Gene: MBD6

114785
-
methyl-CpG binding domain protein 6
protein-coding
12q13.3
Ensembl:ENSG00000166987 Vega:OTTHUMG00000170099 UniprotKB:Q96DN6
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.577e-1 (AD)  3.767e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1148556chr12:57523742 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUP1880.853
MAML10.846
TYK20.835
HDAC70.822
TTC310.821
ZXDC0.819
CRTC30.808
MDM40.804
ARHGEF10.796
PNN0.796

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.534
OR4F29-0.509
PAGE4-0.268
AKAP14-0.256
C22orf42-0.233
UNCX-0.232
FOXB1-0.231
CFC1-0.23
HMX2-0.23
OTP-0.226

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MBD6 mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MBD6 mRNA19770486
C015001arsenitearsenite affects the expression of MBD6 mRNA22959463
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MBD6 mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of MBD6 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of MBD6 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of MBD6 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of MBD6 mRNA26191083
C000944dicrotophosdicrotophos results in increased expression of MBD6 mRNA28302478
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MBD6 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of MBD6 mRNA23649840
C069837fullerene C60fullerene C60 results in increased expression of MBD6 mRNA19167457
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of MBD6 mRNA17183730
C492448ICG 001ICG 001 results in increased expression of MBD6 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MBD6 mRNA25613284
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MBD6 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MBD6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MBD6 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of MBD6 mRNA19167457
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of MBD6 mRNA18593933
C006253pirinixic acidpirinixic acid results in increased expression of MBD6 mRNA18301758
D010936Plant ExtractsPlant Extracts results in decreased expression of MBD6 mRNA23557933
D011794QuercetinQuercetin results in increased expression of MBD6 mRNA21632981
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of MBD6 mRNA21427059
D018038Sodium SeleniteSodium Selenite results in increased expression of MBD6 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MBD6 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MBD6 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MBD6 mRNA26290441
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of MBD6 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MBD6 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MBD6 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of MBD6 mRNA22378314
D014520UrethaneUrethane results in increased expression of MBD6 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of MBD6 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of MBD6 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of MBD6 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of MBD6 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of MBD6 mRNA21427059
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of MBD6 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA bindingNOTIDA20700456  
GO:0003682chromatin binding-IBA21873635  
GO:0003682chromatin binding-IDA20700456  
GO ID GO Term Qualifier Evidence PubMed
GO:0016579protein deubiquitination-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA20700456  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0010369chromocenter-IBA21873635  
GO:0010369chromocenter-IDA20700456  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689603UCH proteinasesTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal