Gene: CHRNB2

1141
EFNL3|nAChRB2
cholinergic receptor nicotinic beta 2 subunit
protein-coding
1q21.3
Ensembl:ENSG00000160716 MIM:118507 Vega:OTTHUMG00000037262 UniprotKB:P17787
NG_008027.1
PubMed|SNP Mapped
ND|AD
34   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.302e-1 (AD)  6.563e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2072661chr1:154576404 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24498305chr1:154540904CHRNB2Gene body1.553e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SVOP0.962
DLG30.961
GRIN2B0.959
RIMKLA0.959
GLT1D10.958
UNC13A0.957
FADS60.957
ATP8A20.957
SCN2B0.953
PLXNA40.952

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.651
RAB13-0.642
REST-0.64
MYL3-0.639
WWTR1-0.637
RNF135-0.635
RAI14-0.624
CSAG1-0.622
CLEC2B-0.621
CNN2-0.62

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00184NicotineSmall Molecule54-11-5ApprovedTarget
DB00514DextromethorphanSmall Molecule125-71-3ApprovedTarget
DB00564CarbamazepineSmall Molecule298-46-4Approved|InvestigationalTarget
DB00572AtropineSmall Molecule51-55-8ApprovedTarget
DB00657MecamylamineSmall Molecule60-40-2Approved|InvestigationalTarget
DB00674GalantamineSmall Molecule357-70-0ApprovedTarget
DB00747ScopolamineSmall Molecule51-34-3Approved|InvestigationalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB00981PhysostigmineSmall Molecule57-47-6Approved|InvestigationalTarget
DB01245DecamethoniumSmall Molecule156-74-1ApprovedTarget
DB01273VareniclineSmall Molecule249296-44-4Approved|InvestigationalTarget
DB05458PozaniclineSmall Molecule161417-03-4InvestigationalTarget
DB05740RPI-78MSmall Molecule-InvestigationalTarget
DB05855RivaniclineSmall Molecule15585-43-0InvestigationalTarget
DB07720EpibatidineSmall Molecule140111-52-0ExperimentalTarget
DB09028CytisineSmall Molecule485-35-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C4825181,2-bis-N-cytisinylethane"1,2-bis-N-cytisinylethane promotes the reaction [CHRNA3 protein binds to CHRNB2 protein]"16273122
C4825181,2-bis-N-cytisinylethane"1,2-bis-N-cytisinylethane promotes the reaction [CHRNA3 protein binds to CHRNB2 protein binds to CHRNB4 protein]"16273122
C4825181,2-bis-N-cytisinylethane"1,2-bis-N-cytisinylethane results in increased localization of [CHRNA3 protein binds to CHRNB2 protein]"16273122
C4825181,2-bis-N-cytisinylethane"1,2-bis-N-cytisinylethane results in increased localization of [CHRNA3 protein binds to CHRNB2 protein binds to CHRNB4 protein]"16273122
C54451613,19-didesmethyl spirolide C"13,19-didesmethyl spirolide C binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]"26063663
C51717013-desmethylspirolide C13-desmethylspirolide C binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]26063663
C4191571-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]11150171
C5696712-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane"2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]"21942635
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased susceptibility to Okadaic Acid]21715663
C0359762,4,2',4'-tetrachlorobiphenyl"2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]"20861069
C0359762,4,2',4'-tetrachlorobiphenyl"[3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]"20861069
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased susceptibility to Okadaic Acid]21715663
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CHRNB2 mRNA"15215175
C1167333-(2-(pyrrolidinyl)methoxy)pyridine3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
C1167333-(2-(pyrrolidinyl)methoxy)pyridineDihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16569710
C1167333-(2-(pyrrolidinyl)methoxy)pyridine3-(2-(pyrrolidinyl)methoxy)pyridine analog affects the activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
C1167333-(2-(pyrrolidinyl)methoxy)pyridine3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]16569710
C0857943,5-dibromo-2-(2,4-dibromophenoxy)phenol"[3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]"20861069
C0857943,5-dibromo-2-(2,4-dibromophenoxy)phenol"3,5-dibromo-2-(2,4-dibromophenoxy)phenol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]"20861069
C0883833-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]7913497
C0883833-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10942032
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CHRNB2 mRNA"18648102
C0415944-nonylphenol4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
C0804174-octylphenol4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
C1097635-(2-azetidinylmethoxy)-2-chloropyridine5-(2-azetidinylmethoxy)-2-chloropyridine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]17115136
C4763785-azidoepibatidine5-azidoepibatidine binds to [CHRNA2 protein co-treated with CHRNB2 protein]12565964
C4267455-iodo-3-(2-azetidinylmethoxy)pyridine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased susceptibility to Okadaic Acid]21715663
C4267455-iodo-3-(2-azetidinylmethoxy)pyridine2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased susceptibility to Okadaic Acid]21715663
C4267455-iodo-3-(2-azetidinylmethoxy)pyridine[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein]21715663
C4267455-iodo-3-(2-azetidinylmethoxy)pyridine[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein modified form]21715663
C4267455-iodo-3-(2-azetidinylmethoxy)pyridine[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]21715663
C4267455-iodo-3-(2-azetidinylmethoxy)pyridine[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased susceptibility to Okadaic Acid21715663
C4267455-iodo-3-(2-azetidinylmethoxy)pyridine[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium21715663
C4267455-iodo-3-(2-azetidinylmethoxy)pyridine[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in increased phosphorylation of GSK3B protein21715663
C4267455-iodo-3-(2-azetidinylmethoxy)pyridine[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in increased phosphorylation of MAPK1 protein21715663
C4267455-iodo-3-(2-azetidinylmethoxy)pyridine[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in increased phosphorylation of MAPK3 protein21715663
C4267455-iodo-3-(2-azetidinylmethoxy)pyridinealpha-conotoxin MII inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium]21715663
C4267455-iodo-3-(2-azetidinylmethoxy)pyridineCalcium affects the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased susceptibility to Okadaic Acid]21715663
C4267455-iodo-3-(2-azetidinylmethoxy)pyridineDihydro-beta-Erythroidine inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium]21715663
C4267455-iodo-3-(2-azetidinylmethoxy)pyridineMecamylamine inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium]21715663
C4267455-iodo-3-(2-azetidinylmethoxy)pyridine5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein21715663
C104288A 85380A 85380 binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]17115136
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of CHRNB2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CHRNB2 mRNA]17585979
C464485acetamipridacetamiprid results in decreased expression of CHRNB227669271
C464485acetamipridacetamiprid results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]16981889|2545928
C464485acetamipridacetamiprid results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]25459289
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]14608492
D000109AcetylcholineAcetylcholine results in increased activity of [NACHRALPHA1 protein binds to CHRNB2 protein]24291321
D000109AcetylcholineAcetylcholine results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]14608492
D000109AcetylcholineAcetylcholine results in increased activity of [NACHRALPHA2 protein co-treated with CHRNB2 protein]14608492
D000109Acetylcholinenereistoxin inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]14608492
D000109Acetylcholinenereistoxin inhibits the reaction [Acetylcholine results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]]14608492
D000109Acetylcholinenereistoxin inhibits the reaction [Acetylcholine results in increased activity of [NACHRALPHA2 protein co-treated with CHRNB2 protein]]14608492
D000109Acetylcholine1-Butanol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]12604691
D000109Acetylcholine"2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]"20861069
D000109Acetylcholine"[3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]"20861069
