRM19827057
C0415944-nonylphenol4-nonylphenol results in decreased expression of CHRM19827057
C0415944-nonylphenol4-nonylphenol results in decreased expression of CHRM19827057
C5685165-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide"5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide binds to CHRM1 protein"21870878
C0084465-methylfurtrethoniumbrucine promotes the reaction [5-methylfurtrethonium binds to CHRM1 protein]9224827
C0084465-methylfurtrethoniumCHRM1 protein binds to 5-methylfurtrethonium9224827
D000109AcetylcholineCHRM1 protein affects the susceptibility to Acetylcholine18367213
D000109AcetylcholineAcetylcholine binds to and results in increased activity of CHRM1 protein10101037
D000109AcetylcholineAcetylcholine binds to CHRM1 protein10069518|1086094
D000109AcetylcholineAcetylcholine results in increased activity of CHRM1 protein11527950
D000109Acetylcholine[Acetylcholine results in increased activity of CHRM1 protein] which results in increased abundance of Calcium11527950
D000109Acetylcholinebrucine analog affects the reaction [Acetylcholine binds to CHRM1 protein]10069518
D000109Acetylcholinebrucine promotes the reaction [Acetylcholine binds to CHRM1 protein]9224827|9495826
D000109Acetylcholinebrucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]10101037
D000109AcetylcholineCHRM1 protein binds to Acetylcholine9224827
D000109AcetylcholineKT 5720 promotes the reaction [Acetylcholine binds to CHRM1 protein]10860942
D000109AcetylcholineQuinuclidinyl Benzilate inhibits the reaction [brucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]]10101037
D000109AcetylcholineAcetylcholine results in increased activity of CHRM1 protein14534362
D000109AcetylcholinePregnenolone inhibits the reaction [Acetylcholine binds to CHRM1 protein]15900516
D000109AcetylcholineProgesterone inhibits the reaction [Acetylcholine binds to CHRM1 protein]15900516
D000109AcetylcholinePropofol inhibits the reaction [Acetylcholine results in increased activity of CHRM1 protein]14534362
D013196DihydrotestosteroneCycloheximide inhibits the reaction [Dihydrotestosterone results in decreased expression of CHRM1 mRNA]17624924
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of CHRM1 mRNA17624924
C439263AM 1241AM 1241 binds to CHRM1 protein18931146
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHRM1 mRNA16483693
D003913DextroamphetamineClozapine inhibits the reaction [Dextroamphetamine results in decreased expression of CHRM1 protein]18806925
D003913DextroamphetamineDextroamphetamine results in decreased expression of CHRM1 protein18806925
D000661Amphetamine[muscarinic toxin 7 binds to and results in decreased activity of CHRM1 protein] inhibits the reaction [Amphetamine results in increased abundance of Nitric Oxide]18991861
D000661Amphetamine[muscarinic toxin 7 binds to and results in decreased activity of CHRM1 protein] inhibits the reaction [Amphetamine results in increased oxidation of Lipids]18991861
C015001arsenitearsenite results in increased methylation of CHRM1 promoter23974009
D001285AtropineAtropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]16439611
D001285AtropineAtropine binds to and results in decreased activity of CHRM1 protein18316702
D001285AtropineAtropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D001285AtropineAtropine binds to and results in decreased activity of CHRM1 protein17613726
D001374AzacitidineAzacitidine affects the expression of CHRM1 mRNA19002953
C037689benzamidebenzamide results in increased expression of CHRM1 mRNA18501976
C037689benzamidebenzamide results in increased expression of CHRM1 protein18501976
D018723Bethanecholbrucine promotes the reaction [Bethanechol binds to CHRM1 protein]9224827
D018723BethanecholCHRM1 protein binds to Bethanechol9224827
D001712BiperidenBiperiden binds to and results in decreased activity of CHRM1 protein21336581
C083806brucinebrucine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]16439611
C083806brucinebrucine affects the reaction [Pirenzepine analog binds to CHRM1 protein]15294002
C083806brucinebrucine analog affects the reaction [Acetylcholine binds to CHRM1 protein]10069518
C083806brucinebrucine analog affects the reaction [N-Methylscopolamine binds to CHRM1 protein]10069518
C083806brucinebrucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM1 protein]9224827
C083806brucinebrucine promotes the reaction [5-methylfurtrethonium binds to CHRM1 protein]9224827
C083806brucinebrucine promotes the reaction [Acetylcholine binds to CHRM1 protein]9224827|9495826
C083806brucinebrucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]10101037
