Gene: CHRM4

1132
HM4|M4R
cholinergic receptor muscarinic 4
protein-coding
11p11.2
Ensembl:ENSG00000180720 MIM:118495 Vega:OTTHUMG00000154371 UniprotKB:P08173
NC_000011.10
PubMed
0   ANCO-SNPs
OD|CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.706e-2 (AD)  6.446e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FADS60.937
SPTB0.931
CHRNB20.93
MMP240.928
GLT1D10.927
GRIN2B0.927
RGS60.927
LHFPL40.926
DLG30.923
LNX10.922

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.645
YES1-0.642
RAB13-0.641
COPZ2-0.623
HEY2-0.622
REST-0.62
ROM1-0.617
WWTR1-0.614
RNF135-0.61
HEBP2-0.602

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00246ZiprasidoneSmall Molecule146939-27-7ApprovedTarget
DB00321AmitriptylineSmall Molecule50-48-6ApprovedTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00340MetixeneSmall Molecule4969-02-2ApprovedTarget
DB00342TerfenadineSmall Molecule50679-08-8Approved|WithdrawnTarget
DB00363ClozapineSmall Molecule5786-21-0ApprovedTarget
DB00376TrihexyphenidylSmall Molecule144-11-6ApprovedTarget
DB00387ProcyclidineSmall Molecule77-37-2ApprovedTarget
DB00408LoxapineSmall Molecule1977-10-2ApprovedTarget
DB00411CarbacholSmall Molecule51-83-2ApprovedTarget
DB00420PromazineSmall Molecule58-40-2ApprovedTarget
DB00424HyoscyamineSmall Molecule101-31-5ApprovedTarget
DB00458ImipramineSmall Molecule50-49-7ApprovedTarget
DB00496DarifenacinSmall Molecule133099-04-4Approved|InvestigationalTarget
DB00540NortriptylineSmall Molecule72-69-5ApprovedTarget
DB00572AtropineSmall Molecule51-55-8ApprovedTarget
DB00622NicardipineSmall Molecule55985-32-5Approved|InvestigationalTarget
DB00715ParoxetineSmall Molecule61869-08-7Approved|InvestigationalTarget
DB00725Homatropine MethylbromideSmall Molecule80-49-9ApprovedTarget
DB00747ScopolamineSmall Molecule51-34-3Approved|InvestigationalTarget
DB00767BenzquinamideSmall Molecule63-12-7WithdrawnTarget
DB00777PropiomazineSmall Molecule362-29-8ApprovedTarget
DB00785CryptenamineSmall Molecule1356-18-9ApprovedTarget
DB00809TropicamideSmall Molecule1508-75-4Approved|InvestigationalTarget
DB00835BrompheniramineSmall Molecule86-22-6ApprovedTarget
DB00934MaprotilineSmall Molecule10262-69-8Approved|InvestigationalTarget
DB01019BethanecholSmall Molecule674-38-4ApprovedTarget
DB01036TolterodineSmall Molecule124937-51-5Approved|InvestigationalTarget
DB01069PromethazineSmall Molecule60-87-7Approved|InvestigationalTarget
DB01085PilocarpineSmall Molecule92-13-7Approved|InvestigationalTarget
DB01142DoxepinSmall Molecule1668-19-5Approved|InvestigationalTarget
DB01151DesipramineSmall Molecule50-47-5Approved|InvestigationalTarget
DB01224QuetiapineSmall Molecule111974-69-7ApprovedTarget
DB01238AripiprazoleSmall Molecule129722-12-9Approved|InvestigationalTarget
DB01239ChlorprothixeneSmall Molecule113-59-7Approved|Investigational|WithdrawnTarget
DB01403MethotrimeprazineSmall Molecule60-99-1Approved|InvestigationalTarget
DB01409TiotropiumSmall Molecule186691-13-4ApprovedTarget
DB01591SolifenacinSmall Molecule242478-37-1ApprovedTarget
DB01625IsopropamideSmall Molecule7492-32-2ApprovedTarget
DB03128AcetylcholineSmall Molecule51-84-3ApprovedTarget
DB05752ALKS 27Small Molecule-InvestigationalTarget
DB06702FesoterodineSmall Molecule286930-02-7ApprovedTarget
DB06787HexocycliumSmall Molecule6004-98-4ApprovedTarget
DB08897AclidiniumSmall Molecule727649-81-2ApprovedTarget
DB09076UmeclidiniumSmall Molecule869185-19-3ApprovedTarget
DB09167DosulepinSmall Molecule113-53-1ApprovedTarget
DB00454PethidineSmall Molecule57-42-1ApprovedTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB00568CinnarizineSmall Molecule298-57-7Approved|InvestigationalTarget
DB00726TrimipramineSmall Molecule739-71-9ApprovedTarget
DB01221KetamineSmall Molecule6740-88-1ApprovedTarget
DB09194EtoperidoneSmall Molecule52942-31-1WithdrawnTarget
ID Drug Name Action PubMed
C5685165-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide"5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide binds to CHRM4 protein"21870878
C0084465-methylfurtrethoniumbrucine promotes the reaction [5-methylfurtrethonium binds to CHRM4 protein]9224827
C0084465-methylfurtrethoniumCHRM4 protein binds to 5-methylfurtrethonium9224827
D000109AcetylcholineAcetylcholine binds to and results in increased activity of CHRM4 protein10101037
D000109AcetylcholineAcetylcholine binds to CHRM4 protein10069518|1670964
D000109Acetylcholinebrucine analog affects the reaction [Acetylcholine binds to CHRM4 protein]10069518
D000109Acetylcholinebrucine N-oxide promotes the reaction [Acetylcholine binds to CHRM4 protein]9495826
D000109Acetylcholinebrucine N-oxide promotes the reaction [Acetylcholine results in increased activity of CHRM4 protein]10101037
