Gene info: ID 114548

Gene: NLRP3

GENE ID: 114548

Description: NLR family pyrin domain containing 3

Gene type: protein-coding

Location: 1q44

dbXrefs: Ensembl:ENSG00000162711 MIM:606416 Vega:OTTHUMG00000040647 UniprotKB:Q96P20

RefSeq: NG_007509.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 14

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.344e-1 (AD) 2.425e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OVGP1	0.749
DENND3	0.737
FNBP4	0.734
KNTC1	0.715
MYO5C	0.71
GOLGA8A	0.71
SYCP2	0.709
NR2C1	0.709
ZNF251	0.698
SCPEP1	0.697

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
BTBD8	-0.317
C7orf61	-0.292
MIA	-0.288
LHFPL1	-0.284
RFTN2	-0.281
DIAPH3	-0.262
HMGB4	-0.262
FOXO4	-0.258
CYP39A1	-0.258
MTRNR2L9	-0.254

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C570894	2,6-diaminopyridine-3,5-bis(thiocyanate)	"2,6-diaminopyridine-3,5-bis(thiocyanate) inhibits the reaction [tetrachlorobenzoquinone results in decreased ubiquitination of NLRP3 protein modified form]"	26901245
C523668	3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine	"3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]"	25308879
C002010	4-(2-aminoethyl)benzenesulfonylfluoride	4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [APP protein results in increased expression of NLRP3 protein]	28004443
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of NLRP3 mRNA	19191707
C003001	7-ketocholesterol	7-ketocholesterol affects the localization of NLRP3 protein	28633109
C003001	7-ketocholesterol	Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of NLRP3 protein]	28633109
C099958	acanthoic acid	acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein]	28964808
D000082	Acetaminophen	Acetaminophen results in increased expression of NLRP3 mRNA	26690555
D000082	Acetaminophen	Acetaminophen affects the expression of NLRP3 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of NLRP3 mRNA	24747151\|2782663
C056165	acetovanillone	acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in decreased ubiquitination of NLRP3 protein]	26901245
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [APP protein results in increased expression of NLRP3 protein]	28004443
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of NLRP3 protein]	26435000
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in decreased ubiquitination of NLRP3 protein]	26901245
D000111	Acetylcysteine	Acetylcysteine results in increased expression of NLRP3 mRNA	24885895
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]	28814068
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of NLRP3 protein]	28814068
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Rotenone results in increased expression of NLRP3 protein]	26086368
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of NLRP3 protein]	28814068
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of NLRP3 protein]	28814068
D020106	Acrylamide	Acrylamide results in decreased expression of NLRP3 mRNA	28959563
D000255	Adenosine Triphosphate	[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein	18604214
D000255	Adenosine Triphosphate	KN 62 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]	26586371
D000255	Adenosine Triphosphate	[Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with resveratrol] results in increased expression of NLRP3 mRNA	24149798
D000255	Adenosine Triphosphate	[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 mRNA	24149798
D000255	Adenosine Triphosphate	[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein	26586371
D000255	Adenosine Triphosphate	[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]	23430110
D000255	Adenosine Triphosphate	[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PML protein]	23430110
D000255	Adenosine Triphosphate	[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]	23430110
D000255	Adenosine Triphosphate	[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein	26086368
D000255	Adenosine Triphosphate	NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]	18604214
D000255	Adenosine Triphosphate	NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]	18604214
D000255	Adenosine Triphosphate	PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]]	23430110
D000255	Adenosine Triphosphate	PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]]	23430110
D000276	Adjuvants, Immunologic	"Adjuvants, Immunologic results in increased activity of NLRP3 protein"	19439372
D000276	Adjuvants, Immunologic	"[Adjuvants, Immunologic results in increased activity of NLRP3 protein] which results in increased activity of CASP1 protein"	19439372
D000276	Adjuvants, Immunologic	"[Adjuvants, Immunologic results in increased activity of NLRP3 protein] which results in increased expression of IL18"	19439372
D000276	Adjuvants, Immunologic	"[Adjuvants, Immunologic results in increased activity of NLRP3 protein] which results in increased expression of IL1B"	19439372
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of NLRP3 gene	27153756
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in increased expression of NLRP3 mRNA"	23195993
D000493	Allopurinol	Allopurinol inhibits the reaction [Glucose results in increased expression of NLRP3 protein]	23647015
D000493	Allopurinol	Allopurinol inhibits the reaction [Fructose results in increased expression of NLRP3 protein]	22426011
D000493	Allopurinol	Allopurinol inhibits the reaction [Glucose results in increased expression of NLRP3 protein]	23647015
D000493	Allopurinol	Allopurinol inhibits the reaction [Streptozocin results in increased expression of NLRP3 mRNA]	23647015
D000493	Allopurinol	Allopurinol inhibits the reaction [Streptozocin results in increased expression of NLRP3 protein]	23647015
D000534	Alum Compounds	NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Alum Compounds] results in increased cleavage of and results in increased secretion of IL1B protein]	18604214
D000534	Alum Compounds	Alum Compounds results in increased activity of NLRP3 protein	19439372
D000534	Alum Compounds	[Alum Compounds results in increased activity of NLRP3 protein] which results in increased activity of CASP1 protein	19439372
D000534	Alum Compounds	[Alum Compounds results in increased activity of NLRP3 protein] which results in increased expression of IL18	19439372
D000534	Alum Compounds	[Alum Compounds results in increased activity of NLRP3 protein] which results in increased expression of IL1B	19439372
D000536	Aluminum Hydroxide	NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]	18604214
C041524	aluminum sulfate	NLRP3 protein promotes the reaction [[Lipopolysaccharides co-treated with aluminum sulfate] results in increased secretion of IL1B protein]	24158569
D000639	Amitriptyline	Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of NLRP3 protein]	28633109
D000639	Amitriptyline	Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of NLRP3 protein]	28633109
D000872	Anthocyanins	Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of NLRP3 protein]	24795233
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of NLRP3 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of NLRP3 gene	25304211
D001194	Asbestos	NLRP3 gene SNP affects the susceptibility to Asbestos	24142982
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in decreased expression of NLRP3 mRNA"	27083413
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in increased expression of NLRP3 mRNA"	22168577
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of NLRP3 mRNA"	23937860\|2488589
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of NLRP3 protein"	23937860
D017638	Asbestos, Crocidolite	"Dactinomycin inhibits the reaction [Asbestos, Crocidolite results in increased expression of NLRP3 mRNA]"	23937860
D017638	Asbestos, Crocidolite	"Interleukin 1 Receptor Antagonist Protein inhibits the reaction [Asbestos, Crocidolite results in increased expression of NLRP3 mRNA]"	23937860
D017638	Asbestos, Crocidolite	"NLRP3 protein affects the reaction [Asbestos, Crocidolite results in increased cleavage of CASP1 protein]"	18403674
D017638	Asbestos, Crocidolite	"NLRP3 protein affects the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]"	18403674
D017638	Asbestos, Crocidolite	"NLRP3 protein promotes the reaction [Asbestos, Crocidolite results in increased secretion of HMGB1 protein]"	23937860
D017638	Asbestos, Crocidolite	"NLRP3 protein promotes the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]"	23937860
D017638	Asbestos, Crocidolite	"NLRP3 protein affects the reaction [Asbestos, Crocidolite results in increased cleavage of CASP1 protein]"	18403674
D017638	Asbestos, Crocidolite	"NLRP3 protein affects the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]"	18403674
D001241	Aspirin	NLRP3 SNP affects the susceptibility to Aspirin	19767079
D001285	Atropine	Atropine results in increased expression of NLRP3 mRNA	28138970
D001379	Azathioprine	Azathioprine results in increased expression of NLRP3 mRNA	24184165
C038044	baicalin	baicalin inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein]	29031535
C006780	bisphenol A	bisphenol A results in decreased expression of NLRP3 mRNA	25181051
D001786	Blood Glucose	[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NLRP3 mRNA	26464617
D001786	Blood Glucose	[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NLRP3 protein	26464617
D001786	Blood Glucose	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NLRP3 mRNA]	26464617
D001786	Blood Glucose	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NLRP3 protein]	26464617
D000069286	Bortezomib	Bortezomib results in decreased expression of NLRP3 mRNA	17659339
D019328	Buthionine Sulfoximine	[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of NLRP3 mRNA	23986454
D019328	Buthionine Sulfoximine	[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of NLRP3 mRNA	26177832
C018475	butyraldehyde	butyraldehyde results in increased expression of NLRP3 mRNA	26079696
D019256	Cadmium Chloride	NLRP3 protein promotes the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]	26809137
D019256	Cadmium Chloride	NLRP3 protein promotes the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of IL1B protein]	26809137
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of NLRP3 protein	27477297
D002251	Carbon Tetrachloride	NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]]	27477297
D002251	Carbon Tetrachloride	tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]	27477297
D004390	Chlorpyrifos	Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of NLRP3 protein]	26435000
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of NLRP3 protein	26435000
D004390	Chlorpyrifos	MitoTEMPO inhibits the reaction [Chlorpyrifos results in increased expression of NLRP3 protein]	26435000
D002784	Cholesterol	Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of NLRP3 protein]	28633109
D002784	Cholesterol	Cholesterol analog affects the localization of NLRP3 protein	28633109
D002784	Cholesterol	SMPD1 protein affects the reaction [Cholesterol analog affects the localization of NLRP3 protein]	28633109
D002784	Cholesterol	[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 mRNA	25833014
D002784	Cholesterol	[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 protein	25833014
D002784	Cholesterol	resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 mRNA]	25833014
D002784	Cholesterol	resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 protein]	25833014
D003035	Cobalt	[tungsten carbide co-treated with Cobalt] results in increased expression of NLRP3 mRNA	18078969
D003471	Cuprizone	Cuprizone results in increased expression of NLRP3 mRNA	27523638
D003513	Cycloheximide	Cycloheximide inhibits the reaction [tetrachlorobenzoquinone results in increased expression of NLRP3 protein]	26901245
D003609	Dactinomycin	"Dactinomycin inhibits the reaction [Asbestos, Crocidolite results in increased expression of NLRP3 mRNA]"	23937860
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of NLRP3 protein	26586371
D003993	Dibutyl Phthalate	KN 62 inhibits the reaction [Dibutyl Phthalate results in increased expression of NLRP3 protein]	26586371
D002945	Cisplatin	"3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]"	25308879
D002945	Cisplatin	Cisplatin results in increased expression of NLRP3 protein	25308879
D004008	Diclofenac	Diclofenac results in increased expression of NLRP3 mRNA	28138970
D004008	Diclofenac	Diclofenac results in increased expression of NLRP3 mRNA	24747151
D004009	Dicloxacillin	Dicloxacillin results in increased expression of NLRP3 mRNA	24747151
D004041	Dietary Fats	Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of NLRP3 protein]	24795233
D004041	Dietary Fats	Dietary Fats affects the localization of NLRP3 protein	26980705
D004041	Dietary Fats	Dietary Fats promotes the reaction [PYCARD protein binds to NLRP3 protein]	24508291
D004041	Dietary Fats	Dietary Fats results in increased expression of NLRP3 mRNA	25016146
D004041	Dietary Fats	Dietary Fats results in increased expression of NLRP3 protein	24795233
D004041	Dietary Fats	NLRP3 gene mutant form inhibits the reaction [Dietary Fats results in decreased expression of CDH5 protein]	26293846
D004041	Dietary Fats	NLRP3 gene mutant form inhibits the reaction [Dietary Fats results in decreased expression of OCLN protein]	26293846
D004041	Dietary Fats	NLRP3 gene mutant form inhibits the reaction [Dietary Fats results in decreased expression of TJP1 protein]	26293846
D004041	Dietary Fats	NLRP3 gene mutant form inhibits the reaction [Dietary Fats results in decreased expression of TJP2 protein]	26293846
D004041	Dietary Fats	NLRP3 gene mutant form inhibits the reaction [Dietary Fats results in increased activity of CASP1 protein]	26293846
D004041	Dietary Fats	NLRP3 gene mutant form inhibits the reaction [Dietary Fats results in increased expression of HMGB1 protein]	26293846
D004041	Dietary Fats	NLRP3 gene mutant form results in decreased susceptibility to Dietary Fats	26293846
D004041	Dietary Fats	NLRP3 protein promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of TJP1 protein]	27783111
D004041	Dietary Fats	NLRP3 protein promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of TJP2 protein]	27783111
D004041	Dietary Fats	NLRP3 protein promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased activity of CASP1 protein]	27783111
D004041	Dietary Fats	PYCARD gene mutant form inhibits the reaction [Dietary Fats promotes the reaction [PYCARD protein binds to NLRP3 protein]]	24508291
D004041	Dietary Fats	SMPD1 protein affects the reaction [Dietary Fats affects the localization of NLRP3 protein]	26980705
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of NLRP3 mRNA	17942915
D004052	Diethylnitrosamine	MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of NLRP3 mRNA]	17942915
D004125	Dimethyldithiocarbamate	Dimethyldithiocarbamate affects the expression of NLRP3 protein	25929180
D004050	Ditiocarb	Ditiocarb affects the expression of NLRP3 protein	25929180
D004050	Ditiocarb	[Ditiocarb co-treated with Zinc] results in decreased expression of NLRP3 protein	25929180
D004317	Doxorubicin	Doxorubicin results in increased expression of NLRP3 mRNA	24885895
D004317	Doxorubicin	MAPK1 promotes the reaction [Doxorubicin results in increased expression of NLRP3 mRNA]	24885895
D004391	Dust	Dust results in increased expression of NLRP3 mRNA	22118940
D004726	Endosulfan	Endosulfan results in increased expression of NLRP3 mRNA	28108160
D004875	Ergosterol	[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 mRNA	25833014
D004875	Ergosterol	[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 protein	25833014
D004875	Ergosterol	resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 mRNA]	25833014
D004875	Ergosterol	resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 protein]	25833014
C083174	erionite	erionite results in increased expression of NLRP3 mRNA	23937860