D000109Acetylcholine"3,5-dibromo-2-(2,4-dibromophenoxy)phenol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]"20861069
D000109Acetylcholine4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D000109Acetylcholine4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D000109AcetylcholineAcetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]15733544
D000109AcetylcholineAcetylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]15885267|1693198
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]12604691|1464565
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]20132834|2275035
D000109AcetylcholineAluminum Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109Acetylcholineantimony trioxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109AcetylcholineAtracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]16931985
D000109AcetylcholineAtracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D000109AcetylcholineAtropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D000109AcetylcholineBentonite inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109Acetylcholinebisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D000109Acetylcholinecisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]16931985
D000109Acetylcholinecisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D000109Acetylcholineclothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]21538459
D000109Acetylcholinedecabromobiphenyl ether inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109Acetylcholinedesformylflustrabromine promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]21905680
D000109AcetylcholineDichlorvos inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D000109AcetylcholineDiethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D000109Acetylcholine[Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11517245
D000109Acetylcholine[Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11517245
D000109AcetylcholineEthinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D000109AcetylcholineFire Trol 934 inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109AcetylcholineFlame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]22547355
D000109AcetylcholineFlame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109AcetylcholineGalantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D000109Acetylcholineimidacloprid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]21538459
D000109AcetylcholineMagnesium Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109Acetylcholinemivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]16931985
D000109Acetylcholinemivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D000109Acetylcholine"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]"20132834
D000109AcetylcholinePancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]16931985
D000109AcetylcholinePancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D000109AcetylcholinePhysostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D000109Acetylcholine[Progesterone co-treated with Acetylcholine] results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]11517245
D000109AcetylcholineRivastigmine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D000109Acetylcholinerocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]16931985
D000109Acetylcholinerocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D000109AcetylcholineScopolamine Hydrobromide promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D000109AcetylcholineTacrine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D000109AcetylcholineTamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D000109Acetylcholinetetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]22547355
D000109Acetylcholinetetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109AcetylcholineTetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]15885267
D000109AcetylcholineTetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]15885267
D000109AcetylcholineToluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]15885267
D000109AcetylcholineToluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]15885267
D000109Acetylcholinetriphenyl phosphate inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000109AcetylcholineTubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D000109AcetylcholineTubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]16931985
D000109AcetylcholineTubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D000109AcetylcholineTubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]11711029
D000109AcetylcholineVecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]16931985
D000109AcetylcholineVecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein alternative form]16569710
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]16569710
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein alternative form]16569710
D000109AcetylcholineEstradiol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16569710
D000109AcetylcholineEstradiol promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]]16569710
D000109AcetylcholineAcetylcholine analog binds to [CHRNA4 protein binds to CHRNB2 protein]19252481
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11812690
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]7808438
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]7808438
D000109AcetylcholineAcetylcholine binds to [CHRNA4 protein binds to CHRNB2 protein]19252481
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]19619141
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]15885267
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]15885267
D000109AcetylcholineAcetylcholine results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]16981889|1904635
D000109AcetylcholineAcetylcholine results in increased activity of [NACHRA1 protein co-treated with NACHRA2 protein co-treated with CHRNB2 protein]19046356
D000109AcetylcholineAcetylcholine results in increased activity of [NACHRA2 protein co-treated with CHRNB2 protein]19046356
D000109AcetylcholineAcetylcholine results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]25459289
D000109AcetylcholineBungarotoxins inhibits the reaction [Acetylcholine results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]]19046356
D000109AcetylcholineBungarotoxins inhibits the reaction [Acetylcholine results in increased activity of [NACHRA1 protein co-treated with NACHRA2 protein co-treated with CHRNB2 protein]]19046356
D000109AcetylcholineBungarotoxins inhibits the reaction [Acetylcholine results in increased activity of [NACHRA2 protein co-treated with CHRNB2 protein]]19046356
D000109Acetylcholine[CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Barium results in increased susceptibility to Acetylcholine]12754307
D000109Acetylcholine[CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Calcium results in increased susceptibility to Acetylcholine]12754307
D000109Acetylcholine[CHRNA4 protein co-treated with CHRNB2 protein] affects the susceptibility to Acetylcholine12754307
D000109Acetylcholine[CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]12754307
D000109Acetylcholine[CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Barium results in increased susceptibility to Acetylcholine]12754307
D000109Acetylcholine[CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]12754307
D000109AcetylcholineDihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
D000109Acetylcholine[Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11517245
D000109AcetylcholineExcitatory Amino Acid Antagonists inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
D000109AcetylcholineFG 9041 inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
D000109AcetylcholineLYNX1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]19619141
D000109AcetylcholineLYPD1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]19619141
D000109AcetylcholineMecamylamine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
D000109Acetylcholine[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB2 protein]12130716
D000109Acetylcholine[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine18385335
D000109AcetylcholineTetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]15885267
D000109AcetylcholineTetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]15885267