C083806brucinebrucine promotes the reaction [Bethanechol binds to CHRM1 protein]9224827
C083806brucinebrucine promotes the reaction [Carbachol binds to CHRM1 protein]9224827
C083806brucinebrucine promotes the reaction [furtrethonium binds to CHRM1 protein]9224827
C083806brucinebrucine promotes the reaction [oxotremorine M binds to CHRM1 protein]9224827
C083806brucinebrucine promotes the reaction [Pilocarpine binds to CHRM1 protein]9224827
C083806brucineQuinuclidinyl Benzilate inhibits the reaction [brucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]]10101037
C083806brucinebrucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride results in increased activity of CHRM1 protein]11024498
C083067brucine N-oxidebrucine N-oxide promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]9495826
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of CHRM1 protein27377441
D019256Cadmium Chloride[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form27377441
D019256Cadmium Chloride[[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in decreased expression of CHAT protein27377441
D019256Cadmium Chloride[[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in increased expression of APP protein modified form27377441
D019256Cadmium Chloride[[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in increased expression of GSK3B mRNA27377441
D019256Cadmium Chloride[[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in increased expression of MAPT protein27377441
D019256Cadmium Chloride[[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in increased expression of MAPT protein modified form27377441
D019256Cadmium Chloride[Cadmium Chloride results in decreased activity of CHRM1 protein] which results in decreased expression of CHAT protein27377441
D019256Cadmium Chloride[Cadmium Chloride results in decreased activity of CHRM1 protein] which results in increased expression of APP protein modified form27377441
D019256Cadmium Chloride[Cadmium Chloride results in decreased activity of CHRM1 protein] which results in increased expression of GSK3B mRNA27377441
D019256Cadmium Chloride[Cadmium Chloride results in decreased activity of CHRM1 protein] which results in increased expression of MAPT protein27377441
D019256Cadmium Chloride[Cadmium Chloride results in decreased activity of CHRM1 protein] which results in increased expression of MAPT protein modified form27377441
D019256Cadmium ChlorideCHRM1 mRNA inhibits the reaction [Cadmium Chloride results in decreased expression of CHAT protein]27377441
D019256Cadmium ChlorideCHRM1 mRNA inhibits the reaction [Cadmium Chloride results in increased expression of APP protein modified form]27377441
D019256Cadmium ChlorideCHRM1 mRNA inhibits the reaction [Cadmium Chloride results in increased expression of GSK3B mRNA]27377441
D019256Cadmium ChlorideCHRM1 mRNA inhibits the reaction [Cadmium Chloride results in increased expression of MAPT protein]27377441
D019256Cadmium ChlorideCHRM1 mRNA inhibits the reaction [Cadmium Chloride results in increased expression of MAPT protein modified form]27377441
D019256Cadmium ChlorideCHRM1 mutant form promotes the reaction [Cadmium Chloride results in increased activity of CASP7 protein]26026611
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of CHRM1 protein27377441
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CHRM1 mRNA27389774
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of CHRM1 promoter22457795
D019256Cadmium ChlorideQuercetin inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM1 mRNA]27389774
D002118Calcium[Acetylcholine results in increased activity of CHRM1 protein] which results in increased abundance of Calcium11527950
D002118Calcium[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium11527950
D002118CalciumCHRM1 protein promotes the reaction [Methacholine Compounds results in increased abundance of Calcium]12456425
D002118Calcium[Pilocarpine results in increased activity of CHRM1 protein] which results in increased abundance of Calcium11527950
D002118Calcium"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]"18316702
D002118Calcium1-oleoyl-2-acetylglycerol promotes the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D002118Calcium2-aminoethoxydiphenyl borate inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D002118CalciumAtropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D002118Calcium[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium18316702
D002118CalciumFlufenamic Acid inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D002118CalciumGadolinium inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D002118CalciumLanthanum inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D002118CalciumPirenzepine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D002118CalciumThapsigargin inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D002118Calcium[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein11553362
D002118Calcium[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine Hydrobromide11553362
D000068896CanagliflozinCanagliflozin affects the reaction [Scopolamine Hydrobromide results in decreased expression of CHRM1 protein]28837785
D000068896CanagliflozinCanagliflozin results in decreased expression of CHRM1 protein28837785
D002217Carbacholbrucine promotes the reaction [Carbachol binds to CHRM1 protein]9224827
D002217CarbacholCarbachol results in increased activity of CHRM1 protein11527950|8683117
D002217Carbachol[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium11527950
D002217Carbachol[Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG mRNA8683117
D002217Carbachol[Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG protein8683117
D002217CarbacholCHRM1 protein binds to Carbachol9224827
D002217Carbachol"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]"18316702
D002217Carbachol1-oleoyl-2-acetylglycerol promotes the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D002217Carbachol2-aminoethoxydiphenyl borate inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D002217CarbacholAtropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D002217CarbacholCarbachol results in increased activity of CHRM1 protein18316702
D002217Carbachol[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium18316702
D002217CarbacholFlufenamic Acid inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D002217CarbacholGadolinium inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D002217CarbacholLanthanum inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D002217CarbacholPirenzepine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D002217CarbacholThapsigargin inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D012721CarbarylCarbaryl results in decreased expression of CHRM19827057
D012721CarbarylCarbaryl results in decreased expression of CHRM19827057
D012721CarbarylCarbaryl results in decreased expression of CHRM19827057
C078040catalpolcatalpol inhibits the reaction [Galactose results in decreased expression of CHRM1 protein]23612000
C059240cevimelinecevimeline binds to and results in increased activity of CHRM1 protein1425975
D008455(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloridebrucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM1 protein]9224827
D008455(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium ChlorideCHRM1 protein binds to (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride9224827
D008455(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium ChlorideCHRM1 protein results in increased susceptibility to (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride11392617
D008455(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to and results in increased activity of CHRM1 protein11024498
D008455(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloridebrucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride results in increased activity of CHRM1 protein]11024498
D008455(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to and results in increased activity of CHRM1 protein19967050
D008455(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride[(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM1 protein] which results in increased abundance of Nitric Oxide18991861
D008455(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride[(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM1 protein] which results in increased oxidation of Lipids18991861
D008455(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium ChlorideMisoprostol inhibits the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to and results in increased activity of CHRM1 protein]2459756
D008455(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chlorideresveratrol inhibits the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to and results in increased activity of CHRM1 protein]19967050
D008455(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to and results in increased activity of CHRM1 protein2459756
D008455(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM1 protein18991861
D004390ChlorpyrifosChlorpyrifos affects the expression of CHRM1 mRNA18812211
D004390ChlorpyrifosChlorpyrifos results in decreased activity of CHRM1 protein17666426
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CHRM1 mRNA16675515
D003024ClozapineClozapine analog binds to CHRM1 protein11997696
D003024ClozapineClozapine binds to CHRM1 protein11997696|1698339
D003024ClozapineClozapine inhibits the reaction [Dextroamphetamine results in decreased expression of CHRM1 protein]18806925
D003024ClozapineClozapine results in increased expression of CHRM1 protein18806925
D003300CopperCopper results in decreased expression of CHRM19827057
D003300CopperCopper results in decreased expression of CHRM19827057
D003435Crotalid VenomsCrotalid Venoms inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]10845706
D003435Crotalid VenomsCrotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]10845706
D003471CuprizoneCuprizone results in decreased expression of CHRM1 mRNA26577399|2752363
D003513CycloheximideCycloheximide inhibits the reaction [Dihydrotestosterone results in decreased expression of CHRM1 mRNA]17624924
D003976DiazinonDiazinon affects the expression of CHRM1 mRNA17452286
D003976DiazinonDiazinon results in decreased expression of CHRM1 mRNA18812211
D004006DichlorvosDichlorvos results in decreased expression of CHRM1 protein19100812
D004006DichlorvosCHRM1 protein affects the susceptibility to Dichlorvos1458168
D004026DieldrinDieldrin results in decreased expression of CHRM1 mRNA18812211
D004041Dietary FatsDietary Fats results in decreased expression of CHRM1 mRNA25016146
D004117DimethoateDimethoate results in decreased expression of CHRM1 mRNA15033006
D004117DimethoateDimethoate results in decreased expression of CHRM1 protein14694657
D004222DisulfotonDisulfoton results in decreased expression of CHRM1 mRNA8856746
D004546Elapid VenomsElapid Venoms results in increased activity of CHRM1 protein11024498
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of CHRM1 mRNA22872703
C020326ferric nitrilotriacetateferric nitrilotriacetate results in decreased expression of CHRM1 mRNA19490752
D005439Flufenamic AcidFlufenamic Acid inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D005444FlunarizineFlunarizine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]9533112
D005459FluoridesFluorides results in decreased expression of CHRM1 mRNA25417050
D005459FluoridesFluorides results in decreased expression of CHRM1 protein25417050
C069837fullerene C60fullerene C60 results in decreased expression of CHRM1 mRNA19167457
C028530furtrethoniumbrucine promotes the reaction [furtrethonium binds to CHRM1 protein]9224827
C028530furtrethoniumCHRM1 protein binds to furtrethonium9224827
D005682GadoliniumGadolinium inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D005690Galactosecatalpol inhibits the reaction [Galactose results in decreased expression of CHRM1 protein]23612000
D005690GalactoseGalactose results in decreased expression of CHRM1 protein23612000
D005702GalantamineGalantamine results in decreased expression of CHRM1 protein28837785
D005703Gallamine TriethiodideGallamine Triethiodide affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]16439611
D005703Gallamine TriethiodideGallamine Triethiodide binds to CHRM1 protein10860942
D005703Gallamine TriethiodideGallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]9846649
D006843Hydrocarbons, Chlorinated"Hydrocarbons, Chlorinated results in decreased expression of CHRM1 mRNA"22872703
D006851Hydrochloric AcidCHRM1 protein affects the susceptibility to Hydrochloric Acid18367213
C082359imidaclopridimidacloprid results in increased expression of CHRM1 mRNA26568164
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CHRM1 mRNA23430699
D007649KetamineKetamine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]12456425
C057416KT 5720KT 5720 affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]16439611
C057416KT 5720KT 5720 promotes the reaction [Acetylcholine binds to CHRM1 protein]10860942
C057416KT 5720KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]10860942
C057416KT 5720Staurosporine affects the reaction [KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]]10860942
C073601KT 5823KT 5823 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]10860942
D007811LanthanumLanthanum inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D008055Lipids[(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM1 protein] which results in increased oxidation of Lipids18991861
D008055Lipids[muscarinic toxin 7 binds to and results in decreased activity of CHRM1 protein] inhibits the reaction [Amphetamine results in increased oxidation of Lipids]18991861
