Gene info: ID 1143

Gene: CHRNB4

GENE ID: 1143

Synonyms: -

Description: cholinergic receptor nicotinic beta 4 subunit

Gene type: protein-coding

Location: 15q25.1

dbXrefs: Ensembl:ENSG00000117971 MIM:118509 Vega:OTTHUMG00000143860 UniprotKB:P30926

RefSeq: NC_000015.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 85

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.088e-1 (AD) 1.000e-12 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LRRC15	0.831
POU4F1	0.83
ITK	0.802
DMBX1	0.801
PLEKHS1	0.784
CALCA	0.776
C2CD4A	0.768
RAX	0.746
MMP10	0.732
MICALCL	0.719

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OMG	-0.329
B3GALT2	-0.287
SEC14L5	-0.286
SNX22	-0.283
SLC7A4	-0.28
C2orf27A	-0.28
TMEM143	-0.27
KBTBD7	-0.266
CHRM1	-0.263
SCGB2B2	-0.263

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00184	Nicotine	Small Molecule	54-11-5	Approved	Target
DB00514	Dextromethorphan	Small Molecule	125-71-3	Approved	Target
DB00674	Galantamine	Small Molecule	357-70-0	Approved	Target
DB00898	Ethanol	Small Molecule	64-17-5	Approved	Target
DB01090	Pentolinium	Small Molecule	144-44-5	Approved	Target
DB01227	Levomethadyl Acetate	Small Molecule	1477-40-3	Approved\|Investigational	Target
DB07720	Epibatidine	Small Molecule	140111-52-0	Experimental	Target

ID	Drug Name	Action	PubMed
C482518	1,2-bis-N-cytisinylethane	"1,2-bis-N-cytisinylethane promotes the reaction [CHRNA3 protein binds to CHRNB2 protein binds to CHRNB4 protein]"	16273122
C482518	1,2-bis-N-cytisinylethane	"1,2-bis-N-cytisinylethane results in increased localization of [CHRNA3 protein binds to CHRNB2 protein binds to CHRNB4 protein]"	16273122
C532668	1-methyl-4-(2-chloro-4-hydroxyphenylthio)piperidine	1-methyl-4-(2-chloro-4-hydroxyphenylthio)piperidine binds to and results in increased activity of CHRNB4 protein	17115136
C569671	2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane	"2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]"	21942635
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of CHRNB4 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of CHRNB4 mRNA"	21346803
C043958	2-butanol	2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
C119207	4-((2-(1-methyl-2-pyrrolidinyl)ethyl)thio)phenol hydrochloride	4-((2-(1-methyl-2-pyrrolidinyl)ethyl)thio)phenol hydrochloride binds to and results in increased activity of CHRNB4 protein	11561092
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNB4 mRNA"	27188386
C041594	4-nonylphenol	4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
C041594	4-nonylphenol	4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
C080417	4-octylphenol	4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNB4 mRNA"	27188386
D000109	Acetylcholine	1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D000109	Acetylcholine	1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D000109	Acetylcholine	2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D000109	Acetylcholine	2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D000109	Acetylcholine	4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D000109	Acetylcholine	4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D000109	Acetylcholine	4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D000109	Acetylcholine	Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]	11821649
D000109	Acetylcholine	Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]	16931985
D000109	Acetylcholine	Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]	9454827
D000109	Acetylcholine	Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]	9454827
D000109	Acetylcholine	Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]	9454827
D000109	Acetylcholine	Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D000109	Acetylcholine	bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D000109	Acetylcholine	bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D000109	Acetylcholine	cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D000109	Acetylcholine	crotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D000109	Acetylcholine	Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D000109	Acetylcholine	Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D000109	Acetylcholine	Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D000109	Acetylcholine	Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D000109	Acetylcholine	Ethinyl Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D000109	Acetylcholine	Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D000109	Acetylcholine	isobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D000109	Acetylcholine	mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D000109	Acetylcholine	n-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D000109	Acetylcholine	Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D000109	Acetylcholine	rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D000109	Acetylcholine	Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D000109	Acetylcholine	tert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D000109	Acetylcholine	Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D000109	Acetylcholine	Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D000109	Acetylcholine	Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]	7808438
D000109	Acetylcholine	Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]	7808438
D000109	Acetylcholine	[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA3 protein binds to CHRNB4 protein]	12130716
D000109	Acetylcholine	[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB4 protein]	12130716
D000109	Acetylcholine	Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]	7808438
D000109	Acetylcholine	Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]	7808438
D000109	Acetylcholine	Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]	7891159
D000109	Acetylcholine	Flufenamic Acid promotes the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	7891159
D000109	Acetylcholine	Flufenamic Acid promotes the reaction [Magnesium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]]	7891159
D000109	Acetylcholine	Magnesium promotes the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	7891159
D000109	Acetylcholine	Niflumic Acid promotes the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	7891159
D000448	Aldicarb	Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]	14644616
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CHRNB4 mRNA	16483693
D000691	Anabasine	Anabasine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]	15615518
D001279	Atracurium	Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D001464	Barium	1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D001464	Barium	1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D001464	Barium	2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D001464	Barium	2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D001464	Barium	Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]	11821649
D001464	Barium	[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium	11821649
D001464	Barium	crotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D001464	Barium	isobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D001464	Barium	n-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D001464	Barium	tert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
C007725	bendiocarb	bendiocarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]	14644616
D004958	Estradiol	Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D004958	Estradiol	Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
C006780	bisphenol A	bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
C006780	bisphenol A	bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
C006780	bisphenol A	bisphenol A results in increased expression of CHRNB4 mRNA	25181051
D002038	Bungarotoxins	Bungarotoxins binds to [NACHRALPHA1 protein co-treated with CHRNB4 protein]	10728888
D002038	Bungarotoxins	Bungarotoxins binds to [NACHRALPHA3 protein co-treated with CHRNB4 protein]	10728888
D020001	1-Butanol	1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D002217	Carbachol	Carbachol inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
D002217	Carbachol	Carbachol binds to [CHRNA3 protein binds to CHRNB4 protein]	15615518
D012721	Carbaryl	Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	14644616
D012721	Carbaryl	Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]	14644616
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of CHRNB4 mRNA	18812211
C101584	cisatracurium	cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
C007153	crotonyl alcohol	crotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D003471	Cuprizone	Cuprizone results in decreased expression of CHRNB4 mRNA	27523638
C004712	cytisine	cytisine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C004712	cytisine	cytisine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]	9454827
C004712	cytisine	cytisine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]	9454827
C004712	cytisine	cytisine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]	9454827
C033019	decamethonium	decamethonium inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
D004026	Dieldrin	Dieldrin results in decreased expression of CHRNB4 mRNA	18812211
D004041	Dietary Fats	Dietary Fats results in increased expression of CHRNB4 mRNA	25016146
D004054	Diethylstilbestrol	Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D004054	Diethylstilbestrol	Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D004079	Dihydro-beta-Erythroidine	Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
