Gene info: ID 1129

Gene: CHRM2

GENE ID: 1129

Synonyms: HM2

Description: cholinergic receptor muscarinic 2

Gene type: protein-coding

Location: 7q33

dbXrefs: Ensembl:ENSG00000181072 MIM:118493 Vega:OTTHUMG00000155658 UniprotKB:P08172

RefSeq: NG_011846.2

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 20

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.029e-1 (AD) 9.744e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs17168826	chr7:136951740 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg26253500	chr7:136641740	CHRM2		2.000e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RASGRP1	0.889
SPHKAP	0.883
XKR4	0.881
EPHA5	0.876
TMEM169	0.875
IL12RB2	0.871
CLSTN2	0.868
ERC2	0.864
B3GALT2	0.861
CNIH3	0.861

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RHOD	-0.599
RAB13	-0.584
FCGRT	-0.552
IMPA2	-0.552
RNF135	-0.545
CHST14	-0.541
EMP3	-0.54
NUPR1	-0.537
ASB4	-0.535
DOK1	-0.531

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00202	Succinylcholine	Small Molecule	306-40-1	Approved	Target
DB00246	Ziprasidone	Small Molecule	146939-27-7	Approved	Target
DB00280	Disopyramide	Small Molecule	3737-09-5	Approved	Target
DB00321	Amitriptyline	Small Molecule	50-48-6	Approved	Target
DB00332	Ipratropium bromide	Small Molecule	22254-24-6	Approved	Target
DB00334	Olanzapine	Small Molecule	132539-06-1	Approved\|Investigational	Target
DB00340	Metixene	Small Molecule	4969-02-2	Approved	Target
DB00342	Terfenadine	Small Molecule	50679-08-8	Approved\|Withdrawn	Target
DB00363	Clozapine	Small Molecule	5786-21-0	Approved	Target
DB00376	Trihexyphenidyl	Small Molecule	144-11-6	Approved	Target
DB00383	Oxyphencyclimine	Small Molecule	125-53-1	Approved	Target
DB00387	Procyclidine	Small Molecule	77-37-2	Approved	Target
DB00392	Ethopropazine	Small Molecule	522-00-9	Approved	Target
DB00408	Loxapine	Small Molecule	1977-10-2	Approved	Target
DB00411	Carbachol	Small Molecule	51-83-2	Approved	Target
DB00420	Promazine	Small Molecule	58-40-2	Approved	Target
DB00424	Hyoscyamine	Small Molecule	101-31-5	Approved	Target
DB00434	Cyproheptadine	Small Molecule	129-03-3	Approved	Target
DB00458	Imipramine	Small Molecule	50-49-7	Approved	Target
DB00462	Methylscopolamine bromide	Small Molecule	155-41-9	Approved	Target
DB00483	Gallamine Triethiodide	Small Molecule	65-29-2	Approved	Target
DB00496	Darifenacin	Small Molecule	133099-04-4	Approved\|Investigational	Target
DB00505	Tridihexethyl	Small Molecule	60-49-1	Withdrawn	Target
DB00508	Triflupromazine	Small Molecule	146-54-3	Approved	Target
DB00517	Anisotropine Methylbromide	Small Molecule	80-50-2	Approved	Target
DB00540	Nortriptyline	Small Molecule	72-69-5	Approved	Target
DB00572	Atropine	Small Molecule	51-55-8	Approved	Target
DB00622	Nicardipine	Small Molecule	55985-32-5	Approved\|Investigational	Target
DB00715	Paroxetine	Small Molecule	61869-08-7	Approved\|Investigational	Target
DB00725	Homatropine Methylbromide	Small Molecule	80-49-9	Approved	Target
DB00728	Rocuronium	Small Molecule	143558-00-3	Approved	Target
DB00747	Scopolamine	Small Molecule	51-34-3	Approved\|Investigational	Target
DB00767	Benzquinamide	Small Molecule	63-12-7	Withdrawn	Target
DB00777	Propiomazine	Small Molecule	362-29-8	Approved	Target
DB00785	Cryptenamine	Small Molecule	1356-18-9	Approved	Target
DB00804	Dicyclomine	Small Molecule	77-19-0	Approved	Target
DB00809	Tropicamide	Small Molecule	1508-75-4	Approved\|Investigational	Target
DB00835	Brompheniramine	Small Molecule	86-22-6	Approved	Target
DB00907	Cocaine	Small Molecule	50-36-2	Approved\|Illicit	Target
DB00934	Maprotiline	Small Molecule	10262-69-8	Approved\|Investigational	Target
DB00986	Glycopyrronium	Small Molecule	740028-90-4	Approved\|Investigational	Target
DB01019	Bethanechol	Small Molecule	674-38-4	Approved	Target
DB01036	Tolterodine	Small Molecule	124937-51-5	Approved\|Investigational	Target
DB01062	Oxybutynin	Small Molecule	5633-20-5	Approved\|Investigational	Target
DB01069	Promethazine	Small Molecule	60-87-7	Approved\|Investigational	Target
DB01075	Diphenhydramine	Small Molecule	58-73-1	Approved\|Investigational	Target
DB01085	Pilocarpine	Small Molecule	92-13-7	Approved\|Investigational	Target
DB01135	Doxacurium chloride	Small Molecule	106819-53-8	Approved	Target
DB01142	Doxepin	Small Molecule	1668-19-5	Approved\|Investigational	Target
DB01148	Flavoxate	Small Molecule	15301-69-6	Approved	Target
DB01151	Desipramine	Small Molecule	50-47-5	Approved\|Investigational	Target
DB01224	Quetiapine	Small Molecule	111974-69-7	Approved	Target
DB01226	Mivacurium	Small Molecule	133814-19-4	Approved	Target
DB01231	Diphenidol	Small Molecule	972-02-1	Approved\|Investigational\|Withdrawn	Target
DB01238	Aripiprazole	Small Molecule	129722-12-9	Approved\|Investigational	Target
DB01239	Chlorprothixene	Small Molecule	113-59-7	Approved\|Investigational\|Withdrawn	Target
DB01336	Metocurine	Small Molecule	5152-30-7	Approved	Target
DB01337	Pancuronium	Small Molecule	-	Approved	Target
DB01338	Pipecuronium	Small Molecule	68399-58-6	Approved	Target
DB01403	Methotrimeprazine	Small Molecule	60-99-1	Approved\|Investigational	Target
DB01409	Tiotropium	Small Molecule	186691-13-4	Approved	Target
DB01591	Solifenacin	Small Molecule	242478-37-1	Approved	Target
DB03128	Acetylcholine	Small Molecule	51-84-3	Approved	Target
DB05752	ALKS 27	Small Molecule	-	Investigational	Target
DB06702	Fesoterodine	Small Molecule	286930-02-7	Approved	Target
DB06787	Hexocyclium	Small Molecule	6004-98-4	Approved	Target
DB08801	Dimetindene	Small Molecule	5636-83-9	Approved\|Investigational	Target
DB08897	Aclidinium	Small Molecule	727649-81-2	Approved	Target
DB09076	Umeclidinium	Small Molecule	869185-19-3	Approved	Target
DB09167	Dosulepin	Small Molecule	113-53-1	Approved	Target
DB09262	Imidafenacin	Small Molecule	170105-16-5	Approved\|Investigational	Target
DB09300	Butylscopolamine	Small Molecule	7182-53-8	Approved\|Investigational	Target
DB00454	Pethidine	Small Molecule	57-42-1	Approved	Target
DB00543	Amoxapine	Small Molecule	14028-44-5	Approved	Target
DB00555	Lamotrigine	Small Molecule	84057-84-1	Approved\|Investigational	Target
DB00568	Cinnarizine	Small Molecule	298-57-7	Approved\|Investigational	Target
DB00726	Trimipramine	Small Molecule	739-71-9	Approved	Target
DB01221	Ketamine	Small Molecule	6740-88-1	Approved	Target
DB09194	Etoperidone	Small Molecule	52942-31-1	Withdrawn	Target

ID	Drug Name	Action	PubMed
C425227	(1-(2,2-diphenyl-(1,3)dioxolan-4-yl)-ethyl)-dimethyl-amine	"(1-(2,2-diphenyl-(1,3)dioxolan-4-yl)-ethyl)-dimethyl-amine analog binds to and results in decreased activity of CHRM2 protein"	11206470
C425227	(1-(2,2-diphenyl-(1,3)dioxolan-4-yl)-ethyl)-dimethyl-amine	"(1-(2,2-diphenyl-(1,3)dioxolan-4-yl)-ethyl)-dimethyl-amine binds to and results in decreased activity of CHRM2 protein"	11206470
C420024	1,3-bis(4-(phthalimidomethoxyiminomethyl)pyridinium-1-yl)propane	"[N-Methylscopolamine binds to CHRM2 protein] affects the reaction [1,3-bis(4-(phthalimidomethoxyiminomethyl)pyridinium-1-yl)propane binds to CHRM2 protein]"	16362429
C420024	1,3-bis(4-(phthalimidomethoxyiminomethyl)pyridinium-1-yl)propane	"[Oxotremorine binds to CHRM2 protein] affects the reaction [1,3-bis(4-(phthalimidomethoxyiminomethyl)pyridinium-1-yl)propane binds to CHRM2 protein]"	16362429
C051942	1-hexacosanol	1-hexacosanol inhibits the reaction [Streptozocin affects the expression of CHRM2 mRNA]	17989502
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CHRM2 mRNA"	27291303
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in decreased expression of CHRM2 mRNA"	20406850
C042375	4-diphenylacetoxy-1,1-dimethylpiperidinium	"4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein]"	11306684
C568516	5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide	"5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide binds to CHRM2 protein"	21870878
C008446	5-methylfurtrethonium	CHRM2 protein binds to 5-methylfurtrethonium	9224827
C008446	5-methylfurtrethonium	eburnamonine promotes the reaction [5-methylfurtrethonium binds to CHRM2 protein]	9224827
D000109	Acetylcholine	Acetylcholine binds to and results in increased activity of CHRM2 protein	10101037
D000109	Acetylcholine	Acetylcholine binds to CHRM2 protein	10069518
D000109	Acetylcholine	brucine analog affects the reaction [Acetylcholine binds to CHRM2 protein]	10069518
D000109	Acetylcholine	CHRM2 protein binds to Acetylcholine	9224827
D000109	Acetylcholine	eburnamonine promotes the reaction [Acetylcholine binds to CHRM2 protein]	9224827
D000109	Acetylcholine	N-chloromethylbrucine inhibits the reaction [Acetylcholine results in increased activity of CHRM2 protein]	10101037
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM2 mRNA]	29253600
D000111	Acetylcysteine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CHRM2 mRNA	22129741
D000171	Acrolein	Acrolein results in decreased expression of CHRM2 protein	17941892
C065959	AFDX 384	AFDX 384 binds to CHRM2 protein	18295336
C065959	AFDX 384	Mercuric Chloride inhibits the reaction [AFDX 384 binds to CHRM2 protein]	18295336
C065959	AFDX 384	Methylmercury Compounds inhibits the reaction [AFDX 384 binds to CHRM2 protein]	18295336
C065959	AFDX 384	Methylmercury Compounds promotes the reaction [AFDX 384 binds to CHRM2 protein]	18295336
C065959	AFDX 384	AFDX 384 binds to CHRM2 protein	14751452
C065959	AFDX 384	DEET promotes the reaction [AFDX 384 binds to CHRM2 protein]	11248143
C065959	AFDX 384	Permethrin promotes the reaction [AFDX 384 binds to CHRM2 protein]	11248143
C065959	AFDX 384	[Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] promotes the reaction [AFDX 384 binds to CHRM2 protein]	14751452
C065959	AFDX 384	[Pyridostigmine Bromide co-treated with Permethrin] promotes the reaction [AFDX 384 binds to CHRM2 protein]	14751452
C065959	AFDX 384	Pyridostigmine Bromide promotes the reaction [AFDX 384 binds to CHRM2 protein]	11248143\|1475145
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of CHRM2 gene	27153756
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of CHRM2 mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CHRM2 mRNA	16483693
C015688	arecaidine	arecaidine binds to and results in increased activity of CHRM2 protein	15251036
C015000	arecaidine esters	arecaidine esters binds to and results in increased activity of CHRM2 protein	18603373
D001115	Arecoline	CHRM2 protein affects the susceptibility to Arecoline	1458168
D001151	Arsenic	Arsenic results in decreased expression of CHRM2 mRNA	24019935
D001285	Atropine	Atropine binds to and results in decreased activity of CHRM2 protein	15140916
D001285	Atropine	Atropine binds to and results in decreased activity of CHRM2 protein	17613726
D001374	Azacitidine	Azacitidine affects the expression of CHRM2 mRNA	19002953
C547126	AZM551248	AZM551248 results in decreased expression of CHRM2 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CHRM2 mRNA	22228805
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CHRM2 mRNA	25566086
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CHRM2 mRNA]	25566086
D018723	Bethanechol	CHRM2 protein binds to Bethanechol	9224827
D018723	Bethanechol	eburnamonine promotes the reaction [Bethanechol binds to CHRM2 protein]	9224827
C006780	bisphenol A	bisphenol A results in increased expression of CHRM2 mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of CHRM2 mRNA	25594700
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in decreased expression of CHRM2 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of CHRM2 mRNA	25181051
C083806	brucine	brucine analog affects the reaction [Acetylcholine binds to CHRM2 protein]	10069518
C083806	brucine	brucine analog affects the reaction [N-Methylscopolamine binds to CHRM2 protein]	10069518
