Gene: ADCY8

114
AC8|ADCY3|HBAC1
adenylate cyclase 8
protein-coding
8q24.22
Ensembl:ENSG00000155897 MIM:103070 Vega:OTTHUMG00000164756 UniprotKB:P40145
NC_000008.11
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.513e-1 (AD)  8.527e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHPF0.795
NTM0.771
PTPRF0.77
TMEM132A0.769
NCAN0.755
OGDH0.751
DCLK20.741
ANO80.738
CRAT0.737
SCAP0.736

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.555
OR4F29-0.479
OR6C74-0.365
WDR72-0.359
GADL1-0.356
DNASE1L3-0.355
MTRNR2L6-0.353
C19orf33-0.35
FMO1-0.344
KRTAP4-5-0.34

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000242Cyclic AMPADCY8 protein results in increased abundance of Cyclic AMP16914643
C015001arsenitearsenite results in increased methylation of ADCY8 promoter23974009
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ADCY8 mRNA18164116
C006780bisphenol Abisphenol A results in decreased expression of ADCY8 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of ADCY8 mRNA25181051
D002220CarbamazepineCarbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY8 protein]19922557
C026690cerous chloridecerous chloride results in decreased expression of ADCY8 mRNA23573234
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of ADCY8 mRNA18636392
D003042CocaineCocaine affects the expression of ADCY8 mRNA20187946
D016572CyclosporineCyclosporine results in decreased expression of ADCY8 mRNA20106945
D003907Dexamethasone[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of ADCY8 mRNA29288687
D003976DiazinonDiazinon results in decreased expression of ADCY8 mRNA17452286
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ADCY8 mRNA18164116
D000431EthanolEthanol results in increased expression of ADCY8 mRNA20655511
D005473FluoxetineFluoxetine results in decreased expression of ADCY8 mRNA17033635
D004397FonofosFonofos results in increased methylation of ADCY8 promoter22847954
C004312glycidolglycidol results in decreased expression of ADCY8 mRNA24915197
D0150561-Methyl-3-isobutylxanthine[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of ADCY8 mRNA29288687
D007649KetamineKetamine results in decreased expression of ADCY8 mRNA20080153
D007854LeadLead affects the expression of ADCY8 mRNA28903495
C008261lead acetatelead acetate results in increased expression of ADCY8 mRNA20542052
C008261lead acetatelead acetate results in increased expression of ADCY8 mRNA11578147
C432503licarin A[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of ADCY8 mRNA29288687
C018091maduramicinmaduramicin results in decreased expression of ADCY8 mRNA29128925
D009020MorphineADCY8 protein affects the susceptibility to Morphine16914643
D009020Morphine[ADCY8 protein co-treated with ADCY1 protein] affects the susceptibility to Morphine16914643
D009020MorphineMorphine affects the expression of ADCY8 mRNA15829634
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ADCY8 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ADCY8 mRNA"25554681
D010100OxygenOxygen deficiency results in increased expression of ADCY8 mRNA24236059
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of ADCY8 mRNA18636392
D010278ParathionParathion results in increased methylation of ADCY8 promoter22847954
D010705PhosgenePhosgene affects the expression of ADCY8 mRNA16300373
D011441PropylthiouracilPropylthiouracil results in increased expression of ADCY8 mRNA24780913
C071262SK&F 82958Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY8 protein]19922557
C071262SK&F 82958[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY8 protein19922557
D053260SootSoot results in decreased expression of ADCY8 mRNA26551751
C012568terbufosterbufos results in increased methylation of ADCY8 promoter22847954
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ADCY8 mRNA20133372
D014635Valproic AcidValproic Acid results in increased expression of ADCY8 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of ADCY8 gene28853863
C066075vanadium pentoxidevanadium pentoxide affects the expression of ADCY8 mRNA26210822

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004016adenylate cyclase activity-TAS-  
GO:0005524ATP binding-IEA-  
GO:0008294calcium- and calmodulin-responsive adenylate cyclase activity-TAS8163524  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003091renal water homeostasis-TAS-  
GO:0006171cAMP biosynthetic process-IBA21873635  
GO:0006171cAMP biosynthetic process-IEA-  
GO:0007165signal transduction-TAS8076676  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-TAS-  
GO:0007611learning or memory-TAS8076676  
GO:0007616long-term memory-IEA-  
GO:0019933cAMP-mediated signaling-IBA21873635  
GO:0071377cellular response to glucagon stimulus-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-TAS8163524  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa04020Calcium signaling pathway
hsa04062Chemokine signaling pathway
hsa04114Oocyte meiosis
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04720Long-term potentiation
hsa04742Taste transduction
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04916Melanogenesis
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04976Bile secretion
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-111885Opioid SignallingTAS
R-HSA-111885Opioid SignallingIEA
R-HSA-111931PKA-mediated phosphorylation of CREBTAS
R-HSA-111933Calmodulin induced eventsTAS
R-HSA-111996Ca-dependent eventsTAS
R-HSA-111997CaM pathwayTAS
R-HSA-112040G-protein mediated eventsTAS
R-HSA-112040G-protein mediated eventsIEA
R-HSA-112043PLC beta mediated eventsTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionIEA
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112315Transmission across Chemical SynapsesIEA
R-HSA-112316Neuronal SystemTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-1430728MetabolismTAS
R-HSA-1489509DAG and IP3 signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-163359Glucagon signaling in metabolic regulationTAS
R-HSA-163615PKA activationTAS
R-HSA-163685Integration of energy metabolismTAS
R-HSA-164378PKA activation in glucagon signallingTAS
R-HSA-170660Adenylate cyclase activating pathwayTAS
R-HSA-170670Adenylate cyclase inhibitory pathwayTAS
R-HSA-170670Adenylate cyclase inhibitory pathwayIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretionTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-418555G alpha (s) signalling eventsIEA
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-418597G alpha (z) signalling eventsIEA
R-HSA-418597G alpha (z) signalling eventsTAS
R-HSA-422356Regulation of insulin secretionTAS
R-HSA-432040Vasopressin regulates renal water homeostasis via AquaporinsTAS
R-HSA-438064Post NMDA receptor activation eventsTAS
R-HSA-442720CREB phosphorylation through the activation of Adenylate CyclaseTAS
R-HSA-442755Activation of NMDA receptor and postsynaptic eventsTAS
R-HSA-445717Aquaporin-mediated transportTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-977443GABA receptor activationTAS
R-HSA-977443GABA receptor activationIEA
R-HSA-977444GABA B receptor activationTAS
R-HSA-977444GABA B receptor activationIEA
R-HSA-991365Activation of GABAB receptorsTAS
R-HSA-991365Activation of GABAB receptorsIEA
R-HSA-997269Inhibition of adenylate cyclase pathwayTAS
R-HSA-997269Inhibition of adenylate cyclase pathwayIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23278386Genetic markers of comorbid depression and alcoholism in women. (2013 Jun)Procopio DOAlcohol Clin Exp Res