D004079	Dihydro-beta-Erythroidine	[CHRNA4 protein binds to CHRNB4 protein] which binds to Dihydro-beta-Erythroidine	9687574
D004079	Dihydro-beta-Erythroidine	Dihydro-beta-Erythroidine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	9687574
D004246	Dimethylphenylpiperazinium Iodide	Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
D004246	Dimethylphenylpiperazinium Iodide	Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]	9454827
D004246	Dimethylphenylpiperazinium Iodide	Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]	9454827
D004246	Dimethylphenylpiperazinium Iodide	Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]	9454827
D004298	Dopamine	CHRNB4 protein results in increased secretion of Dopamine	15542623
C118739	entinostat	entinostat results in increased expression of CHRNB4 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNB4 mRNA"	27188386
C082748	epibatidine	Carbachol inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	cytisine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	decamethonium inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]	12770692
C082748	epibatidine	Hexamethonium inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	methyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	Nicotine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	"2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]"	21942635
C082748	epibatidine	[CHRNB4 protein binds to CHRNA2 protein] which binds to epibatidine	9454827
C082748	epibatidine	[CHRNB4 protein binds to CHRNA3 protein] which binds to epibatidine	9454827
C082748	epibatidine	[CHRNB4 protein binds to CHRNA4 protein] which binds to epibatidine	9454827
C082748	epibatidine	epibatidine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]	22060139
C082748	epibatidine	[CHRNA3 protein binds to CHRNB4 protein] which binds to epibatidine	9687574
C082748	epibatidine	epibatidine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]	15615518
C082748	epibatidine	epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]	15615518
C082748	epibatidine	epibatidine binds to [NACHRALPHA1 protein co-treated with CHRNB4 protein]	10728888
C082748	epibatidine	epibatidine binds to [NACHRALPHA2 protein co-treated with CHRNB4 protein]	10728888
C082748	epibatidine	epibatidine binds to [NACHRALPHA3 protein co-treated with CHRNB4 protein]	10728888
C036251	EPTC	EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	14644616
C036251	EPTC	EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]	14644616
D004997	Ethinyl Estradiol	Ethinyl Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D004997	Ethinyl Estradiol	Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
C052034	fenoxycarb	fenoxycarb results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	14644616
C052034	fenoxycarb	fenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]	14644616
D005439	Flufenamic Acid	Flufenamic Acid promotes the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	7891159
D005439	Flufenamic Acid	Flufenamic Acid promotes the reaction [Magnesium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]]	7891159
D005473	Fluoxetine	Fluoxetine results in decreased expression of CHRNB4 mRNA	21820738
D018738	Hexamethonium	Hexamethonium inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
D018738	Hexamethonium	Hexamethonium results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	9687574
D007052	Ibuprofen	Ibuprofen results in increased expression of CHRNB4 mRNA	28201806
C110702	IEM 1460	IEM 1460 results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	19145339
D007213	Indomethacin	Indomethacin results in increased expression of CHRNB4 mRNA	28201806
C040507	isobutyl alcohol	isobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
C008261	lead acetate	lead acetate results in decreased expression of CHRNB4 mRNA	22641619
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of CHRNB4 mRNA"	24972896
D008274	Magnesium	Flufenamic Acid promotes the reaction [Magnesium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]]	7891159
D008274	Magnesium	Magnesium promotes the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	7891159
D008464	Mecamylamine	Mecamylamine binds to and results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	20100906
D008464	Mecamylamine	Mecamylamine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	9687574
D008627	Mercuric Chloride	[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA3 protein binds to CHRNB4 protein]	12130716
D008627	Mercuric Chloride	[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB4 protein]	12130716
C054634	methyllycaconitine	methyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of CHRNB4 mRNA	24810058
C049430	mivacurium	mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
C524978	N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline	"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]"	17873105
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNB4 protein	15551346
D009532	Nickel	Nickel results in decreased expression of CHRNB4 mRNA	18812211
D009538	Nicotine	Nicotine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
D009538	Nicotine	Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]	9454827
D009538	Nicotine	Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]	9454827
D009538	Nicotine	Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]	9454827
D009538	Nicotine	CHRNB4 protein affects the susceptibility to Nicotine	15275829
D009538	Nicotine	Nicotine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]	15615518
D009538	Nicotine	Nicotine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]	15615518
D009538	Nicotine	Nicotine results in increased activity of CHRNB4 protein	19483072
D009544	Niflumic Acid	Niflumic Acid promotes the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	7891159
C008655	N'-nitrosonornicotine	N'-nitrosonornicotine binds to CHRNB4 protein	18385738
C024999	n-pentanol	n-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of CHRNB4 mRNA]"	21673326
D010197	Pancuronium	Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D019840	2-Propanol	2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D000433	1-Propanol	1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
C005556	propionaldehyde	propionaldehyde results in decreased expression of CHRNB4 mRNA	26079696
D001074	Propoxur	Propoxur results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]	14644616
C061870	rocuronium	rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CHRNB4 mRNA	21427059
D012524	Sarin	Sarin results in decreased expression of CHRNB4 mRNA	19522546
D013629	Tamoxifen	4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D013629	Tamoxifen	bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D013629	Tamoxifen	Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D013629	Tamoxifen	Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D013629	Tamoxifen	Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D020002	tert-Butyl Alcohol	tert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	11821649
D019284	Thapsigargin	Thapsigargin results in decreased expression of CHRNB4 mRNA	22378314
D014403	Tubocurarine	Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
D014403	Tubocurarine	Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D014403	Tubocurarine	Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]	7808438
D014403	Tubocurarine	Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]	7808438
D014403	Tubocurarine	Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	9687574
D014415	Tunicamycin	Tunicamycin results in decreased expression of CHRNB4 mRNA	22378314
D014635	Valproic Acid	Valproic Acid results in increased methylation of CHRNB4 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of CHRNB4 mRNA	21427059
D000068580	Varenicline	Varenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]	16766716
D014673	Vecuronium Bromide	Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
C025643	vinclozolin	vinclozolin results in increased expression of CHRNB4 mRNA	22570695
D015034	Zinc Oxide	Zinc Oxide analog results in decreased expression of CHRNB4 mRNA	27215404
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of CHRNB4 mRNA	27215404

