Gene: CHRNA4

1137
BFNC|EBN|EBN1|NACHR|NACHRA4|NACRA4
cholinergic receptor nicotinic alpha 4 subunit
protein-coding
20q13.33
Ensembl:ENSG00000101204 MIM:118504 Vega:OTTHUMG00000033080 UniprotKB:P43681
NG_011931.1
PubMed|SNP Mapped
ND|AD
49   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.074e-1 (AD)  9.665e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2273500chr20:63355597 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs1044396chr20:63349782 (GRCh38.p7)G>A / G>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs2236196chr20:63346204 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTPRS0.871
WNK20.867
EXTL10.864
KCNC40.863
LYNX10.862
FASN0.854
ZFP410.854
SYT30.854
STX1A0.853
SLC27A40.851

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf87-0.569
IL18RAP-0.561
CFI-0.558
VNN2-0.551
CST7-0.55
CCR2-0.55
CLEC2B-0.546
LILRB2-0.541
GNG11-0.541
PLBD1-0.539

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00184NicotineSmall Molecule54-11-5ApprovedTarget
DB00237ButabarbitalSmall Molecule125-40-6Approved|IllicitTarget
DB00241ButalbitalSmall Molecule77-26-9Approved|IllicitTarget
DB00306TalbutalSmall Molecule115-44-6Approved|IllicitTarget
DB00312PentobarbitalSmall Molecule76-74-4Approved|InvestigationalTarget
DB00418SecobarbitalSmall Molecule76-73-3ApprovedTarget
DB00463MetharbitalSmall Molecule50-11-3WithdrawnTarget
DB00514DextromethorphanSmall Molecule125-71-3ApprovedTarget
DB00564CarbamazepineSmall Molecule298-46-4Approved|InvestigationalTarget
DB00572AtropineSmall Molecule51-55-8ApprovedTarget
DB00599ThiopentalSmall Molecule76-75-5ApprovedTarget
DB00657MecamylamineSmall Molecule60-40-2Approved|InvestigationalTarget
DB00674GalantamineSmall Molecule357-70-0ApprovedTarget
DB00747ScopolamineSmall Molecule51-34-3Approved|InvestigationalTarget
DB00783EstradiolSmall Molecule50-28-2Approved|InvestigationalTarget
DB00794PrimidoneSmall Molecule125-33-7ApprovedTarget
DB00849MethylphenobarbitalSmall Molecule115-38-8ApprovedTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB00981PhysostigmineSmall Molecule57-47-6Approved|InvestigationalTarget
DB01174PhenobarbitalSmall Molecule50-06-6Approved|InvestigationalTarget
DB01245DecamethoniumSmall Molecule156-74-1ApprovedTarget
DB01273VareniclineSmall Molecule249296-44-4Approved|InvestigationalTarget
DB01351AmobarbitalSmall Molecule57-43-2Approved|IllicitTarget
DB01352AprobarbitalSmall Molecule77-02-1Approved|IllicitTarget
DB01353ButethalSmall Molecule77-28-1Approved|IllicitTarget
DB01354HeptabarbitalSmall Molecule509-86-4ApprovedTarget
DB01355HexobarbitalSmall Molecule56-29-1ApprovedTarget
DB01483BarbitalSmall Molecule57-44-3IllicitTarget
DB01496Barbituric acid derivativeSmall MoleculeExperimental|IllicitTarget
DB05458PozaniclineSmall Molecule161417-03-4InvestigationalTarget
DB05740RPI-78MSmall Molecule-InvestigationalTarget
DB07720EpibatidineSmall Molecule140111-52-0ExperimentalTarget
DB09028CytisineSmall Molecule485-35-8Approved|InvestigationalTarget
DB13952Estradiol acetateSmall Molecule4245-41-4Approved|InvestigationalTarget
DB13953Estradiol benzoateSmall Molecule50-50-0Approved|InvestigationalTarget
DB13954Estradiol cypionateSmall Molecule313-06-4Approved|InvestigationalTarget
DB13955Estradiol dienanthateSmall Molecule7732-97-0Approved|InvestigationalTarget
DB13956Estradiol valerateSmall Molecule979-32-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C54451613,19-didesmethyl spirolide C"13,19-didesmethyl spirolide C binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]"26063663
C0657341-(3-chlorophenyl)biguanide1-(3-chlorophenyl)biguanide results in increased activity of [HTR3A protein binds to CHRNA4 protein]9736758
C51717013-desmethylspirolide C13-desmethylspirolide C binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]26063663
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CHRNA4 mRNA"28903501
C4191571-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]11150171
C5696712-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane"2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]"21942635
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [rosiglitazone results in decreased expression of CHRNA4 protein]19139119
C0359762,4,2',4'-tetrachlorobiphenyl"2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]"20861069
C0359762,4,2',4'-tetrachlorobiphenyl"[3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]"20861069
C0459182-methyl-5-HT2-methyl-5-HT results in increased activity of [HTR3A protein binds to CHRNA4 protein]9736758
C1167333-(2-(pyrrolidinyl)methoxy)pyridine3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
C1167333-(2-(pyrrolidinyl)methoxy)pyridineDihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16569710
C1167333-(2-(pyrrolidinyl)methoxy)pyridine3-(2-(pyrrolidinyl)methoxy)pyridine analog affects the activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
C1167333-(2-(pyrrolidinyl)methoxy)pyridine3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]16569710
C0857943,5-dibromo-2-(2,4-dibromophenoxy)phenol"[3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]"20861069
C0857943,5-dibromo-2-(2,4-dibromophenoxy)phenol"3,5-dibromo-2-(2,4-dibromophenoxy)phenol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]"20861069
C0883833-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]7913497
C0883833-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10942032
C0415944-nonylphenol4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
C0804174-octylphenol4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
C1097635-(2-azetidinylmethoxy)-2-chloropyridine5-(2-azetidinylmethoxy)-2-chloropyridine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]17115136
C104288A 85380A 85380 binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]17115136
D000082AcetaminophenAcetaminophen affects the expression of CHRNA4 mRNA17562736
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]14608492
D000109Acetylcholinenereistoxin inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]14608492
D000109Acetylcholine1-Butanol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]12604691
D000109Acetylcholine"2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]"20861069
D000109Acetylcholine"[3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]"20861069
D000109Acetylcholine"3,5-dibromo-2-(2,4-dibromophenoxy)phenol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]"20861069
D000109Acetylcholine4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D000109Acetylcholine4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D000109AcetylcholineAcetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]15733544