D000109AcetylcholineCHRM4 protein binds to Acetylcholine9224827
D000109Acetylcholineeburnamonine promotes the reaction [Acetylcholine binds to CHRM4 protein]9224827
D000109Acetylcholine[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Acetylcholine binds to CHRM4 protein]16709648
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM4 mRNA]29253600
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CHRM4 gene28458013
D000443AlcuroniumAlcuronium binds to CHRM4 protein16709648
D000443AlcuroniumWIN 62577 inhibits the reaction [Alcuronium binds to CHRM4 protein]16709648
C439263AM 1241AM 1241 binds to CHRM4 protein18931146
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHRM4 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of CHRM4 mRNA25929836
D001285AtropineAtropine binds to CHRM4 protein16709648
D001285Atropine[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein]16709648
D001285AtropineAtropine binds to and results in decreased activity of CHRM4 protein17613726
D018723Bethanecholbrucine promotes the reaction [Bethanechol binds to CHRM4 protein]9224827
D018723BethanecholCHRM4 protein binds to Bethanechol9224827
C018465bioallethrin[DDT co-treated with bioallethrin] results in increased expression of CHRM4 mRNA10192214
C006780bisphenol Abisphenol A results in decreased expression of CHRM4 mRNA25181051
C083806brucinebrucine analog affects the reaction [Acetylcholine binds to CHRM4 protein]10069518
C083806brucinebrucine analog affects the reaction [N-Methylscopolamine binds to CHRM4 protein]10069518
C083806brucinebrucine binds to CHRM4 protein16709648
C083806brucinebrucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM4 protein]9224827
C083806brucinebrucine promotes the reaction [5-methylfurtrethonium binds to CHRM4 protein]9224827
C083806brucinebrucine promotes the reaction [Bethanechol binds to CHRM4 protein]9224827
C083806brucinebrucine promotes the reaction [Carbachol binds to CHRM4 protein]9224827
C083806brucinebrucine promotes the reaction [furtrethonium binds to CHRM4 protein]9224827
C083806brucinebrucine promotes the reaction [oxotremorine M binds to CHRM4 protein]9224827
C083806brucinebrucine promotes the reaction [Pilocarpine binds to CHRM4 protein]9224827
C083806brucineWIN 62577 inhibits the reaction [brucine binds to CHRM4 protein]16709648
C083067brucine N-oxidebrucine N-oxide promotes the reaction [Acetylcholine binds to CHRM4 protein]9495826
C083067brucine N-oxidebrucine N-oxide promotes the reaction [Acetylcholine results in increased activity of CHRM4 protein]10101037
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM4 mRNA]29253600
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CHRM4 mRNA29253600
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CHRM4 mRNA27389774
D019256Cadmium ChlorideQuercetin inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM4 mRNA]27389774
D002217Carbacholbrucine promotes the reaction [Carbachol binds to CHRM4 protein]9224827
D002217CarbacholCHRM4 protein binds to Carbachol9224827
D002217CarbacholCarbachol results in increased activity of CHRM4 protein15955028
D002330CarmustineCarmustine results in decreased expression of CHRM4 mRNA15980968
D008455(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM4 protein16709648
D008455(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloridebrucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM4 protein]9224827
D008455(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium ChlorideCHRM4 protein binds to (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride9224827
D008455(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM4 protein]16709648
D004390ChlorpyrifosChlorpyrifos results in decreased activity of CHRM4 protein17666426
D003033Coal TarCoal Tar results in decreased expression of CHRM4 mRNA27858113
D003042CocaineCocaine affects the expression of CHRM4 mRNA20187946
D003435Crotalid VenomsCrotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein]10845706
D003471CuprizoneCuprizone results in decreased expression of CHRM4 mRNA26577399
D003634DDT[DDT co-treated with bioallethrin] results in increased expression of CHRM4 mRNA10192214
D003976DiazinonDiazinon results in increased expression of CHRM4 mRNA18812211
D002945CisplatinCisplatin results in increased expression of CHRM4 mRNA27392435
D004026DieldrinDieldrin affects the expression of CHRM4 mRNA18812211
C016422eburnamonineeburnamonine promotes the reaction [Acetylcholine binds to CHRM4 protein]9224827
C016422eburnamonineeburnamonine promotes the reaction [Pilocarpine binds to CHRM4 protein]9224827
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of CHRM4 mRNA22872703
D005492Folic AcidFolic Acid results in decreased expression of CHRM4 mRNA25006883
C069837fullerene C60fullerene C60 results in decreased expression of CHRM4 mRNA19167457
C028530furtrethoniumbrucine promotes the reaction [furtrethonium binds to CHRM4 protein]9224827
C028530furtrethoniumCHRM4 protein binds to furtrethonium9224827
D005703Gallamine TriethiodideGallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]9846649
D006220HaloperidolCHRM4 affects the susceptibility to Haloperidol21269601
C116689heptane-1,7-bis-(dimethyl-3'-phthalimidopropyl)ammonium bromide"heptane-1,7-bis-(dimethyl-3'-phthalimidopropyl)ammonium bromide binds to CHRM4 protein"16709648
C116689heptane-1,7-bis-(dimethyl-3'-phthalimidopropyl)ammonium bromide"WIN 62577 inhibits the reaction [heptane-1,7-bis-(dimethyl-3'-phthalimidopropyl)ammonium bromide binds to CHRM4 protein]"16709648
C048172himbacinehimbacine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein]8744975
C048172himbacinehimbacine binds to and results in decreased activity of CHRM4 protein8744975
D006843Hydrocarbons, Chlorinated"Hydrocarbons, Chlorinated results in decreased expression of CHRM4 mRNA"22872703
C054938methoctraminemethoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM4 protein]11306684
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CHRM4 mRNA"20188158
D008743Methyl ParathionMethyl Parathion results in decreased activity of CHRM4 protein17666426
D019832N-Methylscopolaminebrucine analog affects the reaction [N-Methylscopolamine binds to CHRM4 protein]10069518
D019832N-MethylscopolamineCHRM4 protein binds to N-Methylscopolamine9224827
D019832N-MethylscopolamineGallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]9846649
D019832N-MethylscopolamineN-Methylscopolamine binds to CHRM4 protein10069518|1670964
D019832N-MethylscopolaminePancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]9846649
D019832N-MethylscopolaminePipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]9846649
D019832N-Methylscopolaminerocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]9846649
D019832N-MethylscopolamineStrychnine promotes the reaction [N-Methylscopolamine binds to CHRM4 protein]9495826
D019832N-MethylscopolamineTropicamide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]9846649
D019832N-MethylscopolamineVecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]9846649
D019832N-MethylscopolamineWIN 51708 promotes the reaction [N-Methylscopolamine binds to CHRM4 protein]16709648
D008799MevinphosMevinphos results in increased activity of CHRM4 protein17395621
D009532NickelNickel affects the expression of CHRM4 mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of CHRM4 mRNA]14575637
D009532NickelNickel results in decreased expression of CHRM4 mRNA18812211
C028007nickel monoxidenickel monoxide results in decreased expression of CHRM4 mRNA19167457
C087567N-methyltropan-3-yl 2-(4-bromophenyl)propionateN-methyltropan-3-yl 2-(4-bromophenyl)propionate binds to CHRM4 protein9495837
C042743oxotremorine Mbrucine promotes the reaction [oxotremorine M binds to CHRM4 protein]9224827
C042743oxotremorine MCHRM4 protein binds to oxotremorine M9224827
D010197PancuroniumPancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]9846649
C086401pentabromodiphenyl etherpentabromodiphenyl ether affects the expression of CHRM4 mRNA27294297
C000593032PGW5 compoundPGW5 compound binds to CHRM4 protein24389121
D010862Pilocarpinebrucine promotes the reaction [Pilocarpine binds to CHRM4 protein]9224827
D010862PilocarpineCHRM4 protein binds to Pilocarpine9224827
D010862Pilocarpineeburnamonine promotes the reaction [Pilocarpine binds to CHRM4 protein]9224827
D010862PilocarpinePilocarpine binds to and results in increased activity of CHRM4 protein9920179
D017300PipecuroniumPipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]9846649
D010936Plant ExtractsPlant Extracts results in decreased expression of CHRM4 mRNA23557933
D011794QuercetinQuercetin inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM4 mRNA]27389774
D011813Quinuclidinyl BenzilateCrotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein]10845706
D011813Quinuclidinyl BenzilateQuinuclidinyl Benzilate binds to CHRM4 protein10845706|1670964
D011813Quinuclidinyl BenzilateWIN 51708 inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein]16709648
D011813Quinuclidinyl Benzilate[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM4 protein]16709648
D011813Quinuclidinyl Benzilate[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Acetylcholine binds to CHRM4 protein]16709648
D011813Quinuclidinyl Benzilate[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein]16709648
D011813Quinuclidinyl Benzilate[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [xanomeline binds to CHRM4 protein]16709648
