Gene: POU6F2

11281
RPF-1|WT5|WTSL
POU class 6 homeobox 2
protein-coding
7p14.1
Ensembl:ENSG00000106536 MIM:609062 Vega:OTTHUMG00000150803 UniprotKB:P78424
NG_016022.2
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.642e-2 (AD)  3.689e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs41437948chr7:39159265 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPNE40.874
SLC24A20.874
CADPS20.869
ZNF385B0.869
CLSTN20.869
IPCEF10.863
FMN10.859
PTPRT0.858
FLRT30.858
EFNA50.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.557
MDFI-0.545
RHOD-0.539
AQP5-0.531
S100A16-0.517
VAMP5-0.514
GNG12-0.513
ASB4-0.512
NUPR1-0.508
EMP3-0.507

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C487081belinostatbelinostat results in increased expression of POU6F2 mRNA27188386
C006780bisphenol Abisphenol A results in decreased expression of POU6F2 mRNA25181051
D010936Plant ExtractsPlant Extracts results in decreased expression of POU6F2 mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of POU6F2 mRNA24058054
D014635Valproic AcidValproic Acid affects the expression of POU6F2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of POU6F2 mRNA24896083

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-TAS8601806  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-TAS8601806  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007402ganglion mother cell fate determination-TAS8601806  
GO:0007417central nervous system development-TAS8601806  
GO:0007601visual perception-TAS8601806  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27033944Long noncoding RNA POU6F2-AS2 is associated with oesophageal squamous cell carcinoma. (2016 Oct)Liu JJ Biochem