Gene: CHRNA7

1139
CHRNA7-2|NACHRA7
cholinergic receptor nicotinic alpha 7 subunit
protein-coding
15q13.3
Ensembl:ENSG00000175344 MIM:118511 Vega:OTTHUMG00000129285 UniprotKB:P36544
NG_009216.1
PubMed|SNP Mapped
ND|AD
31   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.259e-1 (AD)  2.906e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7179733chr15:32081490 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IGSF30.874
RASGRF20.869
LRRTM40.86
VSTM2A0.859
PIP5K1B0.854
GRIA40.84
ZNF804A0.836
CDH180.836
TMEM178B0.836
CBLN40.834

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.532
CSAG1-0.531
ROM1-0.514
HEY2-0.51
RAB13-0.504
TGFB3-0.485
TIMP1-0.476
HEBP2-0.471
RNF135-0.471
HEYL-0.47

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00122CholineSmall Molecule62-49-7Approved|NutraceuticalTarget
DB00184NicotineSmall Molecule54-11-5ApprovedTarget
DB00237ButabarbitalSmall Molecule125-40-6Approved|IllicitTarget
DB00241ButalbitalSmall Molecule77-26-9Approved|IllicitTarget
DB00306TalbutalSmall Molecule115-44-6Approved|IllicitTarget
DB00312PentobarbitalSmall Molecule76-74-4Approved|InvestigationalTarget
DB00418SecobarbitalSmall Molecule76-73-3ApprovedTarget
DB00463MetharbitalSmall Molecule50-11-3WithdrawnTarget
DB00514DextromethorphanSmall Molecule125-71-3ApprovedTarget
DB00599ThiopentalSmall Molecule76-75-5ApprovedTarget
DB00657MecamylamineSmall Molecule60-40-2Approved|InvestigationalTarget
DB00674GalantamineSmall Molecule357-70-0ApprovedTarget
DB00794PrimidoneSmall Molecule125-33-7ApprovedTarget
DB00849MethylphenobarbitalSmall Molecule115-38-8ApprovedTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB01174PhenobarbitalSmall Molecule50-06-6Approved|InvestigationalTarget
DB01199TubocurarineSmall Molecule57-95-4ApprovedTarget
DB01273VareniclineSmall Molecule249296-44-4Approved|InvestigationalTarget
DB01351AmobarbitalSmall Molecule57-43-2Approved|IllicitTarget
DB01352AprobarbitalSmall Molecule77-02-1Approved|IllicitTarget
DB01353ButethalSmall Molecule77-28-1Approved|IllicitTarget
DB01354HeptabarbitalSmall Molecule509-86-4ApprovedTarget
DB01355HexobarbitalSmall Molecule56-29-1ApprovedTarget
DB01483BarbitalSmall Molecule57-44-3IllicitTarget
DB01496Barbituric acid derivativeSmall MoleculeExperimental|IllicitTarget
DB03128AcetylcholineSmall Molecule51-84-3ApprovedTarget
DB05137LobelineSmall Molecule90-69-7InvestigationalTarget
DB05708GTS-21Small Molecule148372-04-7InvestigationalTarget
DB05740RPI-78MSmall Molecule-InvestigationalTarget
DB07720EpibatidineSmall Molecule140111-52-0ExperimentalTarget
DB09028CytisineSmall Molecule485-35-8Approved|InvestigationalTarget
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalTarget
DB00193TramadolSmall Molecule27203-92-5Approved|InvestigationalTarget
DB00202SuccinylcholineSmall Molecule306-40-1ApprovedTarget
DB01043MemantineSmall Molecule19982-08-2Approved|InvestigationalTarget
DB01221KetamineSmall Molecule6740-88-1ApprovedTarget
DB01520TenocyclidineSmall Molecule21500-98-1Experimental|Illicit|InvestigationalTarget
DB06090BradaniclineSmall Molecule639489-84-2InvestigationalTarget
ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]"18450646
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]"18450646
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 mRNA]"18450646
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 protein]"18450646
C0024481,2-linoleoylphosphatidylcholine"1,2-linoleoylphosphatidylcholine promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]"19100751
C0024481,2-linoleoylphosphatidylcholine"1,2-linoleoylphosphatidylcholine results in increased activity of CHRNA7 protein"19100751
C0024481,2-linoleoylphosphatidylcholine"Bungarotoxins inhibits the reaction [1,2-linoleoylphosphatidylcholine results in increased activity of CHRNA7 protein]"19100751
C54451613,19-didesmethyl spirolide C"13,19-didesmethyl spirolide C binds to and results in decreased activity of CHRNA7 protein"26063663
C51717013-desmethylspirolide C13-desmethylspirolide C binds to and results in decreased activity of CHRNA7 protein26063663
C5083881-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium"21715663
C5083881-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] inhibits the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in increased phosphorylation of JAK2 protein]"21715663
C5083881-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] which results in increased uptake of Calcium] inhibits the reaction [CHRNA7 protein results in decreased susceptibility to Okadaic Acid]"21715663
C5083881-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]"20132834|2919179
C5083881-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Carbachol affects the activity of CHRNA7 protein]"29248576
C5083881-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [epibatidine affects the activity of CHRNA7 protein]"29248576
C5083881-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Nicotine affects the activity of CHRNA7 protein]"29248576
C5083881-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]"29191791
C5083881-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased activity of CHRNA7 protein]"20132834
C5083881-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"Bungarotoxins inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]"21715663
C5083881-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"Mecamylamine inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]"21715663
C5083881-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"methyllycaconitine inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]"21715663
C5083881-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein"21715663
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of CHRNA7 mRNA"23829299
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CHRNA7 mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CHRNA7 mRNA"19114083
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in decreased susceptibility to Okadaic Acid]21715663
C0889363-(2,4-dimethoxybenzylidene)anabaseine"3-(2,4-dimethoxybenzylidene)anabaseine binds to and results in increased activity of CHRNA7 protein"10082212
C0889363-(2,4-dimethoxybenzylidene)anabaseine"CHRNA7 protein mutant form results in increased susceptibility to 3-(2,4-dimethoxybenzylidene)anabaseine"10082212
C0889363-(2,4-dimethoxybenzylidene)anabaseine"3-(2,4-dimethoxybenzylidene)anabaseine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]"19448648
C0889363-(2,4-dimethoxybenzylidene)anabaseine"3-(2,4-dimethoxybenzylidene)anabaseine binds to and results in increased activity of CHRNA7 protein"10578459|1094203
C1166663-(4-hydroxy-2-methoxybenzylidene)anabaseine3-(4-hydroxy-2-methoxybenzylidene)anabaseine binds to and results in increased activity of CHRNA7 protein18321476
C1166663-(4-hydroxy-2-methoxybenzylidene)anabaseine[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein18321476
C1166663-(4-hydroxy-2-methoxybenzylidene)anabaseinemethyllycaconitine inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein]18321476
C1166663-(4-hydroxy-2-methoxybenzylidene)anabaseineTetrodotoxin inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein]18321476
