Gene: CSMD2

114784
dJ1007G16.1|dJ1007G16.2|dJ947L8.1
CUB and Sushi multiple domains 2
protein-coding
1p35.1
Ensembl:ENSG00000121904 MIM:608398 Vega:OTTHUMG00000011135 UniprotKB:Q7Z408
NG_053181.1
PubMed|SNP Mapped
8   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.718e-1 (AD)  7.227e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2625684chr1:34039514 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2164581chr1:34025957 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2358756chr1:34014321 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs7536114chr1:33913774 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs911216chr1:33909598 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs7533254chr1:33716230 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs416391chr1:33582668 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6701268chr1:33575591 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTC10.853
CACNA1C0.849
CACNA1D0.841
ABCC50.839
ARL100.838
ZNF3370.837
CHST150.835
TRIO0.835
CELSR30.832
ACTN10.83

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.478
ENDOU-0.428
S100A1-0.428
RBP1-0.419
NXT2-0.418
S100A14-0.404
RARRES2-0.399
ASB4-0.398
FOLR1-0.398
MAPKAPK3-0.398

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CSMD2 mRNA"28973690
D000082AcetaminophenAcetaminophen results in decreased expression of CSMD2 mRNA26690555
D001280AtrazineAtrazine results in decreased expression of CSMD2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CSMD2 gene25435355
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of CSMD2 mRNA21453500
C006780bisphenol Abisphenol A affects the expression of CSMD2 mRNA21786754
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of CSMD2 mRNA24763279
C016366dibenzothiophenedibenzothiophene results in decreased expression of CSMD2 mRNA23656968
D002117CalcitriolCalcitriol results in increased expression of CSMD2 mRNA16002434
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of CSMD2 mRNA24763279
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CSMD2 mRNA26752646
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of CSMD2 mRNA21453500
D053260SootSoot results in increased expression of CSMD2 mRNA26551751
D014635Valproic AcidValproic Acid results in increased methylation of CSMD2 gene28853863
D014635Valproic AcidValproic Acid affects the expression of CSMD2 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22064162Genome-wide association study of comorbid depressive syndrome and alcohol dependence. (2012 Feb)Edwards ACPsychiatr Genet