Gene: CHRNB3

1142
-
cholinergic receptor nicotinic beta 3 subunit
protein-coding
8p11.21
Ensembl:ENSG00000147432 MIM:118508 Vega:OTTHUMG00000165262 UniprotKB:Q05901
NC_000008.11
PubMed|SNP Mapped
CD|ND|AD
35   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.867e-1 (AD)  2.198e-4 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs55828312chr8:42734459 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EPHA50.779
KIAA12170.765
XKR40.761
ROBO20.76
GRIN2A0.753
PTPRR0.751
ZNF385D0.743
SLITRK10.742
BMPER0.739
VWC2L0.738

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.538
RNF135-0.528
TEAD3-0.527
TMEM176A-0.522
STON2-0.517
ROM1-0.515
IMPA2-0.508
TGIF1-0.507
MYL3-0.506
HVCN1-0.502

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00184NicotineSmall Molecule54-11-5ApprovedTarget
DB00674GalantamineSmall Molecule357-70-0ApprovedTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of CHRNB3 mRNA"20406850
D020106AcrylamideAcrylamide results in decreased expression of CHRNB3 mRNA28959563
C103505AM 251AM 251 results in increased expression of CHRNB3 mRNA16500647
D000638AmiodaroneAmiodarone results in increased expression of CHRNB3 mRNA19774075
D001280AtrazineAtrazine results in decreased expression of CHRNB3 mRNA25929836
D001280AtrazineAtrazine results in increased expression of CHRNB3 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CHRNB3 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CHRNB3 mRNA22300585
C006780bisphenol Abisphenol A results in decreased expression of CHRNB3 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of CHRNB3 mRNA12734012
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CHRNB3 mRNA16644059
D002330CarmustineCarmustine results in decreased expression of CHRNB3 mRNA15980968
D004390ChlorpyrifosChlorpyrifos affects the expression of CHRNB3 mRNA18812211
D002994ClofibrateClofibrate results in increased expression of CHRNB3 mRNA22300585
D003976DiazinonDiazinon results in decreased expression of CHRNB3 mRNA17452286
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CHRNB3 mRNA21385734
D009532NickelNickel results in decreased expression of CHRNB3 mRNA18812211
D010100OxygenOxygen deficiency results in decreased expression of CHRNB3 mRNA24205000
D010936Plant ExtractsPlant Extracts results in decreased expression of CHRNB3 mRNA23557933
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of CHRNB3 mRNA]21245298

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0015267channel activity-TAS7690916  
GO:0015276ligand-gated ion channel activity-TAS-  
GO:0015464acetylcholine receptor activityCONTRIBUTES_TOIBA21873635  
GO:0042166acetylcholine bindingCONTRIBUTES_TOIBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-TAS7690916  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007271synaptic transmission, cholinergic-IBA21873635  
GO:0007271synaptic transmission, cholinergic-TAS7690916  
GO:0007274neuromuscular synaptic transmission-IBA21873635  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0035094response to nicotine-IBA21873635  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO:0060079excitatory postsynaptic potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005892acetylcholine-gated channel complex-IBA21873635  
GO:0016021integral component of membrane-NAS8906617  
GO:0030054cell junction-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-181431Acetylcholine binding and downstream eventsTAS
R-HSA-622323Presynaptic nicotinic acetylcholine receptorsTAS
R-HSA-622327Postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629594Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629597Highly calcium permeable nicotinic acetylcholine receptorsTAS
R-HSA-629602Activation of Nicotinic Acetylcholine ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20840187Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence. (2010 Nov)Johnson EOAddiction
28851948Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population. (2017 Aug 29)Wen LSci Rep
27827986Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence. (2016 Nov 7)Zuo LGenes (Basel)
24804708Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior. (2014)Haller GPLoS One
24401102Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans. (2014 May)Culverhouse RCAddiction
24057674Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence. (2014 Feb 1)Haller GHum Mol Genet
16314871Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes. (2006 Mar)Greenbaum LMol Psychiatry
22042774Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. (2012 Feb 1)Haller GHum Mol Genet
28850771A functional U-statistic method for association analysis of sequencing data. (2017 Nov)Jadhav SGenet Epidemiol
17559419Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (2008 Mar)Rigbi AGenes Brain Behav
23899432Nicotinic receptor gene variants interact with attention deficient hyperactive disorder symptoms to predict smoking trajectories from early adolescence to adulthood. (2013 Nov)Lee CTAddict Behav
29621993Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women. (2018 Apr 5)Tomaz PRXBMC Med Genet
25399692Genetics of alcoholism. (2014 Dec)Iyer-Eimerbrink PACurr Psychiatry Rep
21606657Reward-related genes and personality traits in alcohol-dependent individuals: a pilot case control study. (2011)Landgren SNeuropsychobiology
24792900Combined effect between CHRNB3-CHRNA6 region gene variant (rs6474412) and smoking in psoriasis vulgaris severity. (2014 Jul 10)Zhu KJGene
21498873Associations of nicotine intake measures with CHRN genes in Finnish smokers. (2011 Aug)Keskitalo-Vuokko KNicotine Tob Res
27327258Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research. (2016 Jun 21)Wen LTransl Psychiatry
19482438Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence. (2009 Sep)Etter JFAddict Behav
25823894A genetic variant in CHRNB3-CHRNA6 increases risk of esophageal squamous cell carcinoma in Chinese populations. (2015 May)Song YCarcinogenesis
20854418CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences. (2011 Mar)Hoft NRGenes Brain Behav
23319001Significant association of CHRNB3 variants with nicotine dependence in multiple ethnic populations. (2013 Nov)Cui WYMol Psychiatry
26184988Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder. (2015 Sep 30)Kimbrel NAPsychiatry Res
24119711The association between CHRN genetic variants and dizziness at first inhalation of cigarette smoke. (2014 Jan)Pedneault MAddict Behav
19564872Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions. (2009 Oct)Greenbaum LMol Psychiatry
22524403CHRNB3 is more strongly associated with Fagerstrom test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results. (2012 Nov)Rice JPAddiction
21831805[Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population]. (2011 Aug)Zhang XBYi Chuan
17135278Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. (2007 Jan 1)Saccone SFHum Mol Genet
19500157SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample. (2009 Aug)Hoft NRGenes Brain Behav
20584212Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (2010 Oct)Saccone NLGenes Brain Behav
22309839Association study of 45 candidate genes in nicotine dependence in Han Chinese. (2012 May)Wei JAddict Behav
26318101The beta3 subunit of the nicotinic acetylcholine receptor: Modulation of gene expression and nicotine consumption. (2015 Dec)Kamens HMNeuropharmacology
21191315Genetic association of bipolar disorder with the beta(3) nicotinic receptor subunit gene. (2011 Apr)Hartz SMPsychiatr Genet
24731518CHRNB3 c.-57A>G functional promoter change affects Parkinson's disease and smoking. (2014 Sep)Bar-Shira ANeurobiol Aging
25233467Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma. (2014)Tseng TSPLoS One
26283763Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses. (2016 May)Clark SLNicotine Tob Res