C4128954-((3-(5,6-dihydro-4H-(2,3')bipyridinyl-3-ylidene)propenyl)phenyl)dimethylamine"4-((3-(5,6-dihydro-4H-(2,3')bipyridinyl-3-ylidene)propenyl)phenyl)dimethylamine binds to and results in increased activity of CHRNA7 protein"10945867
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]18450646
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]18450646
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 mRNA]18450646
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 protein]18450646
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CHRNA7 protein17459420
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone binds to CHRNA7 protein16835749
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of CHRNA7 protein19027725
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CHRNA7 protein17459420
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone binds to and results in increased activity of CHRNA7 protein17459420
C4763785-azidoepibatidine5-azidoepibatidine binds to CHRNA7 protein12565964
C0267855-hydroxyindole[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein18321476
C0267855-hydroxyindole5-hydroxyindole binds to and results in increased activity of CHRNA7 protein18321476
C0267855-hydroxyindolemethyllycaconitine inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein]18321476
C0267855-hydroxyindoleTetrodotoxin inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein]18321476
C524029A-582941A-582941 binds to and results in increased activity of CHRNA7 protein18848931
C104288A 85380A 85380 inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
D000082AcetaminophenAcetaminophen results in increased expression of CHRNA7 mRNA29067470
D000109AcetylcholineAcetylcholine results in increased activity of CHRNA7 protein14608492|1653390
D000109AcetylcholineBarium promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16533908
D000109AcetylcholineCalcium promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16533908
D000109Acetylcholinenereistoxin inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]14608492
D000109AcetylcholineStrontium promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16533908
D000109Acetylcholine"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]"20132834|2919179
D000109AcetylcholineAcetylcholine binds to and results in increased activity of CHRNA7 protein12626641
D000109AcetylcholineAcetylcholine results in increased activity of CHRNA7 protein10082212|1588526
D000109Acetylcholine[Acetylcholine results in increased activity of CHRNA7 protein] which results in increased uptake of Calcium21051662
D000109AcetylcholineAtracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16931985
D000109Acetylcholinebeta-thujone inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]28395994
D000109AcetylcholineBungarotoxins inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]28395994
D000109AcetylcholineCHRNA7 protein mutant form results in increased susceptibility to Acetylcholine10082212
D000109Acetylcholinecisatracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16931985
D000109Acetylcholinedesformylflustrabromine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]21905680
D000109Acetylcholinemivacurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16931985
D000109Acetylcholine"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]"20132834
D000109AcetylcholinePancuronium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16931985
D000109Acetylcholinerocuronium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16931985
D000109AcetylcholineTetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]15885267
D000109AcetylcholineToluene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]15885267
D000109AcetylcholineTubocurarine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16931985
D000109AcetylcholineVecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16931985
D000109Acetylcholine"1,2-linoleoylphosphatidylcholine promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]"19100751
D000109AcetylcholineAcetylcholine affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
D000109AcetylcholineAcetylcholine results in increased activity of CHRNA7 protein15885267|1910075
D000109AcetylcholineBungarotoxins inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]19448648
D000109Acetylcholinemethyllycaconitine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]19448648
D000109AcetylcholineTetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]15885267
D000109AcetylcholineToluene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]15885267
D000109AcetylcholineAcetylcholine results in increased activity of CHRNA7 protein9397513
D000157AconitineAconitine analog binds to and results in decreased activity of CHRNA7 protein16862215
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CHRNA7 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CHRNA7 mRNA26260870
C025154alpha-cobratoxinalpha-cobratoxin binds to CHRNA7 protein12947760
C087686alpha-conotoxin ImIalpha-conotoxin ImI binds to and results in decreased activity of CHRNA7 protein15542623
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHRNA7 mRNA16483693
C091713anabaseineanabaseine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
C509783anatoxin aanatoxin a inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
C408128AR-R 17779AR-R 17779 results in increased activity of CHRNA7 protein14727003
C408128AR-R 17779AR-R 17779 binds to and results in increased activity of CHRNA7 protein10945867|1679023
D001279AtracuriumAtracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16931985
D001280AtrazineAtrazine results in decreased expression of CHRNA7 mRNA25929836
D001464BariumBarium promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16533908
D004958EstradiolEstradiol affects the expression of CHRNA7 mRNA23557687
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of CHRNA7 mRNA26496021
D004958EstradiolEstradiol results in increased expression of CHRNA7 protein21092740
C005790beta-thujonebeta-thujone inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]28395994
C005790beta-thujonebeta-thujone inhibits the reaction [Choline results in increased activity of CHRNA7 protein]28395994
C528260bis(12)-hupyridone[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to bis(12)-hupyridone23085120
C528260bis(12)-hupyridonebis(12)-hupyridone results in increased activity of CHRNA7 protein23085120
C006780bisphenol Abisphenol A results in decreased expression of CHRNA7 mRNA26364221
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of CHRNA7 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of CHRNA7 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of CHRNA7 mRNA25181051
D002038BungarotoxinsACHE protein alternative form inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]19287501
D002038BungarotoxinsBungarotoxins binds to and results in increased activity of CHRNA7 protein17709503
D002038Bungarotoxins[Bungarotoxins binds to and results in increased activity of CHRNA7 protein] which results in increased transport of Calcium17709503
D002038BungarotoxinsBungarotoxins binds to CHRNA7 protein10216184|1928750
