Gene: BTBD9

114781
dJ322I12.1
BTB domain containing 9
protein-coding
6p21.2
Ensembl:ENSG00000183826 MIM:611237 Vega:OTTHUMG00000014634 UniprotKB:Q96Q07
NG_016545.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.962e-1 (AD)  3.050e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2814889chr6:38551985 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HTT0.95
IQSEC20.947
APBA10.936
MTA30.933
TTBK10.931
SIPA1L10.929
GRAMD1B0.929
LZTS30.927
SYNGAP10.925
KIAA05130.925

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.537
SGMS2-0.501
MYL3-0.496
SNHG18-0.496
C9orf135-0.494
OR4F5-0.491
RAI14-0.483
SEPT10-0.481
HEY2-0.478
CTNNA3-0.468

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of BTBD9 mRNA"21346803
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of BTBD9 mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of BTBD9 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of BTBD9 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of BTBD9 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of BTBD9 mRNA24449571
D001151ArsenicArsenic affects the methylation of BTBD9 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BTBD9 mRNA20064835|2187194
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BTBD9 mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BTBD9 mRNA"26238291
D001629BezafibrateBezafibrate results in increased expression of BTBD9 mRNA18787029
C006780bisphenol Abisphenol A affects the expression of BTBD9 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of BTBD9 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of BTBD9 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of BTBD9 mRNA22079614
C018475butyraldehydebutyraldehyde results in decreased expression of BTBD9 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of BTBD9 promoter22457795
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of BTBD9 mRNA28472532
D003042CocaineCocaine results in increased expression of BTBD9 mRNA17898221
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of BTBD9 mRNA27392435
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of BTBD9 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BTBD9 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of BTBD9 mRNA23550701
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BTBD9 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of BTBD9 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of BTBD9 mRNA24796395
D007854LeadLead results in decreased expression of BTBD9 mRNA19921347
C008261lead acetatelead acetate results in increased expression of BTBD9 mRNA20542052
D008727MethotrexateMethotrexate results in decreased expression of BTBD9 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of BTBD9 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of BTBD9 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BTBD9 mRNA"25620056
D011441PropylthiouracilPropylthiouracil results in increased expression of BTBD9 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BTBD9 mRNA28213091
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BTBD9 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BTBD9 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BTBD9 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BTBD9 mRNA25613284
D014520UrethaneUrethane results in increased expression of BTBD9 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of BTBD9 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007616long-term memory-IEA-  
GO:0008344adult locomotory behavior-IBA21873635  
GO:0042428serotonin metabolic process-IEA-  
GO:0042748circadian sleep/wake cycle, non-REM sleep-IEA-  
GO:0048512circadian behavior-IBA21873635  
GO:0050804modulation of chemical synaptic transmission-IBA21873635  
GO:0050951sensory perception of temperature stimulus-IEA-  
GO:0060586multicellular organismal iron ion homeostasis-IEA-  
GO:1900242regulation of synaptic vesicle endocytosis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26174813New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder. (2015 Sep)Alemany SAm J Med Genet B Neuropsychiatr Genet