D000109AcetylcholineToluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]15885267
D000109AcetylcholineToluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]15885267
D000109AcetylcholineTubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]7808438
D000109AcetylcholineTubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]7808438
D000109AcetylcholineUrethane promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]11812690
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]7891159
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]9397513
D000109AcetylcholineFlufenamic Acid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]7891159
D000109AcetylcholineNiflumic Acid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]7891159
D000122AcetylthiocholineAcetylthiocholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D000443AlcuroniumAlcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D000443AlcuroniumAlcuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
C005915Allura Red AC Dye[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of CHRNB2 protein23429044
C098872alpha-conotoxin MIIalpha-conotoxin MII inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium]21715663
C098872alpha-conotoxin MIIalpha-conotoxin MII results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]18450646
D000536Aluminum HydroxideAluminum Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D000639AmitriptylineCHRNB2 protein results in increased susceptibility to Amitriptyline21905669
D000639AmitriptylineAmitriptyline results in decreased expression of CHRNB2 mRNA21820738
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHRNB2 mRNA16483693
D000691AnabasineAnabasine analog binds to [CHRNA4 protein binds to CHRNB2 protein]15615518
C037554antimony trioxideantimony trioxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D001279AtracuriumAtracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]16931985
D001279AtracuriumAtracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D001285AtropineAtropine binds to [CHRNA4 protein binds to CHRNB2 protein]15733544
D001285AtropineAtropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D001285AtropineAtropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]21791372
D001285AtropineAtropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]21791372
D001464Barium[CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Barium results in increased susceptibility to Acetylcholine]12754307
D001464Barium[CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Barium results in increased susceptibility to Acetylcholine]12754307
D001546BentoniteBentonite inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
C004873beta-erythroidinebeta-erythroidine binds to and results in decreased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
C004873beta-erythroidinebeta-erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
D004958Estradiol[Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11517245
D004958EstradiolEstradiol results in decreased expression of CHRNB2 mRNA19484750
D004958EstradiolEstradiol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16569710
D004958EstradiolEstradiol promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]]16569710
C006780bisphenol Abisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of CHRNB2 gene28505145
C006780bisphenol Abisphenol A results in increased expression of CHRNB2 mRNA29097150
D001761BleomycinBleomycin results in decreased expression of CHRNB2 mRNA15808516
C006796brilliant blue[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of CHRNB2 protein23429044
D002038BungarotoxinsBungarotoxins binds to [NACHRA1 protein co-treated with NACHRA2 protein co-treated with CHRNB2 protein]19046356
D002038BungarotoxinsBungarotoxins binds to [NACHRA2 protein co-treated with CHRNB2 protein]19046356
D002038BungarotoxinsBungarotoxins binds to [NACHRALPHA3 protein co-treated with CHRNB2 protein]10728888
D002038BungarotoxinsBungarotoxins inhibits the reaction [Acetylcholine results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]]19046356
D002038BungarotoxinsBungarotoxins inhibits the reaction [Acetylcholine results in increased activity of [NACHRA1 protein co-treated with NACHRA2 protein co-treated with CHRNB2 protein]]19046356
D002038BungarotoxinsBungarotoxins inhibits the reaction [Acetylcholine results in increased activity of [NACHRA2 protein co-treated with CHRNB2 protein]]19046356
D0200011-Butanol1-Butanol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]12604691
D0200011-Butanol1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]12604691
D0200011-ButanolDihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]12604691
D0200011-ButanolMecamylamine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]12604691
D002118Calcium[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium21715663
D002118Calciumalpha-conotoxin MII inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium]21715663
D002118CalciumCalcium affects the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased susceptibility to Okadaic Acid]21715663
D002118CalciumDihydro-beta-Erythroidine inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium]21715663
D002118CalciumMecamylamine inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium]21715663
D002118Calcium[CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Calcium results in increased susceptibility to Acetylcholine]12754307
D002118Calcium[CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]12754307
D002118Calcium[CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]12754307
D002217CarbacholCarbachol binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D002217CarbacholCarbachol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
D002217CarbacholCarbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]14645658
D002217CarbacholCarbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]14645658
D002217CarbacholCarbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D002217CarbacholCarbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]14645658
D002217CarbacholCarbachol results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D002217CarbacholCarbachol binds to [CHRNA4 protein binds to CHRNB2 protein]15615518
D002217CarbacholCarbachol inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
D002217CarbacholCarbachol results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11708903
D002220CarbamazepineCarbamazepine binds to [CHRNA4 protein binds to CHRNB2 protein]12110613
D012721CarbarylCarbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]14644616
D012721CarbarylCarbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14644616
D002245Carbon DioxideNicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNB2 protein]28235547
D002245Carbon Dioxide[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNB2 protein28235547
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CHRNB2 mRNA16644059
D002714ChlorisondamineChlorisondamine results in decreased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]16569710
D002714ChlorisondamineChlorisondamine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
D004390ChlorpyrifosChlorpyrifos results in increased expression of CHRNB2 mRNA17452286
D002794CholineCholine results in increased activity of [NACHRALPHA1 protein binds to CHRNB2 protein]24291321
D002794CholineCholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D002794CholineCholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C101584cisatracuriumcisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]16931985
C101584cisatracuriumcisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of CHRNB2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CHRNB2 mRNA]17585979
C480342clothianidinclothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]21538459
C480342clothianidinclothianidin results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]16981889|2545928
C480342clothianidinclothianidin results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]25459289
D003042CocaineCHRNB2 protein results in increased susceptibility to Cocaine11282258
D003042CocaineCocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]10336510
D003042CocaineCocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]10336510
