Gene info: ID 11331

Gene: PHB2

GENE ID: 11331

Synonyms: BAP|BCAP37|Bap37|PNAS-141|REA|hBAP|p22

Description: prohibitin 2

Gene type: protein-coding

Location: 12p13.31

dbXrefs: Ensembl:ENSG00000215021 MIM:610704 Vega:OTTHUMG00000168519 UniprotKB:Q99623

RefSeq: NC_000012.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.920e-1 (AD) 7.095e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PSMB4	0.974
ACTG1	0.964
CAPZB	0.955
APEX1	0.953
CSNK2B	0.951
GAPDH	0.951
ACTB	0.951
BRK1	0.948
POLDIP2	0.948
ILF2	0.947

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.879
OR4F29	-0.851
MTRNR2L6	-0.224
MTRNR2L9	-0.203
MTRNR2L10	-0.173
PRDM14	-0.157
ZBTB20	-0.142
CCR8	-0.141
IFNK	-0.141
PRAMEF17	-0.14

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB06774	Capsaicin	Small Molecule	404-86-4	Approved	Target

ID	Drug Name	Action	PubMed
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of PHB2 protein	22527513
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of PHB2 protein"	21673325
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PHB2 mRNA"	19114083
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of PHB2 mRNA"	21346803
C035208	2-amino-4,6-dinitrotoluene	"2-amino-4,6-dinitrotoluene results in decreased expression of PHB2 protein"	26251320
D000082	Acetaminophen	Acetaminophen results in decreased expression of PHB2 mRNA	25704631\|2669055
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of PHB2 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PHB2 mRNA	16483693
D001241	Aspirin	Aspirin results in decreased expression of PHB2 mRNA	15928584
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to PHB2 promoter]	19654925
D004958	Estradiol	Estradiol inhibits the reaction [ESR1 protein binds to PHB2 protein]	18997820
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in decreased expression of PHB2 mRNA	26496021
C006780	bisphenol A	bisphenol A affects the expression of PHB2 mRNA	23557687
C006780	bisphenol A	bisphenol A results in decreased expression of PHB2 mRNA	29275510
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in decreased expression of PHB2 mRNA	26496021
C006780	bisphenol A	[bisphenol A co-treated with Genistein] results in increased methylation of PHB2 gene	28505145
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in increased expression of PHB2 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of PHB2 mRNA	19577632
C006780	bisphenol A	[Fructose co-treated with bisphenol A] results in decreased expression of PHB2 protein	26930160
C013418	bromfenacoum	bromfenacoum results in increased expression of PHB2 protein	28903499
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of PHB2 mRNA	18804290
D002211	Capsaicin	Capsaicin binds to and results in increased localization of PHB2 protein	19116139
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of PHB2 mRNA	16239168
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of PHB2 mRNA	23650126
D002737	Chloroprene	Chloroprene results in increased expression of PHB2 mRNA	23125180
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PHB2 gene	20938992
C030973	cupric oxide	cupric oxide results in increased expression of PHB2 protein	25470785
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of PHB2 protein	20935162
D004052	Diethylnitrosamine	[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of PHB2 protein	20935162
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of PHB2 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PHB2 mRNA	16174780\|1794274
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHB2 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of PHB2 mRNA	17557909
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PHB2 mRNA	16174780
D015025	Zearalenone	Zearalenone results in increased expression of PHB2 protein	25058043
D005485	Flutamide	Flutamide results in increased expression of PHB2 mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PHB2 gene	20938992
D005632	Fructose	[Fructose co-treated with bisphenol A] results in decreased expression of PHB2 protein	26930160
C039281	furan	furan results in increased methylation of PHB2 gene	22079235
D019833	Genistein	[bisphenol A co-treated with Genistein] results in increased methylation of PHB2 gene	28505145
D005839	Gentamicins	Gentamicins results in increased expression of PHB2 mRNA	22061828
D017313	Fenretinide	Fenretinide results in increased expression of PHB2 mRNA	28973697
C492448	ICG 001	ICG 001 results in decreased expression of PHB2 mRNA	26191083
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PHB2 mRNA	25613284
D007854	Lead	Lead affects the expression of PHB2 mRNA	28903495
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PHB2 mRNA	21641980
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PHB2 gene	20938992
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of PHB2 protein	26558463
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of PHB2 protein	24675778
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of PHB2 mRNA	29191790
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of PHB2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of PHB2 mRNA"	25554681
D010426	Pentosan Sulfuric Polyester	Pentosan Sulfuric Polyester results in decreased expression of PHB2 mRNA	28973697
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of PHB2 mRNA	19162173
D010634	Phenobarbital	Phenobarbital affects the expression of PHB2 mRNA	23091169
D010634	Phenobarbital	[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of PHB2 protein	20935162
C006253	pirinixic acid	pirinixic acid results in increased expression of PHB2 mRNA	18301758\|2381119
C006253	pirinixic acid	pirinixic acid results in increased expression of PHB2 mRNA	19162173
C045362	prochloraz	prochloraz results in decreased expression of PHB2 mRNA	21470553
C015586	propiverine	propiverine binds to PHB2 protein	29273565
D012715	Sesame Oil	Sesame Oil results in increased expression of PHB2 mRNA	29191790
D019821	Simvastatin	Simvastatin results in decreased expression of PHB2 protein	20217863
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of PHB2 protein	28918527
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of PHB2 protein	27548804
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PHB2 mRNA	21641980
D013629	Tamoxifen	BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to PHB2 protein]]	18997820
D013629	Tamoxifen	Tamoxifen promotes the reaction [ESR1 protein binds to PHB2 protein]	18997820
D013629	Tamoxifen	Tamoxifen affects the expression of PHB2 mRNA	17555576
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in increased expression of PHB2 mRNA	26496021
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PHB2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHB2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PHB2 promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PHB2 mRNA	18796159
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PHB2 mRNA	25613284
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of PHB2 mRNA	19042947
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of PHB2 mRNA"	24576698
C016837	zinc chloride	zinc chloride results in decreased expression of PHB2 mRNA	19683351