D011813Quinuclidinyl BenzilateWIN 62577 inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein]16709648
D011813Quinuclidinyl Benzilatehimbacine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein]8744975
D011813Quinuclidinyl BenzilateQuinuclidinyl Benzilate binds to CHRM4 protein8744975
D011813Quinuclidinyl BenzilateTropicamide inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein]8744975
D018967RisperidoneCHRM4 affects the susceptibility to Risperidone21269601
C061870rocuroniumrocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]9846649
D012602Scopolamine DerivativesScopolamine Derivatives binds to CHRM4 protein12507038
D012602Scopolamine Derivativesmethoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM4 protein]11306684
D012601Scopolamine HydrobromideCHRM4 protein results in increased susceptibility to Scopolamine Hydrobromide12729838
D013331StrychnineStrychnine promotes the reaction [N-Methylscopolamine binds to CHRM4 protein]9495826
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CHRM4 mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CHRM4 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CHRM4 mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CHRM4 mRNA27913140
D000069447Tiotropium BromideTiotropium Bromide binds to CHRM4 protein21870878
D014236TrichlorfonTrichlorfon affects the expression of CHRM4 mRNA12093157
D014236TrichlorfonTrichlorfon affects the expression of CHRM4 protein12093157
C012589trichostatin Atrichostatin A affects the expression of CHRM4 mRNA28542535
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of CHRM4 mRNA]14575637
D014331TropicamideTropicamide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]9846649
D014331TropicamideTropicamide inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein]8744975
D014331TropicamideTropicamide binds to and results in decreased activity of CHRM4 protein10353596|1525103
D014635Valproic AcidValproic Acid results in increased methylation of CHRM4 gene29154799
D014673Vecuronium BromideVecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]9846649
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CHRM4 gene25560391
C086111WIN 51708WIN 51708 inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein]16709648
C086111WIN 51708WIN 51708 promotes the reaction [N-Methylscopolamine binds to CHRM4 protein]16709648
C086110WIN 62577[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM4 protein]16709648
C086110WIN 62577[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Acetylcholine binds to CHRM4 protein]16709648
C086110WIN 62577[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein]16709648
C086110WIN 62577[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [xanomeline binds to CHRM4 protein]16709648
C086110WIN 62577WIN 62577 inhibits the reaction [Alcuronium binds to CHRM4 protein]16709648
C086110WIN 62577WIN 62577 inhibits the reaction [brucine binds to CHRM4 protein]16709648
C086110WIN 62577"WIN 62577 inhibits the reaction [heptane-1,7-bis-(dimethyl-3'-phthalimidopropyl)ammonium bromide binds to CHRM4 protein]"16709648
C086110WIN 62577WIN 62577 inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein]16709648
C075257xanomeline[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [xanomeline binds to CHRM4 protein]16709648
C075257xanomelinexanomeline binds to CHRM4 protein16709648
C075257xanomelineCHRM4 gene results in increased susceptibility to xanomeline19111716
C075257xanomelineCHRM4 results in increased susceptibility to xanomeline19996296
C075257xanomelinexanomeline binds to and results in increased activity of [CHRM1 protein binds to CHRM4 protein]21211109

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004993G-protein coupled serotonin receptor activity-IBA21873635  
GO:0016907G-protein coupled acetylcholine receptor activity-IBA21873635  
GO:0030594neurotransmitter receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS9603968  
GO:0007166cell surface receptor signaling pathway-TAS2739737  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IBA21873635  
GO:0007197adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway-IBA21873635  
GO:0007213G-protein coupled acetylcholine receptor signaling pathway-TAS3443095  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0008283cell proliferation-TAS2739737  
GO:0040012regulation of locomotion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375280Amine ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-390648Muscarinic acetylcholine receptorsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27269905African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction. (2016 Jun)Levran OPharmacogenomics