D016572CyclosporineCyclosporine results in decreased expression of CHRNB2 mRNA22147139
D016572CyclosporineCyclosporine results in increased methylation of CHRNB2 promoter27989131
C004712cytisinecytisine binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
C004712cytisinecytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
C004712cytisinecytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]20331614
C004712cytisinecytisine binds to [CHRNA4 protein binds to CHRNB2 protein]9336329
C004712cytisinecytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C004712cytisinecytisine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
C004712cytisineNicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]9336329
C004712cytisinepozanicline inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]9336329
C004712cytisinecytisine affects the expression of CHRNB2 protein7756618
C004712cytisinecytisine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]7756618
C004712cytisinecytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10942032|1711513
C004712cytisinecytisine binds to [CHRNA4 protein binds to CHRNB2 protein]11124396
C010902decabromobiphenyl etherdecabromobiphenyl ether inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
C033019decamethoniumdecamethonium binds to and results in decreased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
C033019decamethoniumdecamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
C033019decamethoniumCarbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]14645658
C033019decamethoniumdecamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
C033019decamethoniumdecamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C033019decamethoniumdecamethonium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
C524215desformylflustrabrominedesformylflustrabromine promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]21905680
C529522desnitroimidaclopriddesnitroimidacloprid results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]12460746
D003976DiazinonDiazinon affects the expression of CHRNB2 mRNA17452286
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CHRNB2 mRNA28962523
D004006DichlorvosDichlorvos inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D004041Dietary FatsDietary Fats results in increased expression of CHRNB2 mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D004079Dihydro-beta-ErythroidineCarbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]14645658
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]12604691
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium]21715663
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]20100906
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16569710
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]16569710
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]19047205
D004079Dihydro-beta-Erythroidine[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine10945867|1691538
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine binds to and affects the activity of [CHRNA3 protein binds to CHRNB2 protein]12604094
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]10945867|1260409
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine binds to and results in decreased activity of CHRNB2 protein18385335
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]16601104
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]16601104
D004246Dimethylphenylpiperazinium IodideDimethylphenylpiperazinium Iodide binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D004246Dimethylphenylpiperazinium IodideDimethylphenylpiperazinium Iodide binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
D004246Dimethylphenylpiperazinium IodideDimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D004246Dimethylphenylpiperazinium IodideDimethylphenylpiperazinium Iodide results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
C465368dinotefurandinotefuran results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]16981889|2545928
C465368dinotefurandinotefuran results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]25459289
D004298DopamineNicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine]17227438
D004298Dopamine[pozanicline binds to and results in increased activity of [CHRNA6 protein binds to CHRNB2 protein]] which results in increased secretion of Dopamine19481067
C082748epibatidineepibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
C082748epibatidineepibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
C082748epibatidineTretinoin inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]17203487
C082748epibatidineAcetylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineAcetylthiocholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineAlcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineCarbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineCholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidinecytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidinedecamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineDihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineDimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineepibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]22060139
C082748epibatidineepibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]14645658
C082748epibatidineepibatidine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
C082748epibatidineHexamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineLobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidinemethyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineNicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidinePancuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidinePhysostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidinesubecholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineSuccinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineTubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidineVecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C082748epibatidine"2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]"21942635
C082748epibatidineepibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]19619141
C082748epibatidineepibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNB2 protein]21905669
C082748epibatidineepibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]21905669
C082748epibatidineepibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]11124396|1561551
C082748epibatidineepibatidine binds to [CHRNA4 protein co-treated with CHRNB2 protein]10728888
C082748epibatidineepibatidine binds to [NACHRA2 protein co-treated with CHRNB2 protein]16291090
C082748epibatidineepibatidine binds to [NACHRALPHA1 protein co-treated with CHRNB2 protein]10728888
C082748epibatidineepibatidine binds to [NACHRALPHA2 protein co-treated with CHRNB2 protein]10728888|1629109
C082748epibatidineepibatidine binds to [NACHRALPHA3 protein co-treated with CHRNB2 protein]10728888
C082748epibatidineepibatidine results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]16981889
C082748epibatidineLYNX1 protein promotes the reaction [epibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]19619141
C082748epibatidineLYPD1 protein promotes the reaction [epibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]19619141
C082748epibatidinesazetidine-A analog inhibits the reaction [epibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNB2 protein]]21905669
C082748epibatidinesazetidine-A analog inhibits the reaction [epibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]21905669
C082748epibatidineepibatidine analog binds to and affects the activity of [CHRNA4 protein binds to CHRNB2 protein]20038125
C082748epibatidineepibatidine analog inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
C082748epibatidineepibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]20038125
C082748epibatidineepibatidine inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
C082748epibatidineepibatidine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11708903
C036251EPTCEPTC results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]14644616
C036251EPTCEPTC results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14644616
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11517245
D004997Ethinyl EstradiolEthinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D004997Ethinyl EstradiolTubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]11711029
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11517245
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CHRNB2 mRNA29097150
D018691Excitatory Amino Acid AntagonistsExcitatory Amino Acid Antagonists inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
C005842FD & C Yellow No. 6[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of CHRNB2 protein23429044
C052034fenoxycarbfenoxycarb results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]14644616
C052034fenoxycarbfenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14644616
C056723FG 9041FG 9041 inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
C508049Fire Trol 934Fire Trol 934 inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D005411Flame RetardantsFlame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]22547355
D005411Flame RetardantsFlame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D005439Flufenamic AcidFlufenamic Acid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]7891159
D005505Food Coloring AgentsFood Coloring Agents results in increased expression of CHRNB2 protein23429044
C039281furanfuran results in decreased expression of CHRNB2 mRNA25539665|2619464
D005702GalantamineGalantamine binds to [CHRNA4 protein binds to CHRNB2 protein]15733544
D005702GalantamineGalantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of CHRNB2 gene28505145
D019086Bridged Bicyclo Compounds, Heterocyclic"Bridged Bicyclo Compounds, Heterocyclic binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]"21962147
D006582HexachloropheneHexachlorophene results in decreased expression of CHRNB2 mRNA25943520
D006582HexachloropheneHexachlorophene results in decreased expression of CHRNB2 mRNA25497112
D018738HexamethoniumHexamethonium binds to and results in decreased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D018738HexamethoniumHexamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
D018738HexamethoniumHexamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D018738HexamethoniumHexamethonium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D018738HexamethoniumHexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]7756618
C082359imidaclopridimidacloprid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]21538459
C082359imidaclopridimidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]10377228
C082359imidaclopridimidacloprid binds to [CHRNA4 protein co-treated with CHRNB2 protein]10728888
C082359imidaclopridimidacloprid binds to [NACHRA1 protein co-treated with CHRNB2 protein]18824080
C082359imidaclopridimidacloprid binds to [NACHRA2 protein co-treated with CHRNB2 protein]16291090
C082359imidaclopridimidacloprid binds to [NACHRALPHA1 protein co-treated with CHRNB2 protein]10728888
C082359imidaclopridimidacloprid binds to [NACHRALPHA2 protein co-treated with CHRNB2 protein]10728888|1629109
C082359imidaclopridimidacloprid binds to [NACHRALPHA3 protein co-treated with CHRNB2 protein]10728888
C082359imidaclopridimidacloprid results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]19619141
C082359imidaclopridimidacloprid results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]16981889|1904635
C082359imidaclopridimidacloprid results in increased activity of [NACHRA1 protein co-treated with NACHRA2 protein co-treated with CHRNB2 protein]19046356
C082359imidaclopridimidacloprid results in increased activity of [NACHRA2 protein co-treated with CHRNB2 protein]19046356
C082359imidaclopridimidacloprid results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]25459289
C082359imidaclopridLYNX1 protein promotes the reaction [imidacloprid results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]19619141
C082359imidaclopridLYPD1 protein promotes the reaction [imidacloprid results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]19619141
C082359imidacloprid[NACHRA8 protein co-treated with CHRNB2 protein] affects the susceptibility to imidacloprid25613467
C082359imidaclopridimidacloprid analog inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
C082359imidaclopridimidacloprid analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11708903
C082359imidaclopridimidacloprid inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
C082359imidaclopridimidacloprid promotes the reaction [Nicotine binds to [CHRNA4 protein co-treated with CHRNB2 protein]]11076703
C082359imidaclopridimidacloprid results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11708903
D007203Indigo Carmine[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of CHRNB2 protein23429044
C490152isproniclineispronicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]20167427
D008120Lobeline[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]18448488
D008120Lobeline[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]18448488
D008120Lobeline[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]18448488
D008120LobelineLobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D008120LobelineLobeline results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D008120LobelineLobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]18448488
D008276Magnesium HydroxideMagnesium Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D008464MecamylamineMecamylamine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D008464MecamylamineMecamylamine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]12604691
D008464MecamylamineMecamylamine inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium]21715663
D008464MecamylamineMecamylamine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D008464MecamylamineCHRNB2 protein results in increased susceptibility to Mecamylamine21905669
D008464MecamylamineMecamylamine inhibits the reaction [Tacrine results in increased expression of CHRNB2 protein]8930989
D008464MecamylamineMecamylamine results in decreased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]16569710
D008464MecamylamineMecamylamine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
D008464MecamylamineAtropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]21791372
D008464MecamylamineAtropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]21791372
D008464MecamylamineMecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]21791372
D008464MecamylamineMecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]21791372
D008464MecamylamineMecamylamine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
D008627Mercuric Chloride[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB2 protein]12130716
C012419metanicotinemetanicotine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]19047205
C054634methyllycaconitineCarbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]14645658
C054634methyllycaconitinemethyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C054634methyllycaconitinemethyllycaconitine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
C054634methyllycaconitinemethyllycaconitine results in decreased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]16569710
C054634methyllycaconitinemethyllycaconitine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]"20132834
C049430mivacuriummivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]16931985
C049430mivacuriummivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
C524978N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]"17873105
C419158N-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidineN-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]11150171
D000073943NeonicotinoidsNeonicotinoids results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]19849723
C025633nereistoxinnereistoxin inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]14608492
C025633nereistoxinnereistoxin inhibits the reaction [Acetylcholine results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]]14608492
C025633nereistoxinnereistoxin inhibits the reaction [Acetylcholine results in increased activity of [NACHRALPHA2 protein co-treated with CHRNB2 protein]]14608492
D009538NicotineNicotine binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D009538NicotineNicotine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
D009538NicotineNicotine results in increased activity of [NACHRALPHA1 protein binds to CHRNB2 protein]24291321