C083806	brucine	brucine binds to CHRM2 protein	15647330
C083806	brucine	brucine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	9495826
C083806	brucine	brucine analog promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	12757728
C083067	brucine N-oxide	brucine N-oxide promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	9495826
D019256	Cadmium Chloride	Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM2 mRNA]	29253600
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CHRM2 mRNA	29253600
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CHRM2 mRNA	27389774
D019256	Cadmium Chloride	Quercetin inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM2 mRNA]	27389774
C006890	caracurine	caracurine binds to CHRM2 protein	15647330
D002217	Carbachol	CHRM2 protein binds to Carbachol	9224827
D002217	Carbachol	eburnamonine promotes the reaction [Carbachol binds to CHRM2 protein]	9224827
D002217	Carbachol	Carbachol binds to and results in increased activity of CHRM2 protein	11181912
D002217	Carbachol	"Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"	19002953
D002217	Carbachol	"otenzepad inhibits the reaction [Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]]"	19002953
D002217	Carbachol	Carbachol binds to and results in increased activity of CHRM2 protein	17021048
D002217	Carbachol	[Carbachol binds to and results in increased activity of CHRM2 protein] results in increased activity of [KCNJ3 protein binds to KCNJ6 protein]	17021048
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of CHRM2 mRNA	12832660
D004390	Chlorpyrifos	Chlorpyrifos results in decreased activity of CHRM2 protein	15470232
D004390	Chlorpyrifos	Chlorpyrifos inhibits the reaction [GRK2 protein results in increased phosphorylation of CHRM2 protein]	16824341
D004390	Chlorpyrifos	Chlorpyrifos results in decreased activity of CHRM2 protein	17666426
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of CHRM2 mRNA	17452286\|1881221
D003435	Crotalid Venoms	Crotalid Venoms inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]	10845706
D003435	Crotalid Venoms	Crotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM2 protein]	10845706
D003474	Curcumin	Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHRM2 mRNA]	24952339
C540261	cyclo-L-glycyl-L-2-allylproline	cyclo-L-glycyl-L-2-allylproline results in decreased activity of CHRM2 protein	20188767
C017160	cypermethrin	cypermethrin promotes the reaction [cypermethrin results in decreased expression of CHRM2 mRNA]	25288152
C017160	cypermethrin	cypermethrin promotes the reaction [cypermethrin results in decreased expression of CHRM2 protein]	25288152
C017160	cypermethrin	cypermethrin results in decreased expression of CHRM2 mRNA	25288152
C017160	cypermethrin	cypermethrin results in decreased expression of CHRM2 protein	25288152
C101207	darifenacin	darifenacin binds to and results in decreased activity of CHRM2 protein	15140916
D003671	DEET	DEET affects the activity of CHRM2 protein	14713564
D003671	DEET	DEET promotes the reaction [AFDX 384 binds to CHRM2 protein]	11248143
D003671	DEET	[Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] promotes the reaction [AFDX 384 binds to CHRM2 protein]	14751452
D003976	Diazinon	Diazinon results in decreased activity of CHRM2 protein	15470232
D003976	Diazinon	Diazinon results in increased expression of CHRM2 mRNA	16207942
D003976	Diazinon	Diazinon affects the expression of CHRM2 mRNA	17452286
D003976	Diazinon	Diazinon results in decreased expression of CHRM2 mRNA	18812211
D004006	Dichlorvos	Dichlorvos results in decreased expression of CHRM2 protein	19100812
D004026	Dieldrin	Dieldrin affects the expression of CHRM2 mRNA	18812211
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of CHRM2 mRNA	26033743
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of CHRM2 mRNA	20920545
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CHRM2 mRNA	22129741
D004117	Dimethoate	Dimethoate results in decreased expression of CHRM2 mRNA	15033006
D004117	Dimethoate	Dimethoate results in decreased expression of CHRM2 protein	14694657
C113497	dimethyl-W84	CHRM2 protein binds to dimethyl-W84	16641315
C113497	dimethyl-W84	[CHRM2 protein binds to dimethyl-W84] affects the reaction [CHRM2 protein binds to N-Methylscopolamine]	16641315
D004222	Disulfoton	Disulfoton results in decreased expression of CHRM2 mRNA	8856746
C016422	eburnamonine	eburnamonine promotes the reaction [5-methylfurtrethonium binds to CHRM2 protein]	9224827
C016422	eburnamonine	eburnamonine promotes the reaction [Acetylcholine binds to CHRM2 protein]	9224827
C016422	eburnamonine	eburnamonine promotes the reaction [Bethanechol binds to CHRM2 protein]	9224827
C016422	eburnamonine	eburnamonine promotes the reaction [Carbachol binds to CHRM2 protein]	9224827
C016422	eburnamonine	eburnamonine promotes the reaction [furtrethonium binds to CHRM2 protein]	9224827
C016422	eburnamonine	eburnamonine promotes the reaction [oxotremorine M binds to CHRM2 protein]	9224827
C016422	eburnamonine	eburnamonine promotes the reaction [Pilocarpine binds to CHRM2 protein]	9224827
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of CHRM2 mRNA	22872703
C044894	ethylcholine aziridinium	ethylcholine aziridinium results in increased expression of CHRM2 mRNA	10733153
C044894	ethylcholine aziridinium	ethylcholine aziridinium results in increased expression of CHRM2 protein	10733153
C026098	etiracetam	etiracetam results in decreased expression of CHRM2 protein	15967574
C026098	etiracetam	etiracetam results in increased activity of CHRM2 protein	15967574
C020326	ferric nitrilotriacetate	ferric nitrilotriacetate results in decreased expression of CHRM2 mRNA	19490752
D005632	Fructose	Fructose results in increased expression of CHRM2 mRNA	17707055
D005632	Fructose	Fructose results in increased expression of CHRM2 protein	17707055
C039281	furan	furan results in decreased expression of CHRM2 mRNA	25539665
C028530	furtrethonium	CHRM2 protein binds to furtrethonium	9224827
C028530	furtrethonium	eburnamonine promotes the reaction [furtrethonium binds to CHRM2 protein]	9224827
D005703	Gallamine Triethiodide	CHRM2 protein binds to Gallamine Triethiodide	16641315
D005703	Gallamine Triethiodide	[CHRM2 protein binds to Gallamine Triethiodide] affects the reaction [CHRM2 protein binds to N-Methylscopolamine]	16641315
D005703	Gallamine Triethiodide	[CHRM2 protein binds to Gallamine Triethiodide] promotes the reaction [CHRM2 protein binds to N-Methylscopolamine]	15937215
D005703	Gallamine Triethiodide	Gallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]	9846649
D005703	Gallamine Triethiodide	Gallamine Triethiodide binds to and results in decreased activity of CHRM2 protein	8028781
D005947	Glucose	Glucose results in increased expression of CHRM2 mRNA	18715473
C048172	himbacine	himbacine binds to and results in decreased activity of CHRM2 protein	17180451
D006843	Hydrocarbons, Chlorinated	"Hydrocarbons, Chlorinated results in decreased expression of CHRM2 mRNA"	22872703
C082359	imidacloprid	imidacloprid results in increased expression of CHRM2 protein	18080902
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CHRM2 mRNA	22129741
D007649	Ketamine	Ketamine inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein]	12456425
C057416	KT 5720	KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	10860942
C073601	KT 5823	KT 5823 promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	10860942
D008344	Maneb	[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CHRM2 mRNA	23017109
D008627	Mercuric Chloride	Mercuric Chloride inhibits the reaction [AFDX 384 binds to CHRM2 protein]	18295336
C054938	methoctramine	methoctramine inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]	9846649
C054938	methoctramine	methoctramine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM2 protein]	8744975
C054938	methoctramine	methoctramine binds to and results in decreased activity of CHRM2 protein	10353596\|1168919
C445068	methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate	"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in decreased activity of CHRM2 protein"	28790194
D008767	Methylmercury Compounds	Methylmercury Compounds inhibits the reaction [AFDX 384 binds to CHRM2 protein]	18295336
D008767	Methylmercury Compounds	Methylmercury Compounds promotes the reaction [AFDX 384 binds to CHRM2 protein]	18295336
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CHRM2 mRNA"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased methylation of CHRM2 promoter"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CHRM2 mRNA"	20188158
D008743	Methyl Parathion	Methyl Parathion results in decreased activity of CHRM2 protein	17666426
D008743	Methyl Parathion	Methyl Parathion results in decreased expression of CHRM2 protein	14746346\|1664578
D019832	N-Methylscopolamine	brucine analog affects the reaction [N-Methylscopolamine binds to CHRM2 protein]	10069518
D019832	N-Methylscopolamine	brucine N-oxide promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	9495826
D019832	N-Methylscopolamine	brucine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	9495826
D019832	N-Methylscopolamine	[CHRM2 protein binds to dimethyl-W84] affects the reaction [CHRM2 protein binds to N-Methylscopolamine]	16641315
D019832	N-Methylscopolamine	[CHRM2 protein binds to Gallamine Triethiodide] affects the reaction [CHRM2 protein binds to N-Methylscopolamine]	16641315
D019832	N-Methylscopolamine	[CHRM2 protein binds to Gallamine Triethiodide] promotes the reaction [CHRM2 protein binds to N-Methylscopolamine]	15937215
D019832	N-Methylscopolamine	CHRM2 protein binds to N-Methylscopolamine	16641315\|9224827
D019832	N-Methylscopolamine	Crotalid Venoms inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]	10845706
D019832	N-Methylscopolamine	Gallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]	9846649
D019832	N-Methylscopolamine	KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	10860942
D019832	N-Methylscopolamine	KT 5823 promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	10860942
D019832	N-Methylscopolamine	methoctramine inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]	9846649
D019832	N-Methylscopolamine	N-chloromethylbrucine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	9495826
D019832	N-Methylscopolamine	N-Methylscopolamine binds to CHRM2 protein	10069518\|1084570
D019832	N-Methylscopolamine	Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]	9846649
D019832	N-Methylscopolamine	Pipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]	9846649
D019832	N-Methylscopolamine	rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]	9846649
D019832	N-Methylscopolamine	Staurosporine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	10860942
D019832	N-Methylscopolamine	Strychnine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	9495826
D019832	N-Methylscopolamine	Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]	9846649
D019832	N-Methylscopolamine	N-Methylscopolamine binds to CHRM2 protein	14559291
D019832	N-Methylscopolamine	Pilocarpine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	14559291
D019832	N-Methylscopolamine	brucine analog promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	12757728
D019832	N-Methylscopolamine	N-Methylscopolamine binds to CHRM2 protein	12757728
D019832	N-Methylscopolamine	"[N-Methylscopolamine binds to CHRM2 protein] affects the reaction [1,3-bis(4-(phthalimidomethoxyiminomethyl)pyridinium-1-yl)propane binds to CHRM2 protein]"	16362429
D019832	N-Methylscopolamine	Strychnine analog promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	12757728
D008799	Mevinphos	Mevinphos results in increased activity of CHRM2 protein	17395621
D018727	Muscarinic Antagonists	[Muscarinic Antagonists binds to and results in decreased activity of CHRM2 protein] which results in increased susceptibility to Organophosphorus Compounds	10513339
D015544	Inositol 1,4,5-Trisphosphate	"Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"	19002953
D015544	Inositol 1,4,5-Trisphosphate	"CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate"	19002953
D015544	Inositol 1,4,5-Trisphosphate	"otenzepad inhibits the reaction [Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]]"	19002953
C118330	N-chloromethylbrucine	N-chloromethylbrucine inhibits the reaction [Acetylcholine results in increased activity of CHRM2 protein]	10101037
C118330	N-chloromethylbrucine	N-chloromethylbrucine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	9495826
D009532	Nickel	Nickel affects the expression of CHRM2 mRNA	18812211
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CHRM2 mRNA	27935865
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CHRM2 mRNA	27935865
C025256	nonylphenol	nonylphenol results in decreased expression of CHRM2 mRNA	15620428
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate inhibits the reaction [GRK2 protein results in increased phosphorylation of CHRM2 protein]"	16824341
D009943	Organophosphorus Compounds	[Muscarinic Antagonists binds to and results in decreased activity of CHRM2 protein] which results in increased susceptibility to Organophosphorus Compounds	10513339
C048593	otenzepad	"otenzepad inhibits the reaction [Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]]"	19002953
C048593	otenzepad	otenzepad binds to CHRM2 protein	2606156
C048593	otenzepad	otenzepad results in decreased activity of CHRM2 protein	3754611
C048593	otenzepad	Tacrine inhibits the reaction [otenzepad binds to CHRM2 protein]	2606156
C048593	otenzepad	otenzepad inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM2 protein]	8744975
C048593	otenzepad	otenzepad binds to and results in decreased activity of CHRM2 protein	11804996\|1525103
D010095	Oxotremorine	CHRM2 protein mutant form results in decreased susceptibility to Oxotremorine	12713643
D010095	Oxotremorine	"[Oxotremorine binds to CHRM2 protein] affects the reaction [1,3-bis(4-(phthalimidomethoxyiminomethyl)pyridinium-1-yl)propane binds to CHRM2 protein]"	16362429
C042743	oxotremorine M	CHRM2 protein binds to oxotremorine M	9224827
C042743	oxotremorine M	eburnamonine promotes the reaction [oxotremorine M binds to CHRM2 protein]	9224827
C005419	oxybutynin	oxybutynin binds to and results in decreased activity of CHRM2 protein	15140916
D010100	Oxygen	CHRM2 gene mutant form results in decreased susceptibility to Oxygen	24571919
D010100	Oxygen	CHRM2 gene SNP results in decreased susceptibility to Oxygen	24571919
D010126	Ozone	Ozone results in decreased expression of CHRM2 mRNA	28623178
D010197	Pancuronium	Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]	9846649
D010261	Paraoxon	Paraoxon results in decreased expression of CHRM2 mRNA	21787676
D010269	Paraquat	[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CHRM2 mRNA	23017109
D010278	Parathion	Parathion results in decreased activity of CHRM2 protein	15470232
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether affects the expression of CHRM2 mRNA	27294297
D026023	Permethrin	Permethrin promotes the reaction [AFDX 384 binds to CHRM2 protein]	11248143
D026023	Permethrin	[Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] promotes the reaction [AFDX 384 binds to CHRM2 protein]	14751452
D026023	Permethrin	[Pyridostigmine Bromide co-treated with Permethrin] promotes the reaction [AFDX 384 binds to CHRM2 protein]	14751452
C000593032	PGW5 compound	PGW5 compound binds to CHRM2 protein	24389121
D010695	Phlorhizin	Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 mRNA]	18715473
D010695	Phlorhizin	Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 protein]	18715473
D010852	Picrotoxin	Picrotoxin results in increased expression of CHRM2 mRNA	15170462
D010862	Pilocarpine	Pilocarpine binds to and results in increased activity of CHRM2 protein	15470232
D010862	Pilocarpine	CHRM2 protein binds to Pilocarpine	9224827
D010862	Pilocarpine	eburnamonine promotes the reaction [Pilocarpine binds to CHRM2 protein]	9224827
D010862	Pilocarpine	Pilocarpine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	14559291
D010862	Pilocarpine	Pilocarpine results in decreased expression of CHRM2 protein	14559291
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CHRM2 mRNA	27935865
D017300	Pipecuronium	Pipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]	9846649
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of CHRM2 mRNA	24780913
D011729	Pyridostigmine Bromide	[Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] promotes the reaction [AFDX 384 binds to CHRM2 protein]	14751452
D011729	Pyridostigmine Bromide	[Pyridostigmine Bromide co-treated with Permethrin] promotes the reaction [AFDX 384 binds to CHRM2 protein]	14751452
D011729	Pyridostigmine Bromide	Pyridostigmine Bromide promotes the reaction [AFDX 384 binds to CHRM2 protein]	11248143\|1475145
D011759	Pyrrolidines	Pyrrolidines analog binds to and results in increased activity of CHRM2 protein	16539379
D011759	Pyrrolidines	Pyrrolidines analog binds to CHRM2 protein	16539379
D011794	Quercetin	Quercetin inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM2 mRNA]	27389774
D011813	Quinuclidinyl Benzilate	Crotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM2 protein]	10845706
D011813	Quinuclidinyl Benzilate	Quinuclidinyl Benzilate binds to CHRM2 protein	10845706
D011813	Quinuclidinyl Benzilate	methoctramine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM2 protein]	8744975
D011813	Quinuclidinyl Benzilate	otenzepad inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM2 protein]	8744975
D011813	Quinuclidinyl Benzilate	Quinuclidinyl Benzilate binds to CHRM2 protein	8744975
C059514	resveratrol	resveratrol results in increased expression of CHRM2 mRNA	21937650
C061870	rocuronium	rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]	9846649
C109640	sabcomeline	sabcomeline binds to and results in increased activity of CHRM2 protein	11181912
D012524	Sarin	Sarin affects the activity of CHRM2 protein	21419149
D012602	Scopolamine Derivatives	Scopolamine Derivatives binds to CHRM2 protein	12507038
D012602	Scopolamine Derivatives	"4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein]"	11306684
D012602	Scopolamine Derivatives	Ketamine inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein]	12456425
D012602	Scopolamine Derivatives	Scopolamine Derivatives binds to CHRM2 protein	11306684\|1245642
D012602	Scopolamine Derivatives	Tropicamide inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein]	11306684
C017947	sodium arsenite	Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHRM2 mRNA]	24952339
C017947	sodium arsenite	sodium arsenite results in decreased expression of CHRM2 mRNA	24517892\|2495233
D053260	Soot	Soot results in increased expression of CHRM2 mRNA	26551751
D019311	Staurosporine	Staurosporine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	10860942
D013311	Streptozocin	1-hexacosanol inhibits the reaction [Streptozocin affects the expression of CHRM2 mRNA]	17989502
D013311	Streptozocin	Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 mRNA]	18715473
D013311	Streptozocin	Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 protein]	18715473
D013311	Streptozocin	Streptozocin affects the expression of CHRM2 mRNA	17989502
D013311	Streptozocin	Streptozocin results in increased expression of CHRM2 mRNA	18715473
D013311	Streptozocin	Streptozocin results in increased expression of CHRM2 protein	18715473
D013331	Strychnine	Strychnine binds to CHRM2 protein	15647330
D013331	Strychnine	Strychnine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	9495826
D013331	Strychnine	Strychnine analog promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]	12757728
D013619	Tacrine	Tacrine inhibits the reaction [otenzepad binds to CHRM2 protein]	2606156
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in decreased expression of CHRM2 mRNA	26496021
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CHRM2 mRNA	21570461
D000069447	Tiotropium Bromide	Tiotropium Bromide binds to CHRM2 protein	21870878
D000068737	Tolterodine Tartrate	Tolterodine Tartrate binds to and results in decreased activity of CHRM2 protein	15140916
D014212	Tretinoin	Tretinoin results in decreased expression of CHRM2 mRNA	23724009
D014227	Triazines	Triazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of CHRM2 mRNA]	27469509
D014236	Trichlorfon	[Trichlorfon results in decreased activity of ACHE protein] which affects the localization of CHRM2 protein	12794734
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CHRM2 mRNA"	26179874
D014331	Tropicamide	Tropicamide inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein]	11306684
D017973	Tungsten Compounds	Tungsten Compounds results in decreased expression of CHRM2 mRNA	28666766
C561310	UNC 0638	UNC 0638 results in decreased activity of CHRM2 protein	21743462
D014673	Vecuronium Bromide	Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]	9846649
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CHRM2 gene	25560391
C009680	VX	VX results in decreased expression of CHRM2 protein	29127449
C075257	xanomeline	xanomeline binds to CHRM2 protein	11181912
C581157	XL147	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CHRM2 mRNA	27935865