D008627Mercuric ChlorideMercuric Chloride inhibits the reaction [Pirenzepine binds to CHRM1 protein]18295336
D008688Methacholine CompoundsCHRM1 protein promotes the reaction [Methacholine Compounds results in increased abundance of Calcium]12456425
C054938methoctraminemethoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]11306684
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in decreased activity of CHRM1 protein"28790194
D008767Methylmercury CompoundsMethylmercury Compounds inhibits the reaction [Pirenzepine binds to CHRM1 protein]18295336
D008767Methylmercury CompoundsMethylmercury Compounds promotes the reaction [Pirenzepine binds to CHRM1 protein]18295336
D008743Methyl ParathionMethyl Parathion results in decreased activity of CHRM1 protein17666426
D008743Methyl ParathionMethyl Parathion results in decreased expression of CHRM1 protein14746346|1664578
D019832N-Methylscopolaminebrucine analog affects the reaction [N-Methylscopolamine binds to CHRM1 protein]10069518
D019832N-Methylscopolaminebrucine N-oxide promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]9495826
D019832N-MethylscopolamineCHRM1 protein binds to N-Methylscopolamine9224827
D019832N-MethylscopolamineCrotalid Venoms inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]10845706
D019832N-MethylscopolamineGallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]9846649
D019832N-MethylscopolamineKT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]10860942
D019832N-MethylscopolamineKT 5823 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]10860942
D019832N-MethylscopolamineN-Methylscopolamine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]16439611
D019832N-MethylscopolamineN-Methylscopolamine binds to CHRM1 protein10069518|1084570
D019832N-MethylscopolaminePancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]9846649
D019832N-MethylscopolaminePipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]9846649
D019832N-MethylscopolaminePirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]9846649
D019832N-Methylscopolaminerocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]9846649
D019832N-MethylscopolamineStaurosporine affects the reaction [KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]]10860942
D019832N-Methylscopolaminestaurosporine aglycone promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]10860942
D019832N-MethylscopolamineStaurosporine promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]10860942
D019832N-MethylscopolamineVecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]9846649
D019832N-MethylscopolamineWIN 51708 inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]16709648
D019832N-MethylscopolamineWIN 62577 inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]16709648
D019832N-MethylscopolamineN-Methylscopolamine binds to CHRM1 protein14559291|1613770
D019832N-MethylscopolaminePilocarpine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]16137708
D019832N-MethylscopolaminePilocarpine promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]14559291
D016595MisoprostolMisoprostol inhibits the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to and results in increased activity of CHRM1 protein]2459756
D018727Muscarinic AntagonistsMuscarinic Antagonists results in decreased activity of CHRM1 protein9483405
D018727Muscarinic Antagonists[Muscarinic Antagonists binds to and results in decreased activity of CHRM1 protein] which results in decreased susceptibility to Organophosphorus Compounds10513339
C419876muscarinic toxin 7Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]16439611
C419876muscarinic toxin 7brucine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]16439611
C419876muscarinic toxin 7Gallamine Triethiodide affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]16439611
C419876muscarinic toxin 7KT 5720 affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]16439611
C419876muscarinic toxin 7muscarinic toxin 7 binds to CHRM1 protein16439611
C419876muscarinic toxin 7N-Methylscopolamine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]16439611
C419876muscarinic toxin 7Staurosporine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]16439611
C419876muscarinic toxin 7Tacrine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]16439611
C419876muscarinic toxin 7[muscarinic toxin 7 binds to and results in decreased activity of CHRM1 protein] inhibits the reaction [Amphetamine results in increased abundance of Nitric Oxide]18991861
C419876muscarinic toxin 7[muscarinic toxin 7 binds to and results in decreased activity of CHRM1 protein] inhibits the reaction [Amphetamine results in increased oxidation of Lipids]18991861
