Gene info: ID 1131

Gene: CHRM3

GENE ID: 1131

Synonyms: EGBRS|HM3|PBS

Description: cholinergic receptor muscarinic 3

Gene type: protein-coding

Location: 1q43

dbXrefs: Ensembl:ENSG00000133019 MIM:118494 Vega:OTTHUMG00000039649 UniprotKB:P20309

RefSeq: NG_032046.2

Retrived from: SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.840e-1 (AD) 8.946e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs12080951	chr1:239615360 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs12135445	chr1:239579957 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KIAA1549L	0.971
KCNJ3	0.964
DLGAP1	0.963
AAK1	0.961
SV2B	0.961
PRICKLE1	0.96
ATRNL1	0.959
EPHA4	0.959
OLFM3	0.958
KCTD16	0.958

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HEY2	-0.615
RAB13	-0.6
ACAP1	-0.599
MYL3	-0.578
YES1	-0.573
SNHG18	-0.573
WWTR1	-0.572
CMTM3	-0.57
CSAG1	-0.57
EMP3	-0.569

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00185	Cevimeline	Small Molecule	107233-08-9	Approved	Target
DB00193	Tramadol	Small Molecule	27203-92-5	Approved\|Investigational	Target
DB00202	Succinylcholine	Small Molecule	306-40-1	Approved	Target
DB00246	Ziprasidone	Small Molecule	146939-27-7	Approved	Target
DB00280	Disopyramide	Small Molecule	3737-09-5	Approved	Target
DB00321	Amitriptyline	Small Molecule	50-48-6	Approved	Target
DB00332	Ipratropium bromide	Small Molecule	22254-24-6	Approved	Target
DB00334	Olanzapine	Small Molecule	132539-06-1	Approved\|Investigational	Target
DB00340	Metixene	Small Molecule	4969-02-2	Approved	Target
DB00342	Terfenadine	Small Molecule	50679-08-8	Approved\|Withdrawn	Target
DB00363	Clozapine	Small Molecule	5786-21-0	Approved	Target
DB00376	Trihexyphenidyl	Small Molecule	144-11-6	Approved	Target
DB00383	Oxyphencyclimine	Small Molecule	125-53-1	Approved	Target
DB00387	Procyclidine	Small Molecule	77-37-2	Approved	Target
DB00408	Loxapine	Small Molecule	1977-10-2	Approved	Target
DB00411	Carbachol	Small Molecule	51-83-2	Approved	Target
DB00420	Promazine	Small Molecule	58-40-2	Approved	Target
DB00424	Hyoscyamine	Small Molecule	101-31-5	Approved	Target
DB00434	Cyproheptadine	Small Molecule	129-03-3	Approved	Target
DB00458	Imipramine	Small Molecule	50-49-7	Approved	Target
DB00462	Methylscopolamine bromide	Small Molecule	155-41-9	Approved	Target
DB00477	Chlorpromazine	Small Molecule	50-53-3	Approved\|Investigational	Target
DB00496	Darifenacin	Small Molecule	133099-04-4	Approved\|Investigational	Target
DB00505	Tridihexethyl	Small Molecule	60-49-1	Withdrawn	Target
DB00517	Anisotropine Methylbromide	Small Molecule	80-50-2	Approved	Target
DB00540	Nortriptyline	Small Molecule	72-69-5	Approved	Target
DB00572	Atropine	Small Molecule	51-55-8	Approved	Target
DB00599	Thiopental	Small Molecule	76-75-5	Approved	Target
DB00622	Nicardipine	Small Molecule	55985-32-5	Approved\|Investigational	Target
DB00715	Paroxetine	Small Molecule	61869-08-7	Approved\|Investigational	Target
DB00725	Homatropine Methylbromide	Small Molecule	80-49-9	Approved	Target
DB00729	Diphemanil Methylsulfate	Small Molecule	62-97-5	Approved\|Withdrawn	Target
DB00747	Scopolamine	Small Molecule	51-34-3	Approved\|Investigational	Target
DB00767	Benzquinamide	Small Molecule	63-12-7	Withdrawn	Target
DB00777	Propiomazine	Small Molecule	362-29-8	Approved	Target
DB00785	Cryptenamine	Small Molecule	1356-18-9	Approved	Target
DB00809	Tropicamide	Small Molecule	1508-75-4	Approved\|Investigational	Target
DB00835	Brompheniramine	Small Molecule	86-22-6	Approved	Target
DB00934	Maprotiline	Small Molecule	10262-69-8	Approved\|Investigational	Target
DB00986	Glycopyrronium	Small Molecule	740028-90-4	Approved\|Investigational	Target
DB01019	Bethanechol	Small Molecule	674-38-4	Approved	Target
DB01036	Tolterodine	Small Molecule	124937-51-5	Approved\|Investigational	Target
DB01062	Oxybutynin	Small Molecule	5633-20-5	Approved\|Investigational	Target
DB01069	Promethazine	Small Molecule	60-87-7	Approved\|Investigational	Target
DB01085	Pilocarpine	Small Molecule	92-13-7	Approved\|Investigational	Target
DB01142	Doxepin	Small Molecule	1668-19-5	Approved\|Investigational	Target
DB01151	Desipramine	Small Molecule	50-47-5	Approved\|Investigational	Target
DB01224	Quetiapine	Small Molecule	111974-69-7	Approved	Target
DB01226	Mivacurium	Small Molecule	133814-19-4	Approved	Target
DB01231	Diphenidol	Small Molecule	972-02-1	Approved\|Investigational\|Withdrawn	Target
