Gene: CSMD3

114788
-
CUB and Sushi multiple domains 3
protein-coding
8q23.3
Ensembl:ENSG00000164796 MIM:608399 Vega:OTTHUMG00000157027 UniprotKB:Q7Z407
NC_000008.11
SNP Mapped
5   ANCO-SNPs
CD|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.097e-1 (AD)  4.399e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6996697chr8:113262046 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs10505201chr8:113214414 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1420852chr8:112252548 (GRCh38.p7)C>Gcocaine dependenceSNV(Single Nucleotide Variation)
rs6995441chr8:112243993 (GRCh38.p7)T>Ccocaine dependenceSNV(Single Nucleotide Variation)
rs4876460chr8:112234021 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRC70.918
CSMD10.907
RASAL20.905
PRKAA20.904
CHL10.901
GABRA40.897
EML50.895
CHM0.894
CDC400.894
LRRTM30.893

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.493
ROM1-0.485
RAB13-0.479
HEY2-0.476
COPZ2-0.476
FLT3LG-0.448
RHOD-0.444
MYL3-0.441
CDC42EP5-0.438
SNHG18-0.433

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CSMD3 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CSMD3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CSMD3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CSMD3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CSMD3 mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CSMD3 mRNA"28973690
D000082AcetaminophenAcetaminophen results in decreased expression of CSMD3 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CSMD3 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CSMD3 gene27153756
D001151ArsenicArsenic affects the methylation of CSMD3 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CSMD3 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CSMD3 mRNA20713471
C006780bisphenol Abisphenol A results in decreased expression of CSMD3 mRNA24465770
C006780bisphenol Abisphenol A results in decreased expression of CSMD3 mRNA25181051
D003471CuprizoneCuprizone results in decreased expression of CSMD3 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of CSMD3 mRNA20106945
C052034fenoxycarbfenoxycarb results in increased expression of CSMD3 mRNA27553699
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of CSMD3 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CSMD3 mRNA23103053
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CSMD3 mRNA"25510870
D053260SootSoot results in increased expression of CSMD3 mRNA26551751
D014635Valproic AcidValproic Acid affects the expression of CSMD3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of CSMD3 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0050773regulation of dendrite development-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-ISS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal