| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| TH | 0.69 |
| DAPL1 | 0.674 |
| OTP | 0.67 |
| FOXB1 | 0.665 |
| HMX2 | 0.662 |
| GHRH | 0.655 |
| LHX5 | 0.653 |
| SIM1 | 0.652 |
| C22orf42 | 0.65 |
| FEZF1 | 0.649 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| SPRY1 | -0.346 |
| NEUROD1 | -0.346 |
| LTK | -0.342 |
| CCDC85C | -0.337 |
| WIF1 | -0.305 |
| MYO1B | -0.302 |
| ATP4A | -0.299 |
| ADAM33 | -0.298 |
| SOWAHA | -0.292 |
| THSD1 | -0.291 |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| D020106 | Acrylamide | Acrylamide results in decreased expression of UCN3 mRNA | 28959563 |
| D001151 | Arsenic | Arsenic affects the methylation of UCN3 gene | 25304211 |
| C015001 | arsenite | arsenite results in increased methylation of UCN3 promoter | 23974009 |
| C006780 | bisphenol A | bisphenol A results in increased expression of UCN3 mRNA | 25181051 |
| D004041 | Dietary Fats | Dietary Fats results in decreased expression of UCN3 mRNA | 25016146 |
| D004397 | Fonofos | Fonofos results in increased methylation of UCN3 promoter | 22847954 |
| D008727 | Methotrexate | Methotrexate affects the expression of UCN3 mRNA | 18502557 |
| D010278 | Parathion | Parathion results in increased methylation of UCN3 promoter | 22847954 |
| C006253 | pirinixic acid | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of UCN3 mRNA | 19710929 |
| C012568 | terbufos | terbufos results in increased methylation of UCN3 promoter | 22847954 |
| D014635 | Valproic Acid | Valproic Acid results in increased methylation of UCN3 gene | 29154799 |
| D001335 | Vehicle Emissions | Vehicle Emissions results in decreased methylation of UCN3 gene | 25560391 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0001664 | G-protein coupled receptor binding | - | IBA | 21873635 |
| GO:0005179 | hormone activity | - | IEA | - |
| GO:0051429 | corticotropin-releasing hormone receptor binding | - | IPI | 11329063 |
| GO:0051431 | corticotropin-releasing hormone receptor 2 binding | - | IEA | - |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway | - | IBA | 21873635 |
| GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway | - | IDA | 11329063 |
| GO:0007586 | digestion | - | IEA | - |
| GO:0009749 | response to glucose | - | IEA | - |
| GO:0009755 | hormone-mediated signaling pathway | - | IDA | 11329063 |
| GO:0010469 | regulation of signaling receptor activity | - | IEA | - |
| GO:0031669 | cellular response to nutrient levels | - | IBA | 21873635 |
| GO:0032024 | positive regulation of insulin secretion | - | IEA | - |
| GO:0035902 | response to immobilization stress | - | IEA | - |
| GO:0042594 | response to starvation | - | IEA | - |
| GO:0045838 | positive regulation of membrane potential | - | IEA | - |
| GO:0051412 | response to corticosterone | - | IEA | - |
| GO:0071456 | cellular response to hypoxia | - | IEA | - |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005576 | extracellular region | - | TAS | - |
| GO:0005615 | extracellular space | - | IBA | 21873635 |
| GO:0005622 | intracellular | - | IDA | 11329063 |
| GO:0043196 | varicosity | - | IEA | - |
| GO:0043679 | axon terminus | - | IEA | - |
| KEGG ID | KEGG Term |
|---|
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-HSA-162582 | Signal Transduction | TAS |
| R-HSA-372790 | Signaling by GPCR | TAS |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | TAS |
| R-HSA-500792 | GPCR ligand binding | TAS |