Gene: LMTK3

114783
LMR3|PPP1R101|TYKLM3
lemur tyrosine kinase 3
protein-coding
19q13.33
Ensembl:ENSG00000142235 Vega:OTTHUMG00000183312 UniprotKB:Q96Q04
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.418e-1 (AD)  8.769e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00866814chr19:49017364LMTK3Promoter6.280e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRIN10.951
GRIK50.936
BRSK20.936
PRRT10.935
SNPH0.935
SPTBN40.933
LZTS30.927
TTBK10.927
PIANP0.926
NRXN20.925

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.597
OR4F29-0.554
TFPI2-0.472
SEPT10-0.445
REST-0.442
WWTR1-0.433
C9orf135-0.419
RAI14-0.417
SGMS2-0.412
AGTR1-0.411

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of LMTK3 mRNA27392435
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of LMTK3 mRNA27392435
D007854LeadLead results in increased expression of LMTK3 mRNA19921347
D008694MethamphetamineMethamphetamine results in decreased expression of LMTK3 mRNA26307267
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of LMTK3 mRNA"20188158
D009151Mustard GasMustard Gas results in increased expression of LMTK3 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of LMTK3 protein"21135415
D010936Plant ExtractsPlant Extracts results in decreased expression of LMTK3 mRNA23557933
C005556propionaldehydepropionaldehyde results in increased expression of LMTK3 mRNA26079696
D018038Sodium SeleniteSodium Selenite results in decreased expression of LMTK3 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LMTK3 mRNA24680724
C012589trichostatin Atrichostatin A affects the expression of LMTK3 mRNA28542535
D014635Valproic AcidValproic Acid results in decreased methylation of LMTK3 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0004674protein serine/threonine kinase activity-IEA-  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IEA-  
GO:0010923negative regulation of phosphatase activity-IDA19389623  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005575cellular_component-ND-  
GO:0016021integral component of membrane-IEA-  
GO:0030424axon-IEA-  
GO:0030425dendrite-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24510346Preoperative serum LMTK3 as a novel biomarker in non-small cell lung cancer. (2014 May)Xu ZTumour Biol