D009538Nicotine[CHRNA4 protein binds to CHRNB2 protein] which results in increased susceptibility to Nicotine20943775
D009538Nicotine[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]18448488
D009538Nicotine[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]18448488
D009538Nicotine[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]18448488
D009538NicotineNicotine binds to [CHRNA4 protein binds to CHRNB2 protein]9336329
D009538NicotineNicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]9336329
D009538NicotineNicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D009538NicotineNicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D009538NicotineNicotine results in increased expression of CHRNB2 mRNA20457658
D009538NicotineCHRNB2 promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]21113126
D009538NicotineCHRNB2 protein affects the susceptibility to Nicotine14982698
D009538Nicotinecytisine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]7756618
D009538NicotineHexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]7756618
D009538NicotineNicotine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]19481067
D009538NicotineNicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine]17227438
D009538NicotineNicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]]17227438
D009538NicotineNicotine results in increased expression of CHRNB2 protein7756618
D009538NicotineTubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]7756618
D009538NicotineNicotine affects the activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]16569710
D009538NicotineNicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
D009538Nicotine1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]11150171
D009538NicotineCocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]10336510
D009538NicotineCocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]10336510
D009538Nicotine[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine10945867|1691538
D009538Nicotineimidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]10377228
D009538NicotineN-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]11150171
D009538NicotineNicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein]15615518|1925248
D009538NicotineNicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]10377228|1115017
D009538NicotineNicotine binds to [CHRNA4 protein binds to CHRNB2 protein]15615518|1925248
D009538NicotineNicotine results in decreased expression of CHRNB2 mRNA20060465
D009538NicotineNicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]10336510
D009538NicotineNicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]10336510
D009538NicotineNicotine results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]16981889
D009538NicotineNicotine results in increased expression of [CHRNA4 protein binds to CHRNB2 protein]11124396
D009538NicotineNicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNB2 protein]28235547
D009538NicotineCarbachol inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
D009538Nicotineepibatidine analog inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
D009538Nicotineepibatidine inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
D009538Nicotineimidacloprid analog inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
D009538Nicotineimidacloprid inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
D009538Nicotineimidacloprid promotes the reaction [Nicotine binds to [CHRNA4 protein co-treated with CHRNB2 protein]]11076703
D009538NicotineNicotine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11708903
D009538NicotineNicotine binds to [CHRNA4 protein binds to CHRNB2 protein]11708903
D009538NicotineNicotine binds to [CHRNA4 protein co-treated with CHRNB2 protein]11076703
D009538Nicotinethiacloprid analog inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
D009538Nicotinethiacloprid inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
D009538Nicotinethiacloprid promotes the reaction [Nicotine binds to [CHRNA4 protein co-treated with CHRNB2 protein]]11076703
D009544Niflumic AcidNiflumic Acid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]7891159
C464843nitenpyramnitenpyram results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]16981889
C053765N-methylcarbamylcholineN-methylcarbamylcholine binds to [CHRNA4 protein co-treated with CHRNB2 protein]10728888
C053765N-methylcarbamylcholineN-methylcarbamylcholine binds to [NACHRALPHA1 protein co-treated with CHRNB2 protein]10728888
C053765N-methylcarbamylcholineN-methylcarbamylcholine binds to [NACHRALPHA2 protein co-treated with CHRNB2 protein]10728888
C053765N-methylcarbamylcholineN-methylcarbamylcholine binds to [NACHRALPHA3 protein co-treated with CHRNB2 protein]10728888
C570897NSC668394NSC668394 results in decreased expression of CHRNB2 mRNA27137931
C025589ochratoxin Aochratoxin A results in decreased expression of CHRNB2 mRNA27346841
D019319Okadaic Acid2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased susceptibility to Okadaic Acid]21715663
D019319Okadaic Acid2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased susceptibility to Okadaic Acid]21715663
D019319Okadaic Acid[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein]21715663
D019319Okadaic Acid[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein modified form]21715663
D019319Okadaic Acid[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]21715663
D019319Okadaic Acid[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased susceptibility to Okadaic Acid21715663
D019319Okadaic AcidCalcium affects the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased susceptibility to Okadaic Acid]21715663
D010100OxygenNicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNB2 protein]28235547
D010100Oxygen[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNB2 protein28235547
D010197PancuroniumPancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]16931985
D010197PancuroniumPancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D010197PancuroniumPancuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D010197PancuroniumPancuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D010261ParaoxonAtropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]21791372
D010261ParaoxonAtropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]21791372
D010261ParaoxonMecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]21791372
D010261ParaoxonMecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]21791372
D010261ParaoxonParaoxon results in decreased expression of CHRNB2 mRNA21791372
D010261ParaoxonParaoxon results in decreased expression of CHRNB2 protein21791372
D010269ParaquatNicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]]17227438
D010269ParaquatParaquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]17227438
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CHRNB2 mRNA26254212
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CHRNB2 mRNA26254212
D010830PhysostigminePhysostigmine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D010830PhysostigminePhysostigmine binds to [CHRNA4 protein binds to CHRNB2 protein]15733544
D010830PhysostigminePhysostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D010830PhysostigminePhysostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D010830PhysostigminePhysostigmine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
C576297ponceau 4R[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of CHRNB2 protein23429044
C108326pozaniclinepozanicline binds to [CHRNA4 protein binds to CHRNB2 protein]9336329
C108326pozaniclinepozanicline inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]9336329
C108326pozanicline[CHRNA6 protein binds to CHRNB2 protein] which affects the susceptibility to pozanicline19481067
C108326pozaniclinepozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNA5 protein binds to CHRNB2 protein]19481067
C108326pozaniclinepozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]19481067
C108326pozaniclinepozanicline binds to and results in increased activity of [CHRNA6 protein binds to CHRNB2 protein]19481067
C108326pozanicline[pozanicline binds to and results in increased activity of [CHRNA6 protein binds to CHRNB2 protein]] which results in increased secretion of Dopamine19481067
C108326pozaniclinepozanicline binds to CHRNB2 protein19481067
