Gene: CHRNA2

1135
-
cholinergic receptor nicotinic alpha 2 subunit
protein-coding
8p21.2
Ensembl:ENSG00000120903 MIM:118502 Vega:OTTHUMG00000102083 UniprotKB:Q15822
NG_015827.1
PubMed
0   ANCO-SNPs
ND|AD
12   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.547e-1 (AD)  1.248e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VIP0.867
TAC30.858
ELFN10.828
DLX20.802
PTHLH0.795
DLX10.777
CALB20.777
SHISA80.773
SSTR40.761
GRIN2D0.76

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AQP1-0.575
SFT2D2-0.554
DTHD1-0.551
VRK2-0.536
FAM107B-0.533
SEPT10-0.532
CTNNA3-0.531
KIF19-0.529
ZFP57-0.528
WIPF1-0.525

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00184NicotineSmall Molecule54-11-5ApprovedTarget
DB00411CarbacholSmall Molecule51-83-2ApprovedTarget
DB00416Metocurine IodideSmall Molecule7601-55-0Approved|WithdrawnTarget
DB00483Gallamine TriethiodideSmall Molecule65-29-2ApprovedTarget
DB00514DextromethorphanSmall Molecule125-71-3ApprovedTarget
DB00565Cisatracurium besylateSmall Molecule96946-42-8ApprovedTarget
DB00657MecamylamineSmall Molecule60-40-2Approved|InvestigationalTarget
DB00674GalantamineSmall Molecule357-70-0ApprovedTarget
DB00721ProcaineSmall Molecule59-46-1Approved|InvestigationalTarget
DB00728RocuroniumSmall Molecule143558-00-3ApprovedTarget
DB00732Atracurium besylateSmall Molecule64228-81-5ApprovedTarget
DB00810BiperidenSmall Molecule514-65-8Approved|InvestigationalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB01135Doxacurium chlorideSmall Molecule106819-53-8ApprovedTarget
DB01199TubocurarineSmall Molecule57-95-4ApprovedTarget
DB01226MivacuriumSmall Molecule133814-19-4ApprovedTarget
DB01245DecamethoniumSmall Molecule156-74-1ApprovedTarget
DB01336MetocurineSmall Molecule5152-30-7ApprovedTarget
DB01337PancuroniumSmall Molecule-ApprovedTarget
DB01338PipecuroniumSmall Molecule68399-58-6ApprovedTarget
DB01339VecuroniumSmall Molecule86029-43-8ApprovedTarget
DB05740RPI-78MSmall Molecule-InvestigationalTarget
DB07720EpibatidineSmall Molecule140111-52-0ExperimentalTarget
ID Drug Name Action PubMed
C0439582-butanol2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
C4763785-azidoepibatidine5-azidoepibatidine binds to [CHRNA2 protein co-treated with CHRNB2 protein]12565964
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D000109Acetylcholine1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D000109Acetylcholine1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D000109Acetylcholine2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D000109Acetylcholine2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D000109AcetylcholineAcetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]11821649
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]9454827
D000109AcetylcholineCHRNA2 gene mutant form affects the susceptibility to Acetylcholine19383498
D000109Acetylcholinecrotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D000109Acetylcholineisobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D000109Acetylcholinen-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D000109Acetylcholinetert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]7808438
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]7808438
D000109AcetylcholineTubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]7808438
D000109AcetylcholineTubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]7808438
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CHRNA2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHRNA2 mRNA16483693
D001280AtrazineAtrazine results in increased expression of CHRNA2 mRNA22378314
D001464Barium1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D001464Barium1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D001464Barium2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D001464Barium2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D001464BariumAcetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]11821649
D001464Barium[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium11821649
D001464Bariumcrotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D001464Bariumisobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D001464Bariumn-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D001464Bariumtert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to CHRNA2 promoter]19654925
C004873beta-erythroidinebeta-erythroidine binds to and results in decreased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
C095105bexarotenebexarotene results in increased expression of CHRNA2 mRNA16648578|1763041
C006780bisphenol Abisphenol A results in decreased expression of CHRNA2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CHRNA2 gene28505145
D0200011-Butanol1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CHRNA2 mRNA20360939
D002217CarbacholCarbachol binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D002220CarbamazepineCHRNA2 gene mutant form affects the susceptibility to Carbamazepine19383498
D002245Carbon DioxideNicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA2 protein]28235547
D002245Carbon Dioxide[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA2 protein28235547
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of CHRNA2 mRNA23650126
D002995Clofibric AcidClofibric Acid affects the expression of CHRNA2 mRNA17602206
C007153crotonyl alcoholcrotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
C004712cytisinecytisine binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
C004712cytisinecytisine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]9454827
C033019decamethoniumdecamethonium binds to and results in decreased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D003976DiazinonDiazinon results in decreased expression of CHRNA2 mRNA18812211
D003976DiazinonDiazinon results in increased expression of CHRNA2 mRNA17452286
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CHRNA2 mRNA28962523
D004026DieldrinDieldrin results in decreased expression of CHRNA2 mRNA18812211
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CHRNA2 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of CHRNA2 mRNA]19850644
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CHRNA2 mRNA20360939
D002117CalcitriolCalcitriol results in increased expression of CHRNA2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of CHRNA2 mRNA21592394
D004246Dimethylphenylpiperazinium IodideDimethylphenylpiperazinium Iodide binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D004246Dimethylphenylpiperazinium IodideDimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]9454827