D002038Bungarotoxins"Bungarotoxins inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]"21715663
D002038BungarotoxinsBungarotoxins inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]28395994
D002038BungarotoxinsBungarotoxins inhibits the reaction [epibatidine binds to CHRNA7 protein]21703337
D002038BungarotoxinsBungarotoxins inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]12626641
D002038BungarotoxinsBungarotoxins inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]18450646
D002038BungarotoxinsBungarotoxins inhibits the reaction [PNU-282987 binds to and results in increased activity of CHRNA7 protein]21051662
D002038BungarotoxinsBungarotoxins inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 protein]18450646
D002038BungarotoxinsCarbachol inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]10216184
D002038Bungarotoxinscytisine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]10216184
D002038BungarotoxinsDimethylphenylpiperazinium Iodide inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]10216184
D002038Bungarotoxinsmethyllycaconitine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]10216184
D002038BungarotoxinsNicotine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]10216184|9336329
D002038Bungarotoxinspozanicline inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]9336329
D002038BungarotoxinsTubocurarine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]10216184
D002038BungarotoxinsBungarotoxins binds to CHRNA7 protein9037516
D002038Bungarotoxins[Bungarotoxins results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine24380835
D002038BungarotoxinsCHRNA7 protein binds to Bungarotoxins9495872
D002038BungarotoxinsBungarotoxins binds to and results in decreased activity of CHRNA7 protein15542623
D002038BungarotoxinsBungarotoxins binds to CHRNA7 protein21942635
D002038Bungarotoxins"Bungarotoxins inhibits the reaction [1,2-linoleoylphosphatidylcholine results in increased activity of CHRNA7 protein]"19100751
D002038BungarotoxinsBungarotoxins inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]19448648
D002038BungarotoxinsBungarotoxins inhibits the reaction [Melitten results in increased activity of CHRNA7 protein]19910175
D002038BungarotoxinsBungarotoxins results in decreased activity of CHRNA7 protein19100751
D002038BungarotoxinsBungarotoxins binds to and results in decreased activity of CHRNA7 protein12511591|1686221
D002038BungarotoxinsBungarotoxins binds to CHRNA7 protein12223543
D002038BungarotoxinsBungarotoxins results in decreased activity of CHRNA7 protein15488331|2438083
C018475butyraldehydebutyraldehyde results in increased expression of CHRNA7 mRNA26079696
D002118CalciumCalcium promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16533908
D002118Calcium"[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium"21715663
D002118Calcium"[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] which results in increased uptake of Calcium] inhibits the reaction [CHRNA7 protein results in decreased susceptibility to Okadaic Acid]"21715663
D002118Calcium[Acetylcholine results in increased activity of CHRNA7 protein] which results in increased uptake of Calcium21051662
D002118Calcium[Bungarotoxins binds to and results in increased activity of CHRNA7 protein] which results in increased transport of Calcium17709503
D002118Calcium"Bungarotoxins inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]"21715663
D002118Calcium"Mecamylamine inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]"21715663
D002118Calcium[methyllycaconitine binds to and results in increased activity of CHRNA7 protein] which results in increased transport of Calcium17709503
D002118Calcium"methyllycaconitine inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]"21715663
D002118Calciummethyllycaconitine promotes the reaction [[Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium]17709503
D002118Calcium[Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium17709503
D002118Calcium[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in increased uptake of Calcium21051662
D002118Calcium[Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium17709503
D002118CalciumCalcium binds to and affects the activity of CHRNA7 protein16641314
D002217Carbachol"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Carbachol affects the activity of CHRNA7 protein]"29248576
D002217CarbacholCarbachol affects the activity of CHRNA7 protein29248576
D002217CarbacholCarbachol inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]10216184
D002217CarbacholCarbachol inhibits the reaction [epibatidine binds to CHRNA7 protein]21703337
D002217CarbacholCarbachol affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
D002245Carbon DioxideNicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA7 protein]28235547
D002245Carbon Dioxide[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA7 protein28235547
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CHRNA7 mRNA27163631
D004390ChlorpyrifosCHRNA7 protein affects the reaction [Chlorpyrifos results in increased expression of ACHE mRNA alternative form]27163631
D004390ChlorpyrifosChlorpyrifos affects the expression of CHRNA7 mRNA18977431
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CHRNA7 mRNA17452286
D002794CholineACHE protein alternative form inhibits the reaction [Choline binds to CHRNA7 protein]19287501
D002794Cholinebeta-thujone inhibits the reaction [Choline results in increased activity of CHRNA7 protein]28395994
D002794CholineCholine binds to and results in increased activity of CHRNA7 protein12626641
D002794CholineCholine binds to CHRNA7 protein19287501
D002794CholineCholine results in increased activity of CHRNA7 protein10082212|2839599
D002794CholineCHRNA7 protein mutant form results in increased susceptibility to Choline10082212
D002794Cholinemethyllycaconitine inhibits the reaction [Choline results in increased activity of CHRNA7 protein]28395994
D002794CholineCholine binds to and results in increased activity of CHRNA7 protein19498423
D002794CholineCholine affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
C101584cisatracuriumcisatracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16931985
D003367CotinineCHRNA7 protein mutant form results in increased susceptibility to Cotinine10082212
D003367CotinineCotinine binds to and results in increased activity of CHRNA7 protein10082212
C029892cupric chloridecupric chloride results in decreased expression of CHRNA7 mRNA24650576
D003471CuprizoneCuprizone results in decreased expression of CHRNA7 mRNA25704630|2605778
C004712cytisinecytisine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]10216184
C004712cytisinecytisine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
C524215desformylflustrabrominedesformylflustrabromine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]21905680
D003976DiazinonDiazinon affects the expression of CHRNA7 mRNA18812211
D003976DiazinonDiazinon results in decreased expression of CHRNA7 mRNA17452286
D002945CisplatinCisplatin results in increased expression of CHRNA7 mRNA27392435
D004026DieldrinDieldrin results in increased expression of CHRNA7 mRNA18812211
