Gene: MGLL

11343
HU-K5|HUK5|MAGL|MGL
monoglyceride lipase
protein-coding
3q21.3
Ensembl:ENSG00000074416 MIM:609699 Vega:OTTHUMG00000159641 UniprotKB:Q99685
NC_000003.12
PubMed
0   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.825e-1 (AD)  4.830e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ST6GALNAC60.834
FAM168A0.827
WIZ0.819
TMEM184B0.815
PRRC2A0.814
NSMF0.813
PALM0.808
AGPAT30.807
GIT10.805
GNA110.805

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.734
OR4F29-0.702
CRNDE-0.424
HMX3-0.414
SIM1-0.404
FOXB1-0.402
HMX2-0.399
C22orf42-0.395
IRX5-0.395
CCDC140-0.395

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of MGLL mRNA"23829299
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MGLL mRNA"23146750
C5254852-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole"2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole affects the expression of MGLL mRNA"27665778
C5254852-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole"2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole results in increased expression of MGLL mRNA"27665778
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MGLL mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of MGLL mRNA"19167446
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of MGLL mRNA"28433925
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MGLL mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of MGLL mRNA"23829299
C0925612-octyl-4H-1,3,2-benzodioxaphosphorin-2-oxide"2-octyl-4H-1,3,2-benzodioxaphosphorin-2-oxide results in decreased activity of MGLL protein"16449251
C5052472-oleoylglycerolMGLL protein results in increased degradation of 2-oleoylglycerol19515121
C5052472-oleoylglycerolNitroglycerin promotes the reaction [MGLL protein results in increased degradation of 2-oleoylglycerol]19515121
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MGLL mRNA"23196670
C0792153,5-dihydroxyphenylglycine"3,5-dihydroxyphenylglycine inhibits the reaction [FMR1 gene mutant form results in increased activity of MGLL]"20393458
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MGLL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MGLL mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MGLL mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of MGLL mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of MGLL mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MGLL mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MGLL mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MGLL mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MGLL mRNA16483693
C015001arsenitearsenite results in decreased expression of MGLL mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of MGLL mRNA]18929588
C547126AZM551248AZM551248 results in decreased expression of MGLL mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MGLL mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MGLL mRNA27858113
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of MGLL mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MGLL mRNA20064835
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of MGLL mRNA]22228805
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MGLL mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MGLL mRNA23735875
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MGLL mRNA"19150397
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MGLL mRNA25566086
D001629BezafibrateBezafibrate results in increased expression of MGLL mRNA17118139
C006780bisphenol Abisphenol A results in increased expression of MGLL mRNA27014939
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of MGLL mRNA"28433925
C006780bisphenol Abisphenol A affects the expression of MGLL mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MGLL mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MGLL gene28505145
D002065BuspironeBuspirone results in decreased expression of MGLL mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of MGLL mRNA15336504
D002104CadmiumCadmium results in increased expression of MGLL mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MGLL mRNA25993096
D002220CarbamazepineCarbamazepine affects the expression of MGLL mRNA25979313
D002509CephaloridineCephaloridine results in decreased expression of MGLL mRNA18500788
D004390ChlorpyrifosChlorpyrifos results in decreased activity of MGLL protein23761300|2393353
D004390Chlorpyrifos[Chlorpyrifos results in decreased activity of MGLL protein] which results in increased abundance of glyceryl 2-arachidonate23761300|2664291
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MGLL mRNA20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MGLL mRNA27858113
D002922CiguatoxinsCiguatoxins affects the expression of MGLL mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of MGLL mRNA17585979
D002994ClofibrateClofibrate results in increased expression of MGLL mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MGLL mRNA]17585979
D002994ClofibrateClofibrate results in increased expression of MGLL mRNA12851107|2766577
D002994ClofibrateClofibrate results in increased expression of MGLL protein16470657
C018021cobaltous chloridecobaltous chloride results in decreased expression of MGLL mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of MGLL mRNA24386269
D003042CocaineCocaine affects the expression of MGLL mRNA20187946
D003300CopperCopper results in decreased expression of MGLL mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of MGLL mRNA12860252
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of MGLL mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of MGLL mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of MGLL mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of MGLL mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of MGLL mRNA19770486
D013759DronabinolDronabinol results in decreased expression of MGLL mRNA12237329
D003907DexamethasoneDexamethasone results in increased expression of MGLL mRNA25047013
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGLL mRNA16054899
D003907DexamethasoneDexamethasone results in decreased expression of MGLL mRNA22733784
D003907DexamethasoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGLL mRNA]16054899
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MGLL mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of MGLL mRNA28962523
D002945CisplatinCisplatin results in decreased expression of MGLL mRNA27594783
D004008DiclofenacDiclofenac results in decreased expression of MGLL mRNA26934552
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of MGLL mRNA28433925
D004041Dietary FatsDietary Fats results in decreased expression of MGLL mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of MGLL mRNA16357043
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of MGLL mRNA22648174
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of MGLL mRNA28433925
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of MGLL mRNA22648174
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of MGLL mRNA27405655
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of MGLL mRNA"28433925
D002117CalcitriolCalcitriol results in increased expression of MGLL mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of MGLL mRNA21592394
C010117dihydroxyphenylethylene glycolMGLL protein affects the susceptibility to dihydroxyphenylethylene glycol21911610
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of MGLL mRNA25198161
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MGLL mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MGLL mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of MGLL mRNA23649840
C100419ethyl octylphosphonofluoridateethyl octylphosphonofluoridate results in decreased activity of MGLL protein16449251
D015025Zearalenone[Zearalenone co-treated with CGA protein] results in decreased expression of MGLL protein25058043
D005278FenitrothionFenitrothion analog results in decreased activity of MGLL protein16449251
D011345FenofibrateFenofibrate results in increased expression of MGLL mRNA11798191|1711813
D011345FenofibrateFenofibrate results in increased expression of MGLL mRNA27665778
D018120FinasterideFinasteride results in increased expression of MGLL mRNA24136188
C061365flusilazoleflusilazole results in increased expression of MGLL mRNA22382673
D005485FlutamideFlutamide results in decreased expression of MGLL mRNA24793618
D005492Folic AcidFolic Acid affects the expression of MGLL mRNA17320366
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MGLL mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of MGLL mRNA23649840|2893796
D015248GemfibrozilGemfibrozil results in increased expression of MGLL mRNA27665778
D019833GenisteinGenistein results in decreased expression of MGLL mRNA22553218
D005897GlafenineGlafenine results in decreased expression of MGLL mRNA24136188
D005990GlycerolMGLL protein results in increased chemical synthesis of Glycerol19515121
D005990GlycerolNitroglycerin promotes the reaction [MGLL protein results in increased chemical synthesis of Glycerol]19515121
C094503glyceryl 2-arachidonate[FMR1 gene mutant form results in increased activity of MGLL] which results in increased degradation of glyceryl 2-arachidonate20393458
C094503glyceryl 2-arachidonate[JZL 184 results in decreased activity of MGLL protein] which results in increased abundance of glyceryl 2-arachidonate25030704|2620955
C094503glyceryl 2-arachidonateMGLL gene mutant form results in increased abundance of glyceryl 2-arachidonate25030704
C094503glyceryl 2-arachidonateMGLL protein results in increased degradation of glyceryl 2-arachidonate25030704
C094503glyceryl 2-arachidonateMGLL protein results in increased hydrolysis of glyceryl 2-arachidonate18096503|2620955
C094503glyceryl 2-arachidonate[Chlorpyrifos results in decreased activity of MGLL protein] which results in increased abundance of glyceryl 2-arachidonate23761300|2664291
C094503glyceryl 2-arachidonateJZL 184 inhibits the reaction [MGLL protein results in increased hydrolysis of glyceryl 2-arachidonate]21507991
C094503glyceryl 2-arachidonateMGLL protein results in increased hydrolysis of glyceryl 2-arachidonate21507991
C094503glyceryl 2-arachidonateMGLL protein results in increased degradation of glyceryl 2-arachidonate19515121
C094503glyceryl 2-arachidonateMGLL protein results in increased hydrolysis of glyceryl 2-arachidonate21911610
C094503glyceryl 2-arachidonateMGLL protein results in increased metabolism of glyceryl 2-arachidonate20416378
C094503glyceryl 2-arachidonateMGLL results in increased degradation of glyceryl 2-arachidonate20393458
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in decreased expression of MGLL mRNA16206274
D007213IndomethacinIndomethacin affects the expression of MGLL mRNA17546600
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MGLL mRNA25613284
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGLL mRNA16054899
D0150561-Methyl-3-isobutylxanthineTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGLL mRNA]16054899
D007545IsoproterenolIsoproterenol results in decreased expression of MGLL mRNA20003209
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of MGLL mRNA25119042
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MGLL mRNA24796395|2511904