D000109AcetylcholineAcetylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]12604691|1464565
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]20132834|2275035
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]9454827
D000109AcetylcholineAluminum Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109Acetylcholineantimony trioxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109AcetylcholineAtracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D000109AcetylcholineAtropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D000109AcetylcholineBentonite inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109Acetylcholinebisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D000109Acetylcholinecisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D000109Acetylcholineclothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]21538459
D000109Acetylcholinedecabromobiphenyl ether inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109Acetylcholinedesformylflustrabromine promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]21905680
D000109AcetylcholineDichlorvos inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D000109AcetylcholineDiethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D000109Acetylcholine[Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11517245
D000109Acetylcholine[Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11517245
D000109AcetylcholineEthinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D000109AcetylcholineFire Trol 934 inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109AcetylcholineFlame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]22547355
D000109AcetylcholineFlame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109AcetylcholineGalantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D000109Acetylcholineimidacloprid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]21538459
D000109AcetylcholineMagnesium Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109Acetylcholinemivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D000109Acetylcholine"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]"20132834
D000109AcetylcholinePancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D000109AcetylcholinePhysostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D000109Acetylcholine[Progesterone co-treated with Acetylcholine] results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]11517245
D000109AcetylcholineRivastigmine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D000109Acetylcholinerocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D000109AcetylcholineScopolamine Hydrobromide promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D000109AcetylcholineTacrine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D000109AcetylcholineTamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D000109Acetylcholinetetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]22547355
D000109Acetylcholinetetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109AcetylcholineTetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]15885267
D000109AcetylcholineToluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]15885267
D000109Acetylcholinetriphenyl phosphate inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109AcetylcholineTubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D000109AcetylcholineTubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D000109AcetylcholineTubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]11711029
D000109AcetylcholineVecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D000109AcetylcholineCHRNA4 protein mutant form results in increased susceptibility to Acetylcholine16339034
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]16569710
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein alternative form]16569710
D000109AcetylcholineEstradiol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16569710
D000109AcetylcholineEstradiol promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]]16569710
D000109AcetylcholineAcetylcholine analog binds to [CHRNA4 protein binds to CHRNB2 protein]19252481
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11812690
D000109AcetylcholineAcetylcholine binds to [CHRNA4 protein binds to CHRNB2 protein]19252481
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]15885267
D000109Acetylcholine[CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Barium results in increased susceptibility to Acetylcholine]12754307
D000109Acetylcholine[CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Calcium results in increased susceptibility to Acetylcholine]12754307
D000109Acetylcholine[CHRNA4 protein co-treated with CHRNB2 protein] affects the susceptibility to Acetylcholine12754307
D000109Acetylcholine[CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]12754307
D000109Acetylcholine[CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Barium results in increased susceptibility to Acetylcholine]12754307
D000109Acetylcholine[CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]12754307
D000109AcetylcholineDihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
D000109Acetylcholine[Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11517245
D000109AcetylcholineExcitatory Amino Acid Antagonists inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
D000109AcetylcholineFG 9041 inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
D000109AcetylcholineMecamylamine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
D000109Acetylcholine[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB2 protein]12130716
D000109Acetylcholine[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB4 protein]12130716
D000109Acetylcholine[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine18385335
D000109AcetylcholineTetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]15885267
D000109AcetylcholineToluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]15885267
D000109AcetylcholineUrethane promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]11812690
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]9397513
D000122AcetylthiocholineAcetylthiocholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D020106AcrylamideAcrylamide results in decreased expression of CHRNA4 mRNA28959563
D000443AlcuroniumAlcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D000443AlcuroniumAlcuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D000448AldicarbAldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]14644616
D000452AldrinAldrin results in increased expression of CHRNA4 mRNA18579281
C005915Allura Red AC Dye[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of CHRNA4 protein23429044
D000536Aluminum HydroxideAluminum Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHRNA4 mRNA16483693
D000691AnabasineAnabasine analog binds to [CHRNA4 protein binds to CHRNB2 protein]15615518
C037554antimony trioxideantimony trioxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D001151ArsenicArsenic affects the methylation of CHRNA4 gene25304211
D001279AtracuriumAtracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D001280AtrazineAtrazine results in decreased expression of CHRNA4 mRNA25929836
D001285AtropineAtropine binds to [CHRNA4 protein binds to CHRNB2 protein]15733544
D001285AtropineAtropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D001285AtropineAtropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]21791372
D001285AtropineAtropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]21791372
D001464Barium[CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Barium results in increased susceptibility to Acetylcholine]12754307
D001464Barium[CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Barium results in increased susceptibility to Acetylcholine]12754307
C042253bemesetronbemesetron results in decreased activity of [HTR3A protein binds to CHRNA4 protein]9736758
C007725bendiocarbbendiocarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]14644616
D001546BentoniteBentonite inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of CHRNA4 mRNA26377693
C004873beta-erythroidinebeta-erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
D004958EstradiolEstradiol binds to CHRNA4 protein11517245
D004958Estradiol[Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11517245
D004958EstradiolEstradiol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16569710
D004958EstradiolEstradiol promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]]16569710
C006780bisphenol Abisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
C006780bisphenol Abisphenol A results in decreased methylation of CHRNA4 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of CHRNA4 mRNA21932408
C006780bisphenol Abisphenol A results in decreased expression of CHRNA4 mRNA25181051
C006796brilliant blue[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of CHRNA4 protein23429044
D0200011-Butanol1-Butanol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]12604691
D0200011-Butanol1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]12604691
D0200011-ButanolDihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]12604691
D0200011-ButanolMecamylamine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]12604691
D002118Calcium[CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Calcium results in increased susceptibility to Acetylcholine]12754307
D002118Calcium[CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]12754307
D002118Calcium[CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]12754307
D002217CarbacholCarbachol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
D002217CarbacholCarbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]14645658
D002217CarbacholCarbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]14645658
D002217CarbacholCarbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D002217CarbacholCarbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]14645658
D002217CarbacholCarbachol results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D002217CarbacholCarbachol binds to [CHRNA4 protein binds to CHRNB2 protein]15615518
D002217CarbacholCarbachol inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
D002217CarbacholCarbachol results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11708903
D002220CarbamazepineCarbamazepine binds to [CHRNA4 protein binds to CHRNB2 protein]12110613
D012721CarbarylCarbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14644616
D012721CarbarylCarbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]14644616
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of CHRNA4 mRNA12734012
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of CHRNA4 mRNA18636392
D002714ChlorisondamineChlorisondamine results in decreased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]16569710
D002714ChlorisondamineChlorisondamine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
D002794CholineCholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D002794CholineCholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D002794CholineCholine affects the activity of CHRNA4 protein19047205
C101584cisatracuriumcisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
C480342clothianidinclothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]21538459
D003042CocaineCocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]10336510
D003471CuprizoneCuprizone results in decreased expression of CHRNA4 mRNA26577399
C004712cytisinecytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
C004712cytisinecytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]20331614
C004712cytisinecytisine binds to [CHRNA4 protein binds to CHRNB2 protein]9336329
C004712cytisinecytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C004712cytisinecytisine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
C004712cytisinecytisine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]9454827
C004712cytisineNicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]9336329
C004712cytisinepozanicline inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]9336329
C004712cytisinecytisine affects the expression of CHRNA4 protein7756618
C004712cytisinecytisine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]7756618
C004712cytisinecytisine affects the activity of [HTR3A protein binds to CHRNA4 protein]9736758
C004712cytisinecytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10942032|1711513
C004712cytisinecytisine binds to [CHRNA4 protein binds to CHRNB2 protein]11124396
C010902decabromobiphenyl etherdecabromobiphenyl ether inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
C033019decamethoniumdecamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
C033019decamethoniumCarbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]14645658
C033019decamethoniumdecamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
