| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| TXN2 | 0.956 |
| NDUFB7 | 0.947 |
| AK1 | 0.947 |
| CHMP2A | 0.945 |
| AURKAIP1 | 0.944 |
| COX5B | 0.941 |
| NDUFA13 | 0.94 |
| LAMTOR4 | 0.937 |
| ECHS1 | 0.934 |
| GABARAP | 0.933 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| OR4F5 | -0.842 |
| OR4F29 | -0.821 |
| ZC3H11B | -0.267 |
| FER1L6 | -0.249 |
| PZP | -0.239 |
| MTRNR2L6 | -0.23 |
| HMCN1 | -0.225 |
| KRT73 | -0.222 |
| COL14A1 | -0.222 |
| C2orf83 | -0.221 |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| C495626 | 14-deoxy-11,12-didehydroandrographolide | "14-deoxy-11,12-didehydroandrographolide results in decreased expression of COPE mRNA" | 22101062 |
| D000082 | Acetaminophen | Acetaminophen affects the expression of COPE mRNA | 17562736 |
| D020106 | Acrylamide | Acrylamide results in increased expression of COPE mRNA | 28959563 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in increased expression of COPE mRNA | 27153756 |
| D000535 | Aluminum | [APP protein modified form binds to Aluminum] which results in decreased expression of COPE mRNA | 21298039 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of COPE mRNA | 22228805 |
| C006780 | bisphenol A | [bisphenol A co-treated with Testosterone] results in increased expression of COPE mRNA | 26496021 |
| C006780 | bisphenol A | bisphenol A results in increased expression of COPE mRNA | 25181051 |
| C022777 | bufalin | bufalin results in decreased expression of COPE protein | 23091618 |
| D020122 | tert-Butylhydroperoxide | tert-Butylhydroperoxide results in decreased expression of COPE mRNA | 15336504 |
| D020122 | tert-Butylhydroperoxide | tert-Butylhydroperoxide results in increased expression of COPE mRNA | 18804290 |
| D019256 | Cadmium Chloride | Cadmium Chloride results in decreased expression of COPE mRNA | 18804290 |
| D019256 | Cadmium Chloride | Cadmium Chloride results in decreased methylation of COPE promoter | 22457795 |
| C031180 | chrysene | chrysene results in decreased expression of COPE mRNA | 26377693 |
| D002994 | Clofibrate | Clofibrate results in decreased expression of COPE mRNA | 17585979 |
| C018021 | cobaltous chloride | cobaltous chloride results in decreased expression of COPE mRNA | 19376846 |
| C018021 | cobaltous chloride | cobaltous chloride results in decreased expression of COPE protein | 16622835 |
| D019327 | Copper Sulfate | Copper Sulfate results in increased expression of COPE mRNA | 19264136 |
| D016572 | Cyclosporine | Cyclosporine results in increased expression of COPE mRNA | 20106945|2163298 |
| D000431 | Ethanol | Ethanol affects the expression of COPE mRNA | 24355176 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol affects the expression of COPE mRNA | 17555576 |
| D004997 | Ethinyl Estradiol | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COPE mRNA | 17942748 |
| C082360 | fipronil | fipronil results in decreased expression of COPE mRNA | 23962444 |
| D005485 | Flutamide | Flutamide results in increased expression of COPE mRNA | 24136188 |
| D005897 | Glafenine | Glafenine results in increased expression of COPE mRNA | 24136188 |
| D006830 | Hydralazine | [Hydralazine co-treated with Valproic Acid] results in increased expression of COPE mRNA | 17183730 |
| C492448 | ICG 001 | ICG 001 results in decreased expression of COPE mRNA | 26191083 |
| C440499 | lipopolysaccharide, Escherichia coli O111 B4 | "lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of COPE mRNA" | 19264136 |
| D008344 | Maneb | [Paraquat co-treated with Maneb] results in decreased expression of COPE mRNA | 18386188 |
| D008748 | Methylcholanthrene | Methylcholanthrene results in decreased expression of COPE mRNA | 18804290 |
| D037742 | Nanotubes, Carbon | "Nanotubes, Carbon analog results in increased expression of COPE mRNA" | 25554681 |
| D037742 | Nanotubes, Carbon | "Nanotubes, Carbon results in increased expression of COPE mRNA" | 25554681|2562005 |
| C051752 | nefazodone | nefazodone results in increased expression of COPE mRNA | 24136188 |
| D010126 | Ozone | "[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of COPE mRNA" | 23246600 |
| D017239 | Paclitaxel | COPE protein affects the susceptibility to Paclitaxel | 16217747 |
| D010269 | Paraquat | [Paraquat co-treated with Maneb] results in decreased expression of COPE mRNA | 18386188 |
| D052638 | Particulate Matter | Particulate Matter results in increased expression of COPE mRNA | 15046786 |
| C101816 | perfluoro-n-nonanoic acid | perfluoro-n-nonanoic acid results in increased expression of COPE mRNA | 21984479 |
| D010936 | Plant Extracts | Plant Extracts results in decreased expression of COPE mRNA | 23557933 |
| D011794 | Quercetin | Quercetin results in increased expression of COPE mRNA | 21632981 |
| D012643 | Selenium | Selenium results in increased expression of COPE mRNA | 19244175 |
| D013605 | T-2 Toxin | T-2 Toxin affects the expression of COPE protein | 26141394 |
| D013629 | Tamoxifen | Tamoxifen affects the expression of COPE mRNA | 17555576 |
| D013739 | Testosterone | [bisphenol A co-treated with Testosterone] results in increased expression of COPE mRNA | 26496021 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of COPE mRNA | 21296121 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of COPE mRNA | 21570461 |
| D013749 | Tetrachlorodibenzodioxin | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COPE mRNA | 17942748 |
| D013750 | Tetrachloroethylene | Tetrachloroethylene results in decreased expression of COPE mRNA | 28973375 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in decreased expression of COPE protein | 22595367 |
| D014303 | Trinitrotoluene | Trinitrotoluene affects the expression of COPE mRNA | 21346803 |
| D014635 | Valproic Acid | [Hydralazine co-treated with Valproic Acid] results in increased expression of COPE mRNA | 17183730 |
| D014635 | Valproic Acid | Valproic Acid results in increased methylation of COPE gene | 29154799 |
| D001335 | Vehicle Emissions | Vehicle Emissions results in increased expression of COPE mRNA | 15046786 |
| D014810 | Vitamin E | Vitamin E results in increased expression of COPE mRNA | 19244175 |
| D014874 | Water Pollutants, Chemical | "[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of COPE mRNA" | 23246600 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005198 | structural molecule activity | - | IEA | - |
| GO:0005515 | protein binding | - | IPI | 25416956 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0006888 | ER to Golgi vesicle-mediated transport | - | IBA | 21873635 |
| GO:0006888 | ER to Golgi vesicle-mediated transport | - | TAS | - |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | - | TAS | - |
| GO:0006891 | intra-Golgi vesicle-mediated transport | - | IBA | 21873635 |
| GO:0006891 | intra-Golgi vesicle-mediated transport | - | ISS | - |
| GO:0015031 | protein transport | - | IEA | - |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0000139 | Golgi membrane | - | TAS | - |
| GO:0005654 | nucleoplasm | - | IDA | - |
| GO:0005789 | endoplasmic reticulum membrane | - | TAS | - |
| GO:0005794 | Golgi apparatus | - | IDA | - |
| GO:0005829 | cytosol | - | TAS | - |
| GO:0030126 | COPI vesicle coat | - | IBA | 21873635 |
| GO:0030126 | COPI vesicle coat | - | ISS | - |
| GO:0030133 | transport vesicle | - | TAS | - |
| KEGG ID | KEGG Term |
|---|
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-HSA-199977 | ER to Golgi Anterograde Transport | TAS |
| R-HSA-199991 | Membrane Trafficking | TAS |
| R-HSA-392499 | Metabolism of proteins | TAS |
| R-HSA-446203 | Asparagine N-linked glycosylation | TAS |
| R-HSA-5653656 | Vesicle-mediated transport | TAS |
| R-HSA-597592 | Post-translational protein modification | TAS |
| R-HSA-6807878 | COPI-mediated anterograde transport | TAS |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | TAS |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | TAS |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | TAS |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | TAS |
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