C534333JZL 184JZL 184 results in decreased activity of MGLL protein25030704|2620955
C534333JZL 184[JZL 184 results in decreased activity of MGLL protein] which results in increased abundance of glyceryl 2-arachidonate25030704|2620955
C534333JZL 184JZL 184 inhibits the reaction [MGLL protein results in increased hydrolysis of glyceryl 2-arachidonate]21507991
C534333JZL 184JZL 184 results in decreased activity of MGLL protein21507991
C534333JZL 184JZL 184 results in decreased activity of MGLL protein20416378
C045463leflunomideleflunomide results in decreased expression of MGLL mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of MGLL mRNA"24972896
D008713MethimazoleMethimazole results in increased expression of MGLL mRNA22504374
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MGLL mRNA20938992
C104810methyl arachidonylfluorophosphonatemethyl arachidonylfluorophosphonate results in decreased activity of MGLL protein16466961
C104810methyl arachidonylfluorophosphonatemethyl arachidonylfluorophosphonate results in decreased activity of MGLL protein18657971
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MGLL mRNA23649840
D015735MifepristoneMifepristone results in decreased expression of MGLL mRNA25972201
C523799MRK 003MGLL results in decreased susceptibility to MRK 00319903844
C500085muraglitazarmuraglitazar results in increased expression of MGLL mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MGLL mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MGLL mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MGLL mRNA"25620056
C051752nefazodonenefazodone results in increased expression of MGLL mRNA24136188
C022838nickel chloridenickel chloride affects the expression of MGLL mRNA22110744
C029938nickel sulfatenickel sulfate results in increased expression of MGLL mRNA16780908
C012655nimesulidenimesulide results in increased expression of MGLL mRNA24136188
D005996NitroglycerinNitroglycerin promotes the reaction [MGLL protein results in increased chemical synthesis of Glycerol]19515121
D005996NitroglycerinNitroglycerin promotes the reaction [MGLL protein results in increased degradation of 2-oleoylglycerol]19515121
D005996NitroglycerinNitroglycerin results in increased activity of MGLL protein19515121
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate analog results in decreased activity of MGLL protein"16449251
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased activity of MGLL protein"16449251
D063065OrganophosphonatesOrganophosphonates results in decreased activity of MGLL protein24361246
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MGLL mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of MGLL mRNA18042831
D010278ParathionParathion results in decreased activity of MGLL protein23933531|2621511
D052638Particulate MatterParticulate Matter results in decreased expression of MGLL mRNA24769257
C506614PD 0325901[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of MGLL mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of MGLL mRNA25119042
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in decreased expression of MGLL mRNA28973697
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of MGLL mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MGLL mRNA17681415
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MGLL mRNA16221955|1916217
D010656PhenylephrinePhenylephrine results in decreased expression of MGLL mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MGLL mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MGLL mRNA26272509
D010665PhenylpropanolaminePhenylpropanolamine results in decreased expression of MGLL mRNA16465460
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MGLL mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of MGLL mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of MGLL mRNA11798191|1635704
C006253pirinixic acidpirinixic acid results in increased expression of MGLL mRNA19162173|2248451
D059808PolyphenolsPolyphenols results in increased expression of MGLL mRNA16293270
D017035PravastatinPravastatin results in decreased expression of MGLL mRNA27225895
D017035PravastatinPravastatin affects the expression of MGLL mRNA27225895
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of MGLL mRNA19162173
C045950propiconazolepropiconazole results in decreased expression of MGLL mRNA21278054
C015586propiverinepropiverine binds to MGLL protein29273565
D011441PropylthiouracilPropylthiouracil results in decreased expression of MGLL mRNA24780913
D011441PropylthiouracilPropylthiouracil results in increased expression of MGLL mRNA22504374
C518978prostaglandin E2 glyceryl esterMGLL protein affects the chemical synthesis of and affects the abundance of prostaglandin E2 glyceryl ester18297109
D011794QuercetinQuercetin results in decreased expression of MGLL mRNA25862958
D011794QuercetinQuercetin results in increased expression of MGLL mRNA18095365
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of MGLL mRNA19167446
C059514resveratrol[resveratrol co-treated with Streptozocin] results in decreased expression of MGLL mRNA25905778
C089032rimonabantMGLL protein affects the susceptibility to rimonabant21911610
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGLL mRNA16054899
C089730rosiglitazoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGLL mRNA]16054899
C089730rosiglitazonerosiglitazone results in increased expression of MGLL mRNA21172411|2151530
D012402RotenoneRotenone results in increased expression of MGLL mRNA27900601
C080703SK&F 83959SK&F 83959 results in decreased expression of MGLL protein25852303
D012906SmokeSmoke results in increased expression of MGLL mRNA21095227
C009277sodium arsenatesodium arsenate results in decreased expression of MGLL mRNA16882884
C017947sodium arsenitesodium arsenite affects the methylation of MGLL gene28589171
D012999SomanSoman results in decreased expression of MGLL mRNA19281266
D053260SootSoot results in decreased expression of MGLL mRNA26551751
C075117squalestatin 1squalestatin 1 affects the expression of MGLL mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of MGLL mRNA27225895
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in decreased expression of MGLL mRNA25905778
D016559TacrolimusTacrolimus results in decreased expression of MGLL mRNA25270620
C501413tesaglitazartesaglitazar results in increased expression of MGLL mRNA21515302
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of MGLL mRNA21592394
D013739TestosteroneTestosterone results in increased expression of MGLL mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MGLL mRNA24680724|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of MGLL mRNA16214954
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of MGLL mRNA"28433925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MGLL mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of MGLL mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGLL mRNA]16054899
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MGLL mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MGLL mRNA18796159|1977048
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of MGLL mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MGLL mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MGLL mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MGLL mRNA25613284
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine affects the expression of MGLL protein"25852303
C009495titanium dioxidetitanium dioxide results in decreased expression of MGLL mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MGLL mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MGLL mRNA25729387
D019772TopotecanTopotecan results in decreased expression of MGLL mRNA25729387
D014212TretinoinTretinoin results in decreased expression of MGLL mRNA23724009
C032910triadimefontriadimefon results in decreased expression of MGLL mRNA26705709
C011559tributyltintributyltin results in increased expression of MGLL mRNA21683754
D014241TrichloroethyleneTrichloroethylene results in increased expression of MGLL mRNA19448997
C005445triphenyl phosphatetriphenyl phosphate results in increased expression of MGLL mRNA28163246
C057693troglitazonetroglitazone results in increased expression of MGLL mRNA21515302
C080163trovafloxacintrovafloxacin results in decreased expression of MGLL mRNA24136188
C501835URB602URB602 results in decreased activity of MGLL protein18297109
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of MGLL mRNA15885361
C406224valdecoxibvaldecoxib results in increased expression of MGLL mRNA24136188
D014635Valproic AcidValproic Acid results in increased methylation of MGLL gene29154799
D014635Valproic AcidValproic Acid affects the expression of MGLL mRNA17292431
D014640VancomycinVancomycin results in increased expression of MGLL mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MGLL gene25560391
C025643vinclozolinvinclozolin affects the expression of MGLL mRNA19015723
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of MGLL mRNA"25198161
C070417Win 55212-2MGLL protein affects the susceptibility to Win 55212-221911610

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004622lysophospholipase activity-TAS9495531  
GO:0016298lipase activity-IBA21873635  
GO:0042803protein homodimerization activity-IPI19957260  
GO:0047372acylglycerol lipase activity-IBA21873635  
GO:0047372acylglycerol lipase activity-IDA22969151  
GO:0047372acylglycerol lipase activity-ISS-  
GO:0047372acylglycerol lipase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006629lipid metabolic process-IBA21873635  
GO:0006629lipid metabolic process-TAS9495531  
GO:0006633fatty acid biosynthetic process-IEA-  
GO:0006954inflammatory response-TAS9495531  
GO:0009966regulation of signal transduction-IBA21873635  
GO:0009966regulation of signal transduction-ISS-  
GO:0019369arachidonic acid metabolic process-ISS-  
GO:0019433triglyceride catabolic process-IEA-  
GO:0036155acylglycerol acyl-chain remodeling-TAS-  
GO:0046464acylglycerol catabolic process-IDA22969151  
GO:0046464acylglycerol catabolic process-ISS-  
GO:0050727regulation of inflammatory response-ISS-  
GO:0051930regulation of sensory perception of pain-ISS-  
GO:2000124regulation of endocannabinoid signaling pathway-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005829cytosol-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-IBA21873635  
GO:0019898extrinsic component of membrane-ISS-  
KEGG ID KEGG Term
hsa00561Glycerolipid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114508Effects of PIP2 hydrolysisTAS
R-HSA-1430728MetabolismIEA
R-HSA-1430728MetabolismTAS
R-HSA-1482883Acyl chain remodeling of DAG and TAGTAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-163560Triglyceride catabolismIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-426048Arachidonate production from DAGTAS
R-HSA-556833Metabolism of lipidsIEA
R-HSA-556833Metabolism of lipidsTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-8979227Triglyceride metabolismIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17621164Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population. (2007 Aug)Iwasaki SPsychiatr Genet
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. (2011 May)Kendler KSAlcohol Clin Exp Res