DB01238	Aripiprazole	Small Molecule	129722-12-9	Approved\|Investigational	Target
DB01239	Chlorprothixene	Small Molecule	113-59-7	Approved\|Investigational\|Withdrawn	Target
DB01337	Pancuronium	Small Molecule	-	Approved	Target
DB01338	Pipecuronium	Small Molecule	68399-58-6	Approved	Target
DB01403	Methotrimeprazine	Small Molecule	60-99-1	Approved\|Investigational	Target
DB01409	Tiotropium	Small Molecule	186691-13-4	Approved	Target
DB01591	Solifenacin	Small Molecule	242478-37-1	Approved	Target
DB01625	Isopropamide	Small Molecule	7492-32-2	Approved	Target
DB03128	Acetylcholine	Small Molecule	51-84-3	Approved	Target
DB04365	Arecoline	Small Molecule	63-75-2	Experimental	Target
DB04843	Mepenzolate	Small Molecule	25990-43-6	Approved	Target
DB04924	Itopride	Small Molecule	122898-67-3	Investigational	Target
DB05752	ALKS 27	Small Molecule	-	Investigational	Target
DB06702	Fesoterodine	Small Molecule	286930-02-7	Approved	Target
DB06709	Methacholine	Small Molecule	55-92-5	Approved\|Investigational	Target
DB06787	Hexocyclium	Small Molecule	6004-98-4	Approved	Target
DB08897	Aclidinium	Small Molecule	727649-81-2	Approved	Target
DB09076	Umeclidinium	Small Molecule	869185-19-3	Approved	Target
DB09167	Dosulepin	Small Molecule	113-53-1	Approved	Target
DB09262	Imidafenacin	Small Molecule	170105-16-5	Approved\|Investigational	Target
DB09300	Butylscopolamine	Small Molecule	7182-53-8	Approved\|Investigational	Target
DB09357	Dexpanthenol	Small Molecule	81-13-0	Approved	Target
DB00454	Pethidine	Small Molecule	57-42-1	Approved	Target
DB00543	Amoxapine	Small Molecule	14028-44-5	Approved	Target
DB00555	Lamotrigine	Small Molecule	84057-84-1	Approved\|Investigational	Target
DB00568	Cinnarizine	Small Molecule	298-57-7	Approved\|Investigational	Target
DB00726	Trimipramine	Small Molecule	739-71-9	Approved	Target
DB01221	Ketamine	Small Molecule	6740-88-1	Approved	Target
DB09194	Etoperidone	Small Molecule	52942-31-1	Withdrawn	Target

ID	Drug Name	Action	PubMed
C425227	(1-(2,2-diphenyl-(1,3)dioxolan-4-yl)-ethyl)-dimethyl-amine	"(1-(2,2-diphenyl-(1,3)dioxolan-4-yl)-ethyl)-dimethyl-amine analog binds to and results in decreased activity of CHRM3 protein"	11206470
C425227	(1-(2,2-diphenyl-(1,3)dioxolan-4-yl)-ethyl)-dimethyl-amine	"(1-(2,2-diphenyl-(1,3)dioxolan-4-yl)-ethyl)-dimethyl-amine binds to and results in decreased activity of CHRM3 protein"	11206470
C051942	1-hexacosanol	1-hexacosanol inhibits the reaction [Streptozocin affects the expression of CHRM3 mRNA]	17989502
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CHRM3 mRNA"	19114083
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
C042375	4-diphenylacetoxy-1,1-dimethylpiperidinium	"4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]"	9846649
C042375	4-diphenylacetoxy-1,1-dimethylpiperidinium	"4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]"	11306684
C042375	4-diphenylacetoxy-1,1-dimethylpiperidinium	"4-diphenylacetoxy-1,1-dimethylpiperidinium binds to and results in decreased activity of CHRM3 protein"	10353596\|1168919
C042375	4-diphenylacetoxy-1,1-dimethylpiperidinium	"4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased activity of CHRM3 protein"	15115163
C519669	4-diphenylacetoxy-N-methylpiperidine methobromide	4-diphenylacetoxy-N-methylpiperidine methobromide binds to and results in decreased activity of CHRM3 protein	15105209
C519669	4-diphenylacetoxy-N-methylpiperidine methobromide	Metoclopramide inhibits the reaction [4-diphenylacetoxy-N-methylpiperidine methobromide binds to CHRM3 protein]	15105209
C058297	4-fluorohexahydrosiladifenidol	4-fluorohexahydrosiladifenidol binds to and results in decreased activity of CHRM3 protein	10353596
C568516	5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide	"5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide binds to CHRM3 protein"	21870878
C008446	5-methylfurtrethonium	brucine promotes the reaction [5-methylfurtrethonium binds to CHRM3 protein]	9224827
C008446	5-methylfurtrethonium	CHRM3 protein binds to 5-methylfurtrethonium	9224827
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
D000109	Acetylcholine	Acetylcholine results in increased activity of CHRM3 protein	10101037
D000109	Acetylcholine	N-chloromethylbrucine promotes the reaction [Acetylcholine results in increased activity of CHRM3 protein]	10101037
D000109	Acetylcholine	CHRM3 protein affects the susceptibility to Acetylcholine	18367213
D000109	Acetylcholine	Acetylcholine binds to and results in increased activity of CHRM3 protein	10101037
D000109	Acetylcholine	Acetylcholine binds to CHRM3 protein	10069518\|9495826
D000109	Acetylcholine	brucine analog affects the reaction [Acetylcholine binds to CHRM3 protein]	10069518
D000109	Acetylcholine	brucine N-oxide promotes the reaction [Acetylcholine binds to CHRM3 protein]	9495826
D000109	Acetylcholine	brucine promotes the reaction [Acetylcholine binds to CHRM3 protein]	9224827
D000109	Acetylcholine	CHRM3 protein binds to Acetylcholine	9224827
D000109	Acetylcholine	N-chloromethylbrucine promotes the reaction [Acetylcholine binds to CHRM3 protein]	9495826
D000109	Acetylcholine	N-chloromethylbrucine promotes the reaction [Acetylcholine results in increased activity of CHRM3 protein]	10101037
D000109	Acetylcholine	Acetylcholine results in increased activity of CHRM3 protein	15964566
D000109	Acetylcholine	CHRM3 protein results in increased susceptibility to Acetylcholine	15964566\|1940701
D000109	Acetylcholine	Acetylcholine binds to CHRM3 protein	12435818
D000109	Acetylcholine	Acetylcholine results in increased activity of CHRM3 protein	11755166
D000109	Acetylcholine	Pregnenolone inhibits the reaction [Acetylcholine binds to CHRM3 protein]	15900516
D000109	Acetylcholine	Progesterone inhibits the reaction [Acetylcholine binds to CHRM3 protein]	15900516
D000109	Acetylcholine	WIN 62577 analog inhibits the reaction [Acetylcholine binds to CHRM3 protein]	12435818
D000109	Acetylcholine	WIN 62577 promotes the reaction [Acetylcholine binds to CHRM3 protein]	12435818
D000109	Acetylcholine	Acetylcholine results in increased activity of [CHRM3 protein co-treated with TRPV1 protein]	18826653
D000109	Acetylcholine	capsazepine inhibits the reaction [Acetylcholine results in increased activity of [CHRM3 protein co-treated with TRPV1 protein]]	18826653
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM3 mRNA]	29253600
D000143	Acids	CHRM3 protein affects the reaction [GAST protein results in increased secretion of Acids]	14724830
D000143	Acids	CHRM3 protein affects the reaction [Histamine results in increased secretion of Acids]	14724830
D000143	Acids	CHRM3 protein affects the secretion of Acids	14724830
D000171	Acrolein	Acrolein results in increased expression of CHRM3 protein	17941892
D020106	Acrylamide	Acrylamide affects the expression of CHRM3 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of CHRM3 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of CHRM3 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CHRM3 mRNA	23630614
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of CHRM3 mRNA	28522335
C439263	AM 1241	AM 1241 binds to CHRM3 protein	18931146
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CHRM3 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of CHRM3 mRNA	24449571
D001115	Arecoline	brucine promotes the reaction [Arecoline binds to CHRM3 protein]	9224827
D001115	Arecoline	CHRM3 protein binds to Arecoline	9224827
D001151	Arsenic	Arsenic affects the methylation of CHRM3 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of CHRM3 mRNA	26705709
D001280	Atrazine	Atrazine results in decreased expression of CHRM3 mRNA	25929836
D001285	Atropine	Atropine binds to and results in decreased activity of CHRM3 protein	15140916
D001285	Atropine	Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]	20708676
D001285	Atropine	Atropine binds to and results in decreased activity of CHRM3 protein	17613726
C487081	belinostat	belinostat results in increased expression of CHRM3 mRNA	26272509
C487081	belinostat	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
D004958	Estradiol	[Estradiol co-treated with Plant Preparations] results in decreased expression of CHRM3 mRNA	26945725
D018723	Bethanechol	brucine promotes the reaction [Bethanechol binds to CHRM3 protein]	9224827
D018723	Bethanechol	CHRM3 protein binds to Bethanechol	9224827
C006780	bisphenol A	[bisphenol A co-treated with Genistein] results in increased methylation of CHRM3 gene	28505145
C006780	bisphenol A	bisphenol A results in decreased expression of CHRM3 mRNA	25181051\|2710353
C006780	bisphenol A	bisphenol A results in increased expression of CHRM3 mRNA	29097150
C006780	bisphenol A	bisphenol A results in increased methylation of CHRM3 gene	28505145
C083806	brucine	brucine analog affects the reaction [Acetylcholine binds to CHRM3 protein]	10069518
C083806	brucine	brucine analog affects the reaction [N-Methylscopolamine binds to CHRM3 protein]	10069518
C083806	brucine	brucine binds to and results in increased activity of CHRM3 protein mutant form	20466821
C083806	brucine	brucine binds to CHRM3 protein	15647330
C083806	brucine	brucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM3 protein]	9224827
C083806	brucine	brucine promotes the reaction [5-methylfurtrethonium binds to CHRM3 protein]	9224827
C083806	brucine	brucine promotes the reaction [Acetylcholine binds to CHRM3 protein]	9224827
C083806	brucine	brucine promotes the reaction [Arecoline binds to CHRM3 protein]	9224827
C083806	brucine	brucine promotes the reaction [Bethanechol binds to CHRM3 protein]	9224827
C083806	brucine	brucine promotes the reaction [Carbachol binds to CHRM3 protein]	9224827
C083806	brucine	brucine promotes the reaction [Carbachol results in increased activity of CHRM3 protein mutant form]	20466821
C083806	brucine	brucine promotes the reaction [furtrethonium binds to CHRM3 protein]	9224827
C083806	brucine	brucine promotes the reaction [oxotremorine M binds to CHRM3 protein]	9224827
C083806	brucine	brucine promotes the reaction [Pilocarpine binds to CHRM3 protein]	9224827
C083067	brucine N-oxide	brucine N-oxide promotes the reaction [Acetylcholine binds to CHRM3 protein]	9495826
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CHRM3 mRNA	23741332
D019256	Cadmium Chloride	Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM3 mRNA]	29253600
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CHRM3 mRNA	29253600
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CHRM3 mRNA	27389774
D019256	Cadmium Chloride	Quercetin inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM3 mRNA]	27389774
C071423	capsazepine	capsazepine inhibits the reaction [Acetylcholine results in increased activity of [CHRM3 protein co-treated with TRPV1 protein]]	18826653
C006890	caracurine	caracurine binds to CHRM3 protein	15647330
D002217	Carbachol	Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]	20708676
D002217	Carbachol	brucine promotes the reaction [Carbachol binds to CHRM3 protein]	9224827
D002217	Carbachol	brucine promotes the reaction [Carbachol results in increased activity of CHRM3 protein mutant form]	20466821
D002217	Carbachol	Carbachol binds to and results in increased activity of CHRM3 protein	20466821
D002217	Carbachol	Carbachol binds to and results in increased activity of CHRM3 protein mutant form	20466821
D002217	Carbachol	Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]	20708676
D002217	Carbachol	Carbachol results in increased activity of CHRM3 protein	20708676
D002217	Carbachol	CHRM3 protein binds to Carbachol	9224827
D002217	Carbachol	Guanylyl Imidodiphosphate inhibits the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]]	20708676
D002217	Carbachol	Zinc Oxide promotes the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]]	20708676
D002217	Carbachol	CHRM3 protein affects the susceptibility to Carbachol	14724830
D002217	Carbachol	CHRM3 protein results in increased susceptibility to Carbachol	19407017
D002217	Carbachol	[Metoclopramide binds to and results in decreased activity of CHRM3 protein] which results in decreased susceptibility to Carbachol	15105209
D002217	Carbachol	Carbachol results in increased activity of CHRM3 protein	15255942\|1595502
D002217	Carbachol	Ethanol inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]	15255942
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CHRM3 mRNA	16644059
D008455	(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride	brucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM3 protein]	9224827
D008455	(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride	CHRM3 protein binds to (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride	9224827
D004390	Chlorpyrifos	Chlorpyrifos results in decreased activity of CHRM3 protein	17666426
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of CHRM3 mRNA	18812211
D003300	Copper	Copper deficiency results in increased expression of CHRM3 mRNA	26033743
D003435	Crotalid Venoms	Crotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM3 protein]	10845706
D003471	Cuprizone	Cuprizone results in decreased expression of CHRM3 mRNA	26577399
C101207	darifenacin	darifenacin binds to and results in decreased activity of CHRM3 protein	15140916
C101207	darifenacin	darifenacin binds to and results in decreased activity of CHRM3 protein	11488427
D003847	Deoxyglucose	CHRM3 protein affects the susceptibility to Deoxyglucose	14724830
D003976	Diazinon	Diazinon results in increased expression of CHRM3 mRNA	16207942
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of CHRM3 mRNA	15620428
D004006	Dichlorvos	Dichlorvos results in decreased expression of CHRM3 protein	19100812
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of CHRM3 mRNA	21658437
D002117	Calcitriol	Calcitriol results in decreased expression of CHRM3 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of CHRM3 mRNA	21592394
D004117	Dimethoate	Dimethoate results in increased expression of CHRM3 mRNA	15033005
D004117	Dimethoate	Dimethoate results in decreased expression of CHRM3 mRNA	15033006
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CHRM3 mRNA"	22485181
D004222	Disulfoton	Disulfoton results in decreased expression of CHRM3 mRNA	8856746
C118739	entinostat	entinostat results in increased expression of CHRM3 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of CHRM3 mRNA	22872703
D000431	Ethanol	Ethanol inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]	15255942
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CHRM3 mRNA	29097150
C044894	ethylcholine aziridinium	ethylcholine aziridinium results in increased expression of CHRM3 mRNA	10733153
C044894	ethylcholine aziridinium	ethylcholine aziridinium results in increased expression of CHRM3 protein	10733153
D005459	Fluorides	Fluorides results in decreased expression of CHRM3 mRNA	25417050
D005459	Fluorides	Fluorides results in decreased expression of CHRM3 protein	25417050
D005632	Fructose	Fructose results in increased expression of CHRM3 mRNA	17707055
D005632	Fructose	Fructose results in increased expression of CHRM3 protein	17707055
C039281	furan	furan results in increased expression of CHRM3 mRNA	25539665
C028530	furtrethonium	brucine promotes the reaction [furtrethonium binds to CHRM3 protein]	9224827
C028530	furtrethonium	CHRM3 protein binds to furtrethonium	9224827
D005703	Gallamine Triethiodide	Gallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]	9846649
D005703	Gallamine Triethiodide	Gallamine Triethiodide binds to CHRM3 protein	12435818
D019833	Genistein	[bisphenol A co-treated with Genistein] results in increased methylation of CHRM3 gene	28505145
C004312	glycidol	glycidol results in decreased expression of CHRM3 mRNA	24915197
D006165	Guanylyl Imidodiphosphate	Guanylyl Imidodiphosphate inhibits the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]]	20708676
C046773	hexahydrosiladifenidol	hexahydrosiladifenidol inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM3 protein]	8744975
C046773	hexahydrosiladifenidol	hexahydrosiladifenidol binds to and results in decreased activity of CHRM3 protein	8028781\|8744975\|
D006632	Histamine	CHRM3 protein affects the reaction [Histamine results in increased secretion of Acids]	14724830
D006632	Histamine	CHRM3 protein affects the susceptibility to Histamine	14724830
D006843	Hydrocarbons, Chlorinated	"Hydrocarbons, Chlorinated results in decreased expression of CHRM3 mRNA"	22872703
D006851	Hydrochloric Acid	CHRM3 protein affects the susceptibility to Hydrochloric Acid	18367213
D006851	Hydrochloric Acid	Hydrochloric Acid results in decreased expression of CHRM3 protein	20719367
D007295	Inositol Phosphates	[Taurolithocholic Acid binds to and affects the activity of CHRM3 protein] which results in increased abundance of Inositol Phosphates	12379313
D007649	Ketamine	Ketamine inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]	12456425
C057416	KT 5720	KT 5720 binds to CHRM3 protein	12435818
D007854	Lead	Lead results in increased expression of CHRM3 mRNA	19921347
C054938	methoctramine	methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]	12507038
D008731	Methoxychlor	Methoxychlor results in increased expression of CHRM3 mRNA	27103539
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of CHRM3 mRNA	28001369
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CHRM3 mRNA"	19285098
D008743	Methyl Parathion	Methyl Parathion results in decreased activity of CHRM3 protein	17666426
D019832	N-Methylscopolamine	"4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]"	9846649
