Gene: PARK7

11315
DJ-1|DJ1|GATD2|HEL-S-67p
Parkinsonism associated deglycase
protein-coding
1p36.23
Ensembl:ENSG00000116288 MIM:602533 Vega:OTTHUMG00000001210 UniprotKB:Q99497
NG_008271.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.457e-1 (AD)  5.848e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBL50.977
UQCR100.974
NDUFB40.972
UFC10.97
COPS60.966
CHCHD20.966
COX4I10.965
COX6B10.965
LAMTOR50.962
NDUFB100.962

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.886
OR4F29-0.867
C8orf74-0.213
MTRNR2L6-0.212
PZP-0.211
C2orf83-0.202
KRT73-0.201
KCNJ15-0.201
IL18RAP-0.194
CXCR2-0.193

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in decreased expression of PARK7 mRNA]"22245093
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in decreased expression of PARK7 protein]"22245093
C1185591-bromopropane1-bromopropane results in decreased expression of PARK7 protein21925529
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in decreased expression of PARK7 protein]22245093
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of PARK7 protein]17459145
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of PARK7 mRNA21372141
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of PARK7 protein21372141
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of PARK7 protein]17459145
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of PARK7 protein21372141
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of PARK7 protein21372141
C0757734-phenylbutyric acid[4-phenylbutyric acid results in increased expression of PARK7 protein] which results in decreased susceptibility to Hydrogen Peroxide21372141
C0757734-phenylbutyric acid[4-phenylbutyric acid results in increased expression of PARK7 protein] which results in decreased susceptibility to Oxidopamine21372141
D000082AcetaminophenAcetaminophen results in increased expression of PARK7 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of PARK7 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Paraquat promotes the reaction [Quinones binds to PARK7 protein]]20851755
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Rotenone results in increased expression of PARK7 protein]18377993
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of PARK7 protein"22085607
D000517alpha-Chlorohydrinalpha-Chlorohydrin affects the expression of PARK7 protein26072098
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in increased expression of PARK7 protein26072098|2659704
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of PARK7 protein26597043
D024502alpha-Tocopherolalpha-Tocopherol inhibits the reaction [Rotenone affects the localization of PARK7 protein]16439141
C104223aluminum lactatealuminum lactate results in decreased expression of PARK7 protein26493151
C104223aluminum lactateQuercetin inhibits the reaction [aluminum lactate results in decreased expression of PARK7 protein]26493151
D000638AmiodaroneAmiodarone results in increased expression of PARK7 mRNA24489787
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PARK7 mRNA16483693
D000661AmphetaminePARK7 protein affects the susceptibility to Amphetamine15784737
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of PARK7 mRNA"17331233
D016589AstemizoleAstemizole results in increased expression of PARK7 mRNA20221588
D001554BenzeneBenzene results in decreased expression of PARK7 mRNA16188089
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Paraquat results in increased sulfation of and results in increased oxidation of PARK7 protein]26409479
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydePARK7 protein results in decreased susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde18331584
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydePARK7 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPA1A protein]18331584
D001632BibenzylsBibenzyls inhibits the reaction [Rotenone results in decreased expression of PARK7 protein]28245986
D001632BibenzylsPARK7 protein affects the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]]28245986
D001632BibenzylsPARK7 protein affects the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein]]28245986
D001632BibenzylsPARK7 protein affects the reaction [Bibenzyls promotes the reaction [Rotenone affects the localization of NFE2L2 protein]]28245986
D001632BibenzylsBibenzyls inhibits the reaction [Rotenone results in decreased expression of PARK7 protein]28245986
D001632BibenzylsPARK7 protein affects the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]]28245986
D001632BibenzylsPARK7 protein affects the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein]]28245986
D001632BibenzylsPARK7 protein affects the reaction [[Rotenone co-treated with Bibenzyls] affects the localization of NFE2L2 protein]28245986
C006780bisphenol Abisphenol A promotes the reaction [PARK7 protein binds to ESR1 protein]27156127
C006780bisphenol Abisphenol A affects the localization of PARK7 protein23037695
C006780bisphenol Abisphenol A results in increased expression of PARK7 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of PARK7 mRNA22434021
C032036bromobenzenebromobenzene metabolite binds to PARK7 protein17305373
D020148Butyric AcidButyric Acid results in increased expression of PARK7 mRNA21372141
D020148Butyric AcidButyric Acid results in increased expression of PARK7 protein21372141
D020148Butyric AcidButyric Acid results in increased expression of PARK7 protein21372141
D020148Butyric AcidButyric Acid results in increased expression of PARK7 protein21372141
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PARK7 protein24419708
D002258Carbonyl Cyanide m-Chlorophenyl HydrazonePARK7 gene mutant form promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PARK2 protein]22872702
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PARK7 mRNA28472532
C041167chromium nitratechromium nitrate results in increased expression of PARK7 protein22144121
D003024ClozapineClozapine results in increased expression of PARK7 mRNA14647396
C018021cobaltous chloridecobaltous chloride results in decreased expression of PARK7 mRNA19376846
D003300CopperCopper binds to PARK7 protein23792957
D003300CopperPARK7 protein binds to Copper24567322
D003471CuprizoneCuprizone results in increased expression of PARK7 mRNA27523638
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PARK7 mRNA28659758
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PARK7 mRNA]27941970
D003976DiazinonDiazinon results in decreased expression of PARK7 mRNA21968025
C542282dibutyldi(4-chlorobenzohydroxamato)tin(IV)dibutyldi(4-chlorobenzohydroxamato)tin(IV) results in increased expression of PARK7 mRNA22732634
C542282dibutyldi(4-chlorobenzohydroxamato)tin(IV)dibutyldi(4-chlorobenzohydroxamato)tin(IV) results in increased expression of PARK7 protein22732634
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PARK7 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of PARK7 protein25450742
D002945Cisplatin[Cisplatin co-treated with Lutein] results in decreased expression of PARK7 mRNA24865317
D002945CisplatinCisplatin results in decreased expression of PARK7 mRNA21151649|2486531
C000944dicrotophosdicrotophos results in decreased expression of PARK7 mRNA28302478
D004147DioxinsDioxins affects the expression of PARK7 mRNA20463971
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Lipopolysaccharides results in increased expression of PARK7 protein]11811539
D007980LevodopaLevodopa inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA]25129099
D004317DoxorubicinPARK7 protein results in decreased susceptibility to Doxorubicin24675091
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PARK7 protein23301498
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of PARK7 mRNA25585349
C087876fenazaquinPARK7 mutant form results in increased susceptibility to fenazaquin21219333
C415144fenpyroximatePARK7 protein results in decreased susceptibility to fenpyroximate21219333
D005419FlavonoidsFlavonoids results in decreased expression of PARK7 mRNA18035473
D005485FlutamideFlutamide results in increased expression of PARK7 mRNA21126777
D005978GlutathionePARK7 protein results in increased abundance of Glutathione18331584
D006220HaloperidolHaloperidol results in increased expression of PARK7 mRNA14647396
D006493HeparinHeparin results in increased expression of PARK7 protein17488504
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of PARK7 mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PARK7 protein11811539
D006861Hydrogen PeroxidePARK7 protein results in decreased susceptibility to Hydrogen Peroxide18377993
D006861Hydrogen PeroxideHydrogen Peroxide affects the localization of PARK7 protein22872702
D006861Hydrogen PeroxidePARK2 gene mutant form inhibits the reaction [Hydrogen Peroxide affects the localization of PARK7 protein]22872702
D006861Hydrogen Peroxide[4-phenylbutyric acid results in increased expression of PARK7 protein] which results in decreased susceptibility to Hydrogen Peroxide21372141
C428264indioside Dindioside D results in decreased expression of PARK7 protein18376857
D007213IndomethacinIndomethacin results in increased expression of PARK7 mRNA28201806
D007538IsoniazidIsoniazid affects the expression of PARK7 mRNA24848797
C016527isoquercitrinisoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA]25129099
C067713lactacystinPARK7 protein results in decreased susceptibility to lactacystin18331584
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of PARK7 mRNA"24972896
D008070Lipopolysaccharidesdiphenyleneiodonium inhibits the reaction [Lipopolysaccharides results in increased expression of PARK7 protein]11811539
D008070LipopolysaccharidesLipopolysaccharides affects the localization of PARK7 protein19063952
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PARK7 protein11811539
D008070LipopolysaccharidesPARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]26691871
D008070LipopolysaccharidesPARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]26691871
D008070LipopolysaccharidesPARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]26691871
D008070LipopolysaccharidesSB 203580 promotes the reaction [PARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]]26691871
D008070LipopolysaccharidesSB 203580 promotes the reaction [PARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]26691871
D014975Lutein[Cisplatin co-treated with Lutein] results in decreased expression of PARK7 mRNA24865317
D008345ManganeseManganese results in decreased expression of PARK7 protein20798247
C025340manganese chloride"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in decreased expression of PARK7 mRNA]"22245093
C025340manganese chloride"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in decreased expression of PARK7 protein]"22245093
C025340manganese chloride2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in decreased expression of PARK7 protein]22245093
C025340manganese chloridemanganese chloride results in decreased expression of PARK7 mRNA22245093
C025340manganese chloridemanganese chloride results in decreased expression of PARK7 protein20798247|2224509
C065757meloxicammeloxicam inhibits the reaction [Paraquat promotes the reaction [Quinones binds to PARK7 protein]]20851755
D008628MercuryMercury binds to PARK7 protein23792957
D008628MercuryMercury results in increased expression of PARK7 mRNA16823088
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PARK7 mRNA23458150
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of PARK7 mRNA26558463
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PARK7 mRNA26558463
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PARK7 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PARK7 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PARK7 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"PARK7 protein results in decreased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"15784737
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"PARK7 protein results in decreased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"22043175
D015741MetriboloneMetribolone results in increased expression of PARK7 protein17152098
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PARK7 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PARK7 mRNA]"20230807
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of PARK7 protein19716841
D016627OxidopamineOxidopamine affects the localization of PARK7 protein18377993
D016627OxidopamineOxidopamine promotes the reaction [Quinones binds to PARK7 protein]20851755
D016627OxidopamineOxidopamine results in increased expression of PARK7 mRNA18377993
D016627OxidopamineOxidopamine results in increased expression of PARK7 protein18377993
D016627OxidopaminePARK7 protein results in decreased susceptibility to Oxidopamine18377993
D016627Oxidopamine[4-phenylbutyric acid results in increased expression of PARK7 protein] which results in decreased susceptibility to Oxidopamine21372141
D016627Oxidopamineisoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA]25129099
D016627OxidopamineLevodopa inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA]25129099
D016627OxidopamineOxidopamine results in increased expression of PARK7 mRNA25129099
D016627OxidopamineRutin inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA]25129099
D010269ParaquatAcetylcysteine inhibits the reaction [Paraquat promotes the reaction [Quinones binds to PARK7 protein]]20851755
D010269Paraquatbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Paraquat results in increased sulfation of and results in increased oxidation of PARK7 protein]26409479
D010269Paraquatmeloxicam inhibits the reaction [Paraquat promotes the reaction [Quinones binds to PARK7 protein]]20851755
D010269ParaquatParaquat promotes the reaction [Quinones binds to PARK7 protein]20851755
D010269ParaquatParaquat results in increased expression of PARK7 protein11697128|1181153
D010269ParaquatParaquat results in increased expression of PARK7 protein alternative form14662519
D010269ParaquatParaquat results in increased sulfation of and results in increased oxidation of PARK7 protein26409479
D010269ParaquatPARK7 gene mutant form affects the reaction [Paraquat affects the expression of NFE2L2 protein]17823202
D010269ParaquatPARK7 gene mutant form affects the reaction [Paraquat affects the expression of PSMB5 protein]17823202
D010269ParaquatPARK7 gene mutant form affects the reaction [Paraquat affects the expression of PSMC5 protein]17823202
D010269ParaquatPARK7 protein affects the reaction [Paraquat results in increased abundance of Superoxides]21300143
D010269ParaquatPARK7 protein affects the reaction [Paraquat results in increased cleavage of CASP3 protein]21300143
D010269ParaquatPARK7 protein affects the reaction [Paraquat results in increased cleavage of PARP1 protein]21300143
D010269ParaquatPARK7 protein results in increased susceptibility to Paraquat21300143
D010269ParaquatPARK7 protein results in decreased susceptibility to Paraquat22043175
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of PARK7 protein19854247
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PARK7 mRNA28659758
D015232DinoprostonePARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]26691871
D015232DinoprostoneSB 203580 promotes the reaction [PARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]]26691871
D010695PhlorhizinPhlorhizin results in increased expression of PARK7 mRNA22538082
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PARK7 protein22144121
D011441PropylthiouracilPropylthiouracil results in decreased expression of PARK7 mRNA24780913
C428725pyridabenPARK7 protein results in decreased susceptibility to pyridaben21219333
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PARK7 mRNA28659758
D011794QuercetinQuercetin inhibits the reaction [aluminum lactate results in decreased expression of PARK7 protein]26493151
D011809QuinonesAcetylcysteine inhibits the reaction [Paraquat promotes the reaction [Quinones binds to PARK7 protein]]20851755
D011809Quinonesmeloxicam inhibits the reaction [Paraquat promotes the reaction [Quinones binds to PARK7 protein]]20851755
D011809QuinonesOxidopamine promotes the reaction [Quinones binds to PARK7 protein]20851755
D011809QuinonesParaquat promotes the reaction [Quinones binds to PARK7 protein]20851755
D012402Rotenone4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of PARK7 protein]17459145
D012402RotenoneAcetylcysteine inhibits the reaction [Rotenone results in increased expression of PARK7 protein]18377993
D012402Rotenonealpha-Tocopherol inhibits the reaction [Rotenone affects the localization of PARK7 protein]16439141
D012402Rotenone[BAG5 protein binds to and results in increased degradation of PARK7 protein] which results in increased susceptibility to Rotenone28348719
D012402RotenoneBAG5 protein inhibits the reaction [PARK7 protein results in decreased susceptibility to Rotenone]28348719
D012402RotenoneBAG5 protein inhibits the reaction [Rotenone affects the localization of PARK7 protein]28348719
D012402RotenoneBibenzyls inhibits the reaction [Rotenone results in decreased expression of PARK7 protein]28245986
D012402RotenonePARK7 protein affects the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]]28245986
D012402RotenonePARK7 protein affects the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein]]28245986
D012402RotenonePARK7 protein affects the reaction [Bibenzyls promotes the reaction [Rotenone affects the localization of NFE2L2 protein]]28245986
D012402RotenonePARK7 protein affects the susceptibility to Rotenone20940149|2673906
D012402RotenonePARK7 protein results in decreased susceptibility to Rotenone18331584|1837799
D012402RotenoneRotenone affects the localization of PARK7 protein16439141|1837799
D012402RotenoneRotenone results in decreased expression of PARK7 protein28245986
D012402RotenoneRotenone results in increased expression of PARK7 mRNA18377993
D012402RotenoneRotenone results in increased expression of PARK7 protein17459145|1837799
D012402Rotenone4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of PARK7 protein]17459145
D012402RotenonePARK7 affects the susceptibility to Rotenone16624565
D012402RotenonePARK7 mutant form results in increased susceptibility to Rotenone21219333
D012402RotenonePARK7 protein results in decreased susceptibility to Rotenone18930142
D012402RotenoneRotenone affects the localization of PARK7 protein19063952
D012402RotenoneRotenone results in increased expression of PARK7 mRNA26806867
D012402RotenoneRotenone results in increased expression of PARK7 protein17459145
D012402RotenoneBibenzyls inhibits the reaction [Rotenone results in decreased expression of PARK7 protein]28245986
D012402RotenonePARK7 protein affects the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]]28245986
D012402RotenonePARK7 protein affects the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein]]28245986
D012402RotenonePARK7 protein affects the reaction [[Rotenone co-treated with Bibenzyls] affects the localization of NFE2L2 protein]28245986
D012402RotenonePARK7 protein results in decreased susceptibility to Rotenone22898350
D012402RotenoneRotenone affects the localization of PARK7 protein16439141
D012402RotenoneRotenone results in decreased expression of PARK7 protein28245986
D012402RotenoneRotenone results in increased oxidation of PARK7 protein16439141
D012402RotenonePARK7 protein affects the susceptibility to Rotenone21907265
D012431RutinRutin inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA]25129099
D012524SarinSarin results in decreased expression of PARK7 mRNA19522546
D012524SarinSarin results in decreased expression of PARK7 protein28973502
C093642SB 203580SB 203580 promotes the reaction [PARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]]26691871
C093642SB 203580SB 203580 promotes the reaction [PARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]26691871
D012834SilverSilver results in increased expression of PARK7 mRNA19429238
D018038Sodium SeleniteSodium Selenite results in increased expression of PARK7 mRNA18175754
D010042OuabainPARK7 affects the susceptibility to Ouabain16624565
D013481SuperoxidesPARK7 protein affects the reaction [Paraquat results in increased abundance of Superoxides]21300143
D013605T-2 ToxinT-2 Toxin affects the expression of PARK7 protein26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PARK7 mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PARK7 protein22595367
D014050TolueneToluene affects the expression of PARK7 mRNA21827849
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of PARK7 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of PARK7 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of PARK7 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PARK7 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of PARK7 mRNA23034163
C111237vorinostatvorinostat results in decreased expression of PARK7 protein20543569

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001047core promoter bindingNOTIC15790595  
GO:0003690double-stranded DNA bindingNOTIDA22683601  
GO:0003697single-stranded DNA bindingNOTIDA22683601  
GO:0003713transcription coactivator activity-IGI15790595  
GO:0003713transcription coactivator activity-TAS16731528  
GO:0003729mRNA binding-IDA18626009  
GO:0005102signaling receptor binding-IPI21785459  
GO:0005507copper ion binding-IDA23792957  
GO:0005515protein binding-IPI11477070  15790595  15983381  16632486  17510388  19229105  
19822128  20127688  21097510  21785459  22683601  23743200  
24899725  24947010  25416956  
GO:0008134transcription factor binding-IPI21097510  
GO:0008233peptidase activity-IDA20304780  
GO:0016532superoxide dismutase copper chaperone activity-IDA24567322  
GO:0016684oxidoreductase activity, acting on peroxide as acceptor-IDA24567322  
GO:0019899enzyme binding-IPI19703902  19822128  23743200  
GO:0019900kinase binding-IPI19229105  
GO:0019955cytokine binding-IPI21097510  
GO:0036470tyrosine 3-monooxygenase activator activity-IDA19703902  
GO:0036478L-dopa decarboxylase activator activity-IDA19703902  
GO:0036524protein deglycase activity-IBA21873635  
GO:0036524protein deglycase activity-IDA25416785  
GO:0042802identical protein binding-IPI15502874  15983381  24947010  
GO:0042803protein homodimerization activity-IDA18711745  24144264  24567322  
GO:0044388small protein activating enzyme binding-IPI15983381  
GO:0044390ubiquitin-like protein conjugating enzyme binding-IPI15983381  
GO:0045296cadherin binding-HDA25468996  
GO:0045340mercury ion binding-IDA23792957  
GO:0050681androgen receptor binding-IPI17510388  
GO:0051920peroxiredoxin activity-IEA-  
GO:0070491repressing transcription factor binding-IPI15790595  16731528  
GO:0097110scaffold protein binding-IPI21785459  
GO:1903135cupric ion binding-IDA24567322  
GO:1903136cuprous ion binding-IDA24144264  24567322  
GO:1990381ubiquitin-specific protease binding-IPI21097510  
GO ID GO Term Qualifier Evidence PubMed
GO:0001933negative regulation of protein phosphorylation-IGI15983381  
GO:0002866positive regulation of acute inflammatory response to antigenic stimulus-ISS-  
GO:0006281DNA repair-IDA28596309  
GO:0006469negative regulation of protein kinase activity-IGI15983381  
GO:0006508proteolysis-IEA-  
GO:0006517protein deglycosylation-IDA25416785  
GO:0006517protein deglycosylationNOTIDA27903648  
GO:0006517protein deglycosylation-IMP26995087  
GO:0006914autophagy-IEA-  
GO:0006954inflammatory response-IEA-  
GO:0007005mitochondrion organization-ISS-  
GO:0007265Ras protein signal transduction-TAS14662519  
GO:0007338single fertilization-IEA-  
GO:0008344adult locomotory behavior-IEA-  
GO:0009438methylglyoxal metabolic process-IDA22523093  
GO:0009438methylglyoxal metabolic processNOTIDA27903648  
GO:0010273detoxification of copper ion-IMP23792957  
GO:0010628positive regulation of gene expression-TAS24252804  
GO:0010629negative regulation of gene expression-IDA22683601  
GO:0018323enzyme active site formation via L-cysteine sulfinic acid-IEA-  
GO:0019249lactate biosynthetic process-IDA22523093  
GO:0030073insulin secretion-ISS-  
GO:0031397negative regulation of protein ubiquitination-IDA17015834  24899725  
GO:0032091negative regulation of protein binding-IDA11477070  16731528  17015834  24899725  
GO:0032091negative regulation of protein binding-IGI15983381  
GO:0032091negative regulation of protein binding-IMP21785459  
GO:0032148activation of protein kinase B activity-IC22492997  
GO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process-IDA17015834  
GO:0032757positive regulation of interleukin-8 production-IDA21097510  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IMP22492997  
GO:0033234negative regulation of protein sumoylation-IDA16731528  
GO:0033864positive regulation of NAD(P)H oxidase activity-ISS-  
GO:0034599cellular response to oxidative stress-IDA15983381  19703902  20969476  22683601  
GO:0034599cellular response to oxidative stress-IMP24899725  
GO:0036471cellular response to glyoxal-IDA22523093  
GO:0036526peptidyl-cysteine deglycation-IDA25416785  
GO:0036527peptidyl-arginine deglycation-IDA25416785  
GO:0036528peptidyl-lysine deglycation-IDA25416785  
GO:0036529protein deglycation, glyoxal removal-IBA21873635  
GO:0036529protein deglycation, glyoxal removal-IDA25416785  
GO:0036530protein deglycation, methylglyoxal removal-IDA25416785  
GO:0036530protein deglycation, methylglyoxal removalNOTIDA27903648  
GO:0036531glutathione deglycation-IDA25416785  
GO:0042593glucose homeostasis-ISS-  
GO:0042743hydrogen peroxide metabolic process-IDA20969476  24567322  
GO:0043066negative regulation of apoptotic process-IDA22523093  
GO:0043523regulation of neuron apoptotic process-IDA18711745  20304780  
GO:0043524negative regulation of neuron apoptotic process-IDA22511790  
GO:0045560regulation of TRAIL receptor biosynthetic processNOTIMP21785459  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA21097510  
GO:0045944positive regulation of transcription by RNA polymerase II-IGI15790595  17015834  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP16731528  19703902  22492997  
GO:0046295glycolate biosynthetic process-IDA22523093  
GO:0046826negative regulation of protein export from nucleus-IGI15983381  
GO:0050727regulation of inflammatory response-ISS-  
GO:0050787detoxification of mercury ion-IMP23792957  
GO:0050821protein stabilization-IDA24947010  
GO:0050821protein stabilization-IMP17015834  19229105  
GO:0051091positive regulation of DNA-binding transcription factor activity-IMP17015834  
GO:0051091positive regulation of DNA-binding transcription factor activity-TAS22492997  
GO:0051444negative regulation of ubiquitin-protein transferase activity-IDA24899725  
GO:0051583dopamine uptake involved in synaptic transmission-IEA-  
GO:0051881regulation of mitochondrial membrane potential-IMP23743200  
GO:0051897positive regulation of protein kinase B signaling-IC22492997  
GO:0051899membrane depolarization-IEA-  
GO:0060081membrane hyperpolarization-IEA-  
GO:0060548negative regulation of cell death-IDA14749723  
GO:0060765regulation of androgen receptor signaling pathway-IDA11477070  
GO:0070301cellular response to hydrogen peroxide-IDA14749723  
GO:0090073positive regulation of protein homodimerization activity-IDA24947010  
GO:0098869cellular oxidant detoxification-IEA-  
GO:0106044guanine deglycation-IDA28596309  
GO:0106045guanine deglycation, methylglyoxal removal-IDA28596309  
GO:0106046guanine deglycation, glyoxal removal-IBA21873635  
GO:0106046guanine deglycation, glyoxal removal-IDA28596309  
GO:1900182positive regulation of protein localization to nucleus-IDA21097510  
GO:1900182positive regulation of protein localization to nucleus-IMP22492997  
GO:1901215negative regulation of neuron death-IDA22683601  
GO:1901671positive regulation of superoxide dismutase activity-IDA24567322  
GO:1901984negative regulation of protein acetylation-IDA22683601  
GO:1902177positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway-IEA-  
GO:1902236negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway-IGI14652021  
GO:1902903regulation of supramolecular fiber organization-TAS23626584  
GO:1902958positive regulation of mitochondrial electron transport, NADH to ubiquinone-IMP19822128  
GO:1903073negative regulation of death-inducing signaling complex assembly-IC21785459  
GO:1903094negative regulation of protein K48-linked deubiquitination-IDA21097510  
GO:1903122negative regulation of TRAIL-activated apoptotic signaling pathway-IMP21785459  
GO:1903168positive regulation of pyrroline-5-carboxylate reductase activity-IDA23743200  
GO:1903178positive regulation of tyrosine 3-monooxygenase activity-IDA19703902  
GO:1903181positive regulation of dopamine biosynthetic process-IC16731528  
GO:1903181positive regulation of dopamine biosynthetic process-IDA19703902  
GO:1903189glyoxal metabolic process-IDA22523093  
GO:1903197positive regulation of L-dopa biosynthetic process-IMP16731528  
GO:1903200positive regulation of L-dopa decarboxylase activity-IDA19703902  
GO:1903202negative regulation of oxidative stress-induced cell death-IDA16632486  
GO:1903206negative regulation of hydrogen peroxide-induced cell death-IMP22492997  23743200  
GO:1903208negative regulation of hydrogen peroxide-induced neuron death-IDA15983381  24947010  
GO:1903377negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway-IDA15790595  
GO:1903384negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway-IGI14652021  
GO:1903427negative regulation of reactive oxygen species biosynthetic process-ISS-  
GO:1903428positive regulation of reactive oxygen species biosynthetic process-IEA-  
GO:1903599positive regulation of autophagy of mitochondrion-NAS24531622  
GO:1905259negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway-IDA14752510  
GO:2000157negative regulation of ubiquitin-specific protease activity-IDA21097510  
GO:2000277positive regulation of oxidative phosphorylation uncoupler activity-IEA-  
GO:2000679positive regulation of transcription regulatory region DNA binding-IMP22492997  
GO:2000825positive regulation of androgen receptor activity-IMP17510388  
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-IMP21785459  
GO:2001268negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway-IMP21785459  
GO ID GO Term Qualifier Evidence PubMed
GO:0000785chromatin-IDA16731528  
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA11477070  12446870  14662519  15790595  15983381  18711745  19822128  22683601  
GO:0005737cytoplasm-IDA12446870  15983381  17510388  18711745  19822128  
GO:0005739mitochondrion-IDA15790595  15944198  18711745  19229105  19822128  23743200  
GO:0005739mitochondrion-IMP21785459  
GO:0005747mitochondrial respiratory chain complex Icolocalizes_withIDA19822128  
GO:0005758mitochondrial intermembrane space-IEA-  
GO:0005759mitochondrial matrix-IEA-  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA14662519  15944198  19229105  22683601  
GO:0005829cytosol-IMP21785459  
GO:0005886plasma membrane-IEA-  
GO:0005913cell-cell adherens junction-HDA25468996  
GO:0016605PML body-IDA22683601  
GO:0030424axon-ISS-  
GO:0044297cell body-IEA-  
GO:0045121membrane raft-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA25468996  
GO:0070062extracellular exosome-HDA19056867  19199708  20458337  23533145  
GO:0098793presynapse-IEA-  
KEGG ID KEGG Term
hsa05012Parkinson's disease
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21494699Cancer and Parkinson's disease: the odd couple. (2011 Mar)Gao XDrugs Today (Barc)
29787640Elevated levels of 8-OHdG and PARK7/DJ-1 in peri-implantitis mucosa. (2018 May 22)Kasnak GClin Implant Dent Relat Res