D004041Dietary FatsDietary Fats results in decreased expression of CHRNA7 mRNA23118937
D004041Dietary FatsDietary Fats results in decreased expression of CHRNA7 mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of CHRNA7 mRNA26033743
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CHRNA7 mRNA20360939
D004052DiethylnitrosamineDiethylnitrosamine binds to CHRNA7 protein17459420
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine results in increased activity of CHRNA7 protein mutant form10082212
D004079Dihydro-beta-ErythroidineCHRNA7 protein mutant form affects the susceptibility to Dihydro-beta-Erythroidine10082212
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine binds to and results in decreased activity of CHRNA7 protein10082212
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine results in increased activity of CHRNA7 protein mutant form10082212
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine affects the activity of CHRNA7 protein12604094
D004246Dimethylphenylpiperazinium IodideCHRNA7 protein mutant form results in increased susceptibility to Dimethylphenylpiperazinium Iodide10082212
D004246Dimethylphenylpiperazinium IodideDimethylphenylpiperazinium Iodide inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]10216184
D004246Dimethylphenylpiperazinium IodideDimethylphenylpiperazinium Iodide results in increased activity of CHRNA7 protein10082212
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of CHRNA7 mRNA28939011
C082748epibatidine"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [epibatidine affects the activity of CHRNA7 protein]"29248576
C082748epibatidineBungarotoxins inhibits the reaction [epibatidine binds to CHRNA7 protein]21703337
C082748epibatidineCarbachol inhibits the reaction [epibatidine binds to CHRNA7 protein]21703337
C082748epibatidineepibatidine affects the activity of CHRNA7 protein29248576
C082748epibatidineepibatidine binds to CHRNA7 protein21703337
C082748epibatidinemethyllycaconitine inhibits the reaction [epibatidine binds to CHRNA7 protein]21703337
C082748epibatidinePNU-282987 inhibits the reaction [epibatidine binds to CHRNA7 protein]21703337
C082748epibatidineSAD-128 analog inhibits the reaction [epibatidine binds to CHRNA7 protein]21703337
C082748epibatidineepibatidine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
D004837Epinephrine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine]17498763
D000431EthanolEthanol results in decreased expression of CHRNA7 mRNA15353170
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CHRNA7 mRNA29097150
D005702GalantamineGalantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]25881725
D005702Galantaminemethyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]]25881725
C412815GW 4064GW 4064 results in decreased expression of CHRNA7 mRNA26655953
C082359imidaclopridimidacloprid results in increased activity of CHRNA7 protein9397513
C027724iodo-alpha-bungarotoxiniodo-alpha-bungarotoxin binds to [CHRNA7 protein binds to RIC3 protein]19627445
C027724iodo-alpha-bungarotoxin"3-(2,4-dimethoxybenzylidene)anabaseine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]"19448648
C027724iodo-alpha-bungarotoxinA 85380 inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
C027724iodo-alpha-bungarotoxinAcetylcholine affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
C027724iodo-alpha-bungarotoxinanabaseine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
C027724iodo-alpha-bungarotoxinanatoxin a inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
C027724iodo-alpha-bungarotoxinCarbachol affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
C027724iodo-alpha-bungarotoxinCholine affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
C027724iodo-alpha-bungarotoxincytisine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
C027724iodo-alpha-bungarotoxinDihydro-beta-Erythroidine affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
C027724iodo-alpha-bungarotoxinepibatidine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
C027724iodo-alpha-bungarotoxiniodo-alpha-bungarotoxin binds to CHRNA7 protein19448648
C027724iodo-alpha-bungarotoxinmethyllycaconitine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
C027724iodo-alpha-bungarotoxinNicotine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
C063302KN 62KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]18450646
C063302KN 62KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]18450646
C063302KN 62KN 62 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 mRNA]18450646
C063302KN 62KN 62 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 protein]18450646
D007736Kynurenic AcidKynurenic Acid binds to and results in decreased activity of CHRNA7 protein11334243|1645747
D008120LobelineCHRNA7 protein mutant form affects the susceptibility to Lobeline10082212
D008120LobelineLobeline binds to and results in decreased activity of CHRNA7 protein10082212
D008120LobelineLobeline binds to and results in increased activity of CHRNA7 protein mutant form10082212
C025340manganese chloridemanganese chloride results in decreased expression of CHRNA7 protein25874029
C571852MB327MB327 analog promotes the reaction [Nicotine affects the activity of CHRNA7 protein]29248576
C571852MB327MB327 promotes the reaction [Nicotine affects the activity of CHRNA7 protein]29248576
C571852MB327MB327 promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]29191791
D008464MecamylamineMecamylamine binds to and results in decreased activity of CHRNA7 protein10082212
D008464Mecamylamine"Mecamylamine inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]"21715663
D008464MecamylamineMecamylamine binds to and results in decreased activity of CHRNA7 protein12511591
D008555MelittenBungarotoxins inhibits the reaction [Melitten results in increased activity of CHRNA7 protein]19910175
D008555MelittenMelitten results in increased activity of CHRNA7 protein19910175
D008555Melittenmethyllycaconitine inhibits the reaction [Melitten results in increased activity of CHRNA7 protein]19910175
C054634methyllycaconitine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine18671990
C054634methyllycaconitinemethyllycaconitine binds to CHRNA7 protein19627445
C054634methyllycaconitinemethyllycaconitine binds to and results in decreased activity of CHRNA7 protein10082212
C054634methyllycaconitine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine]17498763
C054634methyllycaconitine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA]17498763
C054634methyllycaconitine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]17498763
C054634methyllycaconitine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]18448488
C054634methyllycaconitine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]18448488
C054634methyllycaconitine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]18448488
C054634methyllycaconitine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGA2B mRNA21385097
C054634methyllycaconitine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGA2B protein21385097
C054634methyllycaconitine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGB3 mRNA21385097