C033019decamethoniumdecamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C033019decamethoniumdecamethonium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
C524215desformylflustrabrominedesformylflustrabromine promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]21905680
C529522desnitroimidaclopriddesnitroimidacloprid results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]12460746
D003976DiazinonDiazinon affects the expression of CHRNA4 mRNA18812211
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CHRNA4 mRNA28962523
D004006DichlorvosDichlorvos inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D004026DieldrinDieldrin affects the expression of CHRNA4 mRNA18812211
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CHRNA4 mRNA24535843
D004054DiethylstilbestrolDiethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D004079Dihydro-beta-Erythroidine[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2B protein]] which results in decreased susceptibility to Nicotine18671990
D004079Dihydro-beta-ErythroidineCarbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]14645658
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]12604691
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]20100906
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16569710
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]16569710
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
D004079Dihydro-beta-Erythroidine[CHRNA4 protein binds to CHRNB4 protein] which binds to Dihydro-beta-Erythroidine9687574
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]19047205
D004079Dihydro-beta-Erythroidine[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine10945867|1691538
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine binds to and results in decreased activity of CHRNA4 protein12511591|1913911
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2B protein]18671990
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]10945867|1260409
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]16601104
D004246Dimethylphenylpiperazinium IodideDimethylphenylpiperazinium Iodide binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
D004246Dimethylphenylpiperazinium IodideDimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D004246Dimethylphenylpiperazinium IodideDimethylphenylpiperazinium Iodide results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D004246Dimethylphenylpiperazinium IodideDimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]9454827
D004298DopamineDopamine results in increased activity of [HTR3A protein binds to CHRNA4 protein]9736758
C082748epibatidineepibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
C082748epibatidineTretinoin inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]17203487
C082748epibatidineAcetylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineAcetylthiocholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineAlcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineCarbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineCholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidine[CHRNB4 protein binds to CHRNA4 protein] which binds to epibatidine9454827
C082748epibatidinecytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidinedecamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineDihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineDimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineepibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]22060139
C082748epibatidineepibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]14645658
C082748epibatidineepibatidine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
C082748epibatidineHexamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineLobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidinemethyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineNicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidinePancuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidinePhysostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidinesubecholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineSuccinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineTubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineVecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineepibatidine binds to CHRNA4 protein17203487
C082748epibatidineTretinoin promotes the reaction [epibatidine binds to CHRNA4 protein]17203487
C082748epibatidine"2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]"21942635
C082748epibatidineepibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]21905669
C082748epibatidineepibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]11124396|1561551
C082748epibatidineepibatidine binds to [CHRNA4 protein co-treated with CHRNB2 protein]10728888
C082748epibatidinesazetidine-A analog inhibits the reaction [epibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]21905669
C082748epibatidineepibatidine analog binds to and affects the activity of [CHRNA4 protein binds to CHRNB2 protein]20038125
C082748epibatidineepibatidine analog inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
C082748epibatidineepibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]20038125
C082748epibatidineepibatidine inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
C082748epibatidineepibatidine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11708903
C036251EPTCEPTC results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14644616
C036251EPTCEPTC results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]14644616
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11517245
D004997Ethinyl EstradiolEthinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D004997Ethinyl EstradiolTubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]11711029
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11517245
D018691Excitatory Amino Acid AntagonistsExcitatory Amino Acid Antagonists inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
C005842FD & C Yellow No. 6[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of CHRNA4 protein23429044
C052034fenoxycarbfenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14644616
C052034fenoxycarbfenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]14644616
C056723FG 9041FG 9041 inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
C508049Fire Trol 934Fire Trol 934 inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D005411Flame RetardantsFlame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]22547355
