Gene: TIRAP

114609
BACTS1|Mal|MyD88-2|wyatt
TIR domain containing adaptor protein
protein-coding
11q24.2
Ensembl:ENSG00000150455 MIM:606252 Vega:OTTHUMG00000140373 UniprotKB:P58753
NG_011523.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.978e-1 (AD)  6.719e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DEPDC50.818
TMEM1770.813
DOPEY20.808
ATG70.805
TUBGCP50.805
IPO90.802
SLC35B40.799
LDB10.799
GTF2H40.795
SLC25A160.795

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.425
S100A8-0.425
PPBP-0.421
RAB13-0.416
FXYD3-0.407
C7orf61-0.398
TGFB3-0.395
CLEC2B-0.392
SFN-0.391
PXDC1-0.382

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TIRAP mRNA"18648102
C5500919,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol"9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TIRAP mRNA]"20590609
C5500919,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol"9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TIRAP protein]"20590609
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TIRAP mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TIRAP mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TIRAP mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TIRAP mRNA22228805
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of TIRAP mRNA26496021
C006780bisphenol Abisphenol A affects the expression of TIRAP mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of TIRAP mRNA26496021
C018475butyraldehydebutyraldehyde results in decreased expression of TIRAP mRNA26079696
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIRAP mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TIRAP mRNA]"20230807
C030583ceric oxideceric oxide analog results in decreased expression of TIRAP mRNA24821434
D002746Chlorpromazine"TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]"23238562
D002746ChlorpromazineTIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein]23238562
D002746ChlorpromazineTIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]23238562
D002746Chlorpromazine"TIRAP gene mutant form inhibits the reaction [Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]]"23238562
D002746Chlorpromazine"TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4]"23238562
D002746ChlorpromazineTIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipoteichoic acid]23238562
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TIRAP gene20938992
C060728cobalt oxidecobalt oxide analog results in decreased expression of TIRAP mRNA24821434
D003703DemecolcineDemecolcine results in decreased expression of TIRAP mRNA23649840
D004008DiclofenacDiclofenac results in increased expression of TIRAP mRNA26934552
C000944dicrotophosdicrotophos results in increased expression of TIRAP mRNA28302478
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of TIRAP mRNA24834073
D004317Doxorubicin[Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of TIRAP mRNA27181935
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TIRAP mRNA17108234
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TIRAP gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of TIRAP mRNA27664576
D062610Fungal Polysaccharides[Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of TIRAP mRNA27181935
D017313FenretinideFenretinide results in increased expression of TIRAP mRNA28973697
C011890kojic acidkojic acid results in decreased expression of TIRAP mRNA16595896
C482199lipopolysaccharide, E coli O55-B5"9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TIRAP mRNA]"20590609
C482199lipopolysaccharide, E coli O55-B5"9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TIRAP protein]"20590609
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of TIRAP mRNA"20590609
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of TIRAP protein"20590609
C440499lipopolysaccharide, Escherichia coli O111 B4"TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]"23238562
C440499lipopolysaccharide, Escherichia coli O111 B4"TIRAP gene mutant form inhibits the reaction [Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]]"23238562
C440499lipopolysaccharide, Escherichia coli O111 B4"TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4]"23238562
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TIRAP mRNA24056979
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of TIRAP mRNA]24056979
C009900lipoteichoic acidTIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein]23238562
C009900lipoteichoic acidTIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]23238562
C009900lipoteichoic acidTIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipoteichoic acid]23238562
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TIRAP gene20938992
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of TIRAP mRNA]24056979
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TIRAP mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIRAP mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TIRAP mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIRAP mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TIRAP mRNA]"20230807