C108326pozanicline[pozanicline binds to CHRNB2 protein] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]19481067
C108326pozanicline[pozanicline binds to CHRNB2 protein] results in increased activity of [CHRNA6 protein binds to CHRNB2 protein]19481067
C108326pozaniclineDihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
C108326pozaniclineExcitatory Amino Acid Antagonists inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
C108326pozaniclineFG 9041 inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
C108326pozaniclineMecamylamine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]18385335
C108326pozanicline[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine18385335
C108326pozaniclinepozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]18385335|2115627
D011374Progesterone[Progesterone co-treated with Acetylcholine] results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]11517245
D011719PyrazinesPyrazines binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]21962147
D011725PyridinesPyridines binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]21962147
D000548Amaranth Dye[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of CHRNB2 protein23429044
D000068836RivastigmineRivastigmine binds to [CHRNA4 protein binds to CHRNB2 protein]15733544
D000068836RivastigmineRivastigmine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
C061870rocuroniumrocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]16931985
C061870rocuroniumrocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
C514816sazetidine-Asazetidine-A analog binds to and affects the activity of [CHRNA4 protein binds to CHRNB2 protein]21905669
C514816sazetidine-Asazetidine-A analog inhibits the reaction [epibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNB2 protein]]21905669
C514816sazetidine-Asazetidine-A analog inhibits the reaction [epibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]21905669
C514816sazetidine-Asazetidine-A binds to [CHRNA4 protein binds to CHRNB2 protein]21274704
C514816sazetidine-Asazetidine-A binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]21905669
D012601Scopolamine HydrobromideScopolamine Hydrobromide binds to [CHRNA4 protein binds to CHRNB2 protein]15733544
D012601Scopolamine HydrobromideScopolamine Hydrobromide promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
C009335subecholinesubecholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
C009335subecholinesubecholine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
C009335subecholinesubecholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D013390SuccinylcholineSuccinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D013605T-2 ToxinT-2 Toxin results in decreased expression of CHRNB2 mRNA26314264
D013619TacrineTacrine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]15733544
D013619TacrineMecamylamine inhibits the reaction [Tacrine results in increased expression of CHRNB2 protein]8930989
D013619TacrineTacrine results in increased expression of CHRNB2 protein8930989
D013629TamoxifenTamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D013645Tartrazine[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of CHRNB2 protein23429044
C419442TC 2559TC 2559 binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]17115136
C020806tetrabromobisphenol Atetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]22547355
C020806tetrabromobisphenol Atetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D013750TetrachloroethyleneTetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]15885267
D013750TetrachloroethyleneTetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]15885267
D013750TetrachloroethyleneTetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]15885267
D013750TetrachloroethyleneTetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]15885267
C417209thiaclopridthiacloprid results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]16981889|2545928
C417209thiaclopridthiacloprid results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]25459289
C417209thiaclopridthiacloprid analog inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
C417209thiaclopridthiacloprid analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11708903
C417209thiaclopridthiacloprid inhibits the reaction [Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]]11708903
C417209thiaclopridthiacloprid promotes the reaction [Nicotine binds to [CHRNA4 protein co-treated with CHRNB2 protein]]11076703
C417209thiaclopridthiacloprid results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]11708903
C416660thiamethoxamthiamethoxam results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]16981889
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CHRNB2 protein26746805
D014050TolueneToluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]15885267
D014050TolueneToluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]15885267
D014050TolueneToluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]15885267
D014050TolueneToluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]15885267
D014212TretinoinTretinoin inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]17203487
D014212TretinoinTretinoin results in increased expression of CHRNB2 mRNA17203487
D014212TretinoinTretinoin results in increased expression of CHRNB2 protein17203487
C005445triphenyl phosphatetriphenyl phosphate inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]22750351
D014403TubocurarineTubocurarine binds to and results in decreased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D014403TubocurarineTubocurarine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]10908297
D014403TubocurarineTubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]11711029
D014403TubocurarineTubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]16931985
D014403TubocurarineTubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D014403TubocurarineTubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D014403TubocurarineTubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]11711029
D014403TubocurarineTubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658
D014403TubocurarineTubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]7756618
D014403TubocurarineTubocurarine results in decreased activity of [CHRNA4 protein alternative form binds to CHRNB2 protein alternative form]16569710
D014403TubocurarineTubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]16569710
D014403TubocurarineTubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]7808438
D014403TubocurarineTubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]7808438
C005460uranyl acetateuranyl acetate results in increased expression of CHRNB2 mRNA19409444
D014520UrethaneUrethane promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]11812690
D014635Valproic AcidValproic Acid results in increased methylation of CHRNB2 gene29154799
D000068580VareniclineVarenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]20207347|2033161
D000068580VareniclineVarenicline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]20100906
D000068580VareniclineVarenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]16766716
D000068580VareniclineVarenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]16766716
D000068580VareniclineVarenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]17115136|1841106
D014673Vecuronium BromideVecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]16931985
D014673Vecuronium BromideVecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]16931985
D014673Vecuronium BromideVecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]14645658
D014673Vecuronium BromideVecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]14645658

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005515protein binding-IPI8663494  27344019  
GO:0015276ligand-gated ion channel activity-TAS20438829  
GO:0015464acetylcholine receptor activityCONTRIBUTES_TOIBA21873635  
GO:0015464acetylcholine receptor activity-IDA8906617  
GO:0022848acetylcholine-gated cation-selective channel activity-IDA8906617  18387948  
GO:0022848acetylcholine-gated cation-selective channel activity-ISS-  
GO:0022848acetylcholine-gated cation-selective channel activity-TAS20438829  
GO:0042166acetylcholine bindingCONTRIBUTES_TOIBA21873635  