D019832	N-Methylscopolamine	brucine analog affects the reaction [N-Methylscopolamine binds to CHRM3 protein]	10069518
D019832	N-Methylscopolamine	Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]	20708676
D019832	N-Methylscopolamine	CHRM3 protein binds to N-Methylscopolamine	9224827
D019832	N-Methylscopolamine	Gallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]	9846649
D019832	N-Methylscopolamine	Guanylyl Imidodiphosphate inhibits the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]]	20708676
D019832	N-Methylscopolamine	N-Methylscopolamine binds to CHRM3 protein	10069518\|1564733
D019832	N-Methylscopolamine	Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]	9846649
D019832	N-Methylscopolamine	Pipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]	9846649
D019832	N-Methylscopolamine	rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]	9846649
D019832	N-Methylscopolamine	Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]	9846649
D019832	N-Methylscopolamine	Zinc Oxide promotes the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]]	20708676
D019832	N-Methylscopolamine	N-Methylscopolamine binds to CHRM3 protein	12435818
D008787	Metoclopramide	[Metoclopramide binds to and results in decreased activity of CHRM3 protein] which results in decreased susceptibility to Carbachol	15105209
D008787	Metoclopramide	Metoclopramide binds to CHRM3 protein	15105209
D008787	Metoclopramide	Metoclopramide inhibits the reaction [4-diphenylacetoxy-N-methylpiperidine methobromide binds to CHRM3 protein]	15105209
C523799	MRK 003	CHRM3 results in increased susceptibility to MRK 003	19903844
C074183	N-(2-chloroethyl)-4-piperidinyl diphenylacetate	N-(2-chloroethyl)-4-piperidinyl diphenylacetate binds to and results in decreased activity of CHRM3 protein	10353596
D009255	Nafenopin	Nafenopin results in increased expression of CHRM3 protein	10903494
C118330	N-chloromethylbrucine	N-chloromethylbrucine promotes the reaction [Acetylcholine results in increased activity of CHRM3 protein]	10101037
C118330	N-chloromethylbrucine	N-chloromethylbrucine promotes the reaction [Acetylcholine binds to CHRM3 protein]	9495826
C118330	N-chloromethylbrucine	N-chloromethylbrucine promotes the reaction [Acetylcholine results in increased activity of CHRM3 protein]	10101037
D009532	Nickel	Nickel results in decreased expression of CHRM3 mRNA	24768652\|2558310
C042743	oxotremorine M	brucine promotes the reaction [oxotremorine M binds to CHRM3 protein]	9224827
C042743	oxotremorine M	CHRM3 protein binds to oxotremorine M	9224827
C005419	oxybutynin	oxybutynin binds to and results in decreased activity of CHRM3 protein	15140916
D010197	Pancuronium	Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]	9846649
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of CHRM3 mRNA	26272509
D010261	Paraoxon	Paraoxon results in decreased expression of CHRM3 mRNA	21787676
D052638	Particulate Matter	Particulate Matter results in increased expression of CHRM3 mRNA	26916448
D052638	Particulate Matter	Particulate Matter results in increased expression of CHRM3 protein	26916448
D052638	Particulate Matter	SB 203580 inhibits the reaction [Particulate Matter results in increased expression of CHRM3 mRNA]	26916448
D052638	Particulate Matter	SB 203580 inhibits the reaction [Particulate Matter results in increased expression of CHRM3 protein]	26916448
D052638	Particulate Matter	U 0126 inhibits the reaction [Particulate Matter results in increased expression of CHRM3 mRNA]	26916448
D052638	Particulate Matter	U 0126 inhibits the reaction [Particulate Matter results in increased expression of CHRM3 protein]	26916448
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether affects the expression of CHRM3 mRNA	27294297
C000593032	PGW5 compound	PGW5 compound binds to CHRM3 protein	24389121
D010852	Picrotoxin	Picrotoxin results in increased expression of CHRM3 mRNA	15170462
D010862	Pilocarpine	brucine promotes the reaction [Pilocarpine binds to CHRM3 protein]	9224827
D010862	Pilocarpine	CHRM3 protein binds to Pilocarpine	9224827
D017300	Pipecuronium	Pipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]	9846649
D028321	Plant Preparations	[Estradiol co-treated with Plant Preparations] results in decreased expression of CHRM3 mRNA	26945725
C531249	Poly(amidoamine)	Poly(amidoamine) analog results in decreased expression of CHRM3 mRNA	23806026
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of CHRM3 mRNA	22714537
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of CHRM3 mRNA	23608068
D011284	Pregnenolone	Pregnenolone inhibits the reaction [Acetylcholine binds to CHRM3 protein]	15900516
D011284	Pregnenolone	Pregnenolone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM3 protein]	15900516
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of CHRM3 mRNA	19162173
D011374	Progesterone	Progesterone inhibits the reaction [Acetylcholine binds to CHRM3 protein]	15900516
D011374	Progesterone	Progesterone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM3 protein]	15900516
C005556	propionaldehyde	propionaldehyde results in increased expression of CHRM3 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil affects the expression of CHRM3 mRNA	24780913
D011794	Quercetin	Quercetin inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM3 mRNA]	27389774
D011813	Quinuclidinyl Benzilate	Crotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM3 protein]	10845706
D011813	Quinuclidinyl Benzilate	Quinuclidinyl Benzilate binds to CHRM3 protein	10845706
D011813	Quinuclidinyl Benzilate	Pregnenolone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM3 protein]	15900516
D011813	Quinuclidinyl Benzilate	Progesterone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM3 protein]	15900516
D011813	Quinuclidinyl Benzilate	hexahydrosiladifenidol inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM3 protein]	8744975
D011813	Quinuclidinyl Benzilate	Quinuclidinyl Benzilate binds to CHRM3 protein	8744975
C059514	resveratrol	resveratrol promotes the reaction [CHRM3 protein binds to GJA1 protein]	17520802
C061870	rocuronium	rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]	9846649
C093642	SB 203580	SB 203580 inhibits the reaction [Particulate Matter results in increased expression of CHRM3 mRNA]	26916448
C093642	SB 203580	SB 203580 inhibits the reaction [Particulate Matter results in increased expression of CHRM3 protein]	26916448
D012602	Scopolamine Derivatives	methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]	12507038
D012602	Scopolamine Derivatives	Scopolamine Derivatives binds to CHRM3 protein	12507038
D012602	Scopolamine Derivatives	"4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]"	11306684
D012602	Scopolamine Derivatives	Ketamine inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]	12456425
D012602	Scopolamine Derivatives	Scopolamine Derivatives binds to CHRM3 protein	11306684\|1245642
D012602	Scopolamine Derivatives	Thiopental inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]	12456425
D012602	Scopolamine Derivatives	Tropicamide inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]	11306684
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of CHRM3 mRNA	23806026\|2589566
D012834	Silver	Silver results in increased expression of CHRM3 mRNA	27131904
C017947	sodium arsenite	sodium arsenite results in increased expression of CHRM3 mRNA	28595984
D000069464	Solifenacin Succinate	Solifenacin Succinate binds to and results in decreased activity of CHRM3 protein	11488427
D019311	Staurosporine	Staurosporine binds to CHRM3 protein	12435818
D013311	Streptozocin	1-hexacosanol inhibits the reaction [Streptozocin affects the expression of CHRM3 mRNA]	17989502
D013311	Streptozocin	Streptozocin affects the expression of CHRM3 mRNA	17989502
D013331	Strychnine	Strychnine binds to CHRM3 protein	15647330
D013331	Strychnine	Strychnine binds to CHRM3 protein	12435818
D013657	Taurodeoxycholic Acid	CHRM3 protein results in increased susceptibility to Taurodeoxycholic Acid	15964566
D013657	Taurodeoxycholic Acid	Taurodeoxycholic Acid results in increased activity of CHRM3 protein	15964566
D013658	Taurolithocholic Acid	Taurolithocholic Acid binds to and affects the activity of CHRM3 protein	12379313
D013658	Taurolithocholic Acid	[Taurolithocholic Acid binds to and affects the activity of CHRM3 protein] which results in increased abundance of Inositol Phosphates	12379313
D013658	Taurolithocholic Acid	Taurolithocholic Acid binds to CHRM3 protein	12464352
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of CHRM3 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of CHRM3 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CHRM3 mRNA	28922406