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	10359819 11302691 17008324 19116139 21328542 21746876
GO:0008022	protein C-terminus binding	-	IPI	19906925
GO:0030331	estrogen receptor binding	-	NAS	10359819
GO:0033218	amide binding	-	IPI	19116139
GO:0047485	protein N-terminus binding	-	IPI	18629613

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000060	protein import into nucleus, translocation	-	IDA	17008324 19116139
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006851	mitochondrial calcium ion transmembrane transport	-	TAS	-
GO:0007005	mitochondrion organization	-	IMP	17008324
GO:0007062	sister chromatid cohesion	-	IDA	23548868
GO:0009611	response to wounding	-	IEA	-
GO:0030449	regulation of complement activation	NOT	IDA	17070910
GO:0031536	positive regulation of exit from mitosis	-	IMP	23548868
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	-	IEA	-
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	-	IEA	-
GO:0043066	negative regulation of apoptotic process	-	IMP	17008324
GO:0043433	negative regulation of DNA-binding transcription factor activity	-	IMP	18629613
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	10359819
GO:0050821	protein stabilization	-	IMP	17008324
GO:0051091	positive regulation of DNA-binding transcription factor activity	-	IDA	18629613
GO:0060744	mammary gland branching involved in thelarche	-	IEA	-
GO:0060749	mammary gland alveolus development	-	IEA	-
GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	-	IEA	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IMP	22417827
GO:0071277	cellular response to calcium ion	-	HEP	21237226
GO:0071300	cellular response to retinoic acid	-	IEA	-
GO:0071456	cellular response to hypoxia	-	IEA	-
GO:1902808	positive regulation of cell cycle G1/S phase transition	-	IMP	23548868

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	HDA	21630459
GO:0005634	nucleus	-	IDA	17008324 19116139
GO:0005634	nucleus	-	ISS	-
GO:0005737	cytoplasm	-	IDA	19116139
GO:0005739	mitochondrion	-	HDA	20833797
GO:0005739	mitochondrion	-	IDA	19906925
GO:0005741	mitochondrial outer membrane	-	IDA	17008324
GO:0005743	mitochondrial inner membrane	-	ISS	-
GO:0005743	mitochondrial inner membrane	-	TAS	-
GO:0009986	cell surface	-	IDA	22417827
GO:0016363	nuclear matrix	-	IDA	21328542
GO:0030424	axon	-	IEA	-
GO:0032991	protein-containing complex	-	IDA	21328542
GO:0071944	cell periphery	-	IDA	19906925

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-382551	Transport of small molecules	TAS
R-HSA-8949215	Mitochondrial calcium ion transport	TAS
R-HSA-8949664	Processing of SMDT1	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22521224	Downregulation of lung mitochondrial prohibitin in COPD. (2012 Jul)	Soulitzis N	Respir Med