GO:0042166acetylcholine binding-IC8906617  
GO:0042166acetylcholine binding-IMP15964197  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001508action potential-IEA-  
GO:0001661conditioned taste aversion-IEA-  
GO:0001666response to hypoxia-IDA12189247  
GO:0006811ion transport-NAS8906617  
GO:0006816calcium ion transport-ISS-  
GO:0006939smooth muscle contraction-ISS-  
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-IDA8906617  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007271synaptic transmission, cholinergic-IBA21873635  
GO:0007271synaptic transmission, cholinergic-ISS-  
GO:0007274neuromuscular synaptic transmission-IBA21873635  
GO:0007601visual perception-ISS-  
GO:0007605sensory perception of sound-ISS-  
GO:0007612learning-IMP15964197  
GO:0007613memory-IMP15964197  
GO:0007626locomotory behavior-ISS-  
GO:0008306associative learning-ISS-  
GO:0008542visual learning-IMP15964197  
GO:0014059regulation of dopamine secretion-ISS-  
GO:0019233sensory perception of pain-ISS-  
GO:0021562vestibulocochlear nerve development-ISS-  
GO:0021631optic nerve morphogenesis-ISS-  
GO:0021771lateral geniculate nucleus development-ISS-  
GO:0021952central nervous system projection neuron axonogenesis-ISS-  
GO:0030890positive regulation of B cell proliferation-ISS-  
GO:0032225regulation of synaptic transmission, dopaminergic-ISS-  
GO:0032226positive regulation of synaptic transmission, dopaminergic-IEA-  
GO:0033603positive regulation of dopamine secretion-ISS-  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0034220ion transmembrane transport-IEA-  
GO:0035094response to nicotine-IBA21873635  
GO:0035094response to nicotine-IDA12189247  
GO:0035095behavioral response to nicotine-IMP17559419  
GO:0035176social behavior-ISS-  
GO:0042053regulation of dopamine metabolic process-ISS-  
GO:0042113B cell activation-ISS-  
GO:0042220response to cocaine-ISS-  
GO:0042320regulation of circadian sleep/wake cycle, REM sleep-ISS-  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0045188regulation of circadian sleep/wake cycle, non-REM sleep-IEA-  
GO:0045471response to ethanol-ISS-  
GO:0045759negative regulation of action potential-ISS-  
GO:0048814regulation of dendrite morphogenesis-ISS-  
GO:0050877nervous system process-IBA21873635  
GO:0050877nervous system process-IMP17900292  
GO:0050890cognition-IMP17559419  
GO:0051291protein heterooligomerization-IEA-  
GO:0051899membrane depolarization-ISS-  
GO:0051963regulation of synapse assembly-ISS-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0060084synaptic transmission involved in micturition-ISS-  
GO:0095500acetylcholine receptor signaling pathway-ISS-  
GO:1905144response to acetylcholine-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005892acetylcholine-gated channel complex-IBA21873635  
GO:0005892acetylcholine-gated channel complex-IDA8906617  
GO:0009897external side of plasma membrane-ISS-  
GO:0016021integral component of membrane-NAS8906617  
GO:0030054cell junction-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0044853plasma membrane raft-ISS-  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-181431Acetylcholine binding and downstream eventsTAS
R-HSA-622323Presynaptic nicotinic acetylcholine receptorsTAS
R-HSA-622327Postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629587Highly sodium permeable acetylcholine nicotinic receptorsTAS
R-HSA-629594Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629597Highly calcium permeable nicotinic acetylcholine receptorsTAS
R-HSA-629602Activation of Nicotinic Acetylcholine ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26441658Agonist and antagonist effects of tobacco-related nitrosamines on human alpha4beta2 nicotinic acetylcholine receptors. (2015)Brusco SFront Pharmacol
23419392The beta2 nicotinic acetylcholine receptor subunit differentially influences ethanol behavioral effects in the mouse. (2013 Mar)Dawson AAlcohol
21606948Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genes. (2012 Aug)Swan GEPharmacogenomics J
11054772Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence. (2000 Oct 9)Silverman MAAm J Med Genet
25774163CHRNA4 rs1044396 is associated with smoking cessation in varenicline therapy. (2015)Rocha Santos JFront Genet
16314871Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes. (2006 Mar)Greenbaum LMol Psychiatry
20854418CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences. (2011 Mar)Hoft NRGenes Brain Behav
23350800Nominal association with CHRNA4 variants and nicotine dependence. (2013 Apr)Kamens HMGenes Brain Behav
17559419Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (2008 Mar)Rigbi AGenes Brain Behav
25640319The possible role of maternal bonding style and CHRNB2 gene polymorphisms in nicotine dependence and related depressive phenotype. (2015 Jun 3)Csala IProg Neuropsychopharmacol Biol Psychiatry
27355804SNPs in NRXN1 and CHRNA5 are associated to smoking and regulation of GABAergic and glutamatergic pathways. (2016 Jul)Perez-Rubio GPharmacogenomics
24428733Association of the CHRNA4 neuronal nicotinic receptor subunit gene with frequency of binge drinking in young adults. (2014 Apr)Coon HAlcohol Clin Exp Res
15790597Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence. (2005 May 1)Li MDHum Mol Genet
21498873Associations of nicotine intake measures with CHRN genes in Finnish smokers. (2011 Aug)Keskitalo-Vuokko KNicotine Tob Res
27327258Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research. (2016 Jun 21)Wen LTransl Psychiatry
22441542Nicotinic acetylcholine receptor expression and susceptibility to cholinergic immunomodulation in human monocytes of smoking individuals. (2012)van der Zanden EPNeuroimmunomodulation
22048466Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials. (2012 Feb)King DPNeuropsychopharmacology
29411706[Maternal bonding style, cholinergic receptor gene polymorphisms in association with smoking-related depressive symptoms]. (2017 Dec)Csala INeuropsychopharmacol Hung
19482438Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence. (2009 Sep)Etter JFAddict Behav
11906688Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2). (2002 Feb)Lueders KKNicotine Tob Res
19755656Nicotinic acetylcholine receptor beta2 subunit (CHRNB2) gene and short-term ability to quit smoking in response to nicotine patch. (2009 Oct)Perkins KACancer Epidemiol Biomarkers Prev
29196725Pharmacogenetic study of seven polymorphisms in three nicotinic acetylcholine receptor subunits in smoking-cessation therapies. (2017 Dec 1)Pintarelli GSci Rep
26184988Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder. (2015 Sep 30)Kimbrel NAPsychiatry Res
23553665Relationship between nicotine dependence and the endophenotype-related trait of cognitive function but not acoustic startle reponses in Japanese patients with schizophrenia. (2013 May)Kishi THum Psychopharmacol
15192278A novel permutation testing method implicates sixteen nicotinic acetylcholine receptor genes as risk factors for smoking in schizophrenia families. (2004)Faraone SVHum Hered
24119711The association between CHRN genetic variants and dizziness at first inhalation of cigarette smoke. (2014 Jan)Pedneault MAddict Behav
15154117A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men. (2004 Jul)Feng YAm J Hum Genet
27428758Nicotinic cholinergic and dopaminergic receptor mRNA expression in male and female rats with high or low preference for nicotine. (2016 Sep)Gozen OAm J Drug Alcohol Abuse
23037950Possible association of nicotinic acetylcholine receptor gene (CHRNA4 and CHRNB2) polymorphisms with nicotine dependence in Japanese males: an exploratory study. (2013 Mar)Chen HIPharmacopsychiatry
18534558Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence. (2008 Dec 1)Li MDBiol Psychiatry
28440896Genome-wide meta-analysis identifies a novel susceptibility signal at CACNA2D3 for nicotine dependence. (2017 Apr 25)Yin XAm J Med Genet B Neuropsychiatr Genet
20736995Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerstrom test for nicotine dependence. (2010 Nov)Wessel JNeuropsychopharmacology
18043764Association of alpha4beta2 nicotinic receptor and heavy smoking in schizophrenia. (2007 Nov)Voineskos SJ Psychiatry Neurosci
19698703Association of nAChR gene haplotypes with heavy alcohol use and body mass. (2009 Dec 11)Landgren SBrain Res