Gene: CYP2U1

113612
P450TEC|SPG49|SPG56
cytochrome P450 family 2 subfamily U member 1
protein-coding
4q25
Ensembl:ENSG00000155016 MIM:610670 Vega:OTTHUMG00000161084 UniprotKB:Q7Z449
NG_007961.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.625e-1 (AD)  1.958e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EXD20.849
MAP3K50.836
YIPF60.832
MTAP0.827
WDR480.825
PTCD30.824
TRIP110.823
NCBP10.82
TMEM2540.82
STAM20.818

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.587
OR4F29-0.521
OR6C74-0.268
AKR1B15-0.253
HMHB1-0.239
CLEC6A-0.232
NANOGNB-0.232
OR4F6-0.226
KRTAP4-3-0.197
NCCRP1-0.197

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CYP2U1 mRNA"28903501
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of CYP2U1 mRNA"28433925
D000082AcetaminophenAcetaminophen results in increased expression of CYP2U1 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CYP2U1 gene27153756
D000638AmiodaroneAmiodarone results in decreased expression of CYP2U1 mRNA24535564
C114007arachidonoylserotoninCYP2U1 protein results in increased oxidation of arachidonoylserotonin24563460
D001104ArbutinArbutin results in increased expression of CYP2U1 mRNA17103032
D001151ArsenicArsenic affects the methylation of CYP2U1 gene25304211
D001151ArsenicArsenic results in decreased methylation of CYP2U1 gene27838757
D001151ArsenicArsenic results in increased expression of CYP2U1 mRNA27838757
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CYP2U1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CYP2U1 mRNA20106945|2163298
C006780bisphenol Abisphenol A results in increased expression of CYP2U1 mRNA29275510
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of CYP2U1 mRNA"28433925
C006780bisphenol Abisphenol A results in decreased expression of CYP2U1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CYP2U1 gene28505145
D000069286BortezomibBortezomib results in increased expression of CYP2U1 mRNA20977926
D016572CyclosporineCyclosporine results in decreased expression of CYP2U1 mRNA20106945|2556210
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CYP2U1 mRNA28433925
D004041Dietary FatsDietary Fats results in increased expression of CYP2U1 mRNA25016146
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CYP2U1 mRNA28433925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of CYP2U1 mRNA19850644
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CYP2U1 mRNA28085963
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of CYP2U1 mRNA]19850644
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of CYP2U1 mRNA"28433925
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CYP2U1 mRNA18164116
D002117CalcitriolCalcitriol results in increased expression of CYP2U1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of CYP2U1 mRNA21592394
D004237DiuronDiuron results in decreased expression of CYP2U1 mRNA21551480
C061365flusilazoleflusilazole results in increased expression of CYP2U1 mRNA28263823
C069837fullerene C60fullerene C60 results in increased expression of CYP2U1 mRNA19167457
C000625836HFPO4 compoundHFPO4 compound results in decreased expression of CYP2U1 mRNA27553808
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CYP2U1 mRNA24796395
C045463leflunomideleflunomide results in decreased expression of CYP2U1 mRNA24136188
D008628MercuryMercury results in increased expression of CYP2U1 mRNA16823088
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CYP2U1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CYP2U1 mRNA"25554681
D009532NickelNickel results in decreased expression of CYP2U1 mRNA25583101
C029938nickel sulfatenickel sulfate results in decreased expression of CYP2U1 mRNA22714537
C464660obeticholic acidobeticholic acid results in increased expression of CYP2U1 mRNA27939613
C016030pantogabpantogab results in decreased expression of CYP2U1 mRNA17379144
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CYP2U1 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of CYP2U1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of CYP2U1 mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYP2U1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of CYP2U1 mRNA23811191
D011192Potassium DichromatePotassium Dichromate results in increased expression of CYP2U1 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of CYP2U1 mRNA28903501
C045362prochlorazprochloraz results in decreased expression of CYP2U1 mRNA20035023
C045950propiconazolepropiconazole results in decreased expression of CYP2U1 mRNA21278054
C045950propiconazolepropiconazole results in increased expression of CYP2U1 mRNA28970091
D011441PropylthiouracilPropylthiouracil results in decreased expression of CYP2U1 mRNA24780913
C016104sodium bichromatesodium bichromate results in decreased expression of CYP2U1 mRNA25993096
D013501Surface-Active AgentsSurface-Active Agents results in decreased expression of CYP2U1 mRNA22467014
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of CYP2U1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of CYP2U1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP2U1 mRNA20035023
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CYP2U1 mRNA28922406
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of CYP2U1 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP2U1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP2U1 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP2U1 mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of CYP2U1 mRNA28973375
D014050TolueneToluene results in increased expression of CYP2U1 mRNA28245982
D014212TretinoinTretinoin results in increased expression of CYP2U1 mRNA16985168
D014212TretinoinTretinoin results in increased expression of CYP2U1 mRNA20488242
C032910triadimefontriadimefon results in increased expression of CYP2U1 mRNA28263823
D014241TrichloroethyleneTrichloroethylene results in decreased expression of CYP2U1 mRNA25549359|2897337
C012589trichostatin Atrichostatin A results in increased expression of CYP2U1 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of CYP2U1 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of CYP2U1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CYP2U1 mRNA19101580|2317975
D014635Valproic AcidValproic Acid affects the expression of CYP2U1 mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of CYP2U1 mRNA24535564
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CYP2U1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004497monooxygenase activity-TAS-  
GO:0005506iron ion binding-IEA-  
GO:0008395steroid hydroxylase activity-IBA21873635  
GO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen-IBA21873635  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-IEA-  
GO:0070330aromatase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006082organic acid metabolic process-IBA21873635  
GO:0006805xenobiotic metabolic process-IBA21873635  
GO:0042738exogenous drug catabolic process-IBA21873635  
GO:0055114oxidation-reduction process-IBA21873635  
GO:0055114oxidation-reduction process-IEA-  
GO:0097267omega-hydroxylase P450 pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0031090organelle membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
KEGG ID KEGG Term
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211958Miscellaneous substratesTAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-2142816Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5579011Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)TAS
R-HSA-5579029Metabolic disorders of biological oxidation enzymesTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25872594Expression of CYP2E1 and CYP2U1 proteins in amygdala and prefrontal cortex: influence of alcoholism and smoking. (2015 May)Toselli FAlcohol Clin Exp Res
25409777Genetic variants associated with lung function: the long life family study. (2014 Nov 1)Thyagarajan BRespir Res
26095139Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR. (2015)Toselli FXenobiotica