C419876muscarinic toxin 7muscarinic toxin 7 binds to and results in decreased activity of CHRM1 protein18991861
D015544Inositol 1,4,5-Trisphosphate"CHRM1 protein affects the abundance of Inositol 1,4,5-Trisphosphate"19002953
C107666N-(2-(1-azabicyclo(3.3.0)octan-5-yl)ethyl)-2-nitroanilineN-(2-(1-azabicyclo(3.3.0)octan-5-yl)ethyl)-2-nitroaniline binds to and results in increased activity of CHRM1 protein9987823
C542801N-(3-oxo-3-(4-(pyridin-4-yl)piperazin-1-yl)propyl)benzo(c)(1,2,5)thiadiazole-4-sulfonamide"N-(3-oxo-3-(4-(pyridin-4-yl)piperazin-1-yl)propyl)benzo(c)(1,2,5)thiadiazole-4-sulfonamide binds to and results in decreased activity of CHRM1 protein"19407080
D009532NickelNickel results in decreased expression of CHRM1 mRNA18812211
D009569Nitric Oxide[(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM1 protein] which results in increased abundance of Nitric Oxide18991861
D009569Nitric Oxide[muscarinic toxin 7 binds to and results in decreased activity of CHRM1 protein] inhibits the reaction [Amphetamine results in increased abundance of Nitric Oxide]18991861
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CHRM1 mRNA27935865
C076029olanzapineolanzapine binds to CHRM1 protein16983399
D009943Organophosphorus Compounds[Muscarinic Antagonists binds to and results in decreased activity of CHRM1 protein] which results in decreased susceptibility to Organophosphorus Compounds10513339
C042743oxotremorine Mbrucine promotes the reaction [oxotremorine M binds to CHRM1 protein]9224827
C042743oxotremorine MCHRM1 protein binds to oxotremorine M9224827
D010197PancuroniumPancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]9846649
D010261ParaoxonParaoxon results in decreased expression of CHRM1 mRNA21787676
D052638Particulate MatterParticulate Matter results in increased expression of CHRM1 mRNA27832168
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CHRM1 mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of CHRM1 mRNA27294297
D010416PentachlorophenolPentachlorophenol results in decreased expression of CHRM1 mRNA23892564
D026023PermethrinPermethrin results in decreased expression of CHRM19827057
D026023PermethrinPermethrin results in decreased expression of CHRM19827057
D026023PermethrinPermethrin results in decreased expression of CHRM19827057
C000593032PGW5 compoundPGW5 compound binds to CHRM1 protein24389121
D010716PhosphatidylinositolsCHRM1 protein mutant form inhibits the reaction [Pilocarpine results in increased hydrolysis of Phosphatidylinositols]12713643
D010852PicrotoxinPicrotoxin results in increased expression of CHRM1 mRNA15170462
D010862Pilocarpinebrucine promotes the reaction [Pilocarpine binds to CHRM1 protein]9224827
D010862PilocarpineCHRM1 protein binds to Pilocarpine9224827
D010862PilocarpinePilocarpine results in increased activity of CHRM1 protein11527950
D010862Pilocarpine[Pilocarpine results in increased activity of CHRM1 protein] which results in increased abundance of Calcium11527950
D010862PilocarpineCHRM1 protein affects the susceptibility to Pilocarpine12713643
D010862PilocarpineCHRM1 protein mutant form inhibits the reaction [Pilocarpine results in increased hydrolysis of Phosphatidylinositols]12713643
D010862PilocarpinePilocarpine results in decreased expression of CHRM1 protein15967574
D010862PilocarpinePilocarpine results in increased activity of CHRM1 protein15967574
D010862PilocarpinePilocarpine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]16137708
D010862PilocarpinePilocarpine promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]14559291
D010862PilocarpinePilocarpine results in decreased expression of CHRM1 protein14559291|1613770
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CHRM1 mRNA27935865
D017300PipecuroniumPipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]9846649
D010890Pirenzepinebrucine affects the reaction [Pirenzepine analog binds to CHRM1 protein]15294002
D010890PirenzepinePirenzepine analog binds to CHRM1 protein15294002
D010890PirenzepinePirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]9846649
D010890PirenzepinePirenzepine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]11306684
D010890PirenzepinePirenzepine binds to and results in decreased activity of CHRM1 protein18316702
D010890PirenzepinePirenzepine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D010890PirenzepineMercuric Chloride inhibits the reaction [Pirenzepine binds to CHRM1 protein]18295336
D010890PirenzepineMethylmercury Compounds inhibits the reaction [Pirenzepine binds to CHRM1 protein]18295336