C054634methyllycaconitine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGB3 protein21385097
C054634methyllycaconitinemethyllycaconitine binds to and results in increased activity of CHRNA7 protein17709503
C054634methyllycaconitine[methyllycaconitine binds to and results in increased activity of CHRNA7 protein] which results in increased transport of Calcium17709503
C054634methyllycaconitine"methyllycaconitine inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]"21715663
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]10216184
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [Choline results in increased activity of CHRNA7 protein]28395994
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [epibatidine binds to CHRNA7 protein]21703337
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]12626641
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [PNU-282987 binds to and results in increased activity of CHRNA7 protein]21051662
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [pozanicline binds to and results in increased activity of CHRNA7 protein]9336329
C054634methyllycaconitinemethyllycaconitine promotes the reaction [[Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium]17709503
C054634methyllycaconitineCHRNA7 protein affects the susceptibility to methyllycaconitine19098233
C054634methyllycaconitinemethyllycaconitine binds to and results in decreased activity of CHRNA7 protein19498423
C054634methyllycaconitine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine11893908
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]]25881725
C054634methyllycaconitine"methyllycaconitine inhibits the reaction [N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]]"25881725
C054634methyllycaconitinemethyllycaconitine analog binds to CHRNA7 protein17098430
C054634methyllycaconitinemethyllycaconitine binds to and results in decreased activity of CHRNA7 protein15523001|1554262
C054634methyllycaconitine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which affects the susceptibility to Nicotine18385335
C054634methyllycaconitine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to bis(12)-hupyridone23085120
C054634methyllycaconitinemethyllycaconitine binds to CHRNA7 protein17218065
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein]18321476
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]19448648
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [Melitten results in increased activity of CHRNA7 protein]19910175
C054634methyllycaconitineNicotine inhibits the reaction [methyllycaconitine binds to CHRNA7 protein]17218065
C054634methyllycaconitinemethyllycaconitine binds to and results in decreased activity of CHRNA7 protein10945867|1189390
D018817N-Methyl-3,4-methylenedioxyamphetamine"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased activity of CHRNA7 protein]"20132834
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]"20132834
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased activity of CHRNA7 protein"20132834
D008743Methyl ParathionMethyl Parathion affects the expression of CHRNA7 mRNA18977431
C049430mivacuriummivacurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16931985
C524978N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline results in decreased activity of CHRNA7 protein"17873105
C513163N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide"methyllycaconitine inhibits the reaction [N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]]"25881725
C513163N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]"25881725
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CHRNA7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CHRNA7 mRNA"25554681
C025633nereistoxinnereistoxin inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]14608492
D009532NickelNickel results in decreased expression of CHRNA7 mRNA18812211
D009538NicotineNicotine results in increased expression of CHRNA7 mRNA24089524
D009538NicotineNicotine results in increased expression of CHRNA7 protein17459420
D009538Nicotine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine18671990
D009538Nicotine"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]"18450646
D009538Nicotine"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]"18450646
D009538Nicotine"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Nicotine affects the activity of CHRNA7 protein]"29248576
D009538Nicotine"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]"29191791
D009538Nicotine4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]18450646
D009538Nicotine4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]18450646
D009538NicotineBungarotoxins inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]12626641
D009538NicotineBungarotoxins inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]18450646
D009538NicotineCHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]18450646
D009538NicotineCHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]18450646
D009538NicotineCHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]16862215
D009538NicotineCHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]18450646
D009538NicotineCHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]18450646
D009538NicotineCHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 mRNA]18450646
D009538NicotineCHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 protein]18450646
D009538NicotineCHRNA7 protein mutant form results in increased susceptibility to Nicotine10082212
D009538NicotineGATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]18450646
D009538NicotineGATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]18450646
D009538Nicotine[GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]24089524
D009538NicotineKN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]18450646
D009538NicotineKN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]18450646
D009538NicotineMB327 analog promotes the reaction [Nicotine affects the activity of CHRNA7 protein]29248576
D009538NicotineMB327 promotes the reaction [Nicotine affects the activity of CHRNA7 protein]29248576
D009538NicotineMB327 promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]29191791
D009538Nicotine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine]17498763
D009538Nicotine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA]17498763
D009538Nicotine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]17498763
D009538Nicotine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]18448488
D009538Nicotine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]18448488
D009538Nicotine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]18448488
D009538Nicotinemethyllycaconitine inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]12626641
D009538Nicotinemethyllycaconitine promotes the reaction [[Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium]17709503
D009538NicotineNicotine affects the activity of CHRNA7 protein29248576
D009538NicotineNicotine binds to and results in increased activity of CHRNA7 protein12626641|9336329
D009538NicotineNicotine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]10216184|9336329