D013874	Thiopental	Thiopental binds to and results in decreased activity of CHRM3 protein	12456425
D013874	Thiopental	Thiopental inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]	12456425
D000069447	Tiotropium Bromide	Tiotropium Bromide binds to CHRM3 protein	21870878
D000068737	Tolterodine Tartrate	Tolterodine Tartrate binds to and results in decreased activity of CHRM3 protein	15140916
D014212	Tretinoin	Tretinoin results in decreased expression of CHRM3 mRNA	23724009
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of CHRM3 mRNA	24935251\|2627250
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of CHRM3 mRNA	21346803
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CHRM3 mRNA"	26179874
D014331	Tropicamide	Tropicamide inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]	11306684
C113580	U 0126	U 0126 inhibits the reaction [Particulate Matter results in increased expression of CHRM3 mRNA]	26916448
C113580	U 0126	U 0126 inhibits the reaction [Particulate Matter results in increased expression of CHRM3 protein]	26916448
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of CHRM3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of CHRM3 mRNA	24383497\|2493525
D014635	Valproic Acid	Valproic Acid results in decreased expression of CHRM3 mRNA	24896083
D014673	Vecuronium Bromide	Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]	9846649
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRM3 mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of CHRM3 mRNA	26272509\|2718838
C086111	WIN 51708	WIN 51708 binds to CHRM3 protein	12435818
C086110	WIN 62577	WIN 62577 analog binds to CHRM3 protein	12435818
C086110	WIN 62577	WIN 62577 analog inhibits the reaction [Acetylcholine binds to CHRM3 protein]	12435818
C086110	WIN 62577	WIN 62577 promotes the reaction [Acetylcholine binds to CHRM3 protein]	12435818
D015034	Zinc Oxide	Zinc Oxide promotes the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]]	20708676
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of CHRM3 mRNA	16330358

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004435	phosphatidylinositol phospholipase C activity	-	TAS	1905013
GO:0004930	G-protein coupled receptor activity	-	IBA	21873635
GO:0004993	G-protein coupled serotonin receptor activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	19575010
GO:0016907	G-protein coupled acetylcholine receptor activity	-	IBA	21873635
GO:0016907	G-protein coupled acetylcholine receptor activity	-	ISS	-
GO:0030594	neurotransmitter receptor activity	-	IBA	21873635
GO:0038023	signaling receptor activity	-	TAS	10940357
GO:0042166	acetylcholine binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003056	regulation of vascular smooth muscle contraction	-	IBA	21873635
GO:0006464	cellular protein modification process	-	TAS	10051746
GO:0006939	smooth muscle contraction	-	IEA	-
GO:0007165	signal transduction	-	TAS	10940357
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	-	IBA	21873635
GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway	-	IBA	21873635
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway	-	ISS	-
GO:0007268	chemical synaptic transmission	-	IBA	21873635
GO:0007399	nervous system development	-	TAS	2739737
GO:0008283	cell proliferation	-	TAS	8063729
GO:0045987	positive regulation of smooth muscle contraction	-	IEA	-
GO:0046541	saliva secretion	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	IDA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	ISS	-
GO:0016323	basolateral plasma membrane	-	IEA	-
GO:0030054	cell junction	-	IEA	-
GO:0030425	dendrite	-	IBA	21873635
GO:0030425	dendrite	-	IEA	-
GO:0032279	asymmetric synapse	-	IEA	-
GO:0043679	axon terminus	-	IEA	-
GO:0045202	synapse	-	IBA	21873635
GO:0045211	postsynaptic membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04810	Regulation of actin cytoskeleton
hsa04970	Salivary secretion
hsa04971	Gastric acid secretion
hsa04972	Pancreatic secretion

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-163685	Integration of energy metabolism	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375280	Amine ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-390648	Muscarinic acetylcholine receptors	TAS
R-HSA-399997	Acetylcholine regulates insulin secretion	IEA
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-422356	Regulation of insulin secretion	IEA
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal