Gene: GLCCI1

113263
FAM117C|GCTR|GIG18|TSSN1
glucocorticoid induced 1
protein-coding
7p21.3
Ensembl:ENSG00000106415 MIM:614283 Vega:OTTHUMG00000151984 UniprotKB:Q86VQ1
NG_032073.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.435e-1 (AD)  3.448e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARK10.948
GLRB0.94
GLS0.939
CNKSR20.938
WDR470.938
SYNJ10.937
FAM126B0.935
BHLHB90.935
PIK3CB0.934
FAM49A0.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.49
HEY2-0.489
CSAG1-0.486
MYL3-0.479
OR4F5-0.475
RAB13-0.472
TFPI2-0.464
RAI14-0.449
RNF135-0.445
YES1-0.444

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of GLCCI1 mRNA"20453058
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of GLCCI1 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GLCCI1 mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GLCCI1 mRNA"28973690
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of GLCCI1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLCCI1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLCCI1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLCCI1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLCCI1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLCCI1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLCCI1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLCCI1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLCCI1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLCCI1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLCCI1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of GLCCI1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of GLCCI1 mRNA17562736
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GLCCI1 mRNA22129741
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of GLCCI1 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GLCCI1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GLCCI1 mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of GLCCI1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of GLCCI1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of GLCCI1 mRNA26364221
C006780bisphenol Abisphenol A affects the methylation of GLCCI1 gene21829099
C006780bisphenol Abisphenol A affects the expression of GLCCI1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GLCCI1 gene28505145
D019327Copper SulfateCopper Sulfate results in increased expression of GLCCI1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of GLCCI1 mRNA25562108
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of GLCCI1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of GLCCI1 mRNA27392435
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GLCCI1 mRNA22129741
C118739entinostatentinostat results in decreased expression of GLCCI1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLCCI1 mRNA"27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GLCCI1 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GLCCI1 mRNA22079256
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of GLCCI1 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of GLCCI1 mRNA21233418
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of GLCCI1 mRNA23649840
D005485FlutamideFlutamide results in increased expression of GLCCI1 mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of GLCCI1 mRNA23649840
C010974glyphosateglyphosate results in increased expression of GLCCI1 mRNA25636363
D017313FenretinideFenretinide results in decreased expression of GLCCI1 mRNA28973697
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GLCCI1 mRNA22129741
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GLCCI1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of GLCCI1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of GLCCI1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of GLCCI1 mRNA24796395
C045463leflunomideleflunomide results in decreased expression of GLCCI1 mRNA19751817
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GLCCI1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GLCCI1 mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GLCCI1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GLCCI1 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of GLCCI1 mRNA19812364
C029938nickel sulfatenickel sulfate results in decreased expression of GLCCI1 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of GLCCI1 mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLCCI1 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of GLCCI1 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLCCI1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of GLCCI1 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GLCCI1 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GLCCI1 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GLCCI1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GLCCI1 mRNA22079256
D011794QuercetinQuercetin results in decreased expression of GLCCI1 mRNA21632981
D053260SootSoot results in decreased expression of GLCCI1 mRNA26551751
C025462sulindac sulfidesulindac sulfide results in increased expression of GLCCI1 mRNA16184548
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GLCCI1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GLCCI1 mRNA19933214|2015994
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GLCCI1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GLCCI1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of GLCCI1 mRNA27760801
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of GLCCI1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of GLCCI1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of GLCCI1 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLCCI1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of GLCCI1 mRNA24935251|2627250
D014415TunicamycinTunicamycin results in decreased expression of GLCCI1 mRNA22378314
D014520UrethaneUrethane results in increased expression of GLCCI1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLCCI1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GLCCI1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GLCCI1 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions affects the methylation of GLCCI1 gene25560391
C025643vinclozolinvinclozolin affects the expression of GLCCI1 mRNA19015723
D024483Vitamin K 3Vitamin K 3 affects the expression of GLCCI1 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29345236GLCCI1 polymorphism rs37973 and asthma treatment response to inhaled corticosteroids. (2018 Jan 17)Rijavec MJ Investig Allergol Clin Immunol
28186150GLCCI1 rs37973: a potential genetic predictor of therapeutic response to inhaled corticosteroids in Chinese chronic obstructive pulmonary disease patients. (2017 Feb 10)Lei YSci Rep
24673601GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids. (2014 May)Izuhara YAllergy