C082748epibatidineepibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
C082748epibatidine[CHRNB4 protein binds to CHRNA2 protein] which binds to epibatidine9454827
C082748epibatidineepibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNB2 protein]21905669
C082748epibatidinesazetidine-A analog inhibits the reaction [epibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNB2 protein]]21905669
D005419FlavonoidsFlavonoids results in increased expression of CHRNA2 mRNA18035473
D018738HexamethoniumHexamethonium binds to and results in decreased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D017313FenretinideFenretinide results in increased expression of CHRNA2 mRNA28973697
C040507isobutyl alcoholisobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D015122MercaptopurineMercaptopurine results in decreased expression of CHRNA2 mRNA23358152
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CHRNA2 mRNA21385734
C500085muraglitazarmuraglitazar results in increased expression of CHRNA2 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CHRNA2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CHRNA2 mRNA"25620056
D009532NickelNickel results in decreased expression of CHRNA2 mRNA18812211
D009538NicotineNicotine binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D009538NicotineCHRNA2 gene mutant form affects the susceptibility to Nicotine19383498
D009538NicotineNicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]9454827
D009538NicotineNicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA2 protein]28235547
C024999n-pentanoln-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D010100OxygenNicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA2 protein]28235547
D010100Oxygen[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA2 protein28235547
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of CHRNA2 mRNA27294297
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CHRNA2 mRNA16221955|2851185
D010634PhenobarbitalPhenobarbital affects the expression of CHRNA2 mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of CHRNA2 mRNA17426115|1830175
C006253pirinixic acidpirinixic acid results in increased expression of CHRNA2 mRNA12832660|1916217
D0198402-Propanol2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
D0004331-Propanol1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
C514816sazetidine-Asazetidine-A analog inhibits the reaction [epibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNB2 protein]]21905669
C017947sodium arsenitesodium arsenite affects the methylation of CHRNA2 gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of CHRNA2 mRNA27862939
D020002tert-Butyl Alcoholtert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]11821649
C501413tesaglitazartesaglitazar results in increased expression of CHRNA2 mRNA21515302
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of CHRNA2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of CHRNA2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CHRNA2 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CHRNA2 mRNA28922406
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CHRNA2 protein26746805
D014241TrichloroethyleneTrichloroethylene results in increased expression of CHRNA2 mRNA25549359
C057693troglitazonetroglitazone results in increased expression of CHRNA2 mRNA28973697
C057693troglitazonetroglitazone results in increased expression of CHRNA2 mRNA21515302
D014403TubocurarineTubocurarine binds to and results in decreased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D014403TubocurarineTubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]7808438
D014403TubocurarineTubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]7808438
D014635Valproic AcidValproic Acid results in increased methylation of CHRNA2 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0015276ligand-gated ion channel activity-TAS-  
GO:0015464acetylcholine receptor activity-IDA8906617  
GO:0022848acetylcholine-gated cation-selective channel activity-IDA8906617  
GO ID GO Term Qualifier Evidence PubMed
GO:0006811ion transport-NAS8906617  
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-IDA8906617  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0034220ion transmembrane transport-IEA-  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO:0051291protein heterooligomerization-IEA-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005892acetylcholine-gated channel complex-IDA8906617  
GO:0016021integral component of membrane-NAS8906617  
GO:0030054cell junction-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-181431Acetylcholine binding and downstream eventsTAS
R-HSA-622323Presynaptic nicotinic acetylcholine receptorsTAS
R-HSA-622327Postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629594Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629597Highly calcium permeable nicotinic acetylcholine receptorsTAS
R-HSA-629602Activation of Nicotinic Acetylcholine ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17559419Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (2008 Mar)Rigbi AGenes Brain Behav
29621993Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women. (2018 Apr 5)Tomaz PRXBMC Med Genet
23943838Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults. (2014 Feb)Cannon DSNicotine Tob Res
27355804SNPs in NRXN1 and CHRNA5 are associated to smoking and regulation of GABAergic and glutamatergic pathways. (2016 Jul)Perez-Rubio GPharmacogenomics
24428733Association of the CHRNA4 neuronal nicotinic receptor subunit gene with frequency of binge drinking in young adults. (2014 Apr)Coon HAlcohol Clin Exp Res
26184988Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder. (2015 Sep 30)Kimbrel NAPsychiatry Res
21498873Associations of nicotine intake measures with CHRN genes in Finnish smokers. (2011 Aug)Keskitalo-Vuokko KNicotine Tob Res
15192278A novel permutation testing method implicates sixteen nicotinic acetylcholine receptor genes as risk factors for smoking in schizophrenia families. (2004)Faraone SVHum Hered
15996750No association between common variations in the neuronal nicotinic acetylcholine receptor alpha2 subunit gene (CHRNA2) and bipolar I disorder. (2005 Jun 30)Lohoff FWPsychiatry Res
24253422Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations. (2014 May)Wang SHum Genet
15048644Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics. (2004 Apr 1)Sullivan PFAm J Med Genet B Neuropsychiatr Genet
19307444Examination of the nicotine dependence (NICSNP) consortium findings in the Iowa adoption studies population. (2009 Mar)Philibert RANicotine Tob Res