D005411Flame RetardantsFlame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of CHRNA4 mRNA]15016801
D005505Food Coloring AgentsFood Coloring Agents results in decreased expression of CHRNA4 protein23429044
D005702GalantamineGalantamine binds to [CHRNA4 protein binds to CHRNB2 protein]15733544
D005702GalantamineGalantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of CHRNA4 mRNA21782745
D019086Bridged Bicyclo Compounds, Heterocyclic"Bridged Bicyclo Compounds, Heterocyclic binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]"21962147
D006582HexachloropheneHexachlorophene results in decreased expression of CHRNA4 mRNA25943520
D018738HexamethoniumHexamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
D018738HexamethoniumHexamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D018738HexamethoniumHexamethonium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D018738HexamethoniumHexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]7756618
D012701SerotoninSerotonin results in increased activity of [HTR3A protein binds to CHRNA4 protein]9736758
C082359imidaclopridimidacloprid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]21538459
C082359imidaclopridimidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]10377228
C082359imidaclopridimidacloprid binds to [CHRNA4 protein co-treated with CHRNB2 protein]10728888
C082359imidaclopridimidacloprid analog inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
C082359imidaclopridimidacloprid analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11708903
C082359imidaclopridimidacloprid inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
C082359imidaclopridimidacloprid promotes the reaction [Nicotine binds to [CHRNA4 protein co-treated with CHRNB2 protein]]11076703
C082359imidaclopridimidacloprid results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11708903
D007203Indigo Carmine[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of CHRNA4 protein23429044
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CHRNA4 mRNA25613284
C490152isproniclineispronicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]20167427
D007736Kynurenic AcidKynurenic Acid results in decreased activity of CHRNA4 protein19616570
C029310lardlard results in increased expression of CHRNA4 mRNA26115784
D008120Lobeline[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]18448488
D008120Lobeline[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]18448488
D008120Lobeline[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]18448488
D008120LobelineLobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D008120LobelineLobeline results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D008120LobelineLobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]18448488
D008276Magnesium HydroxideMagnesium Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D008464MecamylamineMecamylamine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D008464MecamylamineMecamylamine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]12604691
D008464MecamylamineMecamylamine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D008464MecamylamineMecamylamine inhibits the reaction [Tacrine results in increased expression of CHRNA4 protein]8930989
D008464MecamylamineMecamylamine results in decreased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]16569710
D008464MecamylamineMecamylamine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
D008464MecamylamineAtropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]21791372
D008464MecamylamineAtropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]21791372
D008464MecamylamineMecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]21791372
D008464MecamylamineMecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]21791372
D008464MecamylamineMecamylamine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
D008627Mercuric Chloride[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB2 protein]12130716
D008627Mercuric Chloride[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB4 protein]12130716
C012419metanicotinemetanicotine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]19047205
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of CHRNA4 mRNA21782745
C054634methyllycaconitineCarbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]14645658
C054634methyllycaconitinemethyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C054634methyllycaconitinemethyllycaconitine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
C054634methyllycaconitinemethyllycaconitine results in decreased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]16569710
C054634methyllycaconitinemethyllycaconitine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
C054634methyllycaconitinemethyllycaconitine affects the activity of CHRNA4 protein19047205
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]"20132834
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CHRNA4 protein"19594327
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CHRNA4 protein]"19594327
C049430mivacuriummivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
C524978N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]"17873105
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of CHRNA4 mRNA"29244179
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide co-treated with Nicotine] inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNA4 protein]15551346
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNA4 protein15551346
C419158N-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidineN-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]11150171
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CHRNA4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CHRNA4 mRNA"25620056
C025633nereistoxinnereistoxin inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]14608492
D009532NickelNickel results in decreased expression of CHRNA4 mRNA18812211
D009538Nicotine[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2B protein]] which results in decreased susceptibility to Nicotine18671990
D009538NicotineNicotine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
D009538Nicotine[CHRNA4 protein binds to CHRNB2 protein] which results in increased susceptibility to Nicotine20943775
D009538Nicotine[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]18448488
D009538Nicotine[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]18448488
D009538Nicotine[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]18448488
D009538NicotineNicotine binds to [CHRNA4 protein binds to CHRNB2 protein]9336329
D009538NicotineNicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]9336329
D009538NicotineNicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D009538NicotineNicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D009538NicotineNicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]9454827
D009538NicotineNicotine results in increased expression of CHRNA4 protein19139119|2010694
D009538Nicotinerosiglitazone inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]19139119
D009538NicotineCHRNA4 gene polymorphism affects the susceptibility to Nicotine10734154
D009538NicotineCHRNA4 protein affects the susceptibility to Nicotine10942032
D009538NicotineCHRNA4 protein mutant form affects the susceptibility to Nicotine19404753
D009538NicotineCHRNA4 protein mutant form results in increased susceptibility to Nicotine16339034
D009538Nicotinecytisine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]7756618
D009538NicotineHexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]7756618
D009538Nicotine[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide co-treated with Nicotine] inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNA4 protein]15551346
D009538NicotineNicotine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]19481067
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CHRNA4 protein]"19594327
D009538NicotineNicotine results in decreased expression of CHRNA4 mRNA17135361
D009538NicotineNicotine results in increased expression of CHRNA4 protein14500745|1959432
D009538NicotineTubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]7756618
D009538NicotineNicotine affects the activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]16569710
D009538NicotineNicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
D009538Nicotine1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]11150171
D009538NicotineCocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]10336510
D009538Nicotine[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine10945867|1691538
D009538Nicotineimidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]10377228
D009538NicotineN-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]11150171
D009538NicotineNicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein]15615518|1925248
D009538NicotineNicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]10377228|1115017
D009538NicotineNicotine binds to [CHRNA4 protein binds to CHRNB2 protein]15615518|1925248
D009538NicotineNicotine results in decreased expression of CHRNA4 mRNA20060465
D009538NicotineNicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10336510
D009538NicotineNicotine results in increased expression of CHRNA4 mRNA24368670
D009538NicotineNicotine results in increased expression of [CHRNA4 protein binds to CHRNB2 protein]11124396
D009538NicotineCarbachol inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
D009538Nicotineepibatidine analog inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
D009538Nicotineepibatidine inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
D009538Nicotineimidacloprid analog inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
D009538Nicotineimidacloprid inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
D009538Nicotineimidacloprid promotes the reaction [Nicotine binds to [CHRNA4 protein co-treated with CHRNB2 protein]]11076703
D009538NicotineNicotine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11708903
D009538NicotineNicotine binds to [CHRNA4 protein binds to CHRNB2 protein]11708903
D009538NicotineNicotine binds to [CHRNA4 protein co-treated with CHRNB2 protein]11076703
D009538Nicotinethiacloprid analog inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
D009538Nicotinethiacloprid inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
D009538Nicotinethiacloprid promotes the reaction [Nicotine binds to [CHRNA4 protein co-treated with CHRNB2 protein]]11076703
C053765N-methylcarbamylcholineN-methylcarbamylcholine binds to [CHRNA4 protein co-treated with CHRNB2 protein]10728888
D010100OxygenOxygen deficiency results in increased expression of CHRNA4 mRNA24205000
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of CHRNA4 mRNA18636392
D010197PancuroniumPancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D010197PancuroniumPancuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D010197PancuroniumPancuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D010261ParaoxonAtropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]21791372
D010261ParaoxonAtropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]21791372
D010261ParaoxonMecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]21791372
D010261ParaoxonMecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]21791372
D010261ParaoxonParaoxon results in decreased expression of CHRNA4 mRNA21791372
D010261ParaoxonParaoxon results in decreased expression of CHRNA4 protein21791372
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CHRNA4 mRNA26254212
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CHRNA4 mRNA27294297
D010634PhenobarbitalPhenobarbital results in increased expression of CHRNA4 mRNA23091169
D010795Phthalic AcidsPhthalic Acids results in decreased expression of CHRNA4 mRNA21061450
D010830PhysostigminePhysostigmine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D010830PhysostigminePhysostigmine binds to [CHRNA4 protein binds to CHRNB2 protein]15733544
D010830PhysostigminePhysostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D010830PhysostigminePhysostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D010830PhysostigminePhysostigmine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D010936Plant ExtractsPlant Extracts results in decreased expression of CHRNA4 mRNA23557933
C576297ponceau 4R[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of CHRNA4 protein23429044
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CHRNA4 mRNA23608068
C108326pozaniclinepozanicline binds to [CHRNA4 protein binds to CHRNB2 protein]9336329
C108326pozaniclinepozanicline inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]9336329
C108326pozaniclinepozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNA5 protein binds to CHRNB2 protein]19481067
C108326pozaniclinepozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]19481067
C108326pozanicline[pozanicline binds to CHRNB2 protein] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]19481067
C108326pozaniclineDihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
C108326pozaniclineExcitatory Amino Acid Antagonists inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
C108326pozaniclineFG 9041 inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
C108326pozaniclineMecamylamine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
C108326pozanicline[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine18385335
C108326pozaniclinepozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]18385335|2115627
D011374Progesterone[Progesterone co-treated with Acetylcholine] results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]11517245
D001074PropoxurPropoxur results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]14644616
D011441PropylthiouracilPropylthiouracil results in increased expression of CHRNA4 mRNA24780913
D011719PyrazinesPyrazines binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]21962147
D011725PyridinesPyridines binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]21962147
D000548Amaranth Dye[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of CHRNA4 protein23429044
C059514resveratrolresveratrol results in increased expression of CHRNA4 mRNA12569576
D000068836RivastigmineRivastigmine binds to [CHRNA4 protein binds to CHRNB2 protein]15733544
D000068836RivastigmineRivastigmine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
C061870rocuroniumrocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
C089730rosiglitazone2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [rosiglitazone results in decreased expression of CHRNA4 protein]19139119
C089730rosiglitazonerosiglitazone inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]19139119
C089730rosiglitazonerosiglitazone results in decreased expression of CHRNA4 protein19139119
C089730rosiglitazone[rosiglitazone results in increased expression of TP53 protein] promotes the reaction [rosiglitazone results in decreased expression of CHRNA4 protein]19139119
C514816sazetidine-Asazetidine-A analog binds to and affects the activity of [CHRNA4 protein binds to CHRNB2 protein]21905669
C514816sazetidine-Asazetidine-A analog inhibits the reaction [epibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]21905669
C514816sazetidine-Asazetidine-A binds to [CHRNA4 protein binds to CHRNB2 protein]21274704
C514816sazetidine-Asazetidine-A binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]21905669
D012601Scopolamine HydrobromideScopolamine Hydrobromide binds to [CHRNA4 protein binds to CHRNB2 protein]15733544
D012601Scopolamine HydrobromideScopolamine Hydrobromide promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D012643SeleniumSelenium results in increased expression of CHRNA4 mRNA19244175
D012969Sodium FluorideSodium Fluoride results in decreased expression of CHRNA4 protein19900517
C009335subecholinesubecholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C009335subecholinesubecholine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
C009335subecholinesubecholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D013390SuccinylcholineSuccinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D013605T-2 ToxinT-2 Toxin results in decreased expression of CHRNA4 mRNA26314264
D013619TacrineTacrine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D013619TacrineMecamylamine inhibits the reaction [Tacrine results in increased expression of CHRNA4 protein]8930989
D013619TacrineTacrine results in increased expression of CHRNA4 protein8930989
D013629TamoxifenTamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D013645Tartrazine[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of CHRNA4 protein23429044
C419442TC 2559TC 2559 binds to and results in increased activity of CHRNA4 protein19139119
C419442TC 2559TC 2559 binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]17115136
C020806tetrabromobisphenol Atetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]22547355
C020806tetrabromobisphenol Atetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CHRNA4 mRNA24680724|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CHRNA4 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CHRNA4 mRNA26290441
D013750TetrachloroethyleneTetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]15885267
D013750TetrachloroethyleneTetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]15885267
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CHRNA4 mRNA25613284
C417209thiaclopridthiacloprid analog inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
C417209thiaclopridthiacloprid analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11708903
C417209thiaclopridthiacloprid inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
C417209thiaclopridthiacloprid promotes the reaction [Nicotine binds to [CHRNA4 protein co-treated with CHRNB2 protein]]11076703
C417209thiaclopridthiacloprid results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11708903
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CHRNA4 protein26746805
D014050TolueneToluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]15885267
D014050TolueneToluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]15885267
D014212TretinoinTretinoin inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]17203487
D014212TretinoinTretinoin promotes the reaction [epibatidine binds to CHRNA4 protein]17203487
D014212TretinoinTretinoin results in decreased expression of CHRNA4 mRNA17203487
D014212TretinoinTretinoin results in decreased expression of CHRNA4 protein17203487
C005445triphenyl phosphatetriphenyl phosphate inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D014403TubocurarineTubocurarine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
D014403TubocurarineTubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D014403TubocurarineTubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D014403TubocurarineTubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D014403TubocurarineTubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]11711029
D014403TubocurarineTubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D014403TubocurarineTubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]7756618
D014403TubocurarineTubocurarine results in decreased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]16569710
D014403TubocurarineTubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
D014403TubocurarineTubocurarine affects the activity of [HTR3A protein binds to CHRNA4 protein]9736758
D017974Uranium CompoundsUranium Compounds results in increased expression of CHRNA4 mRNA19654044
D014520UrethaneUrethane promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]11812690
D014635Valproic AcidValproic Acid results in increased methylation of CHRNA4 gene29154799
D014635Valproic AcidValproic Acid affects the expression of CHRNA4 mRNA17292431
D014640VancomycinVancomycin results in increased expression of CHRNA4 mRNA18930951
D000068580VareniclineVarenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]20207347|2033161
D000068580VareniclineVarenicline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]20100906
D000068580VareniclineVarenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]16766716
D000068580VareniclineVarenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]17115136|1841106
D014673Vecuronium BromideVecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D014673Vecuronium BromideVecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D014673Vecuronium BromideVecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CHRNA4 gene25560391
D014752Vinyl ChlorideVinyl Chloride results in increased expression of CHRNA4 mRNA18579281
C029297vinylidene chloridevinylidene chloride results in decreased expression of CHRNA4 mRNA26682919
D015034Zinc OxideZinc Oxide analog results in decreased expression of CHRNA4 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005515protein binding-IPI27344019  
GO:0015276ligand-gated ion channel activity-TAS20438829  
GO:0015464acetylcholine receptor activityCONTRIBUTES_TOIBA21873635  
GO:0015464acetylcholine receptor activity-IDA8906617  
GO:0022848acetylcholine-gated cation-selective channel activity-IDA8906617  
GO:0022848acetylcholine-gated cation-selective channel activity-TAS20438829  
GO:0042166acetylcholine bindingCONTRIBUTES_TOIBA21873635  
GO:0042166acetylcholine binding-IC8906617  
GO ID GO Term Qualifier Evidence PubMed
GO:0001508action potential-ISS-  
GO:0001666response to hypoxia-IDA12189247  
GO:0006281DNA repair-IMP16332175  
GO:0006811ion transport-NAS8906617  
GO:0006816calcium ion transport-ISS-  
GO:0006979response to oxidative stress-IMP16332175  
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-IDA8906617  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007268chemical synaptic transmission-NAS7550350  
GO:0007271synaptic transmission, cholinergic-IBA21873635  
GO:0007271synaptic transmission, cholinergic-ISS-  
GO:0007274neuromuscular synaptic transmission-IBA21873635  
GO:0007585respiratory gaseous exchange-IEA-  
GO:0007626locomotory behavior-IEA-  
GO:0014059regulation of dopamine secretion-ISS-  
GO:0019233sensory perception of pain-ISS-  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0034220ion transmembrane transport-IEA-  
GO:0035094response to nicotine-IBA21873635  
GO:0035094response to nicotine-IDA12189247  
GO:0035095behavioral response to nicotine-IMP17955458  
GO:0035640exploration behavior-IEA-  
GO:0042113B cell activation-ISS-  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0042391regulation of membrane potential-ISS-  
GO:0050877nervous system process-IBA21873635  
GO:0050877nervous system process-IMP7550350  17613539  
GO:0050890cognition-IMP14623738  
GO:0051899membrane depolarization-ISS-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0060080inhibitory postsynaptic potential-ISS-  
GO:0095500acetylcholine receptor signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005892acetylcholine-gated channel complex-IBA21873635  
GO:0005892acetylcholine-gated channel complex-IDA8906617  
GO:0009897external side of plasma membrane-ISS-  
GO:0016020membrane-ISS-  
GO:0016021integral component of membrane-NAS8906617  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-ISS-  
GO:0043005neuron projection-IBA21873635  
GO:0043025neuronal cell body-ISS-  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-181431Acetylcholine binding and downstream eventsTAS
R-HSA-622323Presynaptic nicotinic acetylcholine receptorsTAS
R-HSA-622327Postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629587Highly sodium permeable acetylcholine nicotinic receptorsTAS
R-HSA-629594Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629597Highly calcium permeable nicotinic acetylcholine receptorsTAS
R-HSA-629602Activation of Nicotinic Acetylcholine ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23843950Nicotinic acetylcholine receptor subunits alpha4 and alpha5 associated with smoking behaviour and lung cancer are regulated by upstream open reading frames. (2013)Eggert MPLoS One
26125703Association of CHRNA4 gene rs1044396 and rs1044397 polymorphisms with Parkinson's disease symptoms and smoking. (2015 May 12)Zhang LMGenet Mol Res
26441658Agonist and antagonist effects of tobacco-related nitrosamines on human alpha4beta2 nicotinic acetylcholine receptors. (2015)Brusco SFront Pharmacol
15617774Genetic correlation between the free-choice oral consumption of nicotine and alcohol in C57BL/6JxC3H/HeJ F2 intercross mice. (2005 Feb 10)Li XCBehav Brain Res
29240768The association between the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) rs1044396 and Internet gaming disorder in Korean male adults. (2017)Jeong JEPLoS One
27827986Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence. (2016 Nov 7)Zuo LGenes (Basel)
17955458Gene-environment interactions in the development of combined type ADHD: evidence for a synapse-based model. (2007 Dec 5)Todd RDAm J Med Genet B Neuropsychiatr Genet
27054571Association of Common Polymorphisms in the Nicotinic Acetylcholine Receptor Alpha4 Subunit Gene with an Electrophysiological Endophenotype in a Large Population-Based Sample. (2016)Mobascher APLoS One
20854418CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences. (2011 Mar)Hoft NRGenes Brain Behav
23350800Nominal association with CHRNA4 variants and nicotine dependence. (2013 Apr)Kamens HMGenes Brain Behav
19819424Meta-analysis of 15 genome-wide linkage scans of smoking behavior. (2010 Jan 1)Han SBiol Psychiatry
15902904Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients. (2004 Oct-Nov)Kim SAAlcohol
28978081Expression patterns for nicotinic acetylcholine receptor subunit genes in smoking-related lung cancers. (2017 Sep 15)Bordas AOncotarget
28583088Uncovering the transcriptomic and epigenomic landscape of nicotinic receptor genes in non-neuronal tissues. (2017 Jun 5)Zhang BBMC Genomics
24428733Association of the CHRNA4 neuronal nicotinic receptor subunit gene with frequency of binge drinking in young adults. (2014 Apr)Coon HAlcohol Clin Exp Res
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