D010890PirenzepineMethylmercury Compounds promotes the reaction [Pirenzepine binds to CHRM1 protein]18295336
D010890PirenzepinePirenzepine binds to CHRM1 protein18295336
D010890PirenzepinePirenzepine binds to and results in decreased activity of CHRM1 protein12646291|8032910
D010890PirenzepinePirenzepine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]8744975
D010890PirenzepinePirenzepine binds to and results in decreased activity of CHRM1 protein10353596|1102449
C006253pirinixic acidpirinixic acid results in increased expression of CHRM1 mRNA19162173
D010936Plant ExtractsPlant Extracts inhibits the reaction [Scopolamine Hydrobromide results in increased expression of CHRM1 mRNA]26434561
D011284PregnenolonePregnenolone inhibits the reaction [Acetylcholine binds to CHRM1 protein]15900516
D011284PregnenolonePregnenolone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]15900516
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of CHRM1 mRNA19162173
D011374ProgesteroneProgesterone inhibits the reaction [Acetylcholine binds to CHRM1 protein]15900516
D011374ProgesteroneProgesterone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]15900516
D015742PropofolPropofol inhibits the reaction [Acetylcholine results in increased activity of CHRM1 protein]14534362
D015742PropofolPropofol inhibits the reaction [Scopolamine Derivatives results in increased activity of CHRM1 protein]14534362
D011794QuercetinQuercetin inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM1 mRNA]27389774
D011813Quinuclidinyl BenzilateCrotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]10845706
D011813Quinuclidinyl BenzilateQuinuclidinyl Benzilate binds to CHRM1 protein10845706|1670964
D011813Quinuclidinyl BenzilateQuinuclidinyl Benzilate inhibits the reaction [brucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]]10101037
D011813Quinuclidinyl BenzilateWIN 51708 inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]16709648
D011813Quinuclidinyl BenzilateWIN 62577 inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]16709648
D011813Quinuclidinyl BenzilateFlunarizine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]9533112
D011813Quinuclidinyl BenzilateQuinuclidinyl Benzilate binds to CHRM1 protein9533112
D011813Quinuclidinyl BenzilatePregnenolone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]15900516
D011813Quinuclidinyl BenzilateProgesterone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]15900516
D011813Quinuclidinyl BenzilatePirenzepine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]8744975
D011813Quinuclidinyl BenzilateQuinuclidinyl Benzilate binds to CHRM1 protein8744975
D011813Quinuclidinyl BenzilateQuinuclidinyl Benzilate binds to and results in decreased activity of CHRM1 protein9533112
D012110ReserpineReserpine results in decreased expression of CHRM1 protein1506860
D012110ReserpineReserpine results in increased expression of CHRM1 mRNA1506860
C059514resveratrolresveratrol inhibits the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to and results in increased activity of CHRM1 protein]19967050
C061870rocuroniumrocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]9846649
C109640sabcomelinesabcomeline binds to and results in increased activity of CHRM1 protein11181912
D012602Scopolamine Derivatives"4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]"11306684
D012602Scopolamine DerivativesKetamine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]12456425
D012602Scopolamine Derivativesmethoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]11306684
D012602Scopolamine DerivativesPirenzepine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]11306684
D012602Scopolamine DerivativesScopolamine Derivatives binds to CHRM1 protein11306684|1245642
D012602Scopolamine DerivativesPropofol inhibits the reaction [Scopolamine Derivatives results in increased activity of CHRM1 protein]14534362
D012602Scopolamine DerivativesScopolamine Derivatives binds to and results in increased activity of CHRM1 protein14534362
D012601Scopolamine HydrobromidePlant Extracts inhibits the reaction [Scopolamine Hydrobromide results in increased expression of CHRM1 mRNA]26434561
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in increased expression of CHRM1 mRNA26434561
D012601Scopolamine Hydrobromide[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine Hydrobromide11553362
D012601Scopolamine HydrobromideCanagliflozin affects the reaction [Scopolamine Hydrobromide results in decreased expression of CHRM1 protein]28837785
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in decreased expression of CHRM1 protein28837785
