| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| YME1L1 | 0.939 |
| BCLAF1 | 0.934 |
| ARIH1 | 0.932 |
| PLAA | 0.929 |
| SCFD1 | 0.928 |
| KPNA1 | 0.926 |
| PWP1 | 0.923 |
| GOLT1B | 0.921 |
| ARL1 | 0.92 |
| TRAPPC11 | 0.918 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| OR4F5 | -0.604 |
| OR4F29 | -0.549 |
| MTRNR2L6 | -0.314 |
| MTRNR2L9 | -0.298 |
| MTRNR2L10 | -0.284 |
| FOXJ1 | -0.251 |
| CSAG1 | -0.247 |
| NKX6-1 | -0.24 |
| FAM151A | -0.238 |
| KLRC2 | -0.237 |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| D000082 | Acetaminophen | Acetaminophen results in decreased expression of ECD mRNA | 21420995 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased methylation of ECD gene | 27153756 |
| D001151 | Arsenic | Arsenic affects the methylation of ECD gene | 25304211 |
| C006632 | arsenic trioxide | arsenic trioxide results in decreased expression of ECD mRNA | 15894607 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of ECD mRNA | 17879257 |
| C044887 | beta-methylcholine | beta-methylcholine affects the expression of ECD mRNA | 21179406 |
| C006780 | bisphenol A | bisphenol A affects the expression of ECD mRNA | 21786754 |
| D019327 | Copper Sulfate | Copper Sulfate results in increased expression of ECD mRNA | 19549813 |
| D016572 | Cyclosporine | Cyclosporine results in increased expression of ECD mRNA | 25562108 |
| C000944 | dicrotophos | dicrotophos results in decreased expression of ECD mRNA | 28302478 |
| C007738 | fluoranthene | [fluoranthene co-treated with pyrene] results in decreased expression of ECD mRNA | 20117838 |
| C492448 | ICG 001 | ICG 001 results in decreased expression of ECD mRNA | 26191083 |
| D015759 | Ionomycin | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ECD mRNA | 25613284 |
| C482199 | lipopolysaccharide, E coli O55-B5 | "lipopolysaccharide, E coli O55-B5 results in increased expression of ECD mRNA" | 24972896 |
| C030984 | pyrene | [fluoranthene co-treated with pyrene] results in decreased expression of ECD mRNA | 20117838 |
| D011794 | Quercetin | Quercetin results in decreased expression of ECD mRNA | 21632981 |
| C017947 | sodium arsenite | sodium arsenite results in increased expression of ECD mRNA | 17879257 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of ECD mRNA | 21570461 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ECD promoter] | 19654925 |
| D013755 | Tetradecanoylphorbol Acetate | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ECD mRNA | 25613284 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in increased expression of ECD mRNA | 28065790 |
| C015559 | trimellitic anhydride | trimellitic anhydride results in increased expression of ECD mRNA | 19042947 |
| D014520 | Urethane | Urethane results in increased expression of ECD mRNA | 28818685 |
| D001335 | Vehicle Emissions | Vehicle Emissions results in decreased methylation of ECD gene | 25560391 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0003713 | transcription coactivator activity | - | TAS | 9928932 |
| GO:0005515 | protein binding | - | IPI | 23880345 23935490 24656813 26711270 |
| GO:0035035 | histone acetyltransferase binding | - | IDA | 19919181 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0006110 | regulation of glycolytic process | - | TAS | 9928932 |
| GO:0006366 | transcription by RNA polymerase II | - | TAS | 9928932 |
| GO:0006397 | mRNA processing | - | IEA | - |
| GO:0008283 | cell proliferation | - | IEA | - |
| GO:0008380 | RNA splicing | - | IEA | - |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | - | IDA | 19919181 |
| GO:2000045 | regulation of G1/S transition of mitotic cell cycle | - | IEA | - |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005634 | nucleus | - | IBA | 21873635 |
| GO:0005634 | nucleus | - | IDA | 19919181 |
| GO:0005654 | nucleoplasm | - | IDA | - |
| GO:0005737 | cytoplasm | - | IDA | 19919181 |
| GO:0005829 | cytosol | - | IDA | - |
| GO:0097255 | R2TP complex | colocalizes_with | IDA | 26711270 |
| KEGG ID | KEGG Term |
|---|
| Reactome ID | Reactome Term | Evidence |
|---|
| PMID | Title (Year) | Author | Journal |
|---|---|---|---|
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| 12845751 | Effects of cigarette smoke extract on E-cadherin expression in cultured airway epithelial cells. (2000) | Wang X | J Tongji Med Univ |
| 6611202 | Monoclonal antibody phenotyping of interindividual differences in cytochrome P-450-dependent reactions of single and twin human placenta. (1984 Sep) | Fujino T | Cancer Res |
| 20640803 | Computational modeling study of human nicotinic acetylcholine receptor for developing new drugs in the treatment of alcoholism. (2009 Dec) | Hu ZJ | Interdiscip Sci |
| 11775814 | [Effect of cigarette smoke extract on E-cadherin expression of airway epithelial cells]. (1999 Jul) | Wang X | Zhonghua Jie He He Hu Xi Za Zhi |
| 22686320 | Modulation of oxidative DNA damage by repair enzymes XRCC1 and hOGG1. (2012) | Rihs HP | J Toxicol Environ Health A |
| 23888925 | ErbB-2 protein levels in healthy, asymptomatic women. (1996) | Breuer B | Biomarkers |
| 7884573 | The detection of increased amounts of the extracellular domain of the epidermal growth factor receptor in serum during carcinogenesis in asbestosis patients. (1994 Dec) | Partanen R | J Occup Med |
| 9668679 | Influence of concurrent heroin and cocaine abuse on the adrenergic and serotonergic systems in man. (1998 May 30) | Macedo TR | Ann N Y Acad Sci |
| 10609234 | Abnormal liver function in workers exposed to low levels of ethylene dichloride and vinyl chloride monomer. (1999 Dec) | Cheng TJ | J Occup Environ Med |