D009538NicotineNicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]24089524
D009538NicotineNicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]24089524
D009538NicotineNicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]24089524
D009538NicotineNicotine results in decreased expression of CHRNA7 mRNA12628473
D009538NicotineNicotine results in increased activity of CHRNA7 protein10082212|1770950
D009538Nicotine[Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium17709503
D009538NicotineNicotine results in increased expression of and results in increased phosphorylation of CHRNA7 protein17709503
D009538NicotineNicotine results in increased expression of CHRNA710216184
D009538NicotineNicotine results in increased expression of CHRNA7 mRNA17151781|1845064
D009538NicotineNicotine results in increased expression of CHRNA7 protein17459420|1845064
D009538NicotinePyridinium Compounds analog promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]29191791
D009538Nicotine[Bungarotoxins results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine24380835
D009538NicotineCHRNA7 gene polymorphism affects the susceptibility to Nicotine9495872
D009538NicotineCHRNA7 protein affects the susceptibility to Nicotine10942032|1189390
D009538NicotineCHRNA7 protein mutant form results in increased susceptibility to Nicotine11854451
D009538Nicotine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine11893908
D009538NicotineNicotine results in increased expression of CHRNA7 mRNA17135361
D009538NicotineNicotine results in increased expression of CHRNA7 protein14500745
D009538Nicotine[triethyl-(beta-4-stilbenoxyethyl)ammonium results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine24380835
D009538Nicotine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which affects the susceptibility to Nicotine18385335
D009538NicotineNicotine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]19448648
D009538NicotineNicotine inhibits the reaction [methyllycaconitine binds to CHRNA7 protein]17218065
D009538NicotineNicotine results in decreased expression of CHRNA7 mRNA20060465|2732924
D009538NicotineNicotine results in decreased expression of CHRNA7 protein27329243
D009538NicotineNicotine results in increased activity of CHRNA7 protein17241116|1770950
D009538Nicotine[Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium17709503
D009538NicotineNicotine results in increased expression of and results in increased phosphorylation of CHRNA7 protein17709503
D009538NicotineNicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA7 protein]28235547
C005311nornicotinenornicotine results in increased activity of CHRNA7 protein17241116
D019319Okadaic Acid"[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] which results in increased uptake of Calcium] inhibits the reaction [CHRNA7 protein results in decreased susceptibility to Okadaic Acid]"21715663
D019319Okadaic Acid2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in decreased susceptibility to Okadaic Acid]21715663
D019319Okadaic AcidJAK2 protein affects the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in decreased susceptibility to Okadaic Acid]21715663
D019319Okadaic Acid[PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein]21715663
D019319Okadaic Acid[PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein modified form]21715663
D019319Okadaic Acid[PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]21715663
D019319Okadaic Acid[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in decreased susceptibility to Okadaic Acid21715663
D010100OxygenNicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA7 protein]28235547
D010100Oxygen[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA7 protein28235547
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of CHRNA7 mRNA25658374
D010197PancuroniumPancuronium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16931985
D010269ParaquatParaquat results in increased expression of CHRNA7 mRNA18198484
C410127PCB 180PCB 180 results in decreased expression of CHRNA7 mRNA23829299
C086401pentabromodiphenyl etherpentabromodiphenyl ether affects the expression of CHRNA7 mRNA27294297
D010936Plant ExtractsPlant Extracts results in decreased expression of CHRNA7 mRNA23557933
C498513PNU-282987"[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium"21715663
C498513PNU-282987"[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] inhibits the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in increased phosphorylation of JAK2 protein]"21715663
C498513PNU-2829872-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in decreased susceptibility to Okadaic Acid]21715663
C498513PNU-282987"Bungarotoxins inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]"21715663
C498513PNU-282987Bungarotoxins inhibits the reaction [PNU-282987 binds to and results in increased activity of CHRNA7 protein]21051662
C498513PNU-282987JAK2 protein affects the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in decreased susceptibility to Okadaic Acid]21715663
C498513PNU-282987"Mecamylamine inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]"21715663
C498513PNU-282987"methyllycaconitine inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]"21715663
C498513PNU-282987methyllycaconitine inhibits the reaction [PNU-282987 binds to and results in increased activity of CHRNA7 protein]21051662
C498513PNU-282987[PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein]21715663
C498513PNU-282987[PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein modified form]21715663
C498513PNU-282987[PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]21715663
C498513PNU-282987[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in decreased susceptibility to Okadaic Acid21715663
C498513PNU-282987[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in increased phosphorylation of GSK3B protein21715663
C498513PNU-282987[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in increased phosphorylation of JAK2 protein21715663
C498513PNU-282987[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in increased uptake of Calcium21051662
C498513PNU-282987PNU-282987 inhibits the reaction [epibatidine binds to CHRNA7 protein]21703337
C498513PNU-282987PNU-282987 binds to and results in increased activity of CHRNA7 protein18848931
C498513PNU-282987PNU-282987 results in increased activity of CHRNA7 protein25837923
C498513PNU-282987PNU-282987 binds to and results in increased activity of CHRNA7 protein15523001
C498513PNU-282987PNU-282987 binds to and results in increased activity of CHRNA7 protein21051662|2171566
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CHRNA7 mRNA23608068
C108326pozaniclineCHRNA7 protein mutant form results in increased susceptibility to pozanicline10082212
C108326pozaniclinemethyllycaconitine inhibits the reaction [pozanicline binds to and results in increased activity of CHRNA7 protein]9336329
C108326pozaniclinepozanicline binds to and results in increased activity of CHRNA7 protein10082212|9336329
C108326pozaniclinepozanicline inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]9336329