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004930	G-protein coupled receptor activity	-	IBA	21873635
GO:0004993	G-protein coupled serotonin receptor activity	-	IBA	21873635
GO:0008144	drug binding	-	IEA	-
GO:0016907	G-protein coupled acetylcholine receptor activity	-	IBA	21873635
GO:0016907	G-protein coupled acetylcholine receptor activity	-	IDA	24256733
GO:0030594	neurotransmitter receptor activity	-	IBA	21873635
GO:1990763	arrestin family protein binding	-	IPI	11566136

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006940	regulation of smooth muscle contraction	-	IBA	21873635
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	-	IBA	21873635
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	-	TAS	10895079
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	-	TAS	8139539
GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway	-	IBA	21873635
GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway	-	TAS	2739737
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway	-	IDA	24256733
GO:0007268	chemical synaptic transmission	-	IBA	21873635
GO:0007399	nervous system development	-	TAS	2739737
GO:0008016	regulation of heart contraction	-	IBA	21873635
GO:0009615	response to virus	-	IEP	16548883
GO:0061024	membrane organization	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	IDA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	IDA	24256733
GO:0016021	integral component of membrane	-	IDA	11566136
GO:0030054	cell junction	-	IEA	-
GO:0030425	dendrite	-	IBA	21873635
GO:0030425	dendrite	-	IEA	-
GO:0030665	clathrin-coated vesicle membrane	-	TAS	-
GO:0032279	asymmetric synapse	-	IEA	-
GO:0032280	symmetric synapse	-	IEA	-
GO:0043025	neuronal cell body	-	IEA	-
GO:0043679	axon terminus	-	IEA	-
GO:0045202	synapse	-	IBA	21873635
GO:0045211	postsynaptic membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04810	Regulation of actin cytoskeleton