D009151Mustard GasMustard Gas results in increased expression of TIRAP mRNA18955075
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TIRAP mRNA"25554681|2562005
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIRAP mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TIRAP mRNA]"20230807
C046012pentanalpentanal results in decreased expression of TIRAP mRNA26079696
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TIRAP mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of TIRAP mRNA18445702|2081375
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TIRAP mRNA27029645
D011748PyrogallolPyrogallol results in increased expression of TIRAP mRNA20362636
D012715Sesame OilSesame Oil results in increased expression of TIRAP mRNA29191790
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TIRAP mRNA21570461
D014118Toxins, Biological"Toxins, Biological affects the expression of TIRAP mRNA"19682533
D014635Valproic AcidValproic Acid results in decreased expression of TIRAP mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TIRAP gene25560391
D014750VincristineVincristine results in decreased expression of TIRAP mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005080protein kinase C binding-IPI17161867  
GO:0005515protein binding-IPI11544529  17258210  17583698  19509286  19574958  19948740  
21334391  21903422  22155231  24275656  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-ISS-  
GO:0030674protein binding, bridging-NAS19509286  
GO:0035662Toll-like receptor 4 binding-IPI19509286  
GO:0035663Toll-like receptor 2 binding-IPI19509286  
GO:0042802identical protein binding-IPI17258210  24275656  
GO:0042803protein homodimerization activity-ISS-  
GO:0046982protein heterodimerization activity-IDA19509286  
GO ID GO Term Qualifier Evidence PubMed
GO:0002755MyD88-dependent toll-like receptor signaling pathway-TAS19509286  
GO:0006954inflammatory response-IEA-  
GO:0007166cell surface receptor signaling pathway-ISS-  
GO:0007250activation of NF-kappaB-inducing kinase activity-IMP24275656  
GO:0030099myeloid cell differentiation-ISS-  
GO:0030890positive regulation of B cell proliferation-ISS-  
GO:0032496response to lipopolysaccharide-IDA11544529  
GO:0032648regulation of interferon-beta production-ISS-  
GO:0032735positive regulation of interleukin-12 production-ISS-  
GO:0032738positive regulation of interleukin-15 production-IDA18583567  
GO:0032757positive regulation of interleukin-8 production-IMP16301656  
GO:0032760positive regulation of tumor necrosis factor production-IMP16301656  19509286  
GO:0034137positive regulation of toll-like receptor 2 signaling pathway-IMP19509286  
GO:0034141positive regulation of toll-like receptor 3 signaling pathway-ISS-  
GO:0034145positive regulation of toll-like receptor 4 signaling pathway-IMP19509286  
GO:0035665TIRAP-dependent toll-like receptor 4 signaling pathway-IDA11544529  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IMP19509286  
GO:0044130negative regulation of growth of symbiont in host-ISS-  
GO:0045087innate immune response-IEA-  
GO:0045088regulation of innate immune response-IC19509286  
GO:0045410positive regulation of interleukin-6 biosynthetic process-IMP16301656  
GO:0046330positive regulation of JNK cascade-IMP11544529  
GO:0050830defense response to Gram-positive bacterium-ISS-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IMP19509286  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IMP11544529  
GO:00709353'-UTR-mediated mRNA stabilization-IDA15294994  
GO:0071221cellular response to bacterial lipopeptide-ISS-  
GO:0071223cellular response to lipoteichoic acid-ISS-  
GO:0090023positive regulation of neutrophil chemotaxis-ISS-  
GO:0090073positive regulation of protein homodimerization activity-IDA12062447  
GO:2000340positive regulation of chemokine (C-X-C motif) ligand 1 production-ISS-  
GO:2000343positive regulation of chemokine (C-X-C motif) ligand 2 production-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA19948740  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA19948740  
GO:0005886plasma membrane-TAS-  
GO:0030139endocytic vesicle-ISS-  
GO:0032587ruffle membrane-ISS-  
KEGG ID KEGG Term
hsa04620Toll-like receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1236974ER-Phagosome pathwayTAS
R-HSA-1236975Antigen processing-Cross presentationTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1643685DiseaseTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-5260271Diseases of Immune SystemTAS
R-HSA-5602358Diseases associated with the TLR signaling cascadeTAS
R-HSA-5602498MyD88 deficiency (TLR2/4)TAS
R-HSA-5603041IRAK4 deficiency (TLR2/4)TAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26371589A toll-like receptor 9 (rs352140) variant is associated with placental inflammation in newborn infants. (2016)Karody VJ Matern Fetal Neonatal Med