C005556propionaldehydepropionaldehyde results in increased expression of CHRNA7 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of CHRNA7 mRNA24780913
D011726Pyridinium CompoundsPyridinium Compounds analog promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]29191791
C061870rocuroniumrocuronium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16931985
C016845SAD-128SAD-128 analog inhibits the reaction [epibatidine binds to CHRNA7 protein]21703337
C017947sodium arsenitesodium arsenite affects the methylation of CHRNA7 gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of CHRNA7 protein19900517
C516833SSR180711SSR180711 binds to and results in increased activity of CHRNA7 protein18848931
D013324StrontiumStrontium promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16533908
D013498SuraminSuramin results in increased expression of CHRNA7 protein23516405
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of CHRNA7 mRNA26496021
D013750TetrachloroethyleneTetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]15885267
D013750TetrachloroethyleneTetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]15885267
D013779TetrodotoxinTetrodotoxin inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein]18321476
D014028Tobacco Smoke Pollution"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 mRNA]"18450646
D014028Tobacco Smoke Pollution"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 protein]"18450646
D014028Tobacco Smoke Pollution4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 mRNA]18450646
D014028Tobacco Smoke Pollution4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 protein]18450646
D014028Tobacco Smoke PollutionBungarotoxins inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 protein]18450646
D014028Tobacco Smoke PollutionCHRNA3 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 mRNA]18450646
D014028Tobacco Smoke PollutionCHRNA3 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 protein]18450646
D014028Tobacco Smoke PollutionCHRNA7 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]18450646
D014028Tobacco Smoke PollutionCHRNA7 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]18450646
D014028Tobacco Smoke PollutionCHRNA7 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 mRNA]18450646
D014028Tobacco Smoke PollutionCHRNA7 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 protein]18450646
D014028Tobacco Smoke PollutionGATA2 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 mRNA]18450646
D014028Tobacco Smoke PollutionGATA2 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 protein]18450646
D014028Tobacco Smoke PollutionKN 62 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 mRNA]18450646
D014028Tobacco Smoke PollutionKN 62 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 protein]18450646
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CHRNA7 mRNA18450646
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CHRNA7 protein18450646
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CHRNA7 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CHRNA7 protein26746805
D014050TolueneToluene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]15885267
D014050TolueneToluene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]15885267
C052342topiramatetopiramate results in decreased expression of CHRNA7 mRNA16979414
D014212TretinoinTretinoin results in increased expression of CHRNA7 protein17203487
C118602triethyl-(beta-4-stilbenoxyethyl)ammonium[triethyl-(beta-4-stilbenoxyethyl)ammonium results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine24380835
C118602triethyl-(beta-4-stilbenoxyethyl)ammoniumtriethyl-(beta-4-stilbenoxyethyl)ammonium binds to and results in decreased activity of CHRNA7 protein15542623
C118602triethyl-(beta-4-stilbenoxyethyl)ammoniumtriethyl-(beta-4-stilbenoxyethyl)ammonium results in decreased activity of CHRNA7 protein24380835
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CHRNA7 mRNA"26179874
D014403TubocurarineTubocurarine binds to and results in decreased activity of CHRNA7 protein10082212
D014403TubocurarineTubocurarine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16931985
D014403TubocurarineTubocurarine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]10216184
D014520UrethaneUrethane results in increased expression of CHRNA7 mRNA28818685
D000068580VareniclineVarenicline binds to and results in increased activity of [CHRNA7 protein binds to CHRNA7 protein]16766716
D000068580VareniclineVarenicline binds to and results in increased activity of CHRNA7 protein18411066|1995924
D014673Vecuronium BromideVecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]16931985
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CHRNA7 gene25560391
D015034Zinc OxideZinc Oxide analog results in decreased expression of CHRNA7 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of CHRNA7 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-IPI10681545  
GO:0005216ion channel activity-IDA17898229  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005262calcium channel activity-TAS11404397  
GO:0005515protein binding-IPI26905431  27344019  
GO:0015276ligand-gated ion channel activity-TAS-  
GO:0015464acetylcholine receptor activityCONTRIBUTES_TOIBA21873635  
GO:0015464acetylcholine receptor activity-IDA8906617  
GO:0015643toxic substance binding-IDA12508119  
GO:0017081chloride channel regulator activity-IDA8145738  
GO:0022848acetylcholine-gated cation-selective channel activity-IDA8145738  8906617  12508119  18387948  21718690  
GO:0022848acetylcholine-gated cation-selective channel activity-ISS-  
GO:0042166acetylcholine binding-IBA21873635  
GO:0042166acetylcholine binding-IDA8145738  
GO:0042803protein homodimerization activity-IDA8145738  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IDA10771023  
GO:0001666response to hypoxia-IDA12189247  
GO:0001933negative regulation of protein phosphorylation-IEA-  
GO:0001934positive regulation of protein phosphorylation-ISS-  
GO:0001988positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure-IEA-  
GO:0006811ion transport-NAS8906617  
GO:0006816calcium ion transport-IDA8145738  
GO:0006816calcium ion transport-IMP10771023  
GO:0006874cellular calcium ion homeostasis-IMP16280133  
GO:0006897endocytosis-IEA-  
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-IDA8906617  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007271synaptic transmission, cholinergic-IBA21873635  
GO:0007271synaptic transmission, cholinergic-IEA-  
GO:0007611learning or memory-ISS-  
GO:0007613memory-ISS-  
GO:0007613memory-NAS10681545  
GO:0007614short-term memory-ISS-  
GO:0008284positive regulation of cell proliferation-IMP16280133  17498763  
GO:0008306associative learning-IEA-  
GO:0009409response to cold-IEA-  
GO:0014061regulation of norepinephrine secretion-IEA-  
GO:0030317flagellated sperm motility-IEA-  
GO:0032094response to food-IEA-  
GO:0032225regulation of synaptic transmission, dopaminergic-IEA-  
GO:0032691negative regulation of interleukin-1 beta production-IEA-  
GO:0032715negative regulation of interleukin-6 production-IEA-  