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005230	extracellular ligand-gated ion channel activity	CONTRIBUTES_TO	IBA	21873635
GO:0005515	protein binding	-	IPI	27344019
GO:0015276	ligand-gated ion channel activity	-	TAS	20438829
GO:0015464	acetylcholine receptor activity	CONTRIBUTES_TO	IBA	21873635
GO:0015464	acetylcholine receptor activity	-	IDA	8906617
GO:0022848	acetylcholine-gated cation-selective channel activity	-	IDA	18387948
GO:0022848	acetylcholine-gated cation-selective channel activity	-	TAS	8906617 11742001 20438829
GO:0042166	acetylcholine binding	CONTRIBUTES_TO	IBA	21873635
GO:0046982	protein heterodimerization activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001508	action potential	-	IEA	-
GO:0006811	ion transport	-	TAS	8906617
GO:0006939	smooth muscle contraction	-	IEA	-
GO:0006940	regulation of smooth muscle contraction	-	IEA	-
GO:0007165	signal transduction	-	IBA	21873635
GO:0007165	signal transduction	-	IDA	8906617
GO:0007268	chemical synaptic transmission	-	IBA	21873635
GO:0007271	synaptic transmission, cholinergic	-	IBA	21873635
GO:0007271	synaptic transmission, cholinergic	-	TAS	1330682
GO:0007274	neuromuscular synaptic transmission	-	IBA	21873635
GO:0007626	locomotory behavior	-	IEA	-
GO:0034220	ion transmembrane transport	-	IBA	21873635
GO:0034220	ion transmembrane transport	-	IEA	-
GO:0035094	response to nicotine	-	IBA	21873635
GO:0035095	behavioral response to nicotine	-	IEA	-
GO:0042391	regulation of membrane potential	-	IBA	21873635
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0046928	regulation of neurotransmitter secretion	-	NAS	11742001
GO:0050877	nervous system process	-	IBA	21873635
GO:0051291	protein heterooligomerization	-	IEA	-
GO:0051971	positive regulation of transmission of nerve impulse	-	IEA	-
GO:0060079	excitatory postsynaptic potential	-	IEA	-
GO:0060084	synaptic transmission involved in micturition	-	IMP	11450844

