Gene: MAL2

114569
-
mal, T cell differentiation protein 2 (gene/pseudogene)
protein-coding
8q24.12
Ensembl:ENSG00000147676 MIM:609684 Vega:OTTHUMG00000164973 UniprotKB:Q969L2
NC_000008.11
PubMed
0   ANCO-SNPs
CD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.740e-1 (AD)  4.117e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RGS70.971
GDA0.967
PAK10.967
GABRA10.964
GABRB30.962
SCN2A0.961
DCAF60.961
PAK30.96
RBFOX10.96
NSF0.959

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.562
HEY2-0.559
CSAG1-0.555
CNN2-0.534
SNHG18-0.532
YES1-0.529
REST-0.527
RNF135-0.524
RUNX3-0.521
WWTR1-0.519

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MAL2 mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MAL2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MAL2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MAL2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MAL2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MAL2 mRNA"25510870
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of MAL2 mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAL2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MAL2 mRNA21420995|2223033
D000082AcetaminophenAcetaminophen results in increased expression of MAL2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of MAL2 mRNA17562736
D000452AldrinAldrin results in increased expression of MAL2 mRNA18579281
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of MAL2 mRNA"22863853
D001379AzathioprineAzathioprine results in decreased expression of MAL2 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAL2 mRNA21632981
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MAL2 mRNA"26238291
D004958EstradiolEstradiol results in increased expression of MAL2 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of MAL2 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of MAL2 mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of MAL2 mRNA25979313
D002794CholineCholine affects the expression of MAL2 mRNA17616785
D002922CiguatoxinsCiguatoxins affects the expression of MAL2 mRNA18353800
D002994ClofibrateClofibrate affects the expression of MAL2 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in decreased expression of MAL2 mRNA24386269
D003042CocaineCocaine results in increased expression of MAL2 mRNA15009677
D019327Copper SulfateCopper Sulfate results in decreased expression of MAL2 mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased expression of MAL2 mRNA18579281
D016572CyclosporineCyclosporine results in increased expression of MAL2 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of MAL2 mRNA19770486
D003703DemecolcineDemecolcine results in increased expression of MAL2 mRNA23649840
C000944dicrotophosdicrotophos results in decreased expression of MAL2 mRNA28302478
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of MAL2 mRNA27638505
D004237DiuronDiuron results in decreased expression of MAL2 mRNA21551480
C118739entinostatentinostat results in increased expression of MAL2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAL2 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MAL2 mRNA22079256
C082360fipronilfipronil results in increased expression of MAL2 mRNA23962444
D005485FlutamideFlutamide results in increased expression of MAL2 mRNA24136188
C039281furanfuran results in increased expression of MAL2 mRNA24183702
D019833GenisteinGenistein results in increased expression of MAL2 mRNA17341692
D017313FenretinideFenretinide results in increased expression of MAL2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MAL2 mRNA20044591
C492448ICG 001ICG 001 results in increased expression of MAL2 mRNA26191083
D007657Ketone BodiesKetone Bodies results in increased expression of MAL2 mRNA16807920
C045463leflunomideleflunomide results in increased expression of MAL2 mRNA24136188
C042720mercuric bromidemercuric bromide results in increased expression of MAL2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAL2 mRNA"27188386
D008777MethyltestosteroneMethyltestosterone results in decreased expression of MAL2 mRNA29191790
C523184mocetinostatmocetinostat results in increased expression of MAL2 mRNA27255383
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of MAL2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MAL2 mRNA"25620056
C051752nefazodonenefazodone results in increased expression of MAL2 mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of MAL2 mRNA17616710
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MAL2 mRNA"25510870
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of MAL2 mRNA23602845
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAL2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MAL2 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of MAL2 mRNA18301758
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MAL2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MAL2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of MAL2 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of MAL2 mRNA28903501
D011374ProgesteroneProgesterone results in decreased expression of MAL2 mRNA22238285
C045950propiconazolepropiconazole results in increased expression of MAL2 mRNA21278054
D011791QuartzQuartz affects the expression of MAL2 mRNA19836432
D011794QuercetinQuercetin results in decreased expression of MAL2 mRNA21632981
D012715Sesame OilSesame Oil results in increased expression of MAL2 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MAL2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of MAL2 mRNA22431001
D012906SmokeSmoke results in decreased expression of MAL2 mRNA21095227
D012969Sodium FluorideSodium Fluoride results in decreased expression of MAL2 protein27548804
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MAL2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAL2 mRNA21570461|2637764
D014212TretinoinTretinoin results in increased expression of MAL2 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAL2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of MAL2 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in decreased expression of MAL2 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MAL2 mRNA"26179874
C080163trovafloxacintrovafloxacin results in decreased expression of MAL2 mRNA24136188
D014520UrethaneUrethane results in decreased expression of MAL2 mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of MAL2 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAL2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MAL2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MAL2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of MAL2 mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of MAL2 mRNA15901671
D014638VanadatesVanadates results in decreased expression of MAL2 mRNA22714537
D014640VancomycinVancomycin results in decreased expression of MAL2 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MAL2 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of MAL2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12963375  25416956  26871637  27107014  
GO:0019911structural constituent of myelin sheath-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0042552myelination-IBA21873635  
GO:0045056transcytosis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0012505endomembrane system-IEA-  
GO:0016021integral component of membrane-IBA21873635  
GO:0016324apical plasma membrane-IEA-  
GO:0045121membrane raft-IDA23264465  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18357522Expression of transcripts for myelin related genes in postmortem brain from cocaine abusers. (2009 Jan)Kristiansen LVNeurochem Res
28481639Computed Tomography Measure of Lung at Risk and Lung Function Decline in Chronic Obstructive Pulmonary Disease. (2017 Sep 1)Bhatt SPAm J Respir Crit Care Med