GO:0032720negative regulation of tumor necrosis factor production-IDA12508119  
GO:0032720negative regulation of tumor necrosis factor production-IMP12508119  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IEA-  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0034220ion transmembrane transport-IDA21718690  
GO:0035094response to nicotine-IDA8145738  12189247  
GO:0035094response to nicotine-ISS-  
GO:0035095behavioral response to nicotine-IEA-  
GO:0042110T cell activation-IEA-  
GO:0042113B cell activation-IEA-  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0045766positive regulation of angiogenesis-IMP12189247  16280133  
GO:0048149behavioral response to ethanol-IEA-  
GO:0050728negative regulation of inflammatory response-IEA-  
GO:0050808synapse organization-ISS-  
GO:0050877nervous system process-IBA21873635  
GO:0050890cognition-IMP16754836  
GO:0050890cognition-NAS10681545  
GO:0050893sensory processing-ISS-  
GO:0051247positive regulation of protein metabolic process-ISS-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0060112generation of ovulation cycle rhythm-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-ISS-  
GO:0070588calcium ion transmembrane transport-IEA-  
GO:0095500acetylcholine receptor signaling pathway-ISS-  
GO:0097061dendritic spine organization-ISS-  
GO:0098815modulation of excitatory postsynaptic potential-ISS-  
GO:0140059dendrite arborization-ISS-  
GO:1900273positive regulation of long-term synaptic potentiation-ISS-  
GO:1901214regulation of neuron death-ISS-  
GO:1902004positive regulation of amyloid-beta formation-ISS-  
GO:1902430negative regulation of amyloid-beta formation-IGI20708605  
GO:1902991regulation of amyloid precursor protein catabolic process-IGI20708605  
GO:1904645response to amyloid-beta-ISS-  
GO:1905144response to acetylcholine-IDA17898229  
GO:1905144response to acetylcholine-ISS-  
GO:1905906regulation of amyloid fibril formation-ISS-  
GO:1905920positive regulation of CoA-transferase activity-ISS-  
GO:2000463positive regulation of excitatory postsynaptic potential-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA12508119  16280133  21718690  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005892acetylcholine-gated channel complex-IBA21873635  
GO:0005892acetylcholine-gated channel complex-IDA8906617  
GO:0009897external side of plasma membrane-IEA-  
GO:0016021integral component of membrane-NAS8145738  8906617  
GO:0016324apical plasma membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0030673axolemma-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0044853plasma membrane raft-ISS-  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
GO:0098794postsynapse-TAS26224839  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-181431Acetylcholine binding and downstream eventsTAS
R-HSA-622327Postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629594Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629602Activation of Nicotinic Acetylcholine ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19680823Differential regulation of alpha7 nicotinic receptor gene (CHRNA7) expression in schizophrenic smokers. (2010 Jan)Mexal SJ Mol Neurosci
25407004Duplicated copy of CHRNA7 increases risk and worsens prognosis of COPD and lung cancer. (2015 Aug)Yang LEur J Hum Genet
29545933Endogenous CHRNA7-ligand SLURP1 as a potential tumor suppressor and anti-nicotinic factor in pancreatic cancer. (2018 Feb 20)Throm VMOncotarget
25471068Small effects of smoking on visual spatiotemporal processing. (2014 Dec 4)Kunchulia MSci Rep
25545355Genetic variants and early cigarette smoking and nicotine dependence phenotypes in adolescents. (2014)O'Loughlin JPLoS One
19181484Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia. (2009 Apr)Stephens SHSchizophr Res
16314871Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes. (2006 Mar)Greenbaum LMol Psychiatry
20231857Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions. (2011 Feb)Rigbi APharmacogenomics J
24289814Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice. (2014 Feb)Harenza JLGenes Brain Behav
17559419Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (2008 Mar)Rigbi AGenes Brain Behav
28978081Expression patterns for nicotinic acetylcholine receptor subunit genes in smoking-related lung cancers. (2017 Sep 15)Bordas AOncotarget
11803515No association between CHRNA7 microsatellite markers and attention-deficit hyperactivity disorder. (2001 Dec 8)Kent LAm J Med Genet
27355804SNPs in NRXN1 and CHRNA5 are associated to smoking and regulation of GABAergic and glutamatergic pathways. (2016 Jul)Perez-Rubio GPharmacogenomics
21498873Associations of nicotine intake measures with CHRN genes in Finnish smokers. (2011 Aug)Keskitalo-Vuokko KNicotine Tob Res
22441542Nicotinic acetylcholine receptor expression and susceptibility to cholinergic immunomodulation in human monocytes of smoking individuals. (2012)van der Zanden EPNeuroimmunomodulation
22766391Allosteric alpha-7 nicotinic receptor modulation and P50 sensory gating in schizophrenia: a proof-of-mechanism study. (2013 Jan)Winterer GNeuropharmacology
19307444Examination of the nicotine dependence (NICSNP) consortium findings in the Iowa adoption studies population. (2009 Mar)Philibert RANicotine Tob Res
24111888alpha7-nicotinic acetylcholine receptor agonists for cognitive enhancement in schizophrenia. (2014)Freedman RAnnu Rev Med
21970977Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia. (2012 Feb)Stephens SHPsychiatr Genet
29305655CHRFAM7A gene expression in schizophrenia: clinical correlates and the effect of antipsychotic treatment. (2018 Apr)Kalmady SVJ Neural Transm (Vienna)
26184988Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder. (2015 Sep 30)Kimbrel NAPsychiatry Res
27428758Nicotinic cholinergic and dopaminergic receptor mRNA expression in male and female rats with high or low preference for nicotine. (2016 Sep)Gozen OAm J Drug Alcohol Abuse
15192278A novel permutation testing method implicates sixteen nicotinic acetylcholine receptor genes as risk factors for smoking in schizophrenia families. (2004)Faraone SVHum Hered
24119711The association between CHRN genetic variants and dizziness at first inhalation of cigarette smoke. (2014 Jan)Pedneault MAddict Behav
10893492Schizophrenia and smoking: evidence for a common neurobiological basis? (2000 Apr 3)Stassen HHAm J Med Genet
19462340Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores. (2010 Mar)Manchia MWorld J Biol Psychiatry
25498233Natural genetic variability of the neuronal nicotinic acetylcholine receptor subunit genes in mice: Consequences and confounds. (2015 Sep)Wilking JANeuropharmacology
20584212Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (2010 Oct)Saccone NLGenes Brain Behav
18043764Association of alpha4beta2 nicotinic receptor and heavy smoking in schizophrenia. (2007 Nov)Voineskos SJ Psychiatry Neurosci
27249957CHRNA7 Polymorphisms and Dementia Risk: Interactions with Apolipoprotein epsilon4 and Cigarette Smoking. (2016 Jun 2)Weng PHSci Rep
26575444CHRNA7 and CHRFAM7A: psychosis and smoking? Blame the neighbors! (2015 Nov 1)Akbarian SAm J Psychiatry