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	IC	11742001
GO:0005892	acetylcholine-gated channel complex	-	IBA	21873635
GO:0005892	acetylcholine-gated channel complex	-	IDA	8906617
GO:0005892	acetylcholine-gated channel complex	-	TAS	11742001
GO:0016021	integral component of membrane	-	NAS	8906617
GO:0030054	cell junction	-	IEA	-
GO:0035579	specific granule membrane	-	TAS	-
GO:0043005	neuron projection	-	IBA	21873635
GO:0043005	neuron projection	-	IEA	-
GO:0045202	synapse	-	IBA	21873635
GO:0045211	postsynaptic membrane	-	IEA	-
GO:0070821	tertiary granule membrane	-	TAS	-

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-181431	Acetylcholine binding and downstream events	TAS
R-HSA-622323	Presynaptic nicotinic acetylcholine receptors	TAS
R-HSA-622327	Postsynaptic nicotinic acetylcholine receptors	TAS
R-HSA-629587	Highly sodium permeable acetylcholine nicotinic receptors	TAS
R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	TAS
R-HSA-629597	Highly calcium permeable nicotinic acetylcholine receptors	TAS
R-HSA-629602	Activation of Nicotinic Acetylcholine Receptors	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26762739	Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer. (2016 Jan)	Liu Y	J Thorac Oncol
23011884	Functional effect of polymorphisms in 15q25 locus on CHRNA5 mRNA, bulky DNA adducts and TP53 mutations. (2013 Apr 15)	Tekpli X	Int J Cancer
21268243	Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy. (2011 Apr)	Sarginson JE	Am J Med Genet B Neuropsychiatr Genet
21818261	Smoking is associated with, but does not cause, depressed mood in pregnancy--a mendelian randomization study. (2011)	Lewis SJ	PLoS One
23689675	Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents. (2013 Oct)	Nees F	Neuropsychopharmacology
28978081	Expression patterns for nicotinic acetylcholine receptor subunit genes in smoking-related lung cancers. (2017 Sep 15)	Bordas A	Oncotarget
21555077	Aversion to nicotine is regulated by the balanced activity of beta4 and alpha5 nicotinic receptor subunits in the medial habenula. (2011 May 12)	Frahm S	Neuron
23458267	Examination of rare missense variants in the CHRNA5-A3-B4 gene cluster to level of response to alcohol in the San Diego Sibling Pair study. (2013 Aug)	Choquet H	Alcohol Clin Exp Res
28583088	Uncovering the transcriptomic and epigenomic landscape of nicotinic receptor genes in non-neuronal tissues. (2017 Jun 5)	Zhang B	BMC Genomics
18414406	Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. (2009 May)	Wang JC	Mol Psychiatry
19443489	Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. (2009 Aug 15)	Wang JC	Hum Mol Genet
20808433	Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population. (2010 Aug 16)	Li MD	PLoS One
24062692	Nicotinic acetylcholine receptors mediate lung cancer growth. (2013)	Improgo MR	Front Physiol
20886544	Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance. (2010 Dec 5)	Winterer G	Am J Med Genet B Neuropsychiatr Genet
23397474	Polymorphisms of CHRNA5-CHRNA3-CHRNB4 Gene Cluster and NSCLC Risk in Chinese Population. (2012 Dec)	Li Z	Transl Oncol
25555482	Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans. (2015 Mar 1)	Gelernter J	Biol Psychiatry
18759969	In search of causal variants: refining disease association signals using cross-population contrasts. (2008 Aug 29)	Saccone NL	BMC Genet
22956269	Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight. (2012 Dec 15)	Tyrrell J	Hum Mol Genet
26264275	Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium. (2015 Aug 11)	Morris RW	BMJ Open
23591849	Pilot study of CYP2B6 genetic variation to explore the contribution of nitrosamine activation to lung carcinogenesis. (2013 Apr 16)	Wassenaar CA	Int J Mol Sci
23143843	Molecular mechanisms underlying behaviors related to nicotine addiction. (2013 Jan 1)	Picciotto MR	Cold Spring Harb Perspect Med
28972577	Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence. (2017 Oct 3)	Hancock DB	Mol Psychiatry
