Gene: CTRC

11330
CLCR|ELA4
chymotrypsin C
protein-coding
1p36.21
Ensembl:ENSG00000162438 MIM:601405 Vega:OTTHUMG00000002255 UniprotKB:Q99895
NG_009253.1
PubMed
0   ANCO-SNPs
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.761e-1 (AD)  6.140e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYCN0.909
CPB10.901
GP20.893
CELA3B0.891
CELA2A0.887
CTRB10.886
PLA2G1B0.884
PNLIPRP10.88
CELA3A0.875
PNLIP0.866

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYH15-0.204
GREM1-0.191
WDR88-0.188
KIF6-0.183
NPSR1-0.177
KLK6-0.174
FOLH1-0.173
ZNF536-0.172
ADARB2-0.172
UCN3-0.171

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of CTRC mRNA"19162173
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CTRC mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CTRC mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CTRC mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CTRC mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CTRC mRNA"25510870
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CTRC mRNA22129741
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CTRC mRNA16483693
C095105bexarotenebexarotene results in increased expression of CTRC mRNA16648578
C006780bisphenol Abisphenol A affects the expression of CTRC mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CTRC gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CTRC mRNA18804290
D002922CiguatoxinsCiguatoxins affects the expression of CTRC mRNA18353800
D004026DieldrinDieldrin results in increased expression of CTRC mRNA23041725
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CTRC mRNA22129741
D019833GenisteinGenistein results in decreased methylation of CTRC gene28505145
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CTRC mRNA22129741
C008261lead acetatelead acetate results in increased expression of CTRC mRNA20542052|2260969
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CTRC mRNA"24972896
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CTRC mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CTRC mRNA"25620056
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CTRC mRNA"25510870
C006253pirinixic acidpirinixic acid results in increased expression of CTRC mRNA17426115
D011441PropylthiouracilPropylthiouracil results in decreased expression of CTRC mRNA24780913
C016104sodium bichromatesodium bichromate results in decreased expression of CTRC mRNA22561333
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CTRC mRNA26377647
C009495titanium dioxidetitanium dioxide results in increased expression of CTRC mRNA23409001
D014635Valproic AcidValproic Acid results in increased methylation of CTRC gene29154799
C025643vinclozolinvinclozolin results in increased methylation of CTRC promoter22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0008233peptidase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0009235cobalamin metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196741Cobalamin (Cbl, vitamin B12) transport and metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28454201[Identical Variants Different Disease Course - Genetics of Chronic Pancreatitis]. (2017 May)Beer SDtsch Med Wochenschr
25569187The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population. (2015 Jan 8)LaRusch JClin Transl Gastroenterol
28968289Chymotrypsinogen C Genetic Variants, Including c.180TT, Are Strongly Associated With Chronic Pancreatitis in Pediatric Patients. (2017 Dec)Grabarczyk AMJ Pediatr Gastroenterol Nutr
24624459Pancreatitis Overview (1993)LaRusch J-
22608493[Chronic pancreatitis: beyond alcohol]. (2012 Oct)Vaquero Raya ECGastroenterol Hepatol
27253233Frequency of Tabagism and N34S and P55S Mutations of Serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) and R254W Mutation of Chymotrypsin C (CTRC) in Patients With Chronic Pancreatitis and Controls. (2016 Oct)da Costa MZPancreas