Gene: PHF21B

112885
BHC80L|PHF4
PHD finger protein 21B
protein-coding
22q13.31
Ensembl:ENSG00000056487 MIM:616727 Vega:OTTHUMG00000151199 UniprotKB:Q96EK2
NC_000022.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.481e-1 (AD)  6.647e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6007397chr22:44943320 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RFX20.881
SMO0.858
IL17RB0.85
NBPF100.85
SOX90.85
NFATC10.845
PAX60.843
PLEKHA70.842
NHSL10.839
PLCD10.835

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SAMD5-0.566
TYRP1-0.546
AGMAT-0.533
KCNK2-0.528
CNTN6-0.517
EPHA5-0.507
ZNF860-0.506
GABRG3-0.506
PTPRR-0.506
PPEF1-0.504

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHF21B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHF21B mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PHF21B mRNA22230336
C464485acetamipridacetamiprid results in increased expression of PHF21B mRNA27782041
C006780bisphenol Abisphenol A results in decreased expression of PHF21B mRNA25181051
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PHF21B mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PHF21B mRNA27392435
D019422Dietary SucroseDietary Sucrose results in increased expression of PHF21B mRNA26033743
C039281furanfuran results in decreased expression of PHF21B mRNA27387713
C039281furanfuran results in increased methylation of PHF21B gene27387713
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PHF21B mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PHF21B mRNA27392435
D007854LeadLead affects the expression of PHF21B mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PHF21B mRNA25613284
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PHF21B mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHF21B mRNA"27188386
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of PHF21B mRNA16809437
D010936Plant ExtractsPlant Extracts results in decreased expression of PHF21B mRNA23557933
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PHF21B mRNA25895662
D013629TamoxifenTamoxifen results in increased expression of PHF21B mRNA25123088
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PHF21B mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of PHF21B gene26756918
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PHF21B mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of PHF21B mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of PHF21B gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal