Gene: CHRNG

1146
ACHRG
cholinergic receptor nicotinic gamma subunit
protein-coding
2q37.1
Ensembl:ENSG00000196811 MIM:100730 Vega:OTTHUMG00000153327 UniprotKB:P07510
NG_012954.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.832e-1 (AD)  4.297e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09283548chr2:233404220CHRNGPromoter7.426e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KRTAP4-50.623
MTRNR2L30.591
IYD0.588
FOXE10.585
MTRNR2L100.585
TTLL10-AS10.584
C10orf710.58
TPO0.575
UNC45B0.574
OR51I20.563

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UCN-0.353
C9orf163-0.339
MESP1-0.322
HIST3H2A-0.315
SPAG8-0.313
HDDC3-0.303
FGF22-0.296
FTCD-0.295
CCDC24-0.294
HAGHL-0.293

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00674GalantamineSmall Molecule357-70-0ApprovedTarget
ID Drug Name Action PubMed
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]22461452
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]22461452
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]23146756
D000109Acetylcholinepoly-APS inhibits the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]]23146756
D020106AcrylamideAcrylamide results in decreased expression of CHRNG mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHRNG mRNA16483693
D001280AtrazineAtrazine results in decreased expression of CHRNG mRNA25929836
D001507BeclomethasoneBeclomethasone results in increased expression of CHRNG mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CHRNG mRNA22316170
C006780bisphenol Abisphenol A affects the expression of CHRNG mRNA25181051
D002038BungarotoxinsBungarotoxins binds to [NACHRALPHA3 protein co-treated with CHRNG protein]10728888
D002038BungarotoxinsBungarotoxins binds to [CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNG protein]9336329
D002038BungarotoxinsNicotine inhibits the reaction [Bungarotoxins binds to [CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNG protein]]9336329
D002038Bungarotoxinspozanicline inhibits the reaction [Bungarotoxins binds to [CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNG protein]]9336329
D002330CarmustineCarmustine results in decreased expression of CHRNG mRNA15980968
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CHRNG mRNA18812211
D003976DiazinonDiazinon results in decreased expression of CHRNG mRNA17452286
D019422Dietary SucroseDietary Sucrose results in increased expression of CHRNG mRNA26033743
C082748epibatidineepibatidine binds to [NACHRALPHA3 protein co-treated with CHRNG protein]10728888
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CHRNG mRNA23550701
C024565ethylene dichlorideethylene dichloride results in decreased expression of CHRNG mRNA28189721
D005419FlavonoidsFlavonoids results in decreased expression of CHRNG mRNA18035473
C069837fullerene C60fullerene C60 results in decreased expression of CHRNG mRNA19167457
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CHRNG mRNA21385734
C500085muraglitazarmuraglitazar results in decreased expression of CHRNG mRNA21515302
C028007nickel monoxidenickel monoxide results in decreased expression of CHRNG mRNA19167457
D009538NicotineNicotine inhibits the reaction [Bungarotoxins binds to [CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNG protein]]9336329
C053765N-methylcarbamylcholineN-methylcarbamylcholine binds to [NACHRALPHA3 protein co-treated with CHRNG protein]10728888
D010269ParaquatParaquat affects the expression of CHRNG mRNA18198484
C006253pirinixic acidpirinixic acid results in increased expression of CHRNG mRNA20813756
D010936Plant ExtractsPlant Extracts results in decreased expression of CHRNG mRNA23557933
C115254poly-APSpoly-APS inhibits the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]]23146756
C108326pozaniclinepozanicline inhibits the reaction [Bungarotoxins binds to [CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNG protein]]9336329
C089730rosiglitazonerosiglitazone results in decreased expression of CHRNG mRNA21515302
C560328sulfoxaflorsulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]22461452
C501413tesaglitazartesaglitazar results in decreased expression of CHRNG mRNA21515302
C057693troglitazonetroglitazone results in decreased expression of CHRNG mRNA21515302
D014635Valproic AcidValproic Acid results in increased methylation of CHRNG gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0015267channel activity-TAS3967651  
GO:0015276ligand-gated ion channel activity-TAS-  
GO:0015464acetylcholine receptor activityCONTRIBUTES_TOIBA21873635  
GO:0015464acetylcholine receptor activity-TAS3967651  
GO:0042166acetylcholine bindingCONTRIBUTES_TOIBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-TAS8040310  
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-TAS3967651  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007271synaptic transmission, cholinergic-IBA21873635  
GO:0007274neuromuscular synaptic transmission-IBA21873635  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0035094response to nicotine-IBA21873635  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO:0060079excitatory postsynaptic potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS3967651  
GO:0005892acetylcholine-gated channel complex-IBA21873635  
GO:0030054cell junction-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-181431Acetylcholine binding and downstream eventsTAS
R-HSA-622323Presynaptic nicotinic acetylcholine receptorsTAS
R-HSA-622327Postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629587Highly sodium permeable acetylcholine nicotinic receptorsTAS
R-HSA-629602Activation of Nicotinic Acetylcholine ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21498873Associations of nicotine intake measures with CHRN genes in Finnish smokers. (2011 Aug)Keskitalo-Vuokko KNicotine Tob Res
20584212Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (2010 Oct)Saccone NLGenes Brain Behav