Gene: ADCY7

113
AC7
adenylate cyclase 7
protein-coding
16q12.1
Ensembl:ENSG00000121281 MIM:600385 Vega:OTTHUMG00000133172 UniprotKB:P51828
NC_000016.10
PubMed
0   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.218e-1 (AD)  8.680e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SRGAP2B0.804
SRGAP2C0.757
PTPRJ0.754
SMCR80.744
PITPNB0.731
TCP11L10.723
HPS30.719
PLEKHM30.717
ARNTL20.713
SLC12A60.707

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TST-0.458
TLCD1-0.444
ZFHX4-AS1-0.429
SOX3-0.421
S100A1-0.417
SDC4-0.411
MMP28-0.409
NTSR2-0.401
APOM-0.395
PLIN5-0.392

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ADCY7 mRNA19933214
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ADCY7 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADCY7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADCY7 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ADCY7 mRNA29067470
D020106AcrylamideAcrylamide results in decreased expression of ADCY7 mRNA28959563
D015766Albendazole[Ivermectin co-treated with Albendazole] results in increased expression of ADCY7 mRNA16861626
D001280AtrazineAtrazine results in decreased expression of ADCY7 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of ADCY7 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADCY7 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ADCY7 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADCY7 mRNA22228805
D004958EstradiolEstradiol affects the expression of ADCY7 mRNA15598610
C006780bisphenol Abisphenol A results in decreased expression of ADCY7 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of ADCY7 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of ADCY7 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of ADCY7 mRNA18180321
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of ADCY7 mRNA22079614
D002104CadmiumCadmium results in increased expression of ADCY7 mRNA24376830
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADCY7 mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADCY7 mRNA]"20230807
D002220CarbamazepineCarbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY7 protein]19922557
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ADCY7 mRNA17484886|2733941
D002737ChloropreneChloroprene results in decreased expression of ADCY7 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADCY7 mRNA20938992
D003471CuprizoneCuprizone results in increased expression of ADCY7 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of ADCY7 mRNA20106945|2556210
D013759DronabinolDronabinol results in decreased expression of ADCY7 mRNA16616335
D003907DexamethasoneDexamethasone results in decreased expression of ADCY7 mRNA22733784
C000944dicrotophosdicrotophos results in increased expression of ADCY7 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ADCY7 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of ADCY7 mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of ADCY7 mRNA21658437
D002117CalcitriolCalcitriol results in decreased expression of ADCY7 mRNA26485663
D004317Doxorubicin[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of ADCY7 mRNA21040762
C118739entinostatentinostat results in increased expression of ADCY7 mRNA27188386
D004837EpinephrineEpinephrine results in increased expression of ADCY7 mRNA19300450
D004837EpinephrineMetoprolol inhibits the reaction [Epinephrine results in increased expression of ADCY7 mRNA]19300450
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ADCY7 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADCY7 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADCY7 mRNA20938992
C069837fullerene C60fullerene C60 results in decreased expression of ADCY7 mRNA19167457
D019833GenisteinGenistein results in decreased expression of ADCY7 mRNA22228119
D005839GentamicinsGentamicins results in increased expression of ADCY7 mRNA22061828
D017313FenretinideFenretinide results in decreased expression of ADCY7 mRNA28973697
D007559Ivermectin[Ivermectin co-treated with Albendazole] results in increased expression of ADCY7 mRNA16861626
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ADCY7 mRNA23086925|2479639
D048628KetolidesKetolides analog results in increased expression of ADCY7 mRNA24967691
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of ADCY7 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADCY7 mRNA20938992
D008727MethotrexateMethotrexate affects the expression of ADCY7 mRNA18502557
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ADCY7 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ADCY7 mRNA23179753
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADCY7 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADCY7 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADCY7 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ADCY7 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADCY7 mRNA]"20230807
D008790MetoprololMetoprolol inhibits the reaction [Epinephrine results in increased expression of ADCY7 mRNA]19300450
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of ADCY7 mRNA22401849
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ADCY7 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of ADCY7 mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ADCY7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ADCY7 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of ADCY7 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of ADCY7 mRNA16780908
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ADCY7 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADCY7 mRNA]"20230807
D000073878Palm OilPalm Oil results in increased expression of ADCY7 mRNA18042831
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADCY7 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ADCY7 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of ADCY7 mRNA20813756
C071262SK&F 82958Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY7 protein]19922557
C071262SK&F 82958[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY7 protein19922557
D013629TamoxifenTamoxifen affects the expression of ADCY7 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADCY7 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADCY7 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADCY7 mRNA19933214
D013849ThimerosalThimerosal results in decreased expression of ADCY7 mRNA27188386
D014212TretinoinTretinoin results in decreased expression of ADCY7 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of ADCY7 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ADCY7 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ADCY7 mRNA29024780
D014520UrethaneUrethane results in decreased expression of ADCY7 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ADCY7 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ADCY7 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased methylation of ADCY7 gene29154799
D014638VanadatesVanadates results in increased expression of ADCY7 mRNA22714537
C066075vanadium pentoxidevanadium pentoxide affects the expression of ADCY7 mRNA26210822
C025643vinclozolinvinclozolin results in increased methylation of ADCY7 promoter22570695
C111237vorinostatvorinostat results in decreased expression of ADCY7 mRNA18769122

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004016adenylate cyclase activity-IC18541530  23178822  23229509  
GO:0004016adenylate cyclase activity-IDA11113152  17760784  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003091renal water homeostasis-TAS-  
GO:0006171cAMP biosynthetic process-IDA11113152  17760784  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-TAS-  
GO:0060135maternal process involved in female pregnancy-IEA-  
GO:0071361cellular response to ethanol-IDA17760784  
GO:0071377cellular response to glucagon stimulus-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IDA11113152  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa04020Calcium signaling pathway
hsa04062Chemokine signaling pathway
hsa04114Oocyte meiosis
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04916Melanogenesis
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04976Bile secretion
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-111885Opioid SignallingTAS
R-HSA-111885Opioid SignallingIEA
R-HSA-111931PKA-mediated phosphorylation of CREBTAS
R-HSA-111933Calmodulin induced eventsTAS
R-HSA-111996Ca-dependent eventsTAS
R-HSA-111997CaM pathwayTAS
R-HSA-112040G-protein mediated eventsTAS
R-HSA-112040G-protein mediated eventsIEA
R-HSA-112043PLC beta mediated eventsTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionIEA
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112315Transmission across Chemical SynapsesIEA
R-HSA-112316Neuronal SystemTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-1430728MetabolismTAS
R-HSA-1489509DAG and IP3 signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-163359Glucagon signaling in metabolic regulationTAS
R-HSA-163615PKA activationTAS
R-HSA-163685Integration of energy metabolismTAS
R-HSA-164378PKA activation in glucagon signallingTAS
R-HSA-170660Adenylate cyclase activating pathwayTAS
R-HSA-170670Adenylate cyclase inhibitory pathwayTAS
R-HSA-170670Adenylate cyclase inhibitory pathwayIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-418555G alpha (s) signalling eventsIEA
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-418597G alpha (z) signalling eventsIEA
R-HSA-418597G alpha (z) signalling eventsTAS
R-HSA-432040Vasopressin regulates renal water homeostasis via AquaporinsTAS
R-HSA-445717Aquaporin-mediated transportTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-977443GABA receptor activationTAS
R-HSA-977443GABA receptor activationIEA
R-HSA-977444GABA B receptor activationTAS
R-HSA-977444GABA B receptor activationIEA
R-HSA-991365Activation of GABAB receptorsTAS
R-HSA-991365Activation of GABAB receptorsIEA
R-HSA-997269Inhibition of adenylate cyclase pathwayTAS
R-HSA-997269Inhibition of adenylate cyclase pathwayIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21481845Sex-specific role for adenylyl cyclase type 7 in alcohol dependence. (2011 Jun 1)Desrivieres SBiol Psychiatry
9034014Human adenylyl cyclase type 7 contains polymorphic repeats in the 3' untranslated region: investigations of association with alcoholism. (1997 Feb 21)Hellevuo KAm J Med Genet