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375280	Amine ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-390648	Muscarinic acetylcholine receptors	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	TAS
R-HSA-8856828	Clathrin-mediated endocytosis	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
18316677	Using dimensional models of externalizing psychopathology to aid in gene identification. (2008 Mar)	Dick DM	Arch Gen Psychiatry
18634760	Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes. (2008 Oct 15)	Rangaswamy M	Brain Res
17982586	Neurophysiological endophenotypes, CNS disinhibition, and risk for alcohol dependence and related disorders. (2007 Nov 2)	Porjesz B	ScientificWorldJournal
16612210	New findings on the genetic influences on alcohol use and dependence. (2006 May)	Higuchi S	Curr Opin Psychiatry
21176104	Association of CHRM2 polymorphisms with severity of alcohol dependence. (2011 Mar)	Jung MH	Genes Brain Behav
23747232	Cholinergic receptor gene (CHRM2) variation and familial loading for alcohol dependence predict childhood developmental trajectories of P300. (2013 Oct 30)	Hill SY	Psychiatry Res
16000316	CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study. (2005 Aug 15)	Luo X	Hum Mol Genet
16961766	The genetics of alcoholism: identifying specific genes through family studies. (2006 Sep)	Edenberg HJ	Addict Biol
17567401	Alcohol dependence with comorbid drug dependence: genetic and phenotypic associations suggest a more severe form of the disorder with stronger genetic contribution to risk. (2007 Jul)	Dick DM	Addiction
23712313	Genetics and alcoholism. (2013 Aug)	Edenberg HJ	Nat Rev Gastroenterol Hepatol
25155933	Familial risk for alcohol dependence and developmental changes in BMI: the moderating influence of addiction and obesity genes. (2014 Jul)	Lichenstein SD	Pharmacogenomics
21314694	Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. (2011 May)	Kendler KS	Alcohol Clin Exp Res
23963516	Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults. (2013 Sep)	Chorlian DB	Behav Genet
21441226	CHRM2, parental monitoring, and adolescent externalizing behavior: evidence for gene-environment interaction. (2011 Apr)	Dick DM	Psychol Sci
17160701	Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence. (2007 Mar)	Dick DM	Behav Genet
19644963	Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction. (2010 Mar 5)	Mobascher A	Am J Med Genet B Neuropsychiatr Genet
15229186	Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome. (2004 Sep 1)	Wang JC	Hum Mol Genet
16341909	Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholism. (2006 Jan)	Dick DM	Behav Genet
29478862	An exploratory study of candidate gene(s) for Delirium Tremens: Adding the new cholinergic dimension to the conundrum. (2018 Jan)	Malhotra S	Asian J Psychiatr
28361821	Candidate genes for alcohol dependence: A genetic association study from India. (2016 Nov)	Malhotra S	Indian J Med Res