C017947sodium arsenitesodium arsenite affects the methylation of CHRM1 gene28589171
D019311StaurosporineStaurosporine affects the reaction [KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]]10860942
D019311StaurosporineStaurosporine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]16439611
D019311StaurosporineStaurosporine binds to CHRM1 protein10860942
D019311StaurosporineStaurosporine promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]10860942
C049985staurosporine aglyconestaurosporine aglycone promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]10860942
D013619TacrineTacrine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]16439611
D013619TacrineTacrine inhibits the reaction [telenzepine binds to CHRM1 protein]2606156
C066776taurolithocholic acid 3-sulfatetaurolithocholic acid 3-sulfate binds to CHRM1 protein12464352
C046338telenzepineTacrine inhibits the reaction [telenzepine binds to CHRM1 protein]2606156
C046338telenzepinetelenzepine binds to CHRM1 protein2606156
C046338telenzepinetelenzepine binds to and results in decreased activity of CHRM1 protein17180451
D019284ThapsigarginThapsigargin inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]18316702
D000069447Tiotropium BromideTiotropium Bromide binds to CHRM1 protein21870878
C005460uranyl acetateuranyl acetate results in decreased expression of CHRM1 protein19409444
C005460uranyl acetateuranyl acetate results in increased expression of CHRM1 mRNA19409444
D014673Vecuronium BromideVecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]9846649
D001335Vehicle EmissionsVehicle Emissions results in increased expression of CHRM1 mRNA27832168
C086111WIN 51708WIN 51708 inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]16709648
C086111WIN 51708WIN 51708 inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]16709648
C086110WIN 62577WIN 62577 inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]16709648
C086110WIN 62577WIN 62577 inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]16709648
C075257xanomelineCHRM1 gene results in increased susceptibility to xanomeline19111716
C075257xanomelineCHRM1 results in increased susceptibility to xanomeline19996296
C075257xanomelinexanomeline binds to and results in increased activity of [CHRM1 protein binds to CHRM4 protein]21211109
C075257xanomelinexanomeline binds to and results in increased activity of CHRM1 protein11181912|2168229

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004435phosphatidylinositol phospholipase C activity-TAS9614217  
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004993G-protein coupled serotonin receptor activity-IBA21873635  
GO:0008144drug binding-IEA-  
GO:0016907G-protein coupled acetylcholine receptor activity-IBA21873635  
GO:0030594neurotransmitter receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006464cellular protein modification process-TAS1411529  
GO:0007165signal transduction-TAS3443095  9614217  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IBA21873635  
GO:0007197adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway-IBA21873635  
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway-TAS9603968  
GO:0007207phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway-TAS8139539  
GO:0007213G-protein coupled acetylcholine receptor signaling pathway-TAS8139539  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007274neuromuscular synaptic transmission-IEA-  
GO:0007399nervous system development-TAS2739737  
GO:0008283cell proliferation-TAS1905013  
GO:0008284positive regulation of cell proliferation-TAS2739737  
GO:0040012regulation of locomotion-IEA-  
GO:0043270positive regulation of ion transport-IGI14657398  
GO:0046541saliva secretion-IEA-  
GO:0050890cognition-IEA-  
GO:0090316positive regulation of intracellular protein transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IEA-  
GO:0014069postsynaptic density-IEA-  
GO:0016020membrane-TAS7925360  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IBA21873635  
GO:0030425dendrite-IEA-  
GO:0043679axon terminus-IEA-  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375280Amine ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-390648Muscarinic acetylcholine receptorsTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19183167Additive role of tiotropium in severe asthmatics and Arg16Gly in ADRB2 as a potential marker to predict response. (2009 May)Park HWAllergy
27564456DNA methylation profiling in human lung tissue identifies genes associated with COPD. (2016 Aug 26)Morrow JDEpigenetics