Gene: CYGB

114757
HGB|STAP
cytoglobin
protein-coding
17q25.1
Ensembl:ENSG00000161544 MIM:608759 Vega:OTTHUMG00000180289 UniprotKB:Q8WWM9
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.734e-1 (AD)  7.545e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPRIN10.884
GDAP1L10.878
SPINT20.864
GNG30.861
NPM20.861
GAP430.855
TCEAL60.855
CACNB30.855
FXYD60.853
VSTM2L0.853

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.501
OR4F29-0.46
REST-0.458
SGMS2-0.431
RAI14-0.43
BAZ1A-0.426
HEY2-0.412
TGIF1-0.403
SH2D1A-0.402
CNN2-0.4

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of CYGB mRNA"26377693
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CYGB mRNA19933214
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazole2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA25781201
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazole2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA]25781201
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA]25781201
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazolealpha-naphthoflavone inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA]25781201
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazoleCC 401 inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA]25781201
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazoleDactinomycin inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA]25781201
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazoleEUK-134 inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA]25781201
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazolepyrazolanthrone inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA]25781201
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA]25781201
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA]25781201
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYGB mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to CYGB protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CYGB protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYGB mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CYGB mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of CYGB mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of CYGB mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CYGB protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CYGB mRNA21632981|2164198
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of CYGB mRNA28522335
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA]25781201
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CYGB mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of CYGB mRNA"22863853
D016718Arachidonic AcidCYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA]16581302
D016718Arachidonic AcidCYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA]16581302
D016718Arachidonic AcidCYGB protein results in decreased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]16581302
D001152ArsenicalsArsenicals results in increased expression of CYGB mRNA28625800
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CYGB protein]26598702
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CYGB mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CYGB mRNA20064835|2010694
C006780bisphenol Abisphenol A results in increased expression of CYGB mRNA27685785
C006780bisphenol Abisphenol A affects the expression of CYGB mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of CYGB mRNA28721559
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of CYGB mRNA27509014
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CYGB mRNA25993096
C034939cadmium sulfidecadmium sulfide results in increased expression of CYGB mRNA27866839
C034939cadmium sulfide[cadmium telluride co-treated with cadmium sulfide] results in decreased expression of CYGB mRNA20596552
C028337cadmium telluride[cadmium telluride co-treated with cadmium sulfide] results in decreased expression of CYGB mRNA20596552
D002251Carbon TetrachlorideCYGB protein inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]16581302
D002251Carbon TetrachlorideCYGB protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]16581302
D002251Carbon TetrachlorideCYGB protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]16581302
D002251Carbon TetrachlorideCYGB protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]16581302
C525250CC 401CC 401 inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA]25781201
C026690cerous chloridecerous chloride affects the expression of CYGB mRNA28954213
C026690cerous chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of CYGB mRNA28954213
D002726Chlorogenic AcidChlorogenic Acid results in decreased expression of CYGB mRNA20706672
C100187chloropicrinchloropicrin results in decreased expression of CYGB mRNA26352163
D003042CocaineCocaine results in decreased expression of CYGB protein25100957
D016572CyclosporineCyclosporine results in decreased expression of CYGB mRNA25562108
C017160cypermethrincypermethrin results in increased expression of CYGB mRNA21142847
D003545CysteineCysteine inhibits the reaction [Thioacetamide results in increased expression of CYGB protein]15158331
D003609DactinomycinDactinomycin inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA]25781201
C014347decitabinedecitabine results in increased expression of CYGB mRNA25781201
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of CYGB mRNA28659758
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CYGB mRNA27392435
D002945CisplatinCisplatin results in increased expression of CYGB mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of CYGB mRNA25016146
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CYGB mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CYGB mRNA28943392
D004237DiuronDiuron results in decreased expression of CYGB mRNA25152437
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of CYGB mRNA20706672
C074283estradiol 3-benzoateestradiol 3-benzoate promotes the reaction [Thioacetamide results in increased expression of CYGB mRNA]15716488
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CYGB mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYGB mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CYGB mRNA17557909
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CYGB mRNA23649840
C433928EUK-134EUK-134 inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA]25781201
C020326ferric nitrilotriacetateCYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA]16581302
C020326ferric nitrilotriacetateCYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA]16581302
C020326ferric nitrilotriacetateCYGB protein results in decreased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]16581302
D005419FlavonoidsFlavonoids results in increased expression of CYGB mRNA18035473
C039281furanfuran results in increased expression of CYGB mRNA27387713