D000431	Ethanol	acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein]	28964808
D000431	Ethanol	[Ethanol co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein	28964808
D005485	Flutamide	Flutamide results in increased expression of NLRP3 mRNA	28138970
D005485	Flutamide	Flutamide results in increased expression of NLRP3 mRNA	28138970
D005557	Formaldehyde	Formaldehyde results in decreased expression of NLRP3 mRNA	28937961
D005632	Fructose	Allopurinol inhibits the reaction [Fructose results in increased expression of NLRP3 protein]	22426011
D005632	Fructose	Fructose results in increased expression of NLRP3 protein	22426011\|2449131
D005632	Fructose	Quercetin inhibits the reaction [Fructose results in increased expression of NLRP3 protein]	22426011\|2449131
D005632	Fructose	Rutin inhibits the reaction [Fructose results in increased expression of NLRP3 protein]	22426011
C039281	furan	furan results in increased expression of NLRP3 mRNA	27387713
D005947	Glucose	Allopurinol inhibits the reaction [Glucose results in increased expression of NLRP3 protein]	23647015
D005947	Glucose	Glucose results in increased expression of NLRP3 protein	23647015
D005947	Glucose	Quercetin inhibits the reaction [Glucose results in increased expression of NLRP3 protein]	23647015
D005947	Glucose	NLRP3 protein promotes the reaction [Glucose results in decreased expression of TJP1 protein]	27783111
D005947	Glucose	NLRP3 protein promotes the reaction [Glucose results in decreased expression of TJP2 protein]	27783111
D005947	Glucose	NLRP3 protein promotes the reaction [Glucose results in increased secretion of HMGB1 protein]	27783111
D005947	Glucose	NLRP3 protein results in increased susceptibility to Glucose	27783111
D005947	Glucose	Allopurinol inhibits the reaction [Glucose results in increased expression of NLRP3 protein]	23647015
D005947	Glucose	Glucose results in increased expression of NLRP3 protein	23647015\|2903153
D005947	Glucose	Quercetin inhibits the reaction [Glucose results in increased expression of NLRP3 protein]	23647015
D005947	Glucose	rhodioloside inhibits the reaction [Glucose results in increased expression of NLRP3 protein]	29031534
D005905	Glyburide	Glyburide inhibits the reaction [Paraquat results in increased expression of NLRP3 protein]	25338942
D006861	Hydrogen Peroxide	NLRP3 gene mutant form results in decreased susceptibility to Hydrogen Peroxide	23619996
D053590	Interleukin 1 Receptor Antagonist Protein	"Interleukin 1 Receptor Antagonist Protein inhibits the reaction [Asbestos, Crocidolite results in increased expression of NLRP3 mRNA]"	23937860
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NLRP3 mRNA	25613284
D058085	Iron Compounds	Iron Compounds results in increased expression of NLRP3 protein	28483490
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of NLRP3 mRNA	24796395
D007654	Ketoconazole	Ketoconazole results in increased expression of NLRP3 mRNA	28138970
D007654	Ketoconazole	Ketoconazole results in increased expression of NLRP3 mRNA	28138970
C063302	KN 62	KN 62 inhibits the reaction [Dibutyl Phthalate results in increased expression of NLRP3 protein]	26586371
C063302	KN 62	KN 62 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]	26586371
C096429	L 709049	L 709049 inhibits the reaction [Rotenone results in increased expression of NLRP3 protein]	26086368
D008070	Lipopolysaccharides	acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein]	28964808
D008070	Lipopolysaccharides	[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein	18604214
D008070	Lipopolysaccharides	[Ethanol co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein	28964808
D008070	Lipopolysaccharides	KN 62 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]	26586371
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with resveratrol] results in increased expression of NLRP3 mRNA	24149798
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 mRNA	24149798
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein	26586371
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of NLRP3 mRNA	24747151
D008070	Lipopolysaccharides	NLRP3 protein promotes the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]	26809137
D008070	Lipopolysaccharides	NLRP3 protein promotes the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of IL1B protein]	26809137
D008070	Lipopolysaccharides	[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein	18604214
D008070	Lipopolysaccharides	[Uric Acid co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein	18604214
D008070	Lipopolysaccharides	Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]	28814068
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]	23430110
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PML protein]	23430110
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]	23430110
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein	26086368
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of NLRP3 mRNA	22147977\|2589032
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of NLRP3 protein	23430110\|2881406
D008070	Lipopolysaccharides	NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]	18604214
D008070	Lipopolysaccharides	NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]	18604214
D008070	Lipopolysaccharides	NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Alum Compounds] results in increased cleavage of and results in increased secretion of IL1B protein]	18604214
D008070	Lipopolysaccharides	NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]	18604214
D008070	Lipopolysaccharides	NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of CASP1 protein]	18604214
D008070	Lipopolysaccharides	NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased secretion of and results in increased cleavage of IL1B protein]	18604214
D008070	Lipopolysaccharides	NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]	18604214
D008070	Lipopolysaccharides	NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]	18604214
D008070	Lipopolysaccharides	NLRP3 protein promotes the reaction [[Lipopolysaccharides co-treated with aluminum sulfate] results in increased secretion of IL1B protein]	24158569
D008070	Lipopolysaccharides	NLRP3 protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]	24158569
D008070	Lipopolysaccharides	PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]]	23430110
D008070	Lipopolysaccharides	PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]]	23430110
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of NLRP3 mRNA	25613284
D008276	Magnesium Hydroxide	NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]	18604214
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of NLRP3 mRNA	21641980
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NLRP3 mRNA	26378955
D008463	Mebendazole	Mebendazole results in increased expression of NLRP3 mRNA	24747151
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of NLRP3 mRNA	25237059
D008627	Mercuric Chloride	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercuric Chloride results in increased expression of NLRP3 mRNA]	25237059
D008628	Mercury	Mercury results in increased expression of NLRP3 mRNA	25237059
D008628	Mercury	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercury results in increased expression of NLRP3 mRNA]	25237059
D008713	Methimazole	[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of NLRP3 mRNA	26177832
C555916	MitoTEMPO	MitoTEMPO inhibits the reaction [Chlorpyrifos results in increased expression of NLRP3 protein]	26435000
C555916	MitoTEMPO	MitoTEMPO inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in decreased ubiquitination of NLRP3 protein]	26901245
C523799	MRK 003	NLRP3 results in increased susceptibility to MRK 003	19903844
C068250	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercuric Chloride results in increased expression of NLRP3 mRNA]	25237059
C068250	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercury results in increased expression of NLRP3 mRNA]	25237059
D009532	Nickel	Nickel results in increased expression of NLRP3 mRNA	23195993\|2476865
C022838	nickel chloride	NLRP3 protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]	24158569
D009550	Nigericin	NLRP3 protein affects the reaction [Nigericin results in increased secretion of IL1B protein]	18403674
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of NLRP3 mRNA	27935865
D010100	Oxygen	[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NLRP3 mRNA	26464617
D010100	Oxygen	[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NLRP3 protein	26464617
D010100	Oxygen	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NLRP3 mRNA]	26464617
D010100	Oxygen	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NLRP3 protein]	26464617
D019308	Palmitic Acid	baicalin inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein]	29031535
D019308	Palmitic Acid	NLRP3 inhibits the reaction [Palmitic Acid results in increased cleavage of CASP1 protein]	27689324
D019308	Palmitic Acid	NLRP3 inhibits the reaction [Palmitic Acid results in increased expression of IL1B protein]	27689324
D019308	Palmitic Acid	Palmitic Acid results in increased expression of NLRP3 protein	29031535
D019308	Palmitic Acid	tauroursodeoxycholic acid inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein]	29031535
D010269	Paraquat	Paraquat results in increased expression of NLRP3 protein	29054699
D010269	Paraquat	Silymarin inhibits the reaction [Paraquat results in increased expression of NLRP3 protein]	29054699
D010269	Paraquat	Glyburide inhibits the reaction [Paraquat results in increased expression of NLRP3 protein]	25338942
D010269	Paraquat	Paraquat results in increased expression of NLRP3 mRNA	25338942
D010269	Paraquat	Paraquat results in increased expression of NLRP3 protein	25338942
D052638	Particulate Matter	Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of NLRP3 protein]	28814068
D052638	Particulate Matter	Particulate Matter results in increased expression of NLRP3 protein	27158778\|2881406
C046012	pentanal	pentanal results in increased expression of NLRP3 mRNA	26079696
D010672	Phenytoin	[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of NLRP3 mRNA	23986454
D011188	Potassium	Potassium deficiency results in increased activity of NLRP3 protein	21051542
D011188	Potassium	[Potassium deficiency results in increased activity of NLRP3 protein] which results in increased secretion of IL1B protein	21051542
C005556	propionaldehyde	propionaldehyde results in decreased expression of NLRP3 mRNA	26079696
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [APP protein results in increased expression of NLRP3 protein]	28004443
D011794	Quercetin	Quercetin inhibits the reaction [Glucose results in increased expression of NLRP3 protein]	23647015
D011794	Quercetin	Quercetin inhibits the reaction [Fructose results in increased expression of NLRP3 protein]	22426011\|2449131
D011794	Quercetin	Quercetin inhibits the reaction [Glucose results in increased expression of NLRP3 protein]	23647015
D011794	Quercetin	Quercetin inhibits the reaction [Streptozocin results in increased expression of NLRP3 mRNA]	23647015
D011794	Quercetin	Quercetin inhibits the reaction [Streptozocin results in increased expression of NLRP3 protein]	23647015
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of NLRP3 mRNA	19059307
C059514	resveratrol	[Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with resveratrol] results in increased expression of NLRP3 mRNA	24149798
C059514	resveratrol	resveratrol results in increased expression of NLRP3 mRNA	25436977
C059514	resveratrol	resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 mRNA]	25833014
C059514	resveratrol	resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 protein]	25833014
C059514	resveratrol	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NLRP3 mRNA]	26464617
C059514	resveratrol	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NLRP3 protein]	26464617
C009172	rhodioloside	rhodioloside inhibits the reaction [Glucose results in increased expression of NLRP3 protein]	29031534
D012293	Rifampin	Rifampin inhibits the reaction [Rotenone results in increased expression of NLRP3 protein]	26086368
D012402	Rotenone	Acetylcysteine inhibits the reaction [Rotenone results in increased expression of NLRP3 protein]	26086368
D012402	Rotenone	L 709049 inhibits the reaction [Rotenone results in increased expression of NLRP3 protein]	26086368
D012402	Rotenone	NLRP3 gene mutant form inhibits the reaction [Rotenone results in decreased secretion of CCL11 protein]	28903492
D012402	Rotenone	NLRP3 gene mutant form inhibits the reaction [Rotenone results in increased phosphorylation of H2AFX protein]	23619996
D012402	Rotenone	NLRP3 gene mutant form inhibits the reaction [Rotenone results in increased secretion of CXCL1 protein]	28903492
D012402	Rotenone	NLRP3 gene mutant form results in decreased susceptibility to Rotenone	28903492
D012402	Rotenone	NLRP3 gene results in increased susceptibility to Rotenone	28903492
D012402	Rotenone	Rifampin inhibits the reaction [Rotenone results in increased expression of NLRP3 protein]	26086368
D012402	Rotenone	Rotenone results in increased expression of NLRP3 protein	26086368\|2890349
D012431	Rutin	Rutin inhibits the reaction [Fructose results in increased expression of NLRP3 protein]	22426011
C093642	SB 203580	SB 203580 inhibits the reaction [APP protein results in increased expression of NLRP3 protein]	28004443
D012643	Selenium	Selenium results in increased expression of NLRP3 mRNA	17293063
D017632	Asbestos, Serpentine	"NLRP3 protein affects the reaction [Asbestos, Serpentine results in increased expression of CXCL1 protein]"	18403674
D017632	Asbestos, Serpentine	"NLRP3 protein affects the reaction [Asbestos, Serpentine results in increased expression of IL1B protein]"	18403674
D012822	Silicon Dioxide	[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein	18604214
D012822	Silicon Dioxide	NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of CASP1 protein]	18604214
D012822	Silicon Dioxide	NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased secretion of and results in increased cleavage of IL1B protein]	18604214
D012822	Silicon Dioxide	NLRP3 protein affects the reaction [Silicon Dioxide results in increased cleavage of CASP1 protein]	18403674
D012822	Silicon Dioxide	NLRP3 protein affects the reaction [Silicon Dioxide results in increased secretion of IL1B protein]	18403674
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of NLRP3 mRNA	21602193
D012838	Silymarin	Silymarin inhibits the reaction [Paraquat results in increased expression of NLRP3 protein]	29054699
C118258	SN50 peptide	SN50 peptide inhibits the reaction [APP protein results in increased expression of NLRP3 protein]	28004443
D013311	Streptozocin	NLRP3 protein promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of TJP1 protein]	27783111
D013311	Streptozocin	NLRP3 protein promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of TJP2 protein]	27783111
D013311	Streptozocin	NLRP3 protein promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased activity of CASP1 protein]	27783111
D013311	Streptozocin	Allopurinol inhibits the reaction [Streptozocin results in increased expression of NLRP3 mRNA]	23647015
D013311	Streptozocin	Allopurinol inhibits the reaction [Streptozocin results in increased expression of NLRP3 protein]	23647015
D013311	Streptozocin	Quercetin inhibits the reaction [Streptozocin results in increased expression of NLRP3 mRNA]	23647015
D013311	Streptozocin	Quercetin inhibits the reaction [Streptozocin results in increased expression of NLRP3 protein]	23647015
D013311	Streptozocin	Streptozocin results in increased expression of NLRP3 mRNA	23647015
D013311	Streptozocin	Streptozocin results in increased expression of NLRP3 protein	23647015
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of NLRP3 mRNA	21641980
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NLRP3 mRNA	26378955
D013629	Tamoxifen	[Tamoxifen co-treated with ESR1 protein] results in increased expression of NLRP3 mRNA	19059307
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein]	29031535
C000591600	tetrachlorobenzoquinone	"2,6-diaminopyridine-3,5-bis(thiocyanate) inhibits the reaction [tetrachlorobenzoquinone results in decreased ubiquitination of NLRP3 protein modified form]"	26901245
C000591600	tetrachlorobenzoquinone	acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in decreased ubiquitination of NLRP3 protein]	26901245
C000591600	tetrachlorobenzoquinone	Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in decreased ubiquitination of NLRP3 protein]	26901245
C000591600	tetrachlorobenzoquinone	Cycloheximide inhibits the reaction [tetrachlorobenzoquinone results in increased expression of NLRP3 protein]	26901245
C000591600	tetrachlorobenzoquinone	MitoTEMPO inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in decreased ubiquitination of NLRP3 protein]	26901245
C000591600	tetrachlorobenzoquinone	NLRP3 protein promotes the reaction [tetrachlorobenzoquinone results in increased expression of ICAM1 protein]	26901245
C000591600	tetrachlorobenzoquinone	NLRP3 protein promotes the reaction [tetrachlorobenzoquinone results in increased expression of SELE protein]	26901245
C000591600	tetrachlorobenzoquinone	NLRP3 protein promotes the reaction [tetrachlorobenzoquinone results in increased expression of VCAM1 protein]	26901245
C000591600	tetrachlorobenzoquinone	NLRP3 protein promotes the reaction [tetrachlorobenzoquinone results in increased secretion of CASP1 protein modified form]	26901245
C000591600	tetrachlorobenzoquinone	NLRP3 protein promotes the reaction [tetrachlorobenzoquinone results in increased secretion of IL1B protein modified form]	26901245
C000591600	tetrachlorobenzoquinone	NLRP3 protein results in increased susceptibility to tetrachlorobenzoquinone	26901245
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone results in increased expression of and results in decreased ubiquitination of NLRP3 protein	26901245
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone results in increased expression of NLRP3 mRNA	26901245
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NLRP3 mRNA	28922406
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of NLRP3 mRNA	23937860
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NLRP3 mRNA	25613284
C017953	tetramethylpyrazine	NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]]	27477297
C017953	tetramethylpyrazine	tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]	27477297
D013893	Thiram	Thiram affects the expression of NLRP3 protein	25929180
D014028	Tobacco Smoke Pollution	Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of NLRP3 protein]	28814068
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution analog results in increased expression of NLRP3 protein	28814068
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of NLRP3 mRNA	28111298
C002802	tungsten carbide	[tungsten carbide co-treated with Cobalt] results in increased expression of NLRP3 mRNA	18078969
D014527	Uric Acid	NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]	18403674
D014527	Uric Acid	NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]	18403674
D014527	Uric Acid	[Uric Acid co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein	18604214
D014527	Uric Acid	NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of BRCA1 mRNA]	23619996
D014527	Uric Acid	NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCNB1 mRNA]	23619996
D014527	Uric Acid	NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCND1 mRNA]	23619996
D014527	Uric Acid	NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of OGG1 mRNA]	23619996
D014527	Uric Acid	NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of POLB mRNA]	23619996
D014527	Uric Acid	NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of PRIM1 mRNA]	23619996
D014527	Uric Acid	NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RAD51 mRNA]	23619996
D014527	Uric Acid	NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC3 mRNA]	23619996
D014527	Uric Acid	NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC4 mRNA]	23619996
D014527	Uric Acid	NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TTK mRNA]	23619996
D014527	Uric Acid	NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TYMS mRNA]	23619996
D014527	Uric Acid	NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of XRCC1 mRNA]	23619996
D014527	Uric Acid	NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of ATR protein]	23619996
D014527	Uric Acid	NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AFX protein]	23619996
D014527	Uric Acid	NLRP3 gene mutant form results in decreased susceptibility to Uric Acid	23619996
D014527	Uric Acid	NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]	18604214
D014527	Uric Acid	NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]	18604214
D014527	Uric Acid	NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]	18403674
D014527	Uric Acid	NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]	18403674
D001335	Vehicle Emissions	Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of NLRP3 protein]	28814068
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of NLRP3 protein	28814068
C581157	XL147	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of NLRP3 mRNA	27935865
D015032	Zinc	[Ditiocarb co-treated with Zinc] results in decreased expression of NLRP3 protein	25929180
D015039	Ziram	Ziram results in decreased expression of NLRP3 protein	25929180

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	11786556 15020601 15030775 19158675 19337385 22461501 22801494 23582325 23871209 24630722 26347139 26814970
GO:0005524	ATP binding	-	IEA	-
GO:0008134	transcription factor binding	-	ISS	-
GO:0042802	identical protein binding	-	IPI	23582325 24630722
GO:0042834	peptidoglycan binding	-	TAS	15967716
GO:0043565	sequence-specific DNA binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002374	cytokine secretion involved in immune response	-	IEA	-
GO:0002674	negative regulation of acute inflammatory response	-	IMP	11687797
GO:0002830	positive regulation of type 2 immune response	-	ISS	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006915	apoptotic process	-	NAS	12032915
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	IEA	-
GO:0006952	defense response	-	TAS	15967716
GO:0006954	inflammatory response	-	IMP	12093792
GO:0007165	signal transduction	-	NAS	11786556
GO:0009595	detection of biotic stimulus	-	TAS	15967716
GO:0009617	response to bacterium	-	IBA	21873635
GO:0016579	protein deubiquitination	-	TAS	-
GO:0032088	negative regulation of NF-kappaB transcription factor activity	-	IDA	14662828
GO:0032611	interleukin-1 beta production	-	IEA	-
GO:0032621	interleukin-18 production	-	IEA	-
GO:0032736	positive regulation of interleukin-13 production	-	IEA	-
GO:0032753	positive regulation of interleukin-4 production	-	ISS	-
GO:0032754	positive regulation of interleukin-5 production	-	IEA	-
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	-	IBA	21873635
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	-	IDA	15030775
GO:0044546	NLRP3 inflammasome complex assembly	-	IEA	-
GO:0045087	innate immune response	-	IEA	-
GO:0045630	positive regulation of T-helper 2 cell differentiation	-	ISS	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	-
GO:0050701	interleukin-1 secretion	-	IEA	-
GO:0050713	negative regulation of interleukin-1 beta secretion	-	IMP	12483741
GO:0050718	positive regulation of interleukin-1 beta secretion	-	IBA	21873635
GO:0050718	positive regulation of interleukin-1 beta secretion	-	IDA	15030775
GO:0050728	negative regulation of inflammatory response	-	IMP	12483741 16531551 17178985
GO:0050830	defense response to Gram-positive bacterium	-	IEA	-
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IDA	19158675
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IPI	15817483
GO:0051259	protein complex oligomerization	-	TAS	15967716
GO:0051607	defense response to virus	-	IEA	-
GO:0071222	cellular response to lipopolysaccharide	-	IMP	12483741
GO:0071224	cellular response to peptidoglycan	-	IEA	-
GO:1901223	negative regulation of NIK/NF-kappaB signaling	-	IDA	14662828
GO:2000321	positive regulation of T-helper 17 cell differentiation	-	IEA	-
GO:2000553	positive regulation of T-helper 2 cell cytokine production	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IEA	-
GO:0005634	nucleus	-	ISS	-
GO:0005737	cytoplasm	-	IDA	17164409
GO:0005737	cytoplasm	-	TAS	15967716
GO:0005783	endoplasmic reticulum	-	IEA	-
GO:0005829	cytosol	-	TAS	-
GO:0072559	NLRP3 inflammasome complex	-	IDA	15030775

KEGG ID	KEGG Term
hsa04621	NOD-like receptor signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	TAS
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	IEA
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689901	Metalloprotease DUBs	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-622312	Inflammasomes	TAS
R-HSA-622312	Inflammasomes	IEA
R-HSA-844456	The NLRP3 inflammasome	TAS
R-HSA-844456	The NLRP3 inflammasome	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24967817	Anti-TNF treatment response in rheumatoid arthritis patients is associated with genetic variation in the NLRP3-inflammasome. (2014)	Sode J	PLoS One
28147216	An emerging role of Alu RNA in geographic atrophy pathogenesis: the implication for novel therapeutic strategies. (2016 Dec)	Mao X	Discov Med
28135700	The Association between Polymorphism of CARD8 rs2043211 and Susceptibility to Arteriosclerosis Obliterans in Chinese Han Male Population. (2017)	Zhang K	Cell Physiol Biochem
29508284	NLRs as Helpline in the Brain: Mechanisms and Therapeutic Implications. (2018 Mar 6)	Singh S	Mol Neurobiol
28232172	Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions. (2017 May)	Abdul-Muneer PM	Brain Behav Immun
21621776	Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms. (2011 Sep)	Roberts RL	Atherosclerosis
28656364	The critical role of macrophages in the pathogenesis of hidradenitis suppurativa. (2017 Nov)	Shah A	Inflamm Res
29416034	Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis. (2018 Feb 7)	Wu X	Cell Death Dis
24372548	The complex P2X7 receptor/inflammasome in perivascular fat tissue of heavy smokers. (2014)	Rossi C	Eur J Clin Invest
27421477	Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation. (2016 Aug 15)	Hoyt LR	J Immunol
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