Gene: GABARAP

11337
ATG8A|GABARAP-a|MM46
GABA type A receptor-associated protein
protein-coding
17p13.1
Ensembl:ENSG00000170296 MIM:605125 Vega:OTTHUMG00000102156 UniprotKB:O95166
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.219e-1 (AD)  1.091e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHMP2A0.963
MRPL510.951
CSNK2B0.948
LAMTOR10.947
PARK70.946
TXN20.946
COX4I10.945
YWHAE0.944
PRDX10.944
UBXN10.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.914
OR4F29-0.901
FER1L6-0.119
KRT73-0.114
OR6C74-0.114
HMHB1-0.111
SPRR4-0.109
MROH9-0.106
C8orf74-0.105
HTN3-0.104

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0259463-methyladenine3-methyladenine results in decreased expression of GABARAP mRNA21681844
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GABARAP gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GABARAP mRNA16483693
D001205Ascorbic AcidAscorbic Acid results in increased expression of GABARAP mRNA15305145
D001241AspirinAspirin results in decreased expression of GABARAP mRNA15928584
D001280AtrazineAtrazine results in decreased expression of GABARAP mRNA22378314
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GABARAP mRNA28628672
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of GABARAP mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of GABARAP mRNA25181051
D002104CadmiumCadmium results in increased expression of GABARAP mRNA24376830
D002273CarcinogensCarcinogens results in decreased expression of GABARAP mRNA22269147
D002994ClofibrateClofibrate results in increased expression of GABARAP mRNA25270620
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GABARAP mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GABARAP mRNA21266533
C121718dicyclanildicyclanil results in increased expression of GABARAP mRNA15664270
C024629dimethyl phthalatedimethyl phthalate affects the expression of GABARAP mRNA26924002
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of GABARAP mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of GABARAP mRNA23649840
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of GABARAP mRNA17183730
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GABARAP mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GABARAP mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GABARAP mRNA28628672
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GABARAP mRNA23649840
D009153MutagensMutagens results in decreased expression of GABARAP mRNA22269147
C022838nickel chloridenickel chloride results in increased expression of GABARAP mRNA19187980
D010795Phthalic AcidsPhthalic Acids results in increased expression of GABARAP mRNA21061450
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of GABARAP mRNA16079270
C059514resveratrolresveratrol results in increased expression of GABARAP mRNA23750556
D012524SarinSarin results in decreased expression of GABARAP mRNA19522546
D012524SarinSarin results in increased expression of GABARAP mRNA19522546
D020123SirolimusSirolimus results in increased expression of GABARAP mRNA21681844
D012999SomanSoman results in increased expression of GABARAP mRNA19281266
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of GABARAP mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GABARAP mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GABARAP promoter]21889950
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GABARAP mRNA25613284
D014050TolueneToluene affects the expression of GABARAP mRNA21827849
C032910triadimefontriadimefon results in decreased expression of GABARAP mRNA16643972
C012589trichostatin Atrichostatin A results in increased expression of GABARAP mRNA15901671
D014303TrinitrotolueneTrinitrotoluene affects the expression of GABARAP mRNA21346803
D014635Valproic AcidValproic Acid results in increased expression of GABARAP mRNA15901671
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of GABARAP mRNA17183730
D014635Valproic AcidValproic Acid results in increased expression of GABARAP mRNA23665938

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9892355  11096062  11146101  15977068  16169070  16303767  
17353931  17580304  19056683  19154346  19250911  20010802  
20200478  20452972  20562859  20810658  21617041  22267086  
22354992  22421968  22470510  22948227  24089205  24290141  
25126726  25127057  26040720  26347139  28712572  
GO:0008017microtubule binding-IEA-  
GO:0031625ubiquitin protein ligase binding-IPI25127057  
GO:0048487beta-tubulin binding-IDA9892355  
GO:0050811GABA receptor binding-IBA21873635  
GO:0050811GABA receptor binding-IPI9892355  
GO ID GO Term Qualifier Evidence PubMed
GO:0000045autophagosome assembly-IBA21873635  
GO:0000226microtubule cytoskeleton organization-IEA-  
GO:0000422autophagy of mitochondrion-IBA21873635  
GO:0006605protein targeting-TAS9892355  
GO:0006995cellular response to nitrogen starvation-IBA21873635  
GO:0007268chemical synaptic transmission-TAS9892355  
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors-IDA15977068  
GO:0016236macroautophagy-TAS-  
GO:0097352autophagosome maturation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0000421autophagosome membrane-IBA21873635  
GO:0000421autophagosome membrane-IDA15169837  
GO:0000421autophagosome membrane-TAS-  
GO:0005764lysosome-IEA-  
GO:0005776autophagosome-IDA19056683  
GO:0005790smooth endoplasmic reticulum-IEA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0005874microtubule-IEA-  
GO:0005875microtubule associated complex-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0005930axoneme-ISS-  
GO:0015629actin cytoskeleton-IEA-  
GO:0031410cytoplasmic vesicle-IEA-  
GO:0044297cell body-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0097225sperm midpiece-IEA-  
KEGG ID KEGG Term
hsa04140Regulation of autophagy
Reactome ID Reactome Term Evidence
R-HSA-1632852MacroautophagyTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8854214TBC/RABGAPsTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17164261Fine mapping of a linkage region on chromosome 17p13 reveals that GABARAP and DLG4 are associated with vulnerability to nicotine dependence in European-Americans. (2007 Jan 15)Lou XYHum Mol Genet