22042774	Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. (2012 Feb 1)	Haller G	Hum Mol Genet
27871728	The CHRNA5-A3-B4 Gene Cluster and Smoking: From Discovery to Therapeutics. (2016 Dec)	Lassi G	Trends Neurosci
27355804	SNPs in NRXN1 and CHRNA5 are associated to smoking and regulation of GABAergic and glutamatergic pathways. (2016 Jul)	Perez-Rubio G	Pharmacogenomics
21498873	Associations of nicotine intake measures with CHRN genes in Finnish smokers. (2011 Aug)	Keskitalo-Vuokko K	Nicotine Tob Res
19696770	Role of genetic variants in the CHRNA5-CHRNA3-CHRNB4 cluster in nicotine dependence risk: importance of gene-environment interplay. (2009 Sep)	Greenbaum L	Mol Psychiatry
17503330	A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. (2007 Jun)	Lou XY	Am J Hum Genet
20554942	Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study. (2010 Aug 4)	Amos CI	J Natl Cancer Inst
21740894	Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior. (2011 Oct 15)	Tuesta LM	Biochem Pharmacol
21593077	Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. (2011 Dec)	Freathy RM	Int J Epidemiol
22438940	Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking. (2012)	Kapoor M	PLoS One
25603899	Common single nucleotide variants underlying drug addiction: more than a decade of research. (2015 Sep)	Buhler KM	Addict Biol
24478678	Habenular expression of rare missense variants of the beta4 nicotinic receptor subunit alters nicotine consumption. (2014)	Slimak MA	Front Hum Neurosci
19564872	Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions. (2009 Oct)	Greenbaum L	Mol Psychiatry
20485328	Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes. (2010 Aug)	Sherva R	Neuropsychopharmacology
24119711	The association between CHRN genetic variants and dizziness at first inhalation of cigarette smoke. (2014 Jan)	Pedneault M	Addict Behav
26174813	New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder. (2015 Sep)	Alemany S	Am J Med Genet B Neuropsychiatr Genet
20418889	Meta-analysis and imputation refines the association of 15q25 with smoking quantity. (2010 May)	Liu JZ	Nat Genet
21168125	TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood. (2011 Apr 1)	Ducci F	Biol Psychiatry
23094028	Genetic association analysis of complex diseases incorporating intermediate phenotype information. (2012)	Li Y	PLoS One
24082085	Reexposure to nicotine during withdrawal increases the pacemaking activity of cholinergic habenular neurons. (2013 Oct 15)	Gorlich A	Proc Natl Acad Sci U S A
25214750	Genomics and personalized medicine: CHRNA5-CHRNA3-CHRNB4 and smoking cessation treatment. (2013 Dec)	Chen LS	J Food Drug Anal
22539395	Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25. (2012 May)	Chen LS	Genet Epidemiol
24804708	Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior. (2014)	Haller G	PLoS One
19064933	Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans. (2008 Dec 23)	Joslyn G	Proc Natl Acad Sci U S A
21511889	Variant within the promoter region of the CHRNA3 gene associated with FTN dependence is not related to self-reported willingness to quit smoking. (2011 Sep)	Marques-Vidal P	Nicotine Tob Res
25948103	A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans. (2015 Nov)	Jensen KP	Neuropsychopharmacology
18519524	Variants in nicotinic receptors and risk for nicotine dependence. (2008 Sep)	Bierut LJ	Am J Psychiatry
27758088	The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations. (2017 Jan)	Barrie ES	Hum Mutat
25652844	Nicotine dependence in an isolated population of Kashubians from North Poland: a population survey. (2015 Feb 4)	Sieminska A	BMC Public Health
19859904	Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans. (2010 Apr 5)	Li MD	Am J Med Genet B Neuropsychiatr Genet
21229299	Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers. (2011 Mar)	Sakoda LC	Cancer Causes Control
20700436	Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. (2010 Aug 5)	Saccone NL	PLoS Genet
