Gene: TMEM106A

113277
-
transmembrane protein 106A
protein-coding
17q21.31
Ensembl:ENSG00000184988 Vega:OTTHUMG00000180879 UniprotKB:Q96A25
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.459e-1 (AD)  8.721e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A70.914
CD330.902
ADAP20.895
DOCK20.894
CD840.894
NCKAP1L0.888
ARHGAP300.883
LILRA20.881
SASH30.876
LILRB10.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYADML2-0.408
HAS1-0.406
BCL11A-0.406
RTN4R-0.406
KCNIP3-0.402
TMEM179-0.396
KCNB2-0.396
FBLL1-0.393
NEUROD6-0.392
ATP2C2-0.391

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TMEM106A mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TMEM106A mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TMEM106A mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TMEM106A mRNA"25380136
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TMEM106A gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TMEM106A mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of TMEM106A mRNA28522335
C006632arsenic trioxidearsenic trioxide results in increased expression of TMEM106A mRNA26705709
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TMEM106A mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TMEM106A mRNA22228805
D004958EstradiolEstradiol results in decreased expression of TMEM106A mRNA20106945|2163298
D004958EstradiolEstradiol results in increased expression of TMEM106A mRNA19484750
C006780bisphenol Abisphenol A affects the expression of TMEM106A mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of TMEM106A mRNA25181051
C584509C646 compoundC646 compound results in increased expression of TMEM106A mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TMEM106A mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TMEM106A mRNA24982889
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TMEM106A mRNA27339419
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TMEM106A mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of TMEM106A mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of TMEM106A mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TMEM106A mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of TMEM106A mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of TMEM106A mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of TMEM106A mRNA21658437
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of TMEM106A mRNA25380136
D004237DiuronDiuron results in decreased expression of TMEM106A mRNA25152437
D005485FlutamideFlutamide results in increased expression of TMEM106A mRNA24793618
D017313FenretinideFenretinide results in decreased expression of TMEM106A mRNA28973697
C492448ICG 001ICG 001 results in increased expression of TMEM106A mRNA26191083
D007854LeadLead results in increased expression of TMEM106A mRNA19921347
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TMEM106A mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TMEM106A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TMEM106A mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of TMEM106A mRNA25380136
D009532NickelNickel results in increased expression of TMEM106A mRNA24768652|2558310
C022838nickel chloridenickel chloride affects the expression of TMEM106A mRNA22110744
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of TMEM106A mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of TMEM106A mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of TMEM106A mRNA23892564
D011374ProgesteroneProgesterone results in decreased expression of TMEM106A mRNA23012394
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TMEM106A mRNA27029645
D011794QuercetinQuercetin results in decreased expression of TMEM106A mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TMEM106A mRNA25895662
D012834SilverSilver results in decreased expression of TMEM106A mRNA27131904
C016104sodium bichromatesodium bichromate results in increased expression of TMEM106A mRNA25993096
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMEM106A mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TMEM106A mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of TMEM106A mRNA25729387
D019772TopotecanTopotecan results in increased expression of TMEM106A mRNA25729387
C011559tributyltintributyltin results in increased expression of TMEM106A mRNA21683754
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TMEM106A mRNA"26179874
D015032ZincZinc deficiency results in increased expression of TMEM106A mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24975047Transmembrane protein 106A is silenced by promoter region hypermethylation and suppresses gastric cancer growth by inducing apoptosis. (2014 Aug)Xu DJ Cell Mol Med