Gene: CHRNA1

1134
ACHRA|ACHRD|CHRNA|CMS1A|CMS1B|CMS2A|FCCMS|SCCMS
cholinergic receptor nicotinic alpha 1 subunit
protein-coding
2q31.1
Ensembl:ENSG00000138435 MIM:100690 Vega:OTTHUMG00000132357 UniprotKB:P02708
NG_008172.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.628e-1 (AD)  3.550e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RET0.708
DPP40.695
TTC39C0.693
GLIPR10.679
FMN10.676
EFNA50.67
INSM20.666
TTC39B0.663
SPTSSB0.663
SEC16B0.659

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYOM1-0.46
ASB4-0.416
COPZ2-0.39
YES1-0.37
TMEM100-0.37
ZIC4-0.369
HEY2-0.366
MDFI-0.363
ANTXR1-0.359
DOCK1-0.356

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00674GalantamineSmall Molecule357-70-0ApprovedTarget
DB08838AgmatineSmall Molecule306-60-5Experimental|InvestigationalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CHRNA1 mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of CHRNA1 mRNA17585979
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]22461452
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]22461452
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNE protein binds to CHRND protein]16931985
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]22461452
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]22461452
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]19619141
D000109AcetylcholineLYNX1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]19619141
D000109AcetylcholineLYPD1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]19619141
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]23146756
D000109Acetylcholinepoly-APS inhibits the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]]23146756
D020106AcrylamideAcrylamide results in decreased expression of CHRNA1 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHRNA1 mRNA16483693
D001151ArsenicArsenic affects the methylation of CHRNA1 gene25304211
D004958EstradiolEstradiol results in decreased expression of CHRNA1 mRNA19693291
C006780bisphenol Abisphenol A results in increased expression of CHRNA1 mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of CHRNA1 mRNA25181051
D002038BungarotoxinsBungarotoxins binds to CHRNA1 protein11800594
D002038BungarotoxinsBungarotoxins binds to [CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNG protein]9336329
D002038BungarotoxinsNicotine inhibits the reaction [Bungarotoxins binds to [CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNG protein]]9336329
D002038Bungarotoxinspozanicline inhibits the reaction [Bungarotoxins binds to [CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNG protein]]9336329
D002713ChlorineChlorine results in increased expression of CHRNA1 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of CHRNA1 mRNA18636392
D002994ClofibrateClofibrate results in increased expression of CHRNA1 mRNA17585979
D003471CuprizoneCuprizone results in decreased expression of CHRNA1 mRNA26577399
D004026DieldrinDieldrin results in decreased expression of CHRNA1 mRNA23153324
D004041Dietary FatsDietary Fats results in increased expression of CHRNA1 mRNA18042831
D004147DioxinsDioxins affects the expression of CHRNA1 mRNA20463971
D004222DisulfotonDisulfoton results in decreased expression of CHRNA1 mRNA12935443
C082748epibatidineepibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]19619141
C082748epibatidineLYNX1 protein promotes the reaction [epibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]19619141
C082748epibatidineLYPD1 protein promotes the reaction [epibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]19619141
D005419FlavonoidsFlavonoids results in increased expression of CHRNA1 mRNA18035473
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of CHRNA1 mRNA21782745
D006533HeptachlorHeptachlor results in decreased expression of CHRNA1 mRNA23153324
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of CHRNA1 mRNA17183730
D007052IbuprofenIbuprofen results in increased expression of CHRNA1 mRNA28201806
C082359imidaclopridCHRNA1 protein mutant form results in decreased susceptibility to imidacloprid15937112
C082359imidaclopridimidacloprid results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]19619141
C082359imidaclopridLYNX1 protein promotes the reaction [imidacloprid results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]19619141
C082359imidaclopridLYPD1 protein promotes the reaction [imidacloprid results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]19619141
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CHRNA1 mRNA12057914
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of CHRNA1 mRNA21782745
D008917MirexMirex results in decreased expression of CHRNA1 mRNA23153324
D009538NicotineNicotine binds to CHRNA1 protein19690163
D009538NicotinePLAU inhibits the reaction [Nicotine binds to CHRNA1 protein]19690163
D009538NicotineNicotine inhibits the reaction [Bungarotoxins binds to [CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNG protein]]9336329
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CHRNA1 mRNA27935865
D010100OxygenOxygen deficiency results in increased expression of CHRNA1 mRNA26516004
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of CHRNA1 mRNA18636392
D000073878Palm OilPalm Oil results in increased expression of CHRNA1 mRNA18042831
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CHRNA1 mRNA27935865
C115254poly-APSpoly-APS inhibits the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]]23146756
C108326pozaniclinepozanicline inhibits the reaction [Bungarotoxins binds to [CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNG protein]]9336329
D053260SootSoot results in increased expression of CHRNA1 mRNA26551751
D013096SpermineSpermine results in increased expression of CHRNA1 mRNA18673383
C560328sulfoxaflorsulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]22461452
D013739TestosteroneTestosterone results in decreased expression of CHRNA1 mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CHRNA1 mRNA21354282
D013974ThyroxineThyroxine results in increased expression of CHRNA1 mRNA17403546
C012589trichostatin Atrichostatin A results in decreased expression of CHRNA1 mRNA15901671
C012589trichostatin Atrichostatin A results in decreased expression of CHRNA1 mRNA15901671
D014403TubocurarineTubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein]19690163
D014635Valproic AcidValproic Acid results in decreased expression of CHRNA1 mRNA15901671
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of CHRNA1 mRNA17183730
D014635Valproic AcidValproic Acid results in decreased methylation of CHRNA1 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of CHRNA1 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CHRNA1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005216ion channel activity-TAS6688857  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0015276ligand-gated ion channel activity-TAS-  
GO:0015464acetylcholine receptor activityCONTRIBUTES_TOIBA21873635  
GO:0015464acetylcholine receptor activitycontributes_toISS8872460  
GO:0022848acetylcholine-gated cation-selective channel activity-IMP9221765  
GO:0022848acetylcholine-gated cation-selective channel activitycontributes_toISS8872460  
GO:0042166acetylcholine bindingCONTRIBUTES_TOIBA21873635  
GO:0042166acetylcholine bindingcontributes_toISS8872460  
GO ID GO Term Qualifier Evidence PubMed
GO:0003009skeletal muscle contraction-IMP8872460  
GO:0006812cation transport-IEA-  
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-TAS7619526  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007271synaptic transmission, cholinergic-IBA21873635  
GO:0007274neuromuscular synaptic transmission-IBA21873635  
GO:0007274neuromuscular synaptic transmission-IMP9221765  
GO:0007528neuromuscular junction development-IMP9221765  
GO:0019228neuronal action potential-IMP8872460  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0034220ion transmembrane transport-IEA-  
GO:0035094response to nicotine-IBA21873635  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0042391regulation of membrane potential-IMP8872460  9221765  
GO:0046716muscle cell cellular homeostasis-IMP8872460  
GO:0048630skeletal muscle tissue growth-IMP18252226  
GO:0050877nervous system process-IBA21873635  
GO:0050881musculoskeletal movement-IMP18252226  
GO:0050905neuromuscular process-IMP9546329  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0070050neuron cellular homeostasis-IMP8872460  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-ISS8872460  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005892acetylcholine-gated channel complex-IBA21873635  
GO:0005892acetylcholine-gated channel complex-ISS8872460  
GO:0009986cell surface-IDA12928480  
GO:0030054cell junction-IEA-  
GO:0031594neuromuscular junction-IDA9221765  
GO:0031594neuromuscular junction-ISS8872460  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-NAS18252226  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-181431Acetylcholine binding and downstream eventsTAS
R-HSA-622323Presynaptic nicotinic acetylcholine receptorsTAS
R-HSA-622327Postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629594Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629597Highly calcium permeable nicotinic acetylcholine receptorsTAS
R-HSA-629602Activation of Nicotinic Acetylcholine ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15192278A novel permutation testing method implicates sixteen nicotinic acetylcholine receptor genes as risk factors for smoking in schizophrenia families. (2004)Faraone SVHum Hered
23232035Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans. (2012 Nov)Walsh KMOncotarget
19307444Examination of the nicotine dependence (NICSNP) consortium findings in the Iowa adoption studies population. (2009 Mar)Philibert RANicotine Tob Res