21048701	Partial agonists of the alpha3beta4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats. (2011 Feb)	Chatterjee S	Neuropsychopharmacology
23872218	Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors. (2013 Sep 5)	Flora AV	Brain Res
21228559	An exploratory study on the CHRNA3-CHRNA5-CHRNB4 cluster, smoking, and Parkinson's disease. (2011)	Gao J	Neurodegener Dis
19706762	The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. (2009 Sep 1)	Saccone NL	Cancer Res
28900078	[Polymorphic Variants of Glutamate Receptor (GRIK5, GRIN2B) and Serotonin Receptor (HTR2A) Genes Are Associated with Chronic Obstructive Pulmonary Disease]. (2017 Jul-Aug)	Korytina GF	Mol Biol (Mosk)
26283763	Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses. (2016 May)	Clark SL	Nicotine Tob Res
22042234	Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster. (2012 May)	Stephens SH	Behav Genet
20696214	A transcriptional regulatory element critical for CHRNB4 promoter activity in vivo. (2010 Nov 10)	Scofield MD	Neuroscience
23692359	CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users. (2013 Oct)	Zhu AZ	Addiction
21436384	Genetic variability of smoking persistence in African Americans. (2011 May)	Hamidovic A	Cancer Prev Res (Phila)
26220977	A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence. (2015 Oct 15)	Hancock DB	Hum Mol Genet
21747048	Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. (2011 Sep 7)	Wassenaar CA	J Natl Cancer Inst
25572450	Response to Transdermal Selegiline Smoking Cessation Therapy and Markers in the 15q24 Chromosomal Region. (2015 Sep)	Sarginson JE	Nicotine Tob Res
24296975	Nicotine consumption is regulated by a human polymorphism in dopamine neurons. (2014 Aug)	Morel C	Mol Psychiatry
22241830	Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits. (2012 Jun)	Broms U	Nicotine Tob Res
26942719	Chromosome 15q25 (CHRNA3-CHRNB4) Variation Indirectly Impacts Lung Cancer Risk in Chinese Males. (2016)	Zhang Y	PLoS One
23875064	Scrutiny of the CHRNA5-CHRNA3-CHRNB4 smoking behavior locus reveals a novel association with alcohol use in a Finnish population based study. (2013)	Hallfors J	Int J Mol Epidemiol Genet
22884254	Association of nicotine dependence susceptibility gene, CHRNA5, with Parkinson's disease age at onset: gene and smoking status interaction. (2013 Jan)	Greenbaum L	Parkinsonism Relat Disord
26184988	Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder. (2015 Sep 30)	Kimbrel NA	Psychiatry Res
23029550	Associations between variation in CHRNA5-CHRNA3-CHRNB4, body mass index and blood pressure in the Northern Finland Birth Cohort 1966. (2012)	Kaakinen M	PLoS One
26997181	CHRNA5/A3/B4 Variant rs3743078 and Nicotine-Related Phenotypes: Indirect Effects Through Nicotine Craving. (2016 Mar)	Shmulewitz D	J Stud Alcohol Drugs
29416783	Study on polymorphisms in CHRNA5/CHRNA3/CHRNB4 gene cluster and the associated with the risk of non-small cell lung cancer. (2018 Jan 5)	Sun Y	Oncotarget
27613895	Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans. (2017 Apr 1)	Melroy-Greif WE	Nicotine Tob Res
24057674	Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence. (2014 Feb 1)	Haller G	Hum Mol Genet
23061658	Role of CHRNA5-A3 genetic Locus variants and developing drug for chronic obstructive pulmonary disease. (2012)	Lococo F	Curr Med Chem
19429911	A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy. (2009 Aug 1)	Freathy RM	Hum Mol Genet
20584212	Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (2010 Oct)	Saccone NL	Genes Brain Behav
29228387	Association between rs1051730 and smoking during pregnancy in Dutch women. (2017 Dec 8)	Mbarek H	Nicotine Tob Res
25072098	Beyond cigarettes per day. A genome-wide association study of the biomarker carbon monoxide. (2014 Sep)	Bloom AJ	Ann Am Thorac Soc
19628476	Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15. (2009 Oct 15)	Keskitalo K	Hum Mol Genet
19029397	Nicotinic receptor gene variants influence susceptibility to heavy smoking. (2008 Dec)	Stevens VL	Cancer Epidemiol Biomarkers Prev