Gene: CHRNB1

1140
ACHRB|CHRNB|CMS1D|CMS2A|CMS2C|SCCMS
cholinergic receptor nicotinic beta 1 subunit
protein-coding
17p13.1
Ensembl:ENSG00000170175 MIM:100710 Vega:OTTHUMG00000108139 UniprotKB:P11230
NG_008026.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.406e-2 (AD)  4.567e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMED10.827
SNAPIN0.825
PTPMT10.824
SMIM200.812
TMCO10.81
COA40.808
CDK40.806
RAB9A0.805
HIBADH0.795
RFXANK0.793

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.628
OR4F29-0.572
CETP-0.274
OR6C74-0.247
C17orf112-0.222
FER1L6-0.22
UBE2NL-0.216
HMHB1-0.216
FOXE1-0.213
OR52E4-0.204

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00674GalantamineSmall Molecule357-70-0ApprovedTarget
ID Drug Name Action PubMed
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of CHRNB1 mRNA25088246
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]22461452
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]22461452
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNE protein binds to CHRND protein]16931985
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]22461452
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]22461452
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]23146756
D000109Acetylcholinepoly-APS inhibits the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]]23146756
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid binds to and results in increased activity of [CHRNA5 protein co-treated with CHRNB1 protein]8388298
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHRNB1 mRNA16483693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CHRNB1 mRNA18164116
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of CHRNB1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CHRNB1 mRNA20106945
C006780bisphenol Abisphenol A affects the expression of CHRNB1 mRNA25181051
D002038BungarotoxinsBungarotoxins binds to [CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNG protein]9336329
D002038BungarotoxinsNicotine inhibits the reaction [Bungarotoxins binds to [CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNG protein]]9336329
D002038Bungarotoxinspozanicline inhibits the reaction [Bungarotoxins binds to [CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNG protein]]9336329
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CHRNB1 mRNA17484886
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of CHRNB1 mRNA18636392
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHRNB1 mRNA20938992
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of CHRNB1 mRNA15467011
D019327Copper SulfateCopper Sulfate results in decreased expression of CHRNB1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of CHRNB1 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CHRNB1 mRNA24317228
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of CHRNB1 mRNA23640034
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CHRNB1 mRNA17361019|2126653
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CHRNB1 mRNA18164116
D004237DiuronDiuron results in increased expression of CHRNB1 mRNA25152437
C118739entinostatentinostat results in increased expression of CHRNB1 mRNA27188386
D000431EthanolEthanol results in decreased expression of CHRNB1 protein20621659
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHRNB1 mRNA20938992
C039281furanfuran results in increased expression of CHRNB1 mRNA25539665
C015542gaboxadolgaboxadol binds to and results in increased activity of [CHRNA5 protein co-treated with CHRNB1 protein]8388298
D017313FenretinideFenretinide results in increased expression of CHRNB1 mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of CHRNB1 mRNA21396975
D007213IndomethacinIndomethacin results in increased expression of CHRNB1 mRNA28201806
C544151jinfukangjinfukang results in increased expression of CHRNB1 mRNA27392435
D008627Mercuric ChlorideMercuric Chloride inhibits the reaction [AGRN protein results in increased phosphorylation of CHRNB1 protein]15045580
D008694MethamphetamineMethamphetamine results in increased expression of CHRNB1 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHRNB1 mRNA20938992
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CHRNB1 mRNA23519560
D009118MuscimolMuscimol binds to and results in increased activity of [CHRNA5 protein co-treated with CHRNB1 protein]8388298
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CHRNB1 mRNA"25554681
D009538NicotineNicotine inhibits the reaction [Bungarotoxins binds to [CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNG protein]]9336329
D010100OxygenOxygen deficiency results in increased expression of CHRNB1 mRNA26516004
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of CHRNB1 mRNA18636392
D010269ParaquatParaquat results in increased expression of CHRNB1 mRNA17077588
D010936Plant ExtractsPlant Extracts results in decreased expression of CHRNB1 mRNA23557933
C115254poly-APSpoly-APS inhibits the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]]23146756
C108326pozaniclinepozanicline inhibits the reaction [Bungarotoxins binds to [CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNG protein]]9336329
D011441PropylthiouracilPropylthiouracil results in increased expression of CHRNB1 mRNA24780913
C059514resveratrolresveratrol results in decreased expression of CHRNB1 protein18089832
D012524SarinSarin results in decreased expression of CHRNB1 mRNA19522546
C534628SCH 23390SCH 23390 results in decreased expression of CHRNB1 mRNA19564919
C560328sulfoxaflorsulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]22461452
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CHRNB1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CHRNB1 promoter]19654925
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CHRNB1 mRNA23519560
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CHRNB1 mRNA28111298
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CHRNB1 protein26746805
D014638VanadatesVanadates results in decreased expression of CHRNB1 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0015267channel activity-IMP8872460  
GO:0015276ligand-gated ion channel activity-ISS-  
GO:0015464acetylcholine receptor activityCONTRIBUTES_TOIBA21873635  
GO:0015464acetylcholine receptor activitycontributes_toIMP8651643  8872460  
GO:0022848acetylcholine-gated cation-selective channel activitycontributes_toISS-  
GO:0042166acetylcholine bindingCONTRIBUTES_TOIBA21873635  
GO:0042166acetylcholine binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001941postsynaptic membrane organization-IMP8651643  
GO:0003009skeletal muscle contraction-IEA-  
GO:0006812cation transport-IMP8872460  
GO:0006936muscle contraction-IMP8651643  
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-IMP8872460  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007271synaptic transmission, cholinergic-IBA21873635  
GO:0007271synaptic transmission, cholinergic-IMP8872460  
GO:0007274neuromuscular synaptic transmission-IBA21873635  
GO:0007274neuromuscular synaptic transmission-IMP8651643  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0035094response to nicotine-IBA21873635  
GO:0035095behavioral response to nicotine-IMP16874522  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0042391regulation of membrane potential-ISS-  
GO:0048747muscle fiber development-IMP8651643  
GO:0050877nervous system process-IBA21873635  
GO:0050877nervous system process-IMP11104662  
GO:0060079excitatory postsynaptic potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-NAS8872460  
GO:0005892acetylcholine-gated channel complex-IBA21873635  
GO:0005892acetylcholine-gated channel complex-IMP8872460  
GO:0030054cell junction-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045202synapse-IMP8872460  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20584212Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (2010 Oct)Saccone NLGenes Brain Behav
27473937Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence. (2016 Dec)Zuo LAm J Med Genet B Neuropsychiatr Genet
19307444Examination of the nicotine dependence (NICSNP) consortium findings in the Iowa adoption studies population. (2009 Mar)Philibert RANicotine Tob Res