D019833GenisteinGenistein results in decreased expression of CYGB mRNA20706672
D005839GentamicinsGentamicins results in increased expression of CYGB protein21081137|2206182
C010176halofuginonehalofuginone inhibits the reaction [Thioacetamide results in increased expression of CYGB mRNA]17180598
C010176halofuginonehalofuginone inhibits the reaction [Thioacetamide results in increased expression of CYGB protein]17180598
C010176halofuginonehalofuginone results in increased expression of CYGB mRNA17180598
D017313FenretinideFenretinide results in increased expression of CYGB mRNA28973697
D006861Hydrogen PeroxideCYGB protein results in increased metabolism of Hydrogen Peroxide11320098
C078038inchinko-toinchinko-to inhibits the reaction [Thioacetamide results in increased expression of CYGB protein]15288473
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CYGB mRNA27392435
C028521lanthanum chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of CYGB mRNA28954213
C028521lanthanum chloridelanthanum chloride affects the expression of CYGB mRNA28954213
D007854LeadLead affects the expression of CYGB mRNA28903495
C008285linoleic acid hydroperoxideCYGB protein results in increased metabolism of linoleic acid hydroperoxide11320098
D008715MethionineMethionine inhibits the reaction [Thioacetamide results in increased expression of CYGB protein]15158331
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CYGB mRNA"24389112
C029938nickel sulfatenickel sulfate results in decreased expression of CYGB mRNA22714537
C025589ochratoxin Aochratoxin A results in increased expression of CYGB mRNA23358140
C485800osajinosajin results in decreased expression of CYGB mRNA20706672
D010269ParaquatParaquat results in increased expression of CYGB mRNA20388547
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CYGB mRNA26705709
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of CYGB mRNA28659758
C474837pomiferinpomiferin results in decreased expression of CYGB mRNA20706672
D011429PropolisPropolis results in decreased expression of CYGB mRNA20706672
C033607puerarinpuerarin results in decreased expression of CYGB mRNA20706672
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA]25781201
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of CYGB mRNA28659758
D011794QuercetinQuercetin results in increased expression of CYGB mRNA21632981
D015125OxyquinolineOxyquinoline results in increased expression of CYGB mRNA21632981
C059514resveratrolresveratrol results in decreased expression of CYGB mRNA20706672
C529148rosavinrosavin results in decreased expression of CYGB mRNA20706672
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CYGB mRNA21427059
D012834SilverSilver results in decreased expression of CYGB mRNA19429238
D012906SmokeSmoke results in increased expression of CYGB mRNA21095227
C017947sodium arsenitesodium arsenite results in increased expression of CYGB mRNA28229933
D012969Sodium FluorideSodium Fluoride results in increased expression of CYGB protein28918527
D053260SootSoot results in decreased expression of CYGB mRNA26551751
D053260SootSoot results in decreased expression of CYGB mRNA21914721
D053260SootSoot results in increased expression of CYGB mRNA21914721
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYGB mRNA20106945|2163298
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYGB mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYGB mRNA19933214|2821309
D019284ThapsigarginThapsigargin results in decreased expression of CYGB mRNA22378314
D013853ThioacetamideCysteine inhibits the reaction [Thioacetamide results in increased expression of CYGB protein]15158331
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CYGB mRNA28943392
D013853Thioacetamideestradiol 3-benzoate promotes the reaction [Thioacetamide results in increased expression of CYGB mRNA]15716488
D013853Thioacetamidehalofuginone inhibits the reaction [Thioacetamide results in increased expression of CYGB mRNA]17180598
D013853Thioacetamidehalofuginone inhibits the reaction [Thioacetamide results in increased expression of CYGB protein]17180598
D013853Thioacetamideinchinko-to inhibits the reaction [Thioacetamide results in increased expression of CYGB protein]15288473
D013853ThioacetamideMethionine inhibits the reaction [Thioacetamide results in increased expression of CYGB protein]15158331
D013853ThioacetamideThioacetamide results in increased expression of CYGB mRNA11320098|1571648
D013853ThioacetamideThioacetamide results in increased expression of CYGB protein11320098|1515833
D013893ThiramThiram results in decreased expression of CYGB mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CYGB mRNA27441981
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CYGB protein27441981
D014212TretinoinTretinoin results in increased expression of CYGB mRNA20530235
D014212TretinoinTretinoin results in decreased expression of CYGB mRNA23724009
D014415TunicamycinTunicamycin results in decreased expression of CYGB mRNA22378314
D014520UrethaneUrethane results in decreased expression of CYGB mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYGB mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of CYGB mRNA26272509
D014635Valproic AcidValproic Acid results in increased methylation of CYGB gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CYGB mRNA21427059
C025643vinclozolinvinclozolin results in increased expression of CYGB mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004096catalase activity-IEA-  
GO:0004601peroxidase activity-ISS11320098  
GO:0005344oxygen carrier activity-NAS11919282  
GO:0005506iron ion binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0008941nitric oxide dioxygenase activity-TAS-  
GO:0019825oxygen binding-IEA-  
GO:0020037heme binding-IEA-  
GO:0047888fatty acid peroxidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IEA-  
GO:0006979response to oxidative stress-ISS11320098  
GO:0010764negative regulation of fibroblast migration-IEA-  
GO:0015671oxygen transport-NAS11919282  
GO:0015671oxygen transport-TAS-  
GO:0019395fatty acid oxidation-IEA-  
GO:0032966negative regulation of collagen biosynthetic process-IEA-  
GO:0050999regulation of nitric-oxide synthase activity-TAS-  
GO:0098869cellular oxidant detoxification-IEA-  
GO:2000490negative regulation of hepatic stellate cell activation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0016607nuclear speck-IDA-  
GO:0043005neuron projection-IEA-  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-202131Metabolism of nitric oxideTAS
R-HSA-203615eNOS activationTAS
R-HSA-203765eNOS activation and regulationTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-8981607Intracellular oxygen transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27441981Evaluation of globins expression in brain, heart, and lung in rats exposed to side stream cigarette smoke